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Neuroexcitatory Plasma Amino Acids Are Elevated In Migraine

M. Ferrari, J. Odink, K. D. Bos, M. Malessy, G. Bruyn
Published 1990 · Medicine

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To investigate the role of glutamic (Glu) and aspartic acid (Asp) in migraine, we measured the plasma amino acids in migraine patients with and without aura, between and during attacks, and compared the profiles with the plasma amino acid profiles of tension headache patients and healthy controls. Between attacks, migraineurs (notably with aura) had substantially higher plasma Glu and Asp levels than did controls and tension headache patients. In addition, patients with migraine without aura showed low plasma histidine levels. During migraine attacks, Glu (and to a lesser extent Asp) levels were even further increased. The results suggest a defective cellular reuptake mechanism for Glu and Asp in migraineurs, and we hypothesize a similar defect at the neuronal/glial cell level, predisposing the brain of migraineurs to develop spreading depression.
This paper references
10.1056/NEJM196910022811405
Elevation of plasma glutamate in gout. Its possible role in the pathogenesis of hyperuricemia.
A. Pagliara (1969)
10.1159/000114421
Amino acids in urine in spontaneous migraine attacks.
O. Sjaastad (1972)
10.1016/0022-510X(89)90160-3
Release of platelet Met-enkephalin, but not serotonin, in migraine: A platelet response unique to migraine patients?
M. D. Ferrari (1989)
The distribution of amino acids between cellular and extracellular fluids; relation to growth.
H. Christensen (1948)
10.1001/ARCHNEUR.1986.00520100062016
The role of glutamate in neurotransmission and in neurologic disease.
J. T. Greenamyre (1986)
10.1111/j.1526-4610.1989.hed2909590.x
Low Brain Magnesium in Migraine
N. Ramadan (1989)
Intermediary metabolism of carbohydrates and amino acids
HS Maker (1989)
10.1152/AJPENDO.1986.251.1.E117
Glutamine and glutamate kinetics in humans.
D. Darmaun (1986)
Urinary excretion of biogenic amines in migraine and tension headache
MD Ferrari (1989)
Platelet excitatory amino acids in migraine
G Daposandrea (1989)
Wu-Rideout MY-C
LD Stegink (1986)
10.1039/AN9810600968
Determination of tryptophan in feeds and feed ingredients by high-performance liquid chromatography.
A. D. Jones (1981)
10.1111/j.1526-4610.1990.hed3003160.x
Methionine‐Enkephalin in Migraine and Tension Headache. Differences Between Classic Migraine, Common Migraine and Tension Headache, and Changes During Attacks.
M. Ferrari (1990)
10.1212/WNL.38.6.920
Excitatory amino acids are elevated in human epileptic cerebral cortex
A. Sherwin (1988)
10.1016/0303-8467(87)90189-2
Methionine-enkephalin and serotonin in migraine and tension headache
M. D. Ferrari (1987)
Serum amino acids in 3/sec spike-wave epilepsy
NM Van Gelder (1980)
Factors affecting plasma glutamate levels in normal adult subjects
L J Filer (1979)
Biochemistry of glutamate: glutamine and glutathione
A. Meister (1979)
10.1212/WNL.39.9.1239
Serotonin metabolism in migraine
M. Ferrari (1989)
Migraine. Clinical, therapeutic, conceptual and research aspects
F. C. Rose (1988)
10.1002/ANA.410220503
Abnormal glutamate metabolism in amyotrophic lateral sclerosis
A. Plaitakis (1987)
10.1016/0009-8981(71)90433-5
Amino acid metabolism in uraemic patients.
J. Condon (1971)
Biochemical differences between classic migraine, common migraine and tension headache
M D Ferrari
10.1002/ANA.410190202
Glutamate and the pathophysiology of hypoxic–ischemic brain damage
S. Rothman (1986)
10.1136/jnnp.29.3.190
Effects of reserpine on amino-acid excretion in patients with migraine.
R. W. Kimball (1966)
10.1016/0006-8993(88)90690-7
Evidence for a role of the N-methyl-d-aspartate (NMDA) receptor in cortical spreading depression in the rat
R. Marrannes (1988)
10.1126/science.163.3869.826
Monosodium L-Glutamate: Its Pharmacology and Role in the Chinese Restaurant Syndrome
H. Schaumburg (1969)
Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Headache Classification Committee of the International Headache Society.
(1988)
10.1002/NEU.480040406
Mechanisms involved in spreading depression.
A. van Harreveld (1973)
Handbook of neurochemistry, vol3. Metabolism in the nervous system
R P Shank (1983)
10.1038/307462A0
Magnesium gates glutamate-activated channels in mouse central neurones
L. Nowak (1984)
10.1111/j.1471-4159.1975.tb07680.x
CSF amino acids and plasma‐CSF amino acid ratios in adults 1
T. Perry (1975)
The biological and behavioural basis of migraine
M B Kennedy
10.1016/0009-8981(85)90193-7
Determination of glutamine and glutamate in plasma of men and women by ion exchange chromatography.
K. D. Bos (1985)
10.1126/SCIENCE.6121377
Abnormal glutamate metabolism in an adult-onset degenerative neurological disorder.
A. Plaitakis (1982)
Factors in the regulation of glutamate metabolism
HN Munro (1979)
10.1212/WNL.39.4.538
Preliminary observations on brain energy metabolism in migraine studied by in vivo phosphorus 31 NMR spectroscopy
K. Welch (1989)
10.1016/0166-2236(87)90115-9
Cortical spreading depression as a putative migraine mechanism
M. Lauritzen (1987)
10.1016/0006-8993(72)90141-2
Amino acid content of epileptogenic human brain: focal versus surrounding regions.
N. V. van Gelder (1972)
10.1038/182282B0
Metabolism of the Nervous System
J. H. Gaddum (1958)



