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Rapidly Sequential And Fatal Hemorrhaging In A Case Of Cerebral Amyloid Angiopathy

Zachary B. Bulwa, Geoffrey C. Ward, O N Kramer, Birju Rao, Melvin D. Wichter
Published 2016 · Medicine
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Patient: Female, 63 Final Diagnosis: Cerebral amyloid angiopathy Symptoms: Altered mental state • aphasia • hemiplegia Medication: — Clinical Procedure: — Specialty: Neurology Objective: Unusual clinical course Background: Cerebral amyloid angiopathy (CAA) is an increasingly recognized cause of lobar intracerebral hemorrhage (ICH) and cognitive impairment in the aging population. Magnetic resonance imaging (MRI) of cerebral microbleeds is the most reliable option for clinical diagnosis of suspected CAA. The pathophysiology of microbleeds and ICH in CAA is not well understood, but it is thought to be the result of vessel weakening and rupture secondary to amyloid deposition. Little evidence has been established pertaining to the time course of recurrent CAA-related microbleeds or larger hemorrhages. Although several risk factors have been associated with an increased risk of ICH in CAA, there are no current treatment guidelines for recurrent hemorrhaging in CAA. Case Report: We present a rare case of rapidly sequential and fatal lobar hemorrhaging in the setting of suspected CAA, diagnosed by numerous microbleeds on MRI, compounded by the use of subcutaneous heparin in a 63-year-old female patient. Conclusions: This case broadens our understanding of a rarely identified progression of CAA and illustrates the need for further investigation of the use of subcutaneous heparin in the setting of probable CAA.
This paper references
[Cerebral amyloid angiopathy].
T. A. Makotrova (2014)
Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathy
A. Biffi (2010)
Cerebral Microbleeds on Magnetic Resonance Imaging and Anticoagulant-Associated Intracerebral Hemorrhage Risk
Andreas Charidimou (2012)
Cerebral amyloid angiopathy in the elder
A Viswanathan (2011)
Effects of Perindopril-Based Lowering of Blood Pressure on Intracerebral Hemorrhage Related to Amyloid Angiopathy: The PROGRESS Trial
Hisatomi Arima (2010)
Cerebral Amyloid Angiopathy: Emerging Concepts
Masahito Yamada (2015)
Rapidly sequential and fatal hemorrhaging in a case of cerebral amyloid angiopathy © Am J Case Rep This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4
Z B Bulwa (2016)
Cerebral amyloid angiopathy-associated intracerebral hemorrhage: pathology and management.
Prachi Mehndiratta (2012)
Cerebral amyloid angiopathy in the elderly.
Masanori Tomonaga (1981)
Clinical features of nonhypertensive lobar intracerebral hemorrhage related to cerebral amyloid angiopa
M Hirohata (2010)
Use of antithrombotic drugs and the presence of cerebral microbleeds: the Rotterdam Scan Study.
Meike W. Vernooij (2009)
Clinical features of non-hypertensive lobar intracerebral hemorrhage related to cerebral amyloid angiopathy.
Masaru Hirohata (2010)
Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
L. Morgenstern (2010)
Thrombolysis-Related Intracerebral Hemorrhage and Cerebral Amyloid Angiopathy: Accumulating Evidence
Andreas Charidimou (2015)
Hemorrhage Burden Predicts Recurrent Intracerebral Hemorrhage After Lobar Hemorrhage
S. Greenberg (2004)
Statin Use and Microbleeds in Patients With Spontaneous Intracerebral Hemorrhage
D. Haussen (2012)
Brain microbleeds as a potential risk factor for antiplatelet-related intracerebral haemorrhage: hospital-based, case–control study
Simone M. Gregoire (2010)
A risk factor analysis of prospective symptomatic haemorrhage in adult patients with cerebral cavernous malformation
Jin Sue Jeon (2014)
Statin Therapy and the Risk of Intracerebral Hemorrhage: A Meta-Analysis of 31 Randomized Controlled Trials
James S. McKinney (2012)
Risk Factors, Stroke Prevention Treatments, and Prevalence of Cerebral Microbleeds in the Framingham Heart Study
José Rafael Romero (2014)
Warfarin-associated hemorrhage and cerebral amyloid angiopathy
Jonathan Rosand (2000)
Hemorrhage from cerebral cavernous malformations: a systematic pooled analysis.
B. Gross (2017)
Association Between Blood Pressure Control and Risk of Recurrent Intracerebral Hemorrhage.
A. Biffi (2015)
Treatment and prevention of primary intracerebral hemorrhage.
A. Towfighi (2005)
Statin use following intracerebral hemorrhage: a decision analysis.
M. Westover (2011)
Hemorrhage burden predicts recurrent
SM Greenberg (2004)
An Up-to-Date Review on Cerebral Microbleeds.
Y. Wu (2016)
The Pathophysiology and Clinical Presentation of Cerebral Amyloid Angiopathy
E. Auriel (2012)

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