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RET Expression In Papillary Thyroid Cancer From Patients Irradiated In Childhood For Benign Conditions.
B. J. Collins, G. Chiappetta, A. Schneider, M. Santoro, F. Pentimalli, L. Fogelfeld, T. Gierlowski, E. Shore-Freedman, G. Jaffe, A. Fusco
Published 2002 · Medicine
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Both external and internal exposure to radiation have been linked to the development of papillary thyroid cancer. Rearrangement of the gene for RET tyrosine kinase and subsequent expression of this protein has also been found to occur in many papillary thyroid cancers, and with increased frequency in radiation-related cancers following the Chernobyl accident. However, little has been reported on the frequency of RET rearrangements in cancers after exposure to external radiation. We here report on RET protein immunoreactivity in paraffin-embedded thyroid samples from 30 patients with papillary thyroid cancer who received radiation treatment during childhood for benign conditions at Michael Reese Hospital in Chicago, and in 34 patients identified from the tumor registry as having papillary thyroid cancer with no history of therapeutic radiation. The subjects were characterized by sex, age at surgery, and the following attributes of tumor pathology: size, number of lobes involved, number of foci, lymph node metastases, and soft tissue invasion. Representative tissue samples were reacted with an antibody against the RET tyrosine kinase domain whose expression has been shown to correlate highly with RET/PTC rearrangements. A greater percentage of cancers positive for RET immunoreactivity was found in the radiation-exposed group (86.7% vs. 52.9%, P = 0.006). Although the mean age at surgery of the exposed group was lower than the control group, there was no correlation of positive RET immunoreactivity with the age at surgery. No characteristics of the tumors were associated with positive RET immunoreactivity. In summary, the greater incidence of RET-immunopositives in the irradiated group indicates that the expression of RET immunoreactivity is strongly associated with radiation exposure, but the prognostic significance of this is not yet clear.
This paper references
Identification of a novel subtype of H4-RET rearrangement in a thyroid papillary carcinoma and lymph node metastasis.
R. Giannini (2000)
An epidermal growth factor receptor / ret chimera generates mitogenic and transforming signals : evidence for a ret - specific signaling path
G Tallini (1998)
Thyroid cancer occurring as a late consequence of head-and-neck irradiation. Evaluation of 1056 patients.
M. Favus (1976)
RET/PTC oncogene activation defines a subset of papillary thyroid carcinomas lacking evidence of progression to poorly differentiated or undifferentiated tumor phenotypes.
G. Tallini (1998)
Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children.
Y. Nikiforov (1997)
Thyroid diseases: tumors: carcinoma of follicular epithelium
AB Schneider (2000)
ret rearrangements in Japanese pediatric and adult papillary thyroid cancers.
T. Motomura (1998)
Pediatric thyroid cancer after the chernobyl disaster. Pathomorphologic study of 84 cases (1991–1992) from the republic of Belarus
Y. Nikiforov (1994)
Thyroid carcinoma in children and adolescents in Ukraine after the Chernobyl nuclear accident
M. Tronko (1999)
RET/PTC rearrangements in thyroid nodules: studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults.
R. Elisei (2001)
RET receptor expression in thyroid follicular epithelial cell-derived tumors.
G. Bunone (2000)
RET/PTC oncogene activation is an early event in thyroid carcinogenesis.
G. Viglietto (1995)
High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: a strong correlation between RET/PTC3 and the solid-follicular variant.
G. Thomas (1999)
The Chernobyl accident and its consequences: update at the millennium.
R. Tuttle (2000)
RET protein expression has no prognostic impact on the long-term outcome of papillary thyroid carcinoma.
F. Basolo (2001)
Expression and alternative splicing of c-ret RNA in papillary thyroid carcinomas
Ø. Fluge (2001)
Low rate of ret proto‐oncogene activation (PTC/retTPC) in papillary thyroid carcinomas from saudi arabia
M. Zou (1994)
High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation
A. Bounacer (1997)
Low rate of ret proto-oncogene activation (PTC/ret) in papillary thyroid carcinomas
MJ Zou (1994)
Thyroid Cancer Following Exposure to Radioactive Iodine
J. Robbins (2004)
PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas
M. Grieco (1990)
A new form of RET rearrangement in thyroid carcinomas of children after the Chernobyl reactor accident.
S. Klugbauer (1996)
Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype.
M. Santoro (1992)
Oncogenic rearrangements of the RET proto-oncogene in papillary thyroid carcinomas from children exposed to the Chernobyl nuclear accident.
L. Fugazzola (1995)
Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma.
F. Basolo (2002)
Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-chernobyl papillary thyroid carcinomas: biological, phenotypic, and clinical implications.
H. Rabes (2000)
Detection of the PTC/retTPC oncogene in human thyroid cancers.
S. Jhiang (1992)
Childhood exposure due to the Chernobyl accident and thyroid cancer risk in contaminated areas of Belarus and Russia
P. Jacob (1999)
RET activation in adult and childhood papillary thyroid carcinoma using a reverse transcriptase-n-polymerase chain reaction approach on archival-nested material.
G. H. Williams (1996)
Chernobyl-related thyroid cancer in children of Belarus: a case-control study.
