Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Parkinson's Disease Rigidity

R. Cantello, M. Gianelli, D. Bettucci, C. Civardi, M. De Angelis, R. Mutani
Published 1991 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
We studied the EMG potentials evoked in the bilateral first dorsal interosseus muscle by electromagnetic stimulation of the corticomotoneuronal descending system in 10 Parkinson's disease patients and in 10 age- and sex-matched normal controls. We selected patients who did not have tremor but had predominant rigidity with asymmetric body involvement. On the rigid side of the PD patients, the threshold to cortical stimulation was lower than on the contralateral side or than normal values. On average, patients had normal central conduction times, but their motor evoked potentials (MEPs) on the rigid side were larger than those of controls when the cortical stimulus was at rest or during slight tonic contraction of the target muscle. In the latter condition, a silent period shorter than that of controls followed MEPs, whereas the peripheral silent period following ulnar nerve stimulation at the wrist was prolonged. Alpha motor neuron excitability, tested by the F-wave method, was enhanced on the rigid side at rest. In rigidity, spinal motor nuclei may be more responsive than normal to descending inputs from motor cortex, or the entire corticomotoneuron system may prove hyperexcitable under given conditions.
This paper references
10.1038/310407A0
The corticomotoneurone connection is normal in Parkinson's disease
J. Dick (1984)
Modulation of magnetic motor evokedpotentials in normal subjects and rigid parkinsonians
R Cantello
10.1016/S0140-6736(60)92186-3
Diseases of the basal ganglia. Their relation to disorders of movement.
D. Dennybrown (1960)
10.1113/jphysiol.1986.sp016190
The effect of percutaneous motor cortex stimulation on H reflexes in muscles of the arm and leg in intact man.
J. M. Cowan (1986)
10.1007/BF00313788
Assessment of motor neuron excitability in parkinsonian rigidity by the F wave
G. Abbruzzese (2004)
10.1136/jnnp.35.1.77
H reflex studies in patients with Parkinson's disease
J. Mcleod (1972)
10.1212/WNL.40.2.309
Corticofugal projections to the motor nuclei of the brainstem and spinal cord in humans
T. Iwatsubo (1990)
10.1136/jnnp.35.3.373
Levodopa in Parkinsonism: reduction in the electromyographic silent period and its relationship with tremor
D. McLellan (1972)
10.1016/0013-4694(90)90112-W
The influence of stimulus type on the magnetic excitation of nerve structures.
D. Claus (1990)
10.1152/JN.1987.58.5.1168
Motor-unit responses in human wrist flexor and extensor muscles to transcranial cortical stimuli.
B. Calancie (1987)
Chorea Huntington: abnormalities of motor responses evoked by magnetic brain stimulation
B U Meyer
10.1016/S0140-6736(85)92413-4
NON-INVASIVE MAGNETIC STIMULATION OF HUMAN MOTOR CORTEX
A. T. Barker (1985)
10.1212/WNL.36.11.1542
Cerebral blood flow in dementia
M. O’brien (1986)
10.1016/0013-4694(90)90170-O
Late muscular responses to transcranial cortical stimulation in man.
H. Holmgren (1990)
Amplitude changes of the MEP elicited by magnetic stimulation with aging and in Parkinson's disease (PD): further evidence for overlap between western PD and amyotrophic lateral sclerosis
A A Eisen (1990)
10.1136/jnnp.36.3.342
Dynamic spindle reflexes and the rigidity of Parkinsonism
D. McLellan (1973)
10.1016/0168-5597(91)90011-L
Spinal motor neuron excitability during the silent period after cortical stimulation.
P. Fuhr (1991)
Reflex mechanisms inparkinsonian rigidity
D Burke (1977)
Amplitude of the F wave: a potential means of documenting spasticity
A Eisen (1979)
10.1016/0168-5597(91)90074-8
Age-dependent decline in motor evoked potential (MEP) amplitude: with a comment on changes in Parkinson's disease.
A. Eisen (1991)
10.1159/000116448
Pathophysiology of rigidity and akinesia in Parkinson's disease.
