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Facile Synthesis Of A Chitosan Hybrid Of A Laminin‐related Peptide And Its Antimetastatic Effect In Mice

K. Hojo, M. Maeda, YU Mu, H. Kamada, Y. Tsutsumi, YASUHIRO NISHIY Ama, Tomoko Yoshikawa, K. Kurita, LAWRENCE H. Block, T. Mayumi, K. Kawasaki
Published 2000 · Chemistry, Medicine

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Laminin, a cell adhesion protein, consists of three peptide chains (α, β and γ‐1). The β chain contains a Tyr‐Ile‐Gly‐Ser‐Arg (YIGSR) sequence that has been found to inhibit experimental metastasis in mice. We have prepared a hybrid of a water‐soluble chitosan and a laminin‐related peptide, and have examined its inhibitory effect on experimental metastasis in mice.
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