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Gene Expression Signature Of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities Between Tumors And Wounds

H. Chang, Julie B Sneddon, Ash A. Alizadeh, R. Sood, R. West, K. Montgomery, J. Chi, M. van de Rijn, D. Botstein, P. Brown
Published 2004 · Biology, Medicine

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Cancer invasion and metastasis have been likened to wound healing gone awry. Despite parallels in cellular behavior between cancer progression and wound healing, the molecular relationships between these two processes and their prognostic implications are unclear. In this study, based on gene expression profiles of fibroblasts from ten anatomic sites, we identify a stereotyped gene expression program in response to serum exposure that appears to reflect the multifaceted role of fibroblasts in wound healing. The genes comprising this fibroblast common serum response are coordinately regulated in many human tumors, allowing us to identify tumors with gene expression signatures suggestive of active wounds. Genes induced in the fibroblast serum-response program are expressed in tumors by the tumor cells themselves, by tumor-associated fibroblasts, or both. The molecular features that define this wound-like phenotype are evident at an early clinical stage, persist during treatment, and predict increased risk of metastasis and death in breast, lung, and gastric carcinomas. Thus, the transcriptional signature of the response of fibroblasts to serum provides a possible link between cancer progression and wound healing, as well as a powerful predictor of the clinical course in several common carcinomas.
This paper references
contributes to skin carcinogenesis
D Daniel
Putting tumours in context
M. Bissell (2001)
Distinct types
AA Alizadeh (2000)
Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer.
S. Geisler (2001)
MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis
L. Coussens (2000)
SOURCE: A PLoS Biology |
M Diehn (2003)
Identification of a novel protein from adult chicken brain that inhibits neurite outgrowth.
G. A. Clarke (1994)
Lysyl oxidase-related protein-1 promotes tumor fibrosis and tumor progression in vivo.
G. Akiri (2003)
The urokinase plasminogen activator system in cancer: Recent advances and implication for prognosis and therapy
N. Sidenius (2004)
The desmoplastic response to infiltrating breast carcinoma: gene expression at the site of primary invasion and implications for comparisons between tumor types.
C. Iacobuzio-Donahue (2002)
Immune Enhancement of Skin Carcinogenesis by CD4+ T Cells
D. Daniel (2003)
Molecular portraits of human breast tumours
C. Perou (2000)
Software tools for high-throughput analysis and archiving of immunohistochemistry staining data obtained with tissue microarrays.
C. Liu (2002)
Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis
S. Y. Leung (2002)
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors.
G. Bergers (2003)
Cluster analysis and display of genome-wide expression patterns
C. Ferris (1999)
Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses.
A. Bhattacharjee (2001)
Non-steroidal anti-inflammatory drugs and molecular carcinogenesis of colorectal carcinomas
G. Huls (2003)
Tissue microarrays for high-throughput molecular profiling of tumor specimens
J. Kononen (1998)
Diagnosis of multiple cancer types by shrunken centroids of gene expression
R. Tibshirani (2002)
Tumor Induction of VEGF Promoter Activity in Stromal Cells
D. Fukumura (1998)
Prediction of central nervous system embryonal tumour outcome based on gene expression
Scott L. Pomeroy (2002)
Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation.
B. Elenbaas (2001)
SOURCE: a unified genomic resource of functional annotations, ontologies, and gene expression data
M. Diehn (2003)
Epidermolysis bullosa and cancer
R. Mallipeddi (2002)
GO) (http://www. terms that appear in Dataset S1 are angiogensis (GO:0001525), blood coagulation (GO:0007596), complement activation
A molecular signature of metastasis in primary solid tumors
S. Ramaswamy (2003)
Combined overexpression of urokinase, urokinase receptor, and plasminogen activator inhibitor‐1 is associated with breast cancer progression: An immunohistochemical comparison of normal, benign, and malignant breast tissues
V. Costantini (1996)
A Mechanism of Cyclin D1 Action Encoded in the Patterns of Gene Expression in Human Cancer
J. Lamb (2003)
Identification of PLOD2 as Telopeptide Lysyl Hydroxylase, an Important Enzyme in Fibrosis*
Annemarie J van der Slot (2003)
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
T. Sørlie (2001)
Diversity of gene expression in adenocarcinoma of the lung
M. E. Garber (2001)
Page 0009 Serum Response and Cancer Progression
Page 0214 Serum Response and Cancer Progression
Macrophage Migration Inhibitory Factor (MIF)
J. Nishihira (1996)
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring.
T. Golub (1999)
Building A "GenBank" of the Published Literature
R. Roberts (2001)
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
H. Dvorak (1986)
A family of glycoproteins (GP55), which inhibit neurite outgrowth, are members of the Ig superfamily and are related to OBCAM, neurotrimin, LAMP and CEPU-1.
D. J. Wilson (1996)
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
Ash A. Alizadeh (2000)
The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma.
A. Rosenwald (2002)
Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas
Keisuke Kurose (2002)
LOXL2 (Locus Link ID 4017)
Macrophage migration inhibitory factor (MIF): Its potential role in tumor growth and tumor-associated angiogenesis.
J. Nishihira (2003)
Significance analysis of microarrays applied to the ionizing radiation response
V. G. Tusher (2001)
Lysyl oxidase.
R. C. Siegel (1979)
The transcriptional program in the response of human fibroblasts to serum.
V. R. Iyer (1999)
Gene expression profiling predicts clinical outcome of breast cancer
L. J. Veer (2002)
Information access: Building a ‘‘GenBank’
RJ Roberts (2001)
Identification of genes periodically expressed in the human cell cycle and their expression in tumors.
M. Whitfield (2002)
uPAR: a versatile signalling orchestrator
F. Blasi (2002)
Significant up-regulation of a novel gene, CLCP1, in a highly metastatic lung cancer subline as well as in lung cancers in vivo
K. Koshikawa (2002)
Laser capture microdissection-based in vivo genomic profiling of wound keratinocytes identifies similarities and differences to squamous cell carcinoma
Tanja X Pedersen (2003)
Diversity, topographic differentiation, and positional memory in human fibroblasts
H. Chang (2002)
Stereotyped and specific gene expression programs in human innate immune responses to bacteria
J. Boldrick (2002)

