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Baseline Global Longitudinal Strain As A Predictor Of Left Ventricular Dysfunction And Hospitalization For Heart Failure Of Patients With Malignant Lymphoma After Anthracycline Therapy.

K. Hatazawa, H. Tanaka, A. Nonaka, Hiroki Takada, Fumitaka Soga, Y. Hatani, Hiroki Matsuzoe, H. Shimoura, J. Ooka, H. Sano, Y. Mochizuki, K. Matsumoto, K. Hirata
Published 2018 · Medicine

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BACKGROUND Our aim was to investigate the baseline clinical and echocardiographic parameters for predicting left ventricular (LV) dysfunction after anthracycline chemotherapy and heart failure (HF) hospitalization in a single cancer disease. Methods and Results: We studied 73 patients with malignant lymphoma and preserved LV ejection fraction (LVEF). Echocardiography was performed before and after anthracycline chemotherapy. Global longitudinal strain (GLS) was determined from 3 standard apical views. LV dysfunction after anthracycline chemotherapy was defined according to the current definition of cancer therapeutics-related cardiac dysfunction. Long-term (50-month) unfavorable outcome was prespecified as hospitalization for HF. A total of 10 patients had LV dysfunction after anthracycline chemotherapy. Multivariate logistic regression analysis showed that baseline GLS was the only independent predictor of this dysfunction. Receiver-operating characteristic curve analysis identified the optimal GLS cutoff for predicting LV dysfunction after anthracycline chemotherapy as ≤19% (P=0.008). Furthermore, the Kaplan-Meier curve indicated that fewer patients with GLS >19% were hospitalized for HF than among those with GLS ≤19% (log-rank P=0.02). For sequential logistic models, a model based on baseline clinical variables (χ2=2.9) was improved by the addition of baseline LVEF (χ2=9.0; P=0.01), and further improved by the addition of baseline GLS (χ2=13.1, P=0.04). CONCLUSIONS Watchful observation or early therapeutic intervention with established cardioprotective medications may be necessary for patients with malignant lymphoma and preserved LVEF but with abnormal GLS.
This paper references
10.1093/eurheartj/ehw211
2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines:  The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC).
J. Zamorano (2016)
10.1093/ehjci/jev014
Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging.
R. Lang (2015)
10.1200/JCO.2007.14.8742
Left ventricular ejection fraction and cardiotoxicity: is our ear really to the ground?
M. Ewer (2008)
10.1002/cncr.11407
Congestive heart failure in patients treated with doxorubicin
S. Swain (2003)
10.1634/theoncologist.2008-0137
Minimizing cardiotoxicity while optimizing treatment efficacy with trastuzumab: review and expert recommendations.
M. Martín (2009)
10.1136/hrt.2009.173997
Subclinical anthracycline- and trastuzumab-induced cardiotoxicity in the long-term follow-up of asymptomatic breast cancer survivors: a speckle tracking echocardiographic study
E. Ho (2010)
10.1161/CIRCIMAGING.112.973321
Assessment of Echocardiography and Biomarkers for the Extended Prediction of Cardiotoxicity in Patients Treated With Anthracyclines, Taxanes, and Trastuzumab
Heloisa Sawaya (2012)
10.1136/heartjnl-2014-305538
Prognostic implications of global LV dysfunction: a systematic review and meta-analysis of global longitudinal strain and ejection fraction
K. Kalam (2014)
10.1111/echo.12473
Left Ventricular Endocardial Dysfunction in Patients with Preserved Ejection Fraction after Receiving Anthracycline
T. Miyoshi (2014)
10.1093/ehjci/jet159
Use of speckle strain to assess left ventricular responses to cardiotoxic chemotherapy and cardioprotection.
K. Negishi (2014)
10.1093/ehjci/jes217
Myocardial 2D strain echocardiography and cardiac biomarkers in children during and shortly after anthracycline therapy for acute lymphoblastic leukaemia (ALL): a prospective study.
A. Mavinkurve-Groothuis (2013)
10.1093/JNCI/DJK064
Long-term risk of cardiovascular disease in 10-year survivors of breast cancer.
M. Hooning (2007)
10.1093/eurheartj/ehv529
Myocardial strain imaging: how useful is it in clinical decision making?
O. Smiseth (2016)
10.1093/ANNONC/MDF132
Functional monitoring of anthracycline cardiotoxicity: a prospective, blinded, long-term observational study of outcome in 120 patients.
B. V. Jensen (2002)
10.1016/j.echo.2013.02.008
Independent and incremental value of deformation indices for prediction of trastuzumab-induced cardiotoxicity.
K. Negishi (2013)
10.1016/j.echo.2015.02.006
Incremental prognostic value of echocardiographic strain and its association with mortality in cancer patients.
Isaac B Rhea (2015)
10.1016/0002-8703(86)90559-4
Amelioration of adriamycin-induced cardiotoxicity in rabbits by prenylamine and vitamins A and E.
J. Milei (1986)
UNDERLYING CAUSES AND LONG-TERM SURVIVAL IN PATIENTS WITH INITIALLY UNEXPLAINED CARDIOMYOPATHY
M. G (2000)
10.7326/0003-4819-91-5-710
Risk factors for doxorubicin-induced congestive heart failure.
D. V. Von Hoff (1979)
10.1016/j.jacc.2011.06.038
Echocardiographic assessment of myocardial strain.
J. Gorcsan (2011)
10.1016/j.jacc.2014.01.073
Use of myocardial strain imaging by echocardiography for the early detection of cardiotoxicity in patients during and after cancer chemotherapy: a systematic review.
P. Thavendiranathan (2014)
10.1007/s12574-017-0344-6
Echocardiographic evaluation of cardiac function after cancer chemotherapy
Tomoko Negishi (2017)
10.1200/JCO.2005.02.5841
Chemotherapy and cardiotoxicity in older breast cancer patients: a population-based study.
J. Doyle (2005)
10.1002/ejhf.654
2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines
J. Zamorano (2017)
10.1161/01.CIR.0000133187.74800.B9
Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management.
E. T. Yeh (2004)
10.1093/ehjci/jeu192
Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging.
J. Plana (2014)
10.1016/j.echo.2012.10.008
Normal ranges of left ventricular strain: a meta-analysis.
T. Yingchoncharoen (2013)



