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Successful Migraine Prophylaxis With Naproxen Sodium

K. Welch, D. Ellis, P. A. Keenan
Published 1985 · Medicine

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Naproxen sodium, a potent inhibitor of prostaglandin biosynthesis and platelet aggregation, was studied for efficacy in migraine prophylaxis in a randomized, double-blind, placebo-controlled, crossover trial. On naproxen treatment, 52% of the patients had no severe headaches, whereas 19 % had no severe headaches during placebo. Naproxen sodium was much better than placebo when patients' diaries were reviewed for severity of attacks, nausea, vomiting, activity reduction, duration of headache, and decreased use of therapeutic medication. The degree of platelet inhibition did not correlate with efficacy in preventing headache. Naproxen sodium can be recommended as a drug of first choice for migraine prevention.
This paper references
10.1016/S0140-6736(78)92159-1
ASPIRIN PROPHYLAXIS IN MIGRAINE
B. O’Neill (1978)
10.1212/WNL.22.4.366
The treatment of migraine with propranolol
R. Weber (1972)
Clinical trial of a new anti-bradykinin, anti-inflammatory drug, ketoprofen (19,583 RP) in migraine prophylaxis
P Stensrud (1974)
10.1111/j.1526-4610.1980.hed2002096.x
Naproxen in the Prevention of Migraine Attacks. A Double‐blind Placebo‐controlled Cross‐over Study
K. Lindegaard (1980)
10.1136/jcp.24.3.250
An assessment of platelet aggregation induced by 5-hydroxytryptamine
B. Hilton (1971)
10.1159/000308647
Ophthalmoplegic migraine: amelioration by Flufenamic acid, a prostaglandin inhibitor.
J. Rabey (1977)
10.1212/WNL.24.8.705
Effects of prostaglandins on the internal and external carotid blood flow in the monkey
K. Welch (1974)
Clinical and metabolic effects of different doses of prostaglandin E, in man
LA Carlson (1968)
10.1111/j.1526-4610.1976.hed1601024.x
DOUBLE BLIND STUDY OF PROPRANOLOL FOR MIGRAINE PROPHYLAXIS
S. Diamond (1976)
10.1038/194927B0
Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal
G. Born (1962)
Clinical trial of platelet inhibition, using aspirin and dipyridamole in migraine prophylaxis
B. E. Masel (1978)
10.1093/OXFORDJOURNALS.BMB.A071482
Unstable metabolites of arachidonic acid and their role in haemostasis and thrombosis.
S. Moncada (1978)
10.2307/2556170
The use of non-parametric methods in the statistical analysis of the two-period change-over design.
G. Koch (1972)
Migraine attacks: alleviation by an inhibitor of prostaglandin synthesis and action
Y Vardi (1976)
10.1093/BIOMET/56.1.75
An exact test for comparing matched proportions in crossover designs
J. Gart (1969)
10.1111/j.1526-4610.1975.hed1501018.x
“COMPLICATED MIGRAINE” ITS ASSOCIATION WITH INCREASED PLATELET AGGREGABILITY AND ABNORMAL PLASMA COAGULATION FACTORS
Z. Kalendovsky (1975)
10.1212/WNL.26.5.447
Migraine attacks
Y. Vardi (1976)
10.1016/S0140-6736(74)91131-3
A new method for the quantitative detection of platelet aggregates in patients with arterial insufficiency.
K. Wu (1974)
Sjaastad 0. Naproxen in the prevention of migraine attacks: a double-blind placebo-controlled crossover study
K F Lindegaard (1980)
10.1016/S0140-6736(79)90343-X
TOLFENAMIC ACID IS AS EFFECTIVE AS ERGOTAMINE DURING MIGRAINE ATTACKS
H. Hakkarainen (1979)
Platelet aggregability in migraine. Neurology (Minneap) 1977;27:843-8
Couch (1977)
10.1212/WNL.27.9.843
Platelet aggregability in migraine
J. Couch (1977)
Ad Hoc Committee on Classification of Headache: Classification of headache
(1962)
10.1001/ARCHNEUR.1973.00490260039007
Hemodynamic studies within the brain during migraine.
E. Skinhøj (1973)



