Online citations, reference lists, and bibliographies.
← Back to Search

Endothelial Function And Oxidative Stress In Cardiovascular Diseases.

Y. Higashi, K. Noma, M. Yoshizumi, Y. Kihara
Published 2009 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The vascular endothelium is involved in the release of various vasodilators, including nitric oxide (NO), prostacyclin and endothelium-derived hyperpolarizing factor, as well as vasoconstrictors. NO plays an important role in the regulation of vascular tone, inhibition of platelet aggregation, and suppression of smooth muscle cell proliferation. Endothelial dysfunction is the initial step in the pathogenesis of atherosclerosis. Cardiovascular diseases are associated with endothelial dysfunction. It is well known that the grade of endothelial function is a predictor of cardiovascular outcomes. Oxidative stress plays an important role in the pathogenesis and development of cardiovascular diseases. Several mechanisms contribute to impairment of endothelial function. An imbalance of reduced production of NO or increased production of reactive oxygen species, mainly superoxide, may promote endothelial dysfunction. One mechanism by which endothelium-dependent vasodilation is impaired is an increase in oxidative stress that inactivates NO. This review focuses on recent findings and interaction between endothelial function and oxidative stress in cardiovascular diseases.
This paper references
10.1161/01.CIR.0000080893.55729.28
Effect of Different Intensities of Exercise on Endothelium-Dependent Vasodilation in Humans: Role of Endothelium-Dependent Nitric Oxide and Oxidative Stress
C. Goto (2003)
Relationship between the angiotensin-converting enzym genotype and forearm vasodilator response to estrogen replacement therapy in postmenopausal
M Sanada (2001)
10.1056/NEJM199906173402418
Atherosclerosis--an inflammatory disease.
Kenny J. Williams (1999)
10.1016/S0895-7061(01)02317-2
Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals.
Y. Higashi (2002)
10.3109/10641969809053253
Alterations in the vasoreactivity of hypertensive rat aortic rings: role of nitric oxide and superoxide radicals.
L. Hegde (1998)
10.1161/01.RES.86.9.E85
Vascular superoxide production by NAD(P)H oxidase: association with endothelial dysfunction and clinical risk factors.
T. Guzik (2000)
10.1161/01.RES.86.2.E36
Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers : evidence for a dysfunctional nitric oxide synthase.
T. Heitzer (2000)
10.1161/01.CIR.93.6.1107
Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease.
G. Levine (1996)
10.1161/01.RES.0000099062.55042.9A
Rho-Associated Protein Kinase Contributes to Early Atherosclerotic Lesion Formation in Mice
Z. Mallat (2003)
Tissue angiotensin and pathobiology of vascular disease: A unifying hypothesis [Theodore Cooper Lecture
VJ Dzau (2001)
10.1172/JCI114688
Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.
M. Creager (1990)
10.1126/SCIENCE.275.5304.1308
Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase
M. Amano (1997)
10.1161/01.CIR.81.6.1762
Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension.
L. Linder (1990)
10.1161/01.ATV.0000063385.12476.A7
Endothelium-dependent effects of statins.
Sebastian Wolfrum (2003)
10.1161/HC1002.105938
Suppression of Coronary Artery Spasm by the Rho-Kinase Inhibitor Fasudil in Patients With Vasospastic Angina
A. Masumoto (2002)
10.1007/BF00429099
Impaired endothelium-dependent and independent vasodilation in patients with Type 2 (non-insulin-dependent) diabetes mellitus
G. McVeigh (2004)
10.1097/00005344-199204002-00063
Endothelium‐Dependent Forearm Vasodilation to Acetylcholine But Not to Substance P Is Impaired in Patients with Heart Failure
Y. Hirooka (1992)
10.1152/AJPHEART.00190.2002
Exercise training regulates SOD-1 and oxidative stress in porcine aortic endothelium.
