Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Abnormal Facilitation Of The Response To Transcranial Magnetic Stimulation In Patients With Parkinson's Disease

J. Valls-Solé, A. Pascual-Leone, J. Brasil-Neto, A. Cammarota, L. McShane, M. Hallett
Published 1994 · Psychology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
We studied the facilitation of the motor evoked potential (MEP) elicited with transcranial magnetic stimulation by increasing the stimulus intensity and the degree of voluntary activation of the target muscle in patients with Parkinson's disease (PD) and in normal volunteers. The threshold intensity for eliciting MEPs with the muscle at rest did not differ in PD patients and normal subjects. At rest, stimuli of similar intensity, related to the individual's threshold, elicited MEPs with amplitudes consistently larger in patients than in normal subjects, although when we compared the averaged MEP amplitude across all stimulus intensities, the differences reached only borderline statistical significance. Voluntary muscle activation elicited a smaller increase in the MEP area in PD patients than in normal subjects. Increasing the degree of voluntary muscle activation at fixed stimulus intensities elicited a smaller increase of MEP amplitude, duration, and area in PD patients than in normal subjects. These results suggest that control of the excitability of the motor system is abnormal in PD patients, with enhancement of excitability at rest and weak energization during voluntary muscle activation.
This paper references
10.1002/MDS.870010205
Electrophysiology of the corticomotoneurone pathways in patients with movement disorders
P. Thompson (1986)
10.1016/0168-5597(91)90074-8
Age-dependent decline in motor evoked potential (MEP) amplitude: with a comment on changes in Parkinson's disease.
A. Eisen (1991)
10.1017/S0317167100047909
Physiology of basal ganglia disorders: an overview.
M. Hallett (1993)
10.1212/WNL.41.9.1449
Parkinson's disease rigidity
R. Cantello (1991)
Maertens de'Noordhout A. La rigid-it6 parkinsonienne: aspects cliniques e t physiopathologiques
quot Dampvaide (1990)
Raised motor cortical threshold associated with bradykinesia as revealed by transcranial magnetic stimulation in normal man and Parkinson's disease
N J Davey
THE SITE OF FACILITATION OF THE RESPONSE TO CORTICAL STIMULATION DURING VOLUNTARY CONTRACTION IN MAN
A. Berardelli (1985)
10.1016/0168-5597(91)90055-3
Brain excitability and long latency muscular arm responses: non-invasive evaluation in healthy and parkinsonian subjects.
P. Rossini (1991)
10.1113/jphysiol.1987.sp016621
Responses in small hand muscles from magnetic stimulation of the human brain.
C. Hess (1987)
10.1016/0166-2236(90)90110-V
Primate models of movement disorders of basal ganglia origin
M. Delong (1990)
10.1016/0168-5597(91)90029-W
Further observations on the facilitation of muscle responses to cortical stimulation by voluntary contraction.
P. Thompson (1991)
10.1016/S0733-8619(18)30221-4
The role of motor cortex in the pathophysiology of voluntary movement deficits associated with parkinsonism.
R. Watts (1992)
10.1152/JN.1987.58.5.1168
Motor-unit responses in human wrist flexor and extensor muscles to transcranial cortical stimuli.
B. Calancie (1987)
10.1097/00006123-198701000-00032
Some experiences of techniques for stimulation of the human cerebral motor cortex through the scalp.
J. Rothwell (1987)
10.1212/WNL.44.5.884
Akinesia in Parkinson's disease. I. Shortening of simple reaction time with focal, single‐pulse transcranial magnetic stimulation
A. Pascual-Leone (1994)
10.1136/jnnp.50.5.544
Impaired sensorimotor integration in parkinsonism and dyskinesia: a role for corollary discharges?
A. P. Moore (1987)
10.1016/0013-4694(90)90170-O
Late muscular responses to transcranial cortical stimulation in man.
H. Holmgren (1990)
10.1093/BRAIN/110.5.1191
Motor cortex stimulation in intact man. 2. Multiple descending volleys.
B. Day (1987)
10.1093/BRAIN/114.6.2451
Origin of the secondary increase in firing probability of human motor neurons following transcranial magnetic stimulation. Studies in healthy subjects, type I hereditary motor and sensory neuropathy and multiple sclerosis.
K. Mills (1991)
10.1016/0022-510X(90)90018-I
Abnormalities of central motor conduction in Parkinson's disease
R. Kandler (1990)
10.1113/jphysiol.1989.sp017626
Electric and magnetic stimulation of human motor cortex: surface EMG and single motor unit responses.
B. Day (1989)
Motor cortex hyperexcitability in Parkinson's disease [abstract
A Maertens De Noordhout (1992)
10.1113/jphysiol.1989.sp017826
Task‐dependent changes in the size of response to magnetic brain stimulation in human first dorsal interosseous muscle.