This paper is referenced by
10.7326/0003-4819-137-10-200211190-00014
Pharmacologic Management of Acute Attacks of Migraine and Prevention of Migraine Headache
V. Snow (2002)
10.1007/BF02230907
A review of the treatment of primary headaches. Part I: Migraine
M. Leone (2005)
10.1111/j.1526-4610.1987.hed2707392.x
A Comparison of Naproxen Sodium, Acetaminophen and Placebo in the Treatment of Muscle Contraction Headache
D. S. Miller (1987)
10.1111/j.1526-4610.2006.00454.x
Use of a Pine Bark Extract and Antioxidant Vitamin Combination Product as Therapy for Migraine in Patients Refractory to Pharmacologic Medication
S. Chayasirisobhon (2006)
10.1111/j.1526-4610.1988.hed2803180.x
Naproxen Sodium for Muscle Contraction Headache Treatment
J. Sargent (1988)
10.2165/00023210-199606020-00001
Use of Over-the-Counter Drugs in Migraine
S. J. Gilkey (1996)
10.1586/ern.11.123
Evaluation of the use of sumatriptan–naproxen sodium for menstrual migraine and dysmenorrhea
G. Allais (2011)
10.1111/j.1526-4610.1990.hed3011710.x
A Comparative Study of Naproxen Sodium, Pizotyline and Placebo in Migraine Prophylaxis
A. Bellavance (1990)
10.1007/978-1-4612-2124-1_5
Migraine Headache Sample Case Studies
L. Robbins (2000)
Efficacy of Pinus radiata bark extract and vitamin C combination product as a prophylactic therapy for recalcitrant migraine and long-term results.
S. Chayasirisobhon (2013)
10.1111/ncn3.12322
Clinical practice guideline for chronic headache 2013
N. Araki (2019)
10.1111/j.1526-4610.1987.hed2707375.x
The Platelet and Migraine: A Nonspecific Association
R. Joseph (1987)
10.3760/CMA.J.ISSN.1673-4165.2010.01.002
EFNS guideline on the drug treatment of migraine - revised report of an EFNS task force
Cme Article (2009)
Guidelines for the diagnosis and management of migraine in clinical practice
W. Pryse‐Phillips (1997)
Nonsteroidal Anti-Inflammatory and Miscellaneous Drugs in Migraine Prophylaxis
S. Evers (2005)
10.1016/S0306-9877(96)90158-9
Magnesium taurate and fish oil for prevention of migraine.
M. Mccarty (1996)
10.1517/14728214.8.2.437
Emerging drugs in migraine treatment
C. Waeber (2003)
10.1212/WNL.35.12.1828
Author index to volume XXXV
(1985)
Evaluation and treatment of the adult patient with migraine.
Michael J. Polizzotto (2002)
10.1007/978-1-4684-0195-0_2
Migraine Abortive Medication
L. Robbins (1994)
10.1111/j.1468-1331.2006.01411.x
EFNS guideline on the drug treatment of migraine – report of an EFNS task force
S. Evers (2006)
10.1016/S0889-8545(05)70197-2
Diagnosis and management of headache.
J. Lewis (2001)
10.1007/978-1-4684-0195-0_1
Introduction to Migraine
L. Robbins (1994)
10.1111/J.1526-4610.1987.HED2703130.X
Amelioration of Ergotamine Withdrawal Symptoms With Naproxen
N. Mathew (1987)
10.1177/0333102491011S1183
Lornoxicam, A New Non-Steroidal Anti-Iflammatory Drug, in Migraine Prophylaxis: A Double-Blind Multicenter Study
E. Sternieri (1991)
10.1111/j.1526-4610.1988.hed2808550.x
Treatment Review: Non‐Steroid Anti‐Inflammatory Drugs in the Treatment and Long‐Term Prevention of Migraine Attacks
A. Pradalier (1988)
10.1111/j.1526-4610.1993.hed3301022.x
Efficacy of Meclofenamate Sodium versus Placebo in Headache and Craniofacial Pain
F. Mongini (1993)
10.1055/S-0038-1627343
Akuttherapie und Prophylaxe der Migräne - Leitlinie der Deutschen Migräne- und Kopfschmerzgesellschaft und der Deutschen Gesellschaft für Neurologie
S. Evers (2008)
10.1016/S0149-2918(96)80004-X
Clinical presentation and treatment of migraine.
T. Skaer (1996)
10.1007/978-1-4471-3127-4_10
Treatment of Acute Headaches
R. Peatfield (1986)
10.1007/s11606-013-2433-1
Preventive Pharmacologic Treatments for Episodic Migraine in Adults
T. Shamliyan (2013)
10.1080/00325481.1987.11699870
Migraine headache. Working for the best outcome.
S. Diamond (1987)
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