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The Adaptive Response In Radiobiology: Evolving Insights And Implications.

S. Wolff
Published 1998 · Medicine, Biology

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The first of the regularly reproducible experiments to show that very low doses of ionizing radiation, like very low doses of chemical agents, could induce mechanisms whereby cells become better fit to cope with subsequent exposures to high doses were carried out on the induction of chromosome aberrations in cultures of human lymphocytes. If cells that had been exposed to a very low dose (1 cGy) of X rays were subsequently exposed to a relatively high dose (1 Gy), approximately half as many chromosome breaks were induced. Subsequent experiments showed that this adaptive response to low doses requires a certain minimal dose before it becomes active; occurs only within a relatively small window of dose; is dose-rate dependent; and depends on the genetic constitution of the people or animals exposed, with some being unresponsive. It was further shown that the response to the low-dose preexposure was not instantaneous but took approximately 4 to 6 hr to become fully active, and could be prevented if during this period protein synthesis was inhibited, i.e., a necessary protein (enzyme) was being induced. In fact, subsequent experiments with two-dimensional gel electrophoresis showed new proteins in cells irradiated with 1 to 2 cGy. The adaptation induced by low doses of radiation was therefore attributed to the induction of a novel efficient chromosome break repair mechanism that if active at the time of challenge with high doses would lead to less residual damage. This hypothesis was strengthened by a series of experiments in which it was found that inhibitors of poly(ADP-ribose)polymerase, an enzyme implicated in DNA strand break rejoining, could prevent the adaptive response. Although the phenomenon is well established in cellular systems, it is still problematical as to whether or not it will have any utility in establishing risks of ionizing radiation to humans. Newer experiments have now been carried out on the mechanisms underlying the effect and whether or not the effect can manifest itself as a decrease in the number of induced cancers and radiation-induced mortality. Experiments with restriction enzymes now indicate that double-strand breaks in DNA can be triggering events in adaptation. In addition, preliminary experiments on the survival of whole-body irradiated mice have shown that multiple exposures to low adapting doses can have profound effects on survival, and other experiments have shown that adaptation can affect the induction of thymic lymphoma in irradiated mice. It therefore appears that the initial experiments behind the adaptive response have led to a vigorous worldwide effort to understand the basic mechanisms behind it. This effort is stimulated both by a desire to understand the basic cell biology behind the response and a desire to see if indeed this phenomenon affects the estimation of risks of low-level radiation exposure. ImagesFigure 1Figure 2
This paper references
United Nations Scientific Committee on the Effects of Atomic Radiation. 1994 Report to the General Assembly, With Annexes. Sources and Effects of Ionizing Radiation
(1994)
10.1016/B978-0-12-322650-1.50144-2
RELATION BETWEEN DNA REPAIR, CHROMOSOME ABERRATIONS, AND SISTER CHROMATID EXCHANGES
S. Wolff (1978)
10.1093/MUTAGE/8.2.109
Cultured mouse SR-1 cells exposed to low dose of gamma-rays become less susceptible to the induction of mutagenesis by radiation as well as bleomycin.
P. Zhou (1993)
Role of X-ray-inducible genes and proteins in adaptive survival responses. In: Low Dose Irradiation and Biological Defense Mechanisms
M Meyers (1992)
Hypersensitivity to verylow single doses : its relationship to the adaptive response and induced radioresistance
MC Joiner (1992)
10.1093/MUTAGE/2.2.95
Very low doses of X-rays can cause human lymphocytes to become less susceptible to ionizing radiation.
J. Shadley (1987)
10.1073/PNAS.90.15.7200
Isolation of x-ray-inducible transcripts from radioresistant human melanoma cells.
D. Boothman (1993)
Radiation-induced radioresistance in a normal human skin fibroblast cell line
Azzam El (1992)
Radio-adaptive response in mice chronically exposed to low dose rate of y-rays
Ai Gaziev (1992)
10.1093/MUTAGE/1.5.375
Evidence that the [3H]thymidine-induced adaptive response of human lymphocytes to subsequent doses of X-rays involves the induction of a chromosomal repair mechanism.
J. Wiencke (1986)
Low-dose exposures and the induction of adaptation In: Low Dose Irradiation and Biological Defense Mechanisms
S Wolff (1992)
10.1016/0027-5107(89)90101-2
Adaptive response of human lymphocytes to low-level radiation from radioisotopes or X-rays.
K. Sankaranarayanan (1989)
10.1016/0027-5107(72)90007-3
The repair of x-ray-induced chromosome aberrations in stimulated and unstimulated human lymphocytes.
S. Wolff (1972)
10.1289/ehp.isee2017
Environmental Health Perspectives
J. Harington (1976)
Low dose radiation : biological bases of risk assessment
K. Baverstock (1989)
10.2307/3576936
Characterization of the adaptive response to ionizing radiation induced by low doses of X rays to human lymphocytes.