R. Lee (1989)
10.1016/0006-8993(89)91339-5
Electric vs magnetic trans-cranial stimulation of the brain in healthy humans: a comparative study of central motor tracts ‘conductivity’ and ‘excitability’
M. Caramia (1989)
10.1007/978-1-4684-7688-0_6
Functional Consequences of Activity in Spinal Reflex Pathways
J. Rothwell (1987)
Mapping by microstimulation of projections from area 4 to motor units of the baboon's hand
P Andersen (1975)
Spinal segmental and longloop reflexes on spinal motoneurone excitability i n spasticity a n d rigidity. B r a i n
C B Yap
10.1002/ANA.410020206
L‐dopa effects on H‐reflex recovery in Parkinson's disease
D. Sax (1977)
10.1136/jnnp.36.3.334
The electromyographic silent period produced by supramaximal electrical stimulation in normal man
D. McLellan (1973)
10.1016/0013-4694(85)91094-6
Nervous propagation along 'central' motor pathways in intact man: characteristics of motor responses to 'bifocal' and 'unifocal' spine and scalp non-invasive stimulation.
P. Rossini (1985)
10.1136/jnnp.46.1.45
Physiological mechanisms of rigidity in Parkinson's disease.
A. Berardelli (1983)
The anatomic and physiologic bases of motor-evoked potentials.
P. Rossini (1988)
Hemispheric differences in thresholds to transcranial magnetic stimulation
S L Helmers
Stimulation of descending motor pathways in the spinal cord in humans: facilitation of motor responses by voluntary contraction
D Cros (1990)
10.1136/jnnp.30.4.325
Excitability of spinal motor neurones in normal subjects and patients with spasticity, Parkinsonian rigidity, and cerebellar hypotonia.
P. Z. Olsen (1967)
10.1016/0022-510X(90)90018-I
Abnormalities of central motor conduction in Parkinson's disease
R. Kandler (1990)
10.1002/CNE.901950212
Organization of corticospinal neurons in the monkey
E. Murray (1981)
10.1212/WNL.32.5.514
The mysterious motor function of the basal ganglia
C. Marsden (1982)
10.1016/0304-3940(87)90083-8
Different sites of action of electrical and magnetic stimulation of the human brain
B. Day (1987)
10.1093/BRAIN/110.5.1191
Motor cortex stimulation in intact man. 2. Multiple descending volleys.
B. Day (1987)
10.1016/S0140-6736(82)90670-5
SCOPE OF A TECHNIQUE FOR ELECTRICAL STIMULATION OF HUMAN BRAIN, SPINAL CORD, AND MUSCLE
P. Merton (1982)
10.1113/jphysiol.1987.sp016621
Responses in small hand muscles from magnetic stimulation of the human brain.
C. Hess (1987)
Mehls 0. A comparative electromyographic study of the reactions to passive movement in parkinsonism and in normal subjects
W M Landau (1966)
The evaluation of extrapyramidal disease
R C Duvoisin (1971)
10.1136/jnnp.34.5.508
Muscle silent period in Parkinson's disease
D. Higgins (1971)



This paper is referenced by
10.1093/PTJ/78.6.566
Trunk muscle performance in early Parkinson's disease.
K. J. Bridgewater (1998)
10.1002/MUS.880170213
The cortical silent period and amyotrophic lateral sclerosis
A. Prout (1994)
10.1093/BRAIN/121.7.1195
The pathophysiology of primary dystonia.
