Online citations, reference lists, and bibliographies.
← Back to Search

Botulinum Toxin Treatment Of Tremors

J. Jankovic, K. Schwartz
Published 1991 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
We report the results of an open trial of botulinum toxin (Botox) in the treatment of 51 patients with disabling tremors, classified as dystonic (14), essential (12), combination of dystonic and essential (22), parkinsonian (1), peripherally induced (1), and midbrain (1). The average age of the patients was 55.8 years, and duration of symptoms was 13.9 years. During a total of 160 treatment visits, an average of 242 ± 75 units of Botox was injected per visit in cervical muscles of 42 patients with head tremor and 95 ± 38 in forearm muscles of 10 patients with hand tremor; one patient was injected in both. The average peak effect for all patients was rated as 3.0 (0 to 4 scale). Thirty-five (67%) patients improved (peak effect ≥1). The average latency from injection to response was 6.8 days, and the average duration of maximum improvement was 10.5 weeks. Local complications, lasting an average of 20.6 days, were noted in 17 (40%) patients injected for head tremor, consisting chiefly of dysphagia in 12 (29%), transient neck weakness in four (10%), and local pain in two (5%). Six (60%) patients with hand tremor had transient focal weakness. EMG recordings showed decreased amplitude of EMG bursts after Botox treatment. The results of this pilot study indicate that Botox injections can be used to control tremor in patients in whom other forms of therapy have failed.
This paper references

This paper is referenced by
Local botulinum toxin in the treatment of spastic drop foot
R. Dengler (2004)
Benefits and risks of pharmacological and surgical treatments for essential tremor: disease mechanisms and current management
F. Rincon (2005)
Use of Botulinum Neurotoxin in Parkinson’s Disease: A Critical Appraisal
W. H. Jost (2021)
Central and peripheral mechanisms
Joseph Jankovic (2001)
Pharmacological treatment of disabling tremor
Courtney R. Schadt (2005)
A new method for selective measurement of joint movement in hand tremor in Parkinson's disease patients
J. Rozman (2007)
Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine
B. Jabbari (2020)
Clinical Use of Botulinum Neurotoxin: Neuromuscular Disorders
A. Guidubaldi (2014)
Levodopa can worsen tremor associated with dystonia
D. Hensman (2006)
The Challenge of Managing Mild Parkinson's Disease
P. Lewitt (2000)
Botulinum Toxin in Clinical Practice
A. Hughes (2012)
Quantitative assessment of botulinum toxin treatment in 43 patients with head tremor
J. Wissel (1997)
Botulinum toxin in the treatment of tremors, dystonias, sialorrhea and other symptoms associated with Parkinson’s disease
J. K. Sheffield (2007)
CME The Cosmetic Use of Botulinum Toxin
Rod J. Rohrich (2003)
Botulinum toxin a injections for the treatment of hand tremors
R. Trosch (1994)
Guidelines for the therapeutic use of botulinum toxin in movement disorders
A. Berardelli (2005)
Approach to the treatment of limb disorders with botulinum toxin A. Experience with 187 patients.
S. Pullman (1996)
Botulinum toxin treatment for functional disability induced by essential tremor
C. Pacchetti (2000)
Citicoline in the Treatment of Essential Tremor
A. Mubaidin (2011)
Non-ischaemic causes of transient ischaemic attacks and minor strokes.
M. García-Escrig (1994)
Botulinum neurotoxins as therapeutics
R. Mehanna (2014)
Аффиксальный способ словообразования именных основ в якутском языке (на материале отглагольных имен существительных
Иванова Ирина Борисовна (2009)
Essential Tremor and Other Tremors
G. Deuschl (2010)
Botulinumtoxin Typ A
J. J. Lindern (2009)
Achalasia: A review of therapeutic options and outcomes
E. Silveira (2002)
The use of botulinum toxin to treat "striatal" toes.
Nir Giladi (1994)
Properties and use of botulinum toxin and other microbial neurotoxins in medicine.
E. Schantz (1992)
Surgical treatment of dystonia
C. Giller (2003)
Botulinum and Tetanus Neurotoxins
H. Niemann (1993)
Aspetti terapeutici attuali della tossina botulinica in neurologia
S. Sangla (2007)
Botulinum Toxin in the Treatment of Neurological Disorders
M. Denišlič (1994)
Botulinum toxin treatment is not effective for epilepsy partialis continua
D. Tarsy (1995)
See more
Semantic Scholar Logo Some data provided by SemanticScholar