This paper is referenced by
10.1016/S0165-0173(01)00081-9
Spreading depression: a review of the clinical relevance
A. Gorji (2001)
10.1007/s13361-015-1136-8
Large-Scale Mass Spectrometry Imaging Investigation of Consequences of Cortical Spreading Depression in a Transgenic Mouse Model of Migraine
Ricardo J. Carreira (2015)
10.1046/j.1468-2982.2000.00002.x
Are the Periodic Changes of Neurophysiological Parameters During the Pain-Free Interval in Migraine Related to Abnormal Orienting Activity?
M. Siniatchkin (2000)
10.1111/j.1468-2982.2009.01911.x
Low-frequency rTMS of the vertex in the prophylactic treatment of migraine
M. Teepker (2010)
10.1111/j.1468-2982.2006.01234.x
Platelet Glutamate Uptake and Release in Migraine With and Without Aura
M. Vaccaro (2007)
10.1111/j.1468-2982.1999.1901058.x
Lamotrigine in the Prophylactic Treatment of Migraine Aura— A Pilot Study
C. Lampl (1999)
10.1038/sj.bjp.0704325
GABA receptors modulate trigeminovascular nociceptive neurotransmission in the trigeminocervical complex
R. J. Storer (2001)
10.1007/s10072-010-0267-8
Pathogenesis of migraine: from neurotransmitters to neuromodulators and beyond
G. D’Andrea (2010)
10.1046/j.1526-4610.2001.111006119.x
Efficacy of Gabapentin in Migraine Prophylaxis
N. Mathew (2001)
10.1016/J.PHARMTHERA.2005.04.010
New and future migraine therapy.
N. Ramadan (2006)
10.1007/S11916-004-0059-Z
Anticonvulsants in migraine
William B. Young (2004)
10.1111/j.1468-2982.2005.00949.x
Altered Motion Perception in Migraineurs: Evidence for Interictal Cortical Hyperexcitability
A. Antal (2005)
Cerebrospinal Fluid Glutamate Levels in Chronic Migraine Cephalalgia Volume 24 Issue 9 Page 735 -september 2004
B. Santos (2005)
10.1046/j.1526-4610.2001.111006063.x
Aminergic Tone Correlates of Migraine and Tension‐type Headache: A Study Using the Tridimensional Personality Questionnaire
V. Di Piero (2001)
10.1111/j.1526-4610.2007.00727.x
Intracortical Inhibition and Facilitation in Migraine—A Transcranial Magnetic Stimulation Study
M. Siniatchkin (2007)
10.1046/j.1526-4610.1997.3703142.x
Pathogenesis of Posttraumatic Headache and Migraine: A Common Headache Pathway?
R. C. Packard (1997)
10.1046/j.1468-2982.1997.1707761.x
Platelet Sulphotransferase Activity, Plasma Sulphate Levels and Sulphation Capacity in Patients with Migraine and Tension Headache
Z. Alam (1997)
10.1007/s101940170013
Neurophysiology of migraine
G. Sandrini (2001)
10.1007/s00415-002-0834-x
Comparison of cortical excitability in chronic migraine (transformed migraine) and migraine without aura
V. Ozturk (2002)
Intervening in the Life Cycles of Scientific Knowledge Patrick Wilson, The Value of Currency
D. Swanson (1993)
10.1016/0006-8993(93)91644-8
Microdialysis of interstitial amino acids during spreading depression and anoxic depolarization in rat neocortex
M. Fabricius (1993)
10.1517/13543784.3.4.341
NMDA receptors: the first decade
J. Vender (1994)
10.1016/0753-3322(96)84716-0
Deficient habituation of evoked cortical potentials in migraine: a link between brain biology, behavior and trigeminovascular activation?
J. Schoenen (1996)
10.1177/0333102410380755
Visual metacontrast masking in migraine
A. J. Shepherd (2011)
10.1186/s10194-020-01105-6
Neurotransmitter and tryptophan metabolite concentration changes in the complete Freund’s adjuvant model of orofacial pain
E. K. Cseh (2020)
10.1007/s12031-018-1183-2
Different Pain States of Trigeminal Neuralgia Make Significant Changes in the Plasma Proteome and Some Biochemical Parameters: a Preliminary Cohort Study
Asghar Farajzadeh (2018)
10.1016/J.MEHY.2007.04.025
The minicolumnopathy of autism: A link between migraine and gastrointestinal symptoms.
M. Casanova (2008)
10.1186/s10194-018-0885-8
Increased thalamic glutamate/glutamine levels in migraineurs
Adina Bathel (2018)
10.1016/0006-8993(92)91028-D
Cholecystokinin antagonists inhibit in vivo voltammetric signals generated by KCl-induced slow wave depolarization in rat caudate
James W. Wilkerson (1992)
10.1016/S0072-9752(10)97065-6
Current and emerging therapies for migraine prevention and treatment.
C. Waeber (2010)
10.1016/j.pain.2010.07.029
Botulinum neurotoxin type A (BoNTA) decreases the mechanical sensitivity of nociceptors and inhibits neurogenic vasodilation in a craniofacial muscle targeted for migraine prophylaxis
P. Gazerani (2010)
10.1093/BRAIN/117.1.199
Pathophysiology of the migraine aura. The spreading depression theory.
M. Lauritzen (1994)
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