L. Astakhova (1998)
rearrange - ments , in thyroid tumors from patients who had received external radiation
R Elisei (2001)
Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies.
E. Ron (1995)
RET/PTC Activation in Hyalinizing Trabecular Tumors of the Thyroid
M. Papotti (2000)
Prevalence and distribution of ret/ptc 1, 2, and 3 in papillary thyroid carcinoma in New Caledonia and Australia.
E. Chua (2000)
Expression of Ret/PTC1, -2, -3, -delta3 and -4 in German papillary thyroid carcinoma.
B. Mayr (1998)
Thyroid cancer in childhood and adolescence. A report on twenty‐eight cases
Brian J. Duffy (1950)
Radiation‐Induced Tumors of the Head and Neck Following Childhood Irradiation: PROSPECTIVE STUDIES
A. Schneider (1985)
High prevalence of RET rearrangement in thyroid tumors of children from Belarus after the Chernobyl reactor accident.
S. Klugbauer (1995)
Activated RET oncogene in thyroid cancers of children from areas contaminated by Chernobyl accident
Takashi lto (1994)
Molecular genetics of childhood papillary thyroid carcinomas after irradiation: high prevalence of RET rearrangement.
H. Rabes (1998)
An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: evidence for a ret-specific signaling pathway.
M. Santoro (1994)
Tuberculosis treatment programmes in low-income countries
D. Wilkinson (1994)
Dose-response relationships for radiation-induced thyroid cancer and thyroid nodules: evidence for the prolonged effects of radiation on the thyroid.
A. Schneider (1993)
This paper is referenced by
Thyroid Nodules and Carcinoma
A. Corrias (2015)
Differentiated thyroid cancer in children and adults: same or distinct disease?
B. Jarzab (2007)
The influence of the environment on the development of thyroid tumors: a new appraisal.
M. A. Marcello (2014)
Mechanisms of Disease: molecular genetics of childhood thyroid cancers
S. Yamashita (2007)
The pituitary tumor transforming gene in thyroid cancer
G. Lewy (2012)
Papillary Microcarcinoma of the Thyroid
William D. Drucker (2006)
Ultrasound surveillance for radiation-induced thyroid carcinoma in adult survivors of childhood cancer.
Enrico Brignardello (2016)
RET Mediated Gene Expression and Cell-Migration
J. Cockburn (2011)
High frequency of level II-V lymph node involvement in RET/PTC positive papillary thyroid carcinoma.
Y. Wang (2008)
atualização Patogênese dos Tumores Diferenciados da Tiróide (Papilífero e Folicular)
E. Kimura (2005)
RET EXPRESSION AND ITS CORRELATION WITH CLINICOPATHOLOGIC DATA IN PAPILLARY THYROID CARCINOMA
Ante Punda (2018)
Radiation-Induced Thyroid Cancer
James Figge (2016)
Thyroidectomies from patients with history of therapeutic radiation during childhood and adolescence have a unique mutational profile
A. Assaad (2008)
Radiation exposure, young age, and female gender are associated with high prevalence of RET/PTC1 and RET/PTC3 in papillary thyroid cancer: a meta-analysis
Xuan Su (2016)
The effect of cervical X-irradiation on activity index of thyrocytes and plasma TSH: A pre-clinical model for radiation-induced thyroid damage
H. Santen (2005)
Genetic susceptibility to thyroid cancer : contributions of RET polymorphisms
Marina Grazielle Silva dos Santos (2012)
Consenso de diagnstico y manejo de los ndulos tiroideos no palpables
M. ClaudiaCampusano (2004)
Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to gamma-radiation: a model of carcinogenic chromosomal rearrangement induced by ionizing radiation.
C. Caudill (2005)
Endocrine intervention during irradiation does not prevent damage to the thyroid gland.
H. V. van Santen (2006)
Molecular Pathways Targeting the RET Pathway in Thyroid Cancer
Jr. Samuel A. Wells (2009)
Targeting the RET Pathway in Thyroid Cancer
S. Wells (2009)
Radiation-Induced Thyroid Cancer
Yuval Nachalon (2016)
The Etiology, Diagnosis and Treatment of Differentiated Thyroid Carcinoma in Children and Adolescents
Jiangqiao Geng (2014)
The molecular pathways induced by radiation and leading to thyroid carcinogenesis.
Y. Nikiforov (2004)
Molecular prognostic markers in papillary and follicular thyroid cancer: Current status and future directions
D. Handkiewicz-Junak (2010)
Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer.
R. Ciampi (2005)
Central role of RET in thyroid cancer.
M. Santoro (2013)
Childhood Diseases of the Thyroid and Parathyroid Glands
Hannah G. Piper (2012)
Low frequency of BRAF mutations in adult patients with papillary thyroid cancers following childhood radiation exposure.
B. J. Collins (2006)
The significance of gene mutations across eight major cancer types.
P. Paul (2019)
Ultrasound screening for thyroid carcinoma in childhood cancer survivors: a case series.
Enrico Brignardello (2008)
Development of Granulated Adsorbent for Clean-up of Water contaminated by Cesium
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