J. W. Rush (2003)
Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coro 417 Endothelial Function and Oxidative Stress Circulation Journal Vol.73, March 2009 nary heart disease
V Schachinger (2000)
10.1016/S0735-1097(99)00561-6
A comparison of angiotensin-converting enzyme inhibitors, calcium antagonists, beta-blockers and diuretic agents on reactive hyperemia in patients with essential hypertension: a multicenter study.
Y. Higashi (2000)
10.1161/HC4601.099485
Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients With Coronary Artery Disease
T. Heitzer (2001)
10.1016/S0895-7061(01)02322-6
A low-calorie diet improves endothelium-dependent vasodilation in obese patients with essential hypertension.
S. Sasaki (2002)
10.1161/01.CIR.101.9.948
Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction.
J. Suwaidi (2000)
10.1253/CIRCJ.72.654
Vitamin C reversed malfunction of peripheral blood-derived mononuclear cells in smokers through antioxidant properties.
Y. Takeshita (2008)
10.1172/JCI9551
Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training.
T. Fukai (2000)
10.1161/01.HYP.0000067062.92836.9E
Smoking Activates Rho-Kinase in Smooth Muscle Cells of Forearm Vasculature in Humans
K. Noma (2003)
10.1161/01.STR.0000181077.84981.11
Inhibition of Rho Kinase (ROCK) Leads to Increased Cerebral Blood Flow and Stroke Protection
Y. Rikitake (2005)
10.1161/01.HYP.25.4.898
Effects of L-arginine infusion on renal hemodynamics in patients with mild essential hypertension.
Y. Higashi (1995)
Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: What is the clinical significance? Hypertension
RM Touyz (2004)
Tetrahydrobiopterin improves impaired endothelium-dependent vasodilation in patients with essential hypertension
Y Higashi (2002)
10.1161/CIRCULATIONAHA.105.534024
Rho-Kinase Mediates Hyperglycemia-Induced Plasminogen Activator Inhibitor-1 Expression in Vascular Endothelial Cells
Y. Rikitake (2005)
10.1161/01.RES.0000126501.34994.96
Angiotensin II Impairs the Insulin Signaling Pathway Promoting Production of Nitric Oxide by Inducing Phosphorylation of Insulin Receptor Substrate-1 on Ser312 and Ser616 in Human Umbilical Vein Endothelial Cells
F. Andreozzi (2004)
10.1161/01.CIR.101.16.1899
Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease.
V. Schaechinger (2000)
10.1161/01.CIR.0000012543.55874.47
Risk Stratification for Postoperative Cardiovascular Events via Noninvasive Assessment of Endothelial Function: A Prospective Study
N. Gokce (2002)
10.1161/HY1201.096541
Possible Involvement of Rho-Kinase in the Pathogenesis of Hypertension in Humans
A. Masumoto (2001)
10.1016/S1062-1458(01)00468-8
Prognostic Significance of Endothelial Dysfunction in Hypertensive Patients
F. Perticone (2001)
10.1161/CIRCULATIONAHA.105.584623
Decreased Perivascular Fibrosis but Not Cardiac Hypertrophy in ROCK1+/− Haploinsufficient Mice
Y. Rikitake (2005)
10.1161/01.HYP.25.4.699
Comparison of effects of angiotensin I-converting enzyme inhibition and beta-blockade for 2 years on function of small arteries from hypertensive patients.
E. Schiffrin (1995)
10.1074/JBC.M000753200
Cyclic GMP-dependent Protein Kinase Signaling Pathway Inhibits RhoA-induced Ca2+ Sensitization of Contraction in Vascular Smooth Muscle*
V. Sauzeau (2000)
10.1161/HY0202.103271
Important Role of Rho-kinase in the Pathogenesis of Cardiovascular Inflammation and Remodeling Induced by Long-Term Blockade of Nitric Oxide Synthesis in Rats
C. Kataoka (2002)
10.1093/AJH/3.4.317
Imbalance of endothelium-derived relaxing and contracting factors. A new concept in hypertension?
