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Adipose Tissue Lipoprotein Lipase In Chronic Hemodialysis: Role In Plasma Triglyceride Metabolism.
A. Goldberg, D. Sherrard, J. Brunzell
Published 1978 · Medicine
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The role of adipose tissue lipoprotein lipase (LPL) in the pathogenesis of hypertriglyceridemia in uremic patients receiving maintenance hemodialysis was evaluated. The fasting level of adipose tissue LPL activity was reduced below normal (3.4 +/- 2.5 microU/106 cells; n = 23; mean +/- SD) in hypertriglyceridemic dialysis patients (1.5 +/- 0.8; P less than 0.01; n = 15) and did not differ from normal in normotriglyceridemic dialysis patients (2.5 +/- 2.4; P = NS; n = 13). The enzyme activity increased as a function of relative body weight in normotriglyceridemic hemodialysis patients (r = 0.21; P less than 0.05) but not in the hypertriglyceridemic group (r = 0.21; P = NS). There was an abnormal response of LPL to feeding in the hypertriglyceridemic dialysis patients. The postprandial level of LPL was significantly lower in hypertriglyceridemic dialysis patients (2.2 +/- 1.0; n = 9) than in normotriglyceridemic dialysis patients (3.9 +/- 1.9; P less than 0.05; n = 10) or normal controls (4.8 +/- 1.8; P less than 0.01; n = 12). Whereas the postprandial change in LPL was inversely related to the fasting enzyme activity in normotriglyceridemic dialysis patients (r = 0.74; P less than 0.02; n = 10) and in normal controls (r = 0.58; P less than 0.05; n = 12), no such relationship existed in hypertriglyceridemic dialysis patients (r = 0.17; P = NS; n = 9). Furthermore, fasting plasma triglyceride levels in the entire group of dialysis patients were a function of the postprandial level of LPL activity (rs = 0.574; P less than 0.02; n = 19). Since the level of LPL 1) is below normal in both the fasted and fed state in the hypertriglyceridemic hemodialysis patients, 2) is normal in both the fasted and fed state in the normotriglyceridemic hemodialysis patients, and 3) in the fed state is inversely correlated with the fasting plasma triglyceride concentration in the entire group of hemodialysis patients, it is proposed that adipose tissue LPL plays a role in the etiology of hypertriglyceridemia in hemodialysis patients.
This paper references
Hypertriglyceridemia. A metabolic consequence of chronic renal failure.
J. Bagdade (1968)
Relationship of lipoprotein lipase activity to triglyceride uptake in adipose tissue.
A. S. Garfinkel (1967)
Intra- and extracellular forms of lipoprotein lipase in adipose tissue.
P. Nilsson-ehle (1976)
Microscopic fat cell size measurements on frozen-cut adipose tissue in comparison with automatic determinations of osmium-fixed fat cells.
L. Sjöström (1971)
Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests.
J. Brunzell (1976)
A comparative study of post-heparin lipolytic activity and a purified human plasma triacylglycerol lipase.
C. Ehnholm (1974)
Effects of prolonged fast on lipoprotein lipase activity eluted from human adipose tissue.
B. Persson (1970)
Release of lipoprotein lipase activity from isolated fat cells. II. Effect of heparin.
J. E. Stewart (1974)
Effect of nutritional status on rat adipose tissue, muscle and post-heparin plasma clearing factor lipase activities: their relationship to triglyceride fatty acid uptake by fat-cells and to plasma insulin concentrations.
A. Cryer (1976)
Lipoprotein lipase activity of human adipose tissue in health and in some diseases with hyperlipidemia as a common feature.
B. Persson (1973)
Hormone-fuel concentrations in anephric subjects. Effect of hemodialysis (with special reference to amino acids).
O. Ganda (1976)
Effect of fat cell size, restrictive diet and diabetes on lipoprotein lipase release by human adipose tissue.
B. Guy-grand (1975)
ENDOCRINOLOGY AND METABOLISM IN UREMIA AND DIALYSIS: A CLINICAL REVIEW
H. Feldman (1975)
Inhibition of lipoprotein lipase by uremic plasma, a possible cause of hypertriglyceridemia.