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Colorectal cancer cell lines lack the molecular heterogeneity of clinical colorectal tumors.
J. T. Auman (2010)
Gender differences in UVB induced cutaneous inflammation and skin carcinogenesis
J. Thomas‐Ahner (2007)
Boosting method via the sparse learner approach for high-dimensional gene expression data
M. Pritchard (2010)
The effect of substance P (SP) on adhesion of Jurkat leukemia cells and squamous carcinoma cells (SCC) to vascular endothelial cells and role in metastasis
Moustafa Elhousiny (2019)
The impact of expression profiling on prognostic and predictive testing in breast cancer
J. Reis-Filho (2006)
Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells.
Pravin J Mishra (2008)
The Genomic Analysis of Lactic Acidosis and Acidosis Response in Human Cancers
J. Chen (2008)
Dynamic modularity in protein interaction networks predicts breast cancer outcome
I. F. Taylor (2009)
An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers.
A. Witkiewicz (2009)
IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients
M. Rajski (2010)
Linking Interactome to Disease: A Network-Based Analysis of Metastatic Relapse in Breast Cancer
M. Garcia (2011)
Rebecca Ceder (2011)
Exploring the Interaction Between Cindr and JNK Signaling in Drosophila
Van Rensburg (2016)
Gene signatures revisited.
S. Baker (2012)
Combined static and dynamic analysis for determining the quality of time-series expression profiles
I. Simon (2005)
Gene expression profiling of breast cancer to select women for adjuvant chemotherapy.
BlueCross BlueShield (2008)
Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer.
J. Smith (2010)
Therapeutically exploiting STAT3 activity in cancer — using tissue repair as a road map
Jennifer Huynh (2018)
Pancreatic Cancer Associated Fibroblasts (CAF): Under-Explored Target for Pancreatic Cancer Treatment
J. Norton (2020)
The use of a comprehensive tumour xenograft dataset to validate gene signatures relevant for radiation response.
M. H. Starmans (2009)
Biological and Clinical Significance of MAD2L1 and BUB1, Genes Frequently Appearing in Expression Signatures for Breast Cancer Prognosis
Z. Wang (2015)
Additive effect of the AZGP1, PIP, S100A8 and UBE2C molecular biomarkers improves outcome prediction in breast carcinoma
T. Parris (2014)
Preliminary evaluation of the wound healing effect of Vitex doniana sweet (Verbenaceae) in mice.
K. Amégbor (2012)
Molecular genetic tests in the prediction of the prognosis of breast cancer
F. Stoddard (2011)
Interleukin-6 receptor in spindle-shaped stromal cells, a prognostic determinant of early breast cancer
V. Labovsky (2016)
Calcium-Binding Proteins S100A8 and S100A9 as Novel Diagnostic Markers in Human Prostate Cancer
Alexander Hermani (2005)
Identification of new genes associated with breast cancer progression by gene expression analysis of predefined sets of neoplastic tissues
D. Cimino (2008)
A Radiation-Derived Gene Expression Signature Predicts Clinical Outcome for Breast Cancer Patients
Brian D. Piening (2009)
Microarray data mining: facing the challenges
G. Piatetsky-Shapiro (2003)
Novel prognostic immunohistochemical biomarker panel for estrogen receptor-positive breast cancer.
B. Ring (2006)
Clinical and therapeutic perspectives of gene expression profiling for breast cancer.
V. Chiuri (2007)
New tools for assessing breast cancer recurrence.
Phuong Dinh (2008)
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