T. Luescher (1990)
10.1172/JCI118623
Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.
S. Rajagopalan (1996)
Angiotensin converting enzyme inhibition and angiotensin II AT1-receptor blockade reduce the levels of asymmetrical N(G), N(G)-dimethylarginine in human essential hypertension.
C. Delles (2002)
10.1161/01.HYP.0000138070.47616.9D
Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance?
R. Touyz (2004)
10.1152/AJPHEART.01006.2003
Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aorta.
L. Jin (2004)
10.1161/01.CIR.87.1.86
Hypertension and Left Ventricular Hypertrophy Are Associated With Impaired Endothelium‐Mediated Relaxation in Human Coronary Resistance Vessels
C. B. Treasure (1993)
10.1006/BBRC.1996.5986
Myosin binding subunit of smooth muscle myosin phosphatase at the cell-cell adhesion sites in MDCK cells.
N. Inagaki (1997)
10.1016/J.JACC.2006.06.082
Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness.
K. Noma (2007)
10.1016/0735-1097(96)82380-1
Impaired vascular reactivity in insulin-dependent diabetes mellitus is related to disease duration and low density lipoprotein cholesterol levels.
P. Clarkson (1996)
10.1161/01.HYP.37.2.444
Endothelial Dysfunction in Salt-Sensitive Essential Hypertension
E. Bragulat (2001)
10.1253/CIRCJ.CJ-08-0072
Beneficial effects of exogenous tetrahydrobiopterin on left ventricular remodeling after myocardial infarction in rats: the possible role of oxidative stress caused by uncoupled endothelial nitric oxide synthase.
Tomoya Masano (2008)
10.1161/01.ATV.0000142813.33538.82
Inhibition of Rho-Kinase Leads to Rapid Activation of Phosphatidylinositol 3-Kinase/Protein Kinase Akt and Cardiovascular Protection
S. Wolfrum (2004)
10.1038/40187
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
M. Uehata (1997)
Effect of the angiotensin II type 1 receptor blocker candesartan on endothelial function in patients with essential
L Ghiadoni (2000)
10.1016/S0140-6736(89)91013-1
EFFECTS OF ENDOTHELIUM-DERIVED NITRIC OXIDE ON PERIPHERAL ARTERIOLAR TONE IN MAN
P. Vallance (1989)
10.1093/EURHEARTJ/EHL079
TNF-α induces endothelial dysfunction in diabetic adults, an effect reversible by the PPAR-γ agonist pioglitazone
F. Martens (2006)
10.1084/JEM.189.11.1699
Exercise Provides Direct Biphasic Cardioprotection via Manganese Superoxide Dismutase Activation
N. Yamashita (1999)
10.1161/01.ATV.0000133604.20182.CF
Vascular protection: superoxide dismutase isoforms in the vessel wall.
F. Faraci (2004)
10.1161/01.HYP.37.4.1047
Theodore Cooper Lecture: Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis.
V. Dzau (2001)
10.1097/00005344-199903000-00012
Acute simultaneous stimulation of nitric oxide and oxygen radicals by angiotensin II in humans in vivo.
L. Dijkhorst-Oei (1999)
10.1056/NEJM200002173420702
Effect of exercise on coronary endothelial function in patients with coronary artery disease.
R. Hambrecht (2000)
10.1161/01.ATV.15.11.2032
The interstitium of the human arterial wall contains very large amounts of extracellular superoxide dismutase.
P. Strålin (1995)
10.1097/00005344-200203000-00007
Tetrahydrobiopterin Improves Impaired Endothelium-Dependent Forearm Vasodilation in Patients with Heart Failure
S. Setoguchi (2002)
10.1056/NEJM199502233320801
Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease.
C. B. Treasure (1995)
10.1016/S0002-9149(00)00857-2
Late prognostic value of flow-mediated dilation in the brachial artery of patients with chest pain.