This paper is referenced by
10.1016/j.hlc.2019.04.023
Echocardiography and Cardio-Oncology.
Tomoko Negishi (2019)
10.1253/circj.CJ-18-0836
Early Prediction of Cardiotoxicity From Cancer Chemotherapy - Can Baseline Strain Identify High-Risk Patients?
K. Nakanishi (2018)
10.1111/echo.14944
Role of myocardial strain imaging in surveillance and management of cancer therapeutics-related cardiac dysfunction: A systematic review.
Pei-Chun McGregor (2020)
10.1253/circj.CJ-19-0420
Utilization of Artificial Intelligence in Echocardiography.
K. Kusunose (2019)
10.1152/ajpheart.00618.2018
Possible mechanism of late systolic mitral valve prolapse: systolic superior shift of leaflets secondary to annular dilatation that causes papillary muscle traction.
S. Hei (2019)
10.1016/j.ccl.2019.07.006
Echocardiography Imaging of Cardiotoxicity.
Y. Kang (2019)
10.1007/s12574-020-00502-9
Practical guidance for echocardiography for cancer therapeutics-related cardiac dysfunction
Tetsuari Onishi (2020)
10.1007/s12350-020-02368-x
Towards pre-treatment imaging prediction of chemotherapy-related cardiotoxicity
Rodolfo Ferrando Castagnetto (2020)
10.1007/s11886-020-01348-4
Radiomics in Echocardiography: Deep Learning and Echocardiographic Analysis
K. Kusunose (2020)
10.1007/s10554-020-01976-5
Association between clinical risk factors and left ventricular function in patients with breast cancer following chemotherapy
K. Yamashita (2020)
10.1007/s10396-019-00947-1
Echocardiography and cancer therapeutics-related cardiac dysfunction
H. Tanaka (2019)
10.1007/s12410-019-9519-z
The Role of Echocardiography in Cardio-oncology Patients: Contemporary Indications and Future Directions
Saiuj Bhat (2019)
10.1007/s12574-018-0408-2
Utility of strain imaging in conjunction with heart failure stage classification for heart failure patient management
H. Tanaka (2018)
10.1016/j.ijcard.2020.08.019
Impact of hypertension on left ventricular function in patients after anthracycline chemotherapy for malignant lymphoma.
Yusuke Tanaka (2020)
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