A. Berardelli (1998)
10.1097/01.WNP.0000150975.83249.71
How Salient is the Silent Period? The Role of the Silent Period in the Prognosis of Upper Extremity Motor Recovery After Severe Stroke
A. A. van Kuijk (2005)
10.1016/j.clinph.2007.10.014
The clinical diagnostic utility of transcranial magnetic stimulation: Report of an IFCN committee
R. Chen (2008)
10.1002/MDS.870120309
Sensory and motor evoked potentials in multiple system atrophy: A comparative study with Parkinson's disease
G. Abbruzzese (1997)
10.1016/j.clinph.2010.01.031
Slow (1Hz) repetitive transcranial magnetic stimulation (rTMS) induces a sustained change in cortical excitability in patients with Parkinson’s disease
S. Filipovic (2010)
he Effect of Exercise Training in Improving Motor erformance and Corticomotor Excitability in People With arly Parkinson ’ s Disease eth
E. Fisher (2008)
10.1046/j.1468-1331.1998.510005.x
Neuroimaging in European academic neurology: present status and future organization
J. Baron (1998)
10.1097/YIC.0b013e32832c2639
Neurobiology of repeated transcranial magnetic stimulation in the treatment of anxiety: a critical review
S. Pallanti (2009)
10.1017/CBO9780511545047.013
The Circuitry of the Human Spinal Cord: The pathophysiology of spasticity and parkinsonian rigidity
E. Pierrot-Deseilligny (2005)
10.1007/978-3-642-47601-3_7
Befunde bei verschiedenen Krankheiten
C. Fauth (1992)
10.1109/TNSRE.2018.2800052
Impact of Targeted Assistance of Multiarticular Finger Musculotendons on the Coordination of Finger Muscles During Isometric Force Production
S. Lee (2018)
Transcranial magnetic stimulation in patients with transient ischemic attacks.
Wen-Jang Wong (2004)
10.1212/WNL.57.1.55
Effects of motor imagery on motor cortical output topography in Parkinson’s disease
M. Filippi (2001)
10.1016/S1388-2457(02)00188-8
Abnormal conditioning effect of transcranial magnetic stimulation on soleus H-reflex during voluntary movement in Parkinson's disease
H. Morita (2002)
10.2217/NMT.11.16
The role of exercise in facilitating basal ganglia function in Parkinson's disease.
G. Petzinger (2011)
10.1016/S1090-0233(03)00025-X
Transcranial magnetic stimulation: review of the technique, basic principles and applications.
H. Nollet (2003)
10.1212/WNL.56.6.716
Effects of internal globus pallidus stimulation on motor cortex excitability
R. Chen (2001)
10.1016/S1388-2457(01)00642-3
Relation between changes in long-latency stretch reflexes and muscle stiffness in Parkinson's disease – comparison before and after unilateral pallidotomy
R. Hayashi (2001)
Parkinsonian rigidity.
P. Delwaide (2001)
10.1038/srep46675
WINCS Harmoni: Closed-loop dynamic neurochemical control of therapeutic interventions
K. Lee (2017)
10.1212/WNL.42.10.1951
Magnetic brain stimulation: the silent period after the motor evoked potential.
R. Cantello (1992)
10.1016/B978-0-444-53497-2.00031-0
Central motor conduction time.
K. Udupa (2013)
10.1002/ANA.410370208
Changes in excitability of motor cortical circuitry in patients with parkinson's disease
M. C. Ridding (1995)
Diagnostic Value of Magnetic Motor Evoked Potential Parameters in Intramedullary Myelopathy
Sang Hyeok Seo (2006)
10.1007/s00221-006-0397-7
Intrinsic hand muscles and digit independence on the preferred and non-preferred hands of humans
K. Reilly (2006)
10.3389/fnins.2019.00602
Impaired Motor Skill Acquisition Using Mirror Visual Feedback Improved by Transcranial Direct Current Stimulation (tDCS) in Patients With Parkinson’s Disease
M. Horiba (2019)
Pathophysiology of bradykinesia in Parkinson's
A. Berardelli (2001)
10.1111/j.1440-1819.1995.tb01879.x
Prolonged silent periods produced by magnetic cortical stimulation in patients with cerebellar ataxia
K. Nakashima (1995)
10.1007/s10072-019-04147-0
Different cortical excitability profiles in hereditary brain iron and copper accumulation
R. Dubbioso (2019)
10.1097/WNP.0000000000000037
Inadequate Modulation of Excitability With Voluntary Dorsiflexion in Parkinson's Disease
H. Morita (2014)
See more
Semantic Scholar Logo Some data provided by SemanticScholar