Online citations, reference lists, and bibliographies.
← Back to Search

Effect Of Fasting Blood Glucose Level On Heart Rate Variability Of Healthy Young Adults

Mohamed Faisal Lutfi, R. F. Elhakeem
Published 2016 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
Background Previous studies reported increased risk of cardiac events in subjects with fasting blood glucose (FBG) levels lower than the diagnostic threshold of diabetes mellitus. However, whether increased cardiac events in those with upper normal FBG is secondary to the shift of their cardiac sympathovagal balance towards sympathetic predominance is unknown. Aims To assess the association between FBG levels and cardiac autonomic modulation (CAM) in euglycaemic healthy subjects based on heart rate variability (HRV) derived indices. Subjects and Methods The study enrolled 42 healthy young adults. Following sociodemographic and clinical assessment, blood samples were collected to measure FBG levels. Five minutes ECG recordings were performed to all participants to obtain frequency domain HRV measurements, namely the natural logarithm (Ln) of total power (LnTP), very low frequency (LnVLF), low frequency (LnLF) and high frequency (LnHF), low frequency/ high frequency ratio (LnLF/HF), normalized low frequency (LF Norm) and high frequency (HF Norm). Results FBG levels correlated positively with LnHF (r = 0.33, P = 0.031) and HF Norm (r = 0.35, P = 0.025) and negatively with LF Norm (r = -0.35, P = 0.025) and LnLF/HF (r = -0.33, P = 0.035). LnHF and HF Norm were significantly decreased in subjects with the lower (4.00 (1.34) ms2/Hz and 33.12 (11.94) n.u) compared to those with the upper FBG quartile (5.64 (1.63) ms2/Hz and 49.43 (17.73) n.u, P = 0.013 and 0.032 respectively). LF Norm and LnLF/HF were significantly increased in subjects with the lower (66.88 (11.94) n.u and 0.73 (0.53)) compared to those with the higher FBG quartile (50.58 (17.83) n.u and 0.03 (0.79), P = 0.032 and 0.038 respectively). Conclusion The present study is the first to demonstrate that rise of blood glucose concentration, within physiological range, is associated with higher parasympathetic, but lower sympathetic CAM. Further researches are needed to set out the glycemic threshold beyond which further increase in glucose level readjusts sympathovagal balance towards sympathetic predominance again.
This paper references
10.1002/(SICI)1096-9136(199608)13:8<709::AID-DIA158>3.0.CO;2-8
Acute Effect of Insulin on Autonomic Regulation of the Cardiovascular System: A Study by Heart Rate Spectral Analysis
F. Bellavere (1996)
10.1093/OXFORDJOURNALS.EURHEARTJ.A014868
Heart rate variability. Standards of measurement, physiological interpretation, and clinical use
M. Malik (1996)
10.1161/01.CIR.93.5.1043
Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology.
A. J. Camm (1996)
10.2337/diacare.21.3.360
High Blood Glucose Concentration Is a Risk Factor for Mortality in Middle-Aged Nondiabetic Men: 20-year follow-up in the Whitehall Study, the Paris Prospective Study, and the Helsinki Policemen Study
B. Balkau (1998)
10.1152/ajpregu.1999.276.1.R178
Hyperinsulinemia produces cardiac vagal withdrawal and nonuniform sympathetic activation in normal subjects.
P. van de Borne (1999)
10.2337/DIACARE.22.1.45
Fasting blood glucose: an underestimated risk factor for cardiovascular death. Results from a 22-year follow-up of healthy nondiabetic men.
J. Bjørnholt (1999)
10.1046/j.1365-2362.2000.00626.x
Effects of glucose ingestion on cardiac autonomic nervous system in healthy centenarians: differences with aged subjects
Paolisso (2000)
10.2337/DIACARE.23.6.826
Is there a glycemic threshold for impaired autonomic control?
L. Watkins (2000)
10.2337/DIABETES.54.3.744
Effects of sustained insulin-induced hypoglycemia on cardiovascular autonomic regulation in type 1 diabetes.