T. Neunteufl (2000)
in humans
A Masumoto (2001)
10.1161/01.RES.87.3.179
Oxidant signaling in vascular cell growth, death, and survival : a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling.
K. Irani (2000)
10.1161/01.CIR.103.6.799
Comparative Effect of ACE Inhibition and Angiotensin II Type 1 Receptor Antagonism on Bioavailability of Nitric Oxide in Patients With Coronary Artery Disease: Role of Superoxide Dismutase
B. Hornig (2001)
TNF-alpha induces endothelial dysfunction in diabetic adults, an effect reversible by the PPAR-gamma agonist pioglitazone.
F. Martens (2006)
Rho-Kinase Is an Important Therapeutic Target in Cardiovascular Medicine
HiroakiShimokawa (2005)
10.1007/978-1-4615-6039-5
Nitric Oxide and the Kidney
M. Goligorsky (1997)
10.1161/01.HYP.33.1.591
Daily aerobic exercise improves reactive hyperemia in patients with essential hypertension.
Y. Higashi (1999)
10.1023/A:1022182201534
Vitamins, Antioxidants and Endothelial Function in Coronary Artery Disease
B. Hornig (2004)
10.1016/S0735-1097(03)00994-X
The clinical implications of endothelial dysfunction.
M. Widlansky (2003)
10.1074/jbc.273.10.5542
Regulation of the Association of Adducin with Actin Filaments by Rho-associated Kinase (Rho-kinase) and Myosin Phosphatase*
K. Kimura (1998)
10.1172/JCI119131
Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.
E. Stroes (1997)
10.1016/J.ATHEROSCLEROSIS.2005.07.025
Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production.
Y. Higashi (2006)
10.1006/BBRC.2000.2898
Shear stress enhances glutathione peroxidase expression in endothelial cells.
S. Takeshita (2000)
10.1126/SCIENCE.279.5350.509
Rho GTPases and the actin cytoskeleton.
A. Hall (1998)
10.1161/01.CIR.100.11.1194
Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide.
Y. Higashi (1999)
10.1056/NEJMOA013591
Endothelial function and oxidative stress in renovascular hypertension.
Y. Higashi (2002)
10.1038/21224
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
S. Dimmeler (1999)
10.1161/01.RES.87.10.840
Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress.
H. Cai (2000)
10.1161/01.HYP.35.1.501
Effect of the angiotensin II type 1 receptor blocker candesartan on endothelial function in patients with essential hypertension.
L. Ghiadoni (2000)
10.1172/JCI118394
Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.
H. Ting (1996)
10.1097/00005344-200203000-00001
Rho-kinase as a Novel Therapeutic Target in Treatment of Cardiovascular Diseases
H. Shimokawa (2002)
10.1016/S0266-6138(88)80001-9
What is clinical significance?
A. Thomson (1988)
10.1074/JBC.M302227200
Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols
Nermin Kuzkaya (2003)
10.1056/NEJM199007053230106
Regulatory functions of the vascular endothelium.
J. Vane (1990)
Reactive oxygen species , vascular oxidative stress , and redox signaling in
RM Touyz
10.1161/01.HYP.25.2.201
Impaired endothelium-dependent vasodilation of large epicardial and resistance coronary arteries in patients with essential hypertension. Different responses to acetylcholine and substance P.
K. Egashira (1995)
10.1161/01.CIR.0000115644.35804.8B
Avoiding Papillary Muscle Infarction With Myocardial Contrast Echocardiographic Guidance of Nonsurgical Septal Reduction Therapy for Hypertrophic Obstructive Cardiomyopathy
S. Nagueh (2004)
10.1016/S0895-7061(02)02278-1
Angiotensin Converting Enzyme Inhibition and Angiotensin II AT1-Receptor Blockade Reduce the Levels of Asymmetrical NG, NG-Dimethylarginine in Human Essential Hypertension*
C. Delles (2002)
10.1161/01.HYP.20.2.175
Captopril improves impaired endothelium-dependent vasodilation in hypertensive patients.
