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鲑鱼降钙素PLGA微球缓释载体 Salmon Calcitonin-Loaded PLGA Microspheres As A Sustained-Release Vehicle

吴瑞雪
Published 2017 · Materials Science

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本文制备六种不同分子量和末端基团的载鲑鱼降钙素PLGA微球(SCT-PLGA MS),优选合适微球用于废用性骨质疏松症在骨折损伤部位缓释药物。载药微球平均粒径均为120 μm,形态圆整;包封率均高于60%,载药量约为0.5%;差示扫描量热(DSC)测试结果表明SCT包载在于PLGA微球中,并以无定形态存在;体外释放结果表明分子量为20 kDa的-COOH末端载药微球(SCT-PLGA-20 COOH MS) 40 天累积释放百分率达79%以上,具有良好的缓释作用;体外降解中SCT-PLGA-20 COOH MS pH值随时间延长下降速率高于其他微球。因此,本研究中SCT-PLGA-20 COOH MS有望用于治疗废用性骨质疏松症。 In this study, to optimize appropriate poly(d,l-lactic-co-glycolic acid) microspheres (PLGA MS) to release SCT in the treatment of disuse osteoporosis, six kinds of SCT-PLGA MS with different mo-lecular weight and terminal groups were prepared. SCT-PLGA MS had an average particle size of about 120 μm, an encapsulation efficiency of 60%, and a drug loading of 0.5%. The result of differential scanning calorimetry (DSC) evidenced that SCT had been entrapped as an amorphous form in MS matrix. For SCT-PLGA-20 COOH MS, the cumulative release was above 79% at 40 d. PH value of SCT-PLGA-20 COOH MS decreased more rapidly than that of MS with -CH3 in the degradation. In conclusion, SCT-PLGA-20 COOH MS is promising in the treatment of disuse osteoporosis.
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