M. Koivikko (2005)
10.2337/DIACARE.29.03.06.DC05-2009
Power spectral analysis of heart rate variability during the 100-g oral glucose tolerance test in pregnant women.
A. Weissman (2006)
Power spectral analysis of heart rate variability during the 100-g oral glucose tolerance test in pregnant women. Diabetes Care
A Weissman (2006)
10.1016/J.IJCARD.2007.06.047
Alterations of an average heart rate change heart rate variability due to mathematical reasons.
J. Sacha (2008)
10.3945/ajcn.2008.26299
Blunted sympathetic neural response to oral glucose in obese subjects with the insulin-resistant metabolic syndrome.
N. Straznicky (2009)
10.1136/heartjnl-2011-300033
Five-minute heart rate variability can predict obstructive angiographic coronary disease
D. Kotecha (2011)
10.1113/expphysiol.2010.056259
Low‐frequency power of heart rate variability is not a measure of cardiac sympathetic tone but may be a measure of modulation of cardiac autonomic outflows by baroreflexes
D. Goldstein (2011)
10.1134/S0362119711010154
Assessment of insulin resistance in normoglycemic young adults
B. Preethi (2011)
Review article: Heart rate variability
MF Lutfi (2011)
Reduced Heart Rate Variability Among YouthWith Type 1 Diabetes The SEARCH CVD study
M. Jaiswal (2012)
10.2337/dc12-0463
Reduced Heart Rate Variability Among Youth With Type 1 Diabetes
M. Jaiswal (2012)
10.4103/2230-8210.91203
Does hypoglycemia cause cardiovascular events?
Sandeep Chopra (2012)
10.4103/0970-2113.99111
Autonomic modulations in patients with bronchial asthma based on short-term heart rate variability
Mohamed Faisal Lutfi (2012)
Effect of blood pressure on heart rate variability
Mohamed Faisal Lutfi (2012)
Does hypoglycemia cause cardiovascular events? Indian Journal of Endocrinology and Metabolism
S Chopra (2012)
10.1089/dia.2013.0147
Impact of glycemic control on heart rate variability in youth with type 1 diabetes: the SEARCH CVD study.
M. Jaiswal (2013)
10.1111/psyp.12027
The utility of low frequency heart rate variability as an index of sympathetic cardiac tone: a review with emphasis on a reanalysis of previous studies.
G. A. Reyes del Paso (2013)
10.1016/B978-0-444-52902-2.00007-2
Testing the autonomic nervous system.
R. Freeman (2013)
10.1016/j.ijcard.2013.03.038
How to strengthen or weaken the HRV dependence on heart rate--description of the method and its perspectives.
J. Sacha (2013)
10.2147/NDT.S57523
Heart rate variability measurement and clinical depression in acute coronary syndrome patients: narrative review of recent literature
P. Harris (2014)
10.3389/fphys.2015.00385
Interaction Between Heart Rate Variability and Heart Rate in Pediatric Population
J. Gąsior (2015)
10.1097/HJH.0000000000000511
Relationship between right ventricular remodeling and heart rate variability in arterial hypertension
M. Tadic (2015)
10.3389/fphys.2015.00055
An introduction to heart rate variability: methodological considerations and clinical applications
G. Billman (2015)
10.1186/s12890-015-0118-8
Patterns of heart rate variability and cardiac autonomic modulations in controlled and uncontrolled asthmatic patients
Mohamed Faisal Lutfi (2015)



This paper is referenced by
10.1007/978-981-16-4115-2_4
Prediction of Blood Glucose Level Based on Lipid Profile and Blood Pressure Using Multiple Linear Regression Model
(2021)
10.1016/J.BUILDENV.2021.107678
Effect of hypoxia on human cognitive ability and indoor oxygen environment demand for sojourners at high altitude
Yanfeng Liu (2021)
10.1134/S0362119721020031
Heart Rate Variability as a Potential Non-invasive Marker of Blood Glucose Level
L. Jarman (2021)
10.1016/j.dsx.2020.07.035
"Comparison of cardiovascular autonomic activity (heart rate variability and baroreceptor sensitivity) in young healthy females during fasting and hyperglycaemia".
Farrukh Majeed (2020