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Biofunctionalized Tilted Fiber Bragg Gratings For Label-free Immunosensing.
Séverine Maguis, G. Laffont, P. Ferdinand, B. Carbonnier, K. Kham, T. Mekhalif, Marie-Claude Millot
Published 2008 · Materials Science, Medicine
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We present a study aimed at developing a label-free optical fiber biosensor for detection and quantification of biomolecules in real-time. The biosensor based on a Tilted Fiber Bragg Grating (TFBG) transduces a binding event between the probe and target molecules into a change in the refractive index of the medium surrounding the fiber. This work describes the experimental results obtained with three methods for immobilizing biomolecular probes on a TFBG silica cladding surface. Bovine serum albumin (BSA) and anti-BSA are used to assess the performances of the TFBG based biosensor in each configuration.
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