T. Murase (1975)
SERIAL STUDIES ON THE METABOLISM OF HUMAN ADIPOSE TISSUE. I. LIPOGENESIS AND FREE FATTY ACID UPTAKE AND RELEASE IN SMALL ASPIRATED SAMPLES OF SUBCUTANEOUS FAT.
J. Hirsch (1964)
Lipoprotein lipase activity in adipose tissue and in postheparin plasma in human obesity.
M. R. Taskinen (1977)
The role of clearing-factor lipase (lipoprotein lipase) in the transport of plasma triglycerides.
D. S. Robinson (1975)
Prevalence of serum lipid abnormalities in chronic hemodialysis.
J. Brunzell (1977)
Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic Rats
C. R. Morgan (1963)
Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction.
J. Goldstein (1973)
Human Adipose Tissue Lipoprotein Lipase: Comparison of Assay Methods and Expressions of Activity 1
O. Pykälistö (1975)
Uremic lipemia: an unrecognized abnormality in triglyceride synthesis and removal.
J. Bagdade (1968)
Selective deficiency of hepatic triglyceride lipase in uremic patients.
R. Mordasini (1977)
SITES OF LIPOPROTEIN LIPASE ACTIVITY IN ADIPOSE TISSUE PERFUSED WITH CHYLOMICRONS
E. J. Blanchette-Mackie (1971)
Effects of chronic uremia, hemodialysis, and renal transplantation on plasma lipids and lipoproteins in man.
J. Bagdade (1976)
Defective triglyceride removal in lipemia associated with peritoneal dialysis and haemodialysis.
D. Cattran (1976)
Determinants of human adipose tissue lipoprotein lipase. Effect of diabetes and obesity on basal- and diet-induced activity.
O. Pykälistö (1975)
Comparison of the triglyceride lipase of liver, adipose tissue, and postheparin plasma.
J. Larosa (1972)
Relation between incorporation of triglyceride fatty acids and heparin-released lipoprotein lipase from adipose tissue slices
A. Bezman (1962)
Sequential induction of two species of lipoprotein lipase.
A. S. Garfinkel (1973)
Tissue lipoprotein lipase in normal individuals and in individuals with exogenous hypertriglyceridemia and the relationship of this enzyme to assimilation of fat.
W. Harlan (1967)
Evidence that hemodialysis does not improve the glucose tolerance of patients with chronic renal failure.
R. S. Swenson (1974)
Plasma post-heparin lipolytic activity and triglyceride clearance in uremic and hemodialysis patients and renal allograft recipients.
Ibels Sl (1976)
Effect of nutrition on species of lipoprotein lipase.
M. Schotz (1972)
Changes in glucose tolerance, insulin, serum lipids and lipoproteins in patients with renal failure on intermittent haemodialysis
K. Arora (1973)
Reversal of decreased human adipose tissue lipoprotein lipase and hypertriglyceridemia after treatment of hypothyroidism.
O. Pykälistö (1976)
Studies on the nature and causes of hyperlipidaemia in uraemia, maintenance dialysis and renal transplantation.
L. Ibels (1975)
Inhibition of Postheparin Lipolytic Activity in Uremia and its Relationship to Hypertriglyceridemia 1
J. Boyer (1970)
Lipids and lipoproteins in chronic uraemia. A study of the influence of regular haemodialysis.
J. C. Daubresse (1976)
INCREASED ADIPOSE-TISSUE LIPOPROTEIN-LIPASE ACTIVITY IN MODERATELY OBESE MEN AFTER WEIGHT REDUCTION
R. Schwartz (1978)
Chromatographically homogeneous lecithin from egg phospholipids
W. Singleton (1965)
Adipocyte metabolism in endogenous hypertriglyceridemia.
B. Larsson (1975)
Separation of molecular species of lipoprotein lipase from adipose tissue.
A. S. Garfinkel (1972)
Effects of insulin on lipoprotein lipase activity in the rat heart and adipose tissue.