J. Shadley (1987)
10.1038/287861A0
Evidence for an adaptive DNA repair pathway in CHO and human skin fibroblast cell lines
L. Samson (1980)
10.1016/0165-1161(86)90027-0
Exposure of human lymphocytes to ionizing radiation reduces mutagenesis by subsequent ionizing radiation.
B. J. Sanderson (1986)
10.1016/S0027-5107(96)00118-2
Hypersensitivity to very-low single radiation doses: its relationship to the adaptive response and induced radioresistance.
M. Joiner (1996)
10.1016/0165-7992(89)90107-3
Inhibition of the adaptive response of human lymphocytes to very low doses of ionizing radiation by the protein synthesis inhibitor cycloheximide.
J. H. Youngblom (1989)
X-rayinducible transcripts and altered cell cycle regulation are involved in adaptive survival responses in human cells
M Meyers (1994)
10.1080/09553009114550161
Adaptive response to dominant lethality of mature (class A) and immature (class B) oocytes of D. melanogaster to low doses of ionizing radiation: effects in repair-proficient (yw) and repair-deficient strains (mei 41D5 and mus 302D1).
H. Fritz-Niggli (1991)
10.1016/0027-5107(87)90217-X
Chromosomal responses to ionizing radiation reminiscent of an adaptive response in cultured Chinese hamster cells.
T. Ikushima (1987)
Low - dose exposures and the induction of adaptation
S Wolff (1989)
Radio-adaptive response: involvement of induction of specific gene expression by low doses of ionizing radiation
T Ikushima (1992)
Report to the General Assembly, With Annexes. Sources and Effects of Ionizing Radiation
(1994)
10.1016/0027-5107(89)90102-4
Variability of the adaptive response to ionizing radiations in humans.
A. Bosi (1989)
10.1016/S0027-5107(96)00125-X
Role of radioadaptation on radiation-induced thymic lymphoma in mice.
D. Bhattacharjee (1996)
10.1080/09553008814550401
Human lymphocytes exposed to low doses of ionizing radiations become refractory to high doses of radiation as well as to chemical mutagens that induce double-strand breaks in DNA.
S. Wolff (1988)
The adaptive response of human lymphocytes to very low doses of ionizing radiation : a case of induced chromosomal repair with the induction of specific proteins
S Wolff (1989)
Radio - adaptive response in mice chronically exposed to low dose rate of yrays
AI Gaziev (1990)
10.1016/0165-7992(91)90001-K
Human lymphocytes exposed to low doses of X-rays are less susceptible to radiation-induced mutagenesis.
K. Kelsey (1991)
10.1016/S0027-5107(96)00126-1
Two types of X-ray-induced radioresistance in mice: presence of 4 dose ranges with distinct biological effects.
M. Yonezawa (1996)
10.1126/SCIENCE.1354393
Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction.
P. Liang (1992)
10.1093/NAR/21.14.3269
Distribution and cloning of eukaryotic mRNAs by means of differential display: refinements and optimization.
P. Liang (1993)
10.1016/0027-5107(80)90094-9
Molecular mechanisms involved in the production of chromosomal aberrations. II. Utilization of Neurospora endonuclease for the study of aberration production by X-rays in G1 and G2 stages of the cell cycle.
A. T. Natarajan (1980)
Isolation of Xrayinducible transcripts from radioresistant human melanoma cells
DA Boothman (1992)
10.1080/09553009014551541
Induction of cytogenetic adaptive response of somatic and germ cells in vivo and in vitro by low-dose X-irradiation.
L. Cai (1990)
10.1016/0278-6915(84)90101-7
Induced mutagenesis. Molecular mechanisms and their implications for environmental protection.
C. Lawrence (1983)
10.2307/3578262
Decreased deletion mutation in radioadapted human lymphoblasts.
O. Rigaud (1993)
Hypersensitivity to very-low single doses: its relationship to the adaptive response and induced radioresistance
Mc Joiner (1996)
Indications of strain specificity for the induction of adaptive response to ionizing radiation in mice
A Wojcik
10.1007/978-1-4684-4382-0_12
The induction of resistance to alkylation damage in mammalian cells.
L. Samson (1983)
Role of Xrayinducible genes and proteins in adaptive survival responses
M Meyers (1992)
10.1126/SCIENCE.6695170
Adaptive response of human lymphocytes to low concentrations of radioactive thymidine.
G. Olivieri (1984)



This paper is referenced by
10.1007/BF02702568
Adaptive response and split-dose effect of radiation on the survival of mice
Ashu Bhan Tiku (2007)
10.2203/dose-response.06-110.Morgan
Will Radiation-Induced Bystander Effects or Adaptive Responses Impact on the Shape of the Dose Response Relationships at Low Doses of Ionizing Radiation?
W. Morgan (2006)
10.20381/RUOR-13166
APM2 is a novel mediator of cisplatin resistance in a variety of cancer cell types in vitro and in xenograft models of cancer
B. J. Scott (2009)
10.1007/978-3-030-44518-8_10
Multiple Dynamics in Tumor Microenvironment Under Radiotherapy.