A. Datta (1989)



This paper is referenced by
10.1212/01.WNL.0000163772.56128.A8
Dopaminergic drugs restore facilitatory premotor-motor interactions in Parkinson disease
P. Mir (2005)
10.1201/B14174-10
Neurophysiological (Mainly Transcranial Magnetic Stimulation) Techniques to Test Functional Neuroanatomy of Cortico-Cortical Connectivity
M. Ridding (2012)
10.3389/fnhum.2017.00309
Effects of More-Affected vs. Less-Affected Motor Cortex tDCS in Parkinson’s Disease
G. Cosentino (2017)
10.1212/WNL.56.6.716
Effects of internal globus pallidus stimulation on motor cortex excitability
R. Chen (2001)
Pathophysiology of adductor spasmodic dysphonia: A TMS study
Sharyl A Samargia (2012)
10.1007/s00406-002-0387-0
Increased transcranial magnetic motor threshold after ECT
M. Sommer (2002)
10.1212/WNL.60.5.885-a
Effects of subthalamic nucleus (STN) stimulation on motor cortex excitability
T. Loddenkemper (2003)
10.1016/0168-5597(94)90148-1
Responses of the soleus muscle to transcranial magnetic stimulation.
J. Valls-Solé (1994)
Interhemispheric modulation of corticomotor excitability following i-wave periodicity transcranial magnetic brain stimulation (iTMS)
Lucy Catherine Millar (2006)
10.1016/j.neuroscience.2007.08.033
Cortical inhibition in Parkinson’s disease: New insights from early, untreated patients
R. Cantello (2007)
10.1016/j.clinph.2010.07.016
Neurophysiological evaluation of motor corticospinal pathways by TMS in idiopathic early-onset Parkinson’s disease
A. Perretti (2011)
10.1007/BF00229631
Effects of diazepam, baclofen and thiopental on the silent period evoked by transcranial magnetic stimulation in humans
M. Inghilleri (2004)
10.1016/j.jneumeth.2020.108957
Non-invasive brain stimulation for Parkinson’s disease: Clinical evidence, latest concepts and future goals: A systematic review
J. Madrid (2021)
10.1016/j.bbr.2020.112835
Elite competitive swimmers exhibit higher motor cortical inhibition and superior sensorimotor skills in a water environment
D. Sato (2020)
10.1002/mds.22284
Subthalamic nucleus stimulation restores corticospinal facilitation in Parkinson's disease
M. Poetter-Nerger (2008)
10.1212/WNL.58.11.1665
Effects of subthalamic nucleus stimulation on motor cortex excitability in Parkinson’s disease
D. Cunic (2002)
10.3233/JPD-130212
Corticomotor excitability in Parkinson's disease during observation, imagery and imitation of action: effects of rehabilitation using wii fit and comparison to healthy controls.
J. Esculier (2014)
10.1016/S0013-4694(97)00097-7
Clinical applications of motor evoked potentials.
P. Rossini (1998)
10.1016/S1388-2457(00)00267-4
Motor cortical dysfunction disclosed by single and double magnetic stimulation in patients with fibromyalgia
A. Salerno (2000)
10.1093/BRAIN/AWF200
Altered sensorimotor integration in Parkinson's disease.
G. Lewis (2002)
10.1016/0304-3940(96)12575-1
Enhancement of human motor cortex inhibition by the dopamine receptor agonist pergolide: evidence from transcranial magnetic stimulation
U. Ziemann (1996)
10.1002/ANA.410370208
Changes in excitability of motor cortical circuitry in patients with parkinson's disease
M. C. Ridding (1995)
10.1155/2016/8764238
Mirror Visual Feedback to Improve Bradykinesia in Parkinson's Disease
G. Bonassi (2016)
10.1002/mds.21565
Asymmetric corticomotor excitability correlations in early Parkinson's disease
A. Wu (2007)
10.1016/j.clinph.2012.09.016
History of exposure to dopaminergic medication does not affect motor cortex plasticity and excitability in Parkinson’s disease
A. Kacar (2013)
10.1016/j.brs.2013.01.002
Abnormal Corticospinal Excitability in Patients with Disorders of Consciousness
N. Lapitskaya (2013)
10.11606/T.39.2016.TDE-29042016-112750
Efeitos do treinamento de força e do treinamento de força com instabilidade sobre os sintomas, funcionalidade, adaptações neuromusculares e a qualidade de vida de pacientes com doença de parkinson: estudo controlado e randomizado
Carla da Silva Batista (2016)
10.1016/j.brainres.2008.05.024
Effects of posture-related changes in motor cortical output on central oscillatory activity of pathological origin in humans
R. Mazzocchio (2008)
10.1007/s00221-005-0205-9
Modulation of short-latency intracortical inhibition in human primary motor cortex during synchronised versus syncopated finger movements
W. Byblow (2005)
10.1007/s00221-011-2829-2
Short-interval intracortical inhibition in Parkinson’s disease using anterior-posterior directed currents
R. Hanajima (2011)
10.1016/j.physbeh.2015.01.014
A new neurometric dissection of the area-under-curve-associated jiggle of the motor evoked potential induced by transcranial magnetic stimulation
F. E. León-Sarmiento (2015)
10.1097/YIC.0b013e32832c2639
Neurobiology of repeated transcranial magnetic stimulation in the treatment of anxiety: a critical review
S. Pallanti (2009)
See more
Semantic Scholar Logo Some data provided by SemanticScholar