J. Borensztajn (1972)
Lipoprotein Lipase Activity and Uptake of Exogenous Triglycerides in Fat Cells of Different Size
P. Björntorp (1975)
Morphological changes in the adipocyte during fat deposition and mobilization.
R. Goldrick (1967)
This paper is referenced by
Reduced thermic effect of feeding in obesity: role of norepinephrine.
R. Schwartz (1983)
Decreased VLDL apoprotein CII/apoprotein CIII ratio may be seen in both normotriglyceridemic and hypertriglyceridemic patients on chronic hemodialysis treatment.
Y. Wakabayashi (1987)
Changes in lipoproteins induced by the remnant kidney tissue or binephrectomy in chronic uremic patients treated by hemodialysis.
D. Robert (1989)
Endurance exercise training. An effective therapeutic modality for hemodialysis patients.
H. Harter (1985)
Lipid abnormalities in patients with chronic kidney disease: implications for the pathophysiology of atherosclerosis.
W. Keane (2013)
Adipose tissue lipoprotein lipase activity in type III hyperlipoproteinemia.
A. Goldberg (1979)
Cardiovascular risk factors in chronic renal failure and hemodialysis populations.
K. W. Ma (1992)
慢性血液透析患者の中間型リポ蛋白 (IDL) の性状
園部 美弥彦 (1987)
Postheparin lipolytic activity in acute and chronic renal failure.
K. Gupta (1994)
Study on the inhibitory effect of uremic plasma on lipoprotein lipase.
S. Yukawa (1992)
Alteration of the lipid and apolipoprotein contents of lipoprotein (a) in haemodialysis patients
V. Hugue (1996)
Alterations in plasma levels of apolipoprotein A-IV in various clinical entities
Y. Miyata (2007)
Expression of Apolipoprotein B in the Kidney Attenuates Renal Lipid Accumulation*
Marcin Krzystanek (2010)
The Serum Paraoxonase Activity in Patients with Chronic Renal Failure and Hyperlipidemia
G. Paragh (1998)
Dyslipidemia of chronic renal failure: the nature, mechanisms, and potential consequences.
N. Vaziri (2006)
Effect of uremia on HDL composition, vascular inflammation, and atherosclerosis in wild-type mice.
C. Bang (2007)
Lipoprotein heterogeneity in end-stage renal disease.
J. Joven (1993)
Different types of heparin in haemodialysis: long-term effects on post-heparin lipases.
M. Árnadóttir (1994)
High-Density Lipoprotein Cholesterol Sub fractions in Chronic Uremia
J. Rubiés-prat (1987)
Carnitine depletion as a probable cause of hyperlipidemia in uremic patients on maintenance hemodialysis.
M. Maebashi (1983)
Postheparin plasma triglyceride lipases in chronic hemodialysis: evidence for a role for hepatic lipase in lipoprotein metabolism.
D. Applebaum-Bowden (1979)
Chylomicronemia syndrome. Interaction of genetic and acquired hypertriglyceridemia.
J. Brunzell (1982)
Pathogenesis of dyslipoproteinemia in renal insufficiency: the role of lipoprotein lipase and hepatic lipase.
M. Árnadóttir (1997)
進 湯川 (1983)
Influence of end-stage renal failure on concentrations of free apolipoprotein A-1 in serum.
F. Duval (1989)
Down-regulation of VLDL receptor expression in chronic experimental renal failure.
N. Vaziri (1997)
Lipoprotein lipase in hemodialysis patients and healthy controls : effects of heparin
B. Näsström (2004)
Apolipoprotein and lipid abnormalities in uremic children on hemodialysis.
T. Ohta (1985)
Lipoprotein abnormalities in hyperlipidemic and normolipidemic men on hemodialysis with chronic renal failure.
M. Sentí (1992)
Increased lipoprotein-remnant formation in chronic renal failure.
P. Nestel (1982)
Lipoprotein lipase: its physiological and clinical significance.
M. Hamosh (1983)
Factors of increase in serum triglyceride-rich lipoproteins in uremic rats.
J. B. Roullet (1985)See more