Y. Hirooka (1992)
10.1038/21218
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
D. Fulton (1999)
10.1016/0735-1097(94)90164-3
Effect of antioxidant vitamins on low density lipoprotein oxidation and impaired endothelium-dependent vasodilation in patients with hypercholesterolemia.
D. Gilligan (1994)
10.1172/JCI116634
Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension.
A. Zeiher (1993)
10.1161/01.HYP.35.5.1055
Vascular NADH/NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats.
G. Zalba (2000)
10.1016/S0735-1097(01)01191-3
Relationship between the angiotensin-converting enzyme genotype and the forearm vasodilator response to estrogen replacement therapy in postmenopausal women.
M. Sanada (2001)
10.1161/01.ATV.0000176193.83629.C8
Rho-Kinase Is an Important Therapeutic Target in Cardiovascular Medicine
H. Shimokawa (2005)
10.1056/NEJM199007053230105
Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension.
J. Panza (1990)
10.1152/AJPHEART.01305.2004
Reactive oxygen species from smooth muscle mitochondria initiate cold-induced constriction of cutaneous arteries.
S. Bailey (2005)
10.1161/01.CIR.0000129501.88485.1F
Endothelial function: a critical determinant in atherosclerosis?
U. Landmesser (2004)
10.1253/CIRCJ.71.736
Measurement of flow-mediated vasodilation of the brachial artery: a comparison of measurements in the seated and supine positions.
J. Soga (2007)
10.1161/01.HYP.13.6.658
Endothelium and Control of Vascular Function State of the Art Lecture
P. VanHoutte (1989)
Effects of L - arginine infusion on renal hemodynamics in patients with mild essential
Y Higashi (1995)



This paper is referenced by
10.3945/an.114.005728
A review and critical analysis of the scientific literature related to 100% fruit juice and human health.
D. Hyson (2015)
10.4155/fmc-2016-0241
Synthesis and biological evaluation of tanshinone IIA derivatives as novel endothelial protective agents.
Xiaoling Bi (2017)
10.1007/s12012-017-9442-y
Acetaminophen Poisoning May Increase Coronary Artery Disease Risk: A Nationwide Cohort Study
Yu-Ting Chung (2017)
10.1111/jcmm.14406
Dihydromyricetin protects HUVECs of oxidative damage induced by sodium nitroprusside through activating PI3K/Akt/FoxO3a signalling pathway
X. Zhang (2019)
10.1007/978-981-13-8273-4_22
Oxidative Stress Mechanisms in Type 2 Diabetes Induced Coronary Heart Disease
Keerthi Kupsal (2019)
Mechanisms of augmented coronary artery constriction following exposure to diesel exhaust
Tom W. Cherng (2010)
Blood flow patterns, arterial Reynolds number, exercise, and endothelial function
Alvaro N. Gurovich (2010)
10.17077/ETD.BS27R0P3
A prospective, 3-year follow-up study of vascular function and cardiac autonomic control following renal transplantation
K. Ferrante (2012)
Cerebrovascular integrity maintenance and inflammation in atherosclerosis animal models
V. D. Cataldo (2016)
The role of non-myocytes in drug-induced cardiovascular toxicity
Stephanie M. Ravenscroft (2014)
10.1080/14767058.2018.1494145
Effect of severe hyperemesis gravidarum on maternal vascular endothelial health: evaluation of soluble adhesion molecules
E. Sahin (2018)
EFFECT OF L-ARGININE SUPPLEMENTATION ON ANTIOXIDANT ENZYME ACTIVITY, TOTAL ANTIOXIDANT CAPACITY AND BODY COMPOSITION IN PATIENTS WITH PRE-DIABETES
S. Fazelian (2013)
10.1016/j.jep.2014.04.025
Paeonol protects against premature senescence in endothelial cells by modulating Sirtuin 1 pathway.
