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Meige Syndrome In The Spectrum Of Lewy Body Disease

M. Mark, J. Sage, D. Dickson, R. Heikkila, L. Manzino, Karl O. Schwarz, R. Duvoisin
Published 1994 · Medicine

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We report a patient with Meige syndrome (segmental cranial dystonia) who had neuropathology changes of Parkinson's disease on postmortem examination. Neuropathologic examination showed typical and atypical Lewy bodies in the pigmented nuclei of the brainstem (substantia nigra, locus ceruleus), the nucleus basalis of Meynert, and the nucleus ambiguus. Neurochemical analysis of postmortem brain tissue showed evidence for decreased dopamine turnover in the substantia nigra, striatum, and nucleus accumbens. We propose that some cases of Meige syndrome may be included in the spectrum of Lewy body disease.
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