J. Huang (2020)
10.1093/TOXSCI/KFH241
No-observed effect levels for carcinogenicity and for in vivo mutagenicity of a genotoxic carcinogen.
M. Hoshi (2004)
10.1097/HP.0b013e3181b08a20
DOES SCIENTIFIC EVIDENCE SUPPORT A CHANGE FROM THE LNT MODEL FOR LOW-DOSE RADIATION RISK EXTRAPOLATION?
D. Averbeck (2009)
Efectos de vecindad de la radiación ionizante y sus implicaciones en radioterapia y radioprotección
F. Saraví (2009)
10.1016/j.mrfmmm.2015.03.011
Effect of chronic low dose natural radiation in human peripheral blood mononuclear cells: Evaluation of DNA damage and repair using the alkaline comet assay.
P. V. Kumar (2015)
FOLLOWING EXPOSURES TO IONIZING RADIATION Article 5 3-2007 DOE PROGRAM — DEVELOPING A SCIENTIFIC BASIS FOR RESPONSES TO LOW-DOSE EXPOSURES : IMPACT ON DOSE-RESPONSE RELATIONSHIPS
A. L. Brooks (2019)
10.1111/j.1447-0594.2004.00254.x
Hormesis and intervention of aging: An emerging paradigm in gerontology
S. Goto (2004)
10.2203/dose-response.003.04.009
Stochastic Thresholds: A Novel Explanation of Nonlinear Dose-Response Relationships for Stochastic Radiobiological Effects
B. Scott (2006)
10.4022/jafib.801
Age-Dependent Impact of Fluoroscopic Radiation on the Gender of Off-Spring: An International Survey of Cardiologists.
J. Pillarisetti (2013)
10.1002/jez.2405
Beyond corticosterone: The acute stress response increases DNA damage in house sparrows.
Brenna M G Gormally (2020)
10.3390/ijerph17082898
Multiple Stressor Effects of Radon and Phthalates in Children: Background Information and Future Research
W. Kwan (2020)
10.1259/BJR/63353075
Evidence for beneficial low level radiation effects and radiation hormesis.
L. Feinendegen (2005)
10.1016/j.mrfmmm.2007.11.003
Analysis of spontaneous and bleomycin-induced chromosome damage in peripheral lymphocytes of long-haul aircrew members from Argentina.
A. Bolzán (2008)
10.1080/09553000902740143
Evaluation of radioadaptive response induced in CHO-K1 cells in a non-traditional model
C. Grillo (2009)
10.1002/EM.20354
Characteristics of the adaptive response in cultured salmon cells exposed to ionizing radiation
M. Kilemade (2008)
10.1093/mutage/gev032
Radio-adaptive response of base excision repair genes and proteins in human peripheral blood mononuclear cells exposed to gamma radiation.
S. Toprani (2015)
10.1158/0008-5472.CAN-10-1181
Evidence of an adaptive response targeting DNA nonhomologous end joining and its transmission to bystander cells.
H. Klammer (2010)
10.1177/1559325818796331
Health Impacts of Low-Dose Ionizing Radiation: Current Scientific Debates and Regulatory Issues
A. Vaiserman (2018)
10.1016/j.redox.2020.101654
Genome-wide transcriptional effects of deletions of sulphur metabolism genes in Drosophila melanogaster
O. Zatsepina (2020)
10.1016/S0300-9084(99)80049-2
Radiation inducible DNA repair processes in eukaryotes.
F. Eckardt-Schupp (1999)
10.1269/JRR.10107
Low-dose gamma-rays and simulated solar particle event protons modify splenocyte gene and cytokine expression patterns.
A. Rizvi (2011)
10.1088/1748-0221/10/02/P02010
Development of a PET cyclotron based irradiation setup for proton radiobiology
Sharif Ghithan (2015)
Radio-adaptive response in human lymphocytes
V. Gillette (2002)
In vivo recombination after chronic damage exposure falls to below spontaneous levels in "recombomice".
O. Kovalchuk (2004)
10.1080/09553000600567996
Low dose gamma-irradiation differentially modulates antioxidant defense in liver and lungs of Balb/c mice
P. Avti (2005)
10.1504/IJLR.2006.009510
Dose-effect relationship and estimation of the carcinogenic effects of low doses of ionizing radiation: the joint report of the Académie des Sciences (Paris) and of the Académie Nationale de Médecine.
M. Tubiana (2005)
10.1155/2013/649747
Oxidized Extracellular DNA as a Stress Signal in Human Cells
A. V. Ermakov (2013)
10.2203/dose-response.12-036.Belchior
Dose and Time Dependence of Targeted and Untargeted Effects after Very Low doses of α-Particle Irradiation of Human Lung Cancer Cells
A. Belchior (2012)
The Ionizing Radiation-Induced Bystander Effect: Evidence, Mechanism, and Signi fi cance
E. Azzam (2018)
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