J. Jamal (2014)
10.1371/journal.pone.0065486
Cardiovascular Changes in Atherosclerotic ApoE-Deficient Mice Exposed to Co60 (γ) Radiation
P. Kumarathasan (2013)
10.1111/j.1476-5381.2011.01500.x
Decreased production of neuronal NOS‐derived hydrogen peroxide contributes to endothelial dysfunction in atherosclerosis
L. Capettini (2011)
The Role of Argininosuccinate Synthase Serine 328 Phosphorylation in Nitric Oxide Production
Ricci Thompson Haines (2012)
10.1016/j.etp.2014.06.004
The protective effects of vitamin C on the DNA damage, antioxidant defenses and aorta histopathology in chronic hyperhomocysteinemia induced rats.
M. Boyacioglu (2014)
10.1186/s12944-020-1188-z
Phytoconstituents of an ethanolic pod extract of Prosopis cineraria triggers the inhibition of HMG-CoA reductase and the regression of atherosclerotic plaque in hypercholesterolemic rabbits
H. Ram (2020)
10.1155/2020/5967434
Farrerol Directly Targets GSK-3β to Activate Nrf2-ARE Pathway and Protect EA.hy926 Cells against Oxidative Stress-Induced Injuries
C. Yan (2020)
10.1212/WNL.0000000000009093
Vegetarian diet and incidence of total, ischemic, and hemorrhagic stroke in 2 cohorts in Taiwan
Tina H T Chiu (2020)
10.1016/j.ijcard.2019.12.065
Hyperglycemia-induced endothelial dysfunction is alleviated by thioredoxin mimetic peptides through the restoration of VEGFR-2-induced responses and improved cell survival.
Pia Hemling (2019)
10.1016/j.heliyon.2020.e04394
Melatonin receptor 1A gene polymorphism rs13140012 and serum melatonin in atherosclerotic versus non-atherosclerotic Egyptian ESRD patients: pilot study
Aliaa Aly El Aghoury (2020)
10.1038/oby.2010.169
Insulin Resistance and Oxidative Stress Influence Colony‐Forming Unit‐Endothelial Cells Capacity in Obese Patients
E. Miller-Kasprzak (2011)
10.2217/bmm.11.28
Elevated plasma myeloperoxidase levels in relation to circulating inflammatory markers in coronary artery disease.
S. Z. Samsamshariat (2011)
Hypotensive Statin Effect - from Pathophysiology to
Agnieszka M. Tycinska (2014)
10.6002/ECT.2012.0224
Fasting serum long-acting natriuretic peptide correlates with the ankle brachial index in renal transplant recipients.
Guan-Jin Ho (2013)
10.1161/HYPERTENSIONAHA.117.09612
Endothelial Function Is Impaired in Patients Receiving Antihypertensive Drug Treatment Regardless of Blood Pressure Level: FMD-J Study (Flow-Mediated Dilation Japan)
T. Maruhashi (2017)
Impact of Exercise Training on Blood Pressure and Endothelial Function in Individuals with Systemic Hypertension
Waclawovsky ()
10.5114/aoms.2018.74026
Renin-angiotensin system inhibitor attenuates oxidative stress induced human coronary artery endothelial cell dysfunction via the PI3K/AKT/mTOR pathway
X. Shi (2019)
Nitrite uptake and metabolism in human erythrocytes : a source of vascular nitric oxide?
A. Pinder (2009)
10.1007/s12012-015-9324-0
Endothelial Function in Patients with Hematologic Malignancies Undergoing High-Dose Chemotherapy Followed by Hematopoietic Stem Cell Transplantation
M. Poręba (2015)
10.2174/138161212799436593
Role of renin-angiotensin system in inflammation, immunity and aging.
Luciano S. A. Capettini (2012)
See more
Semantic Scholar Logo Some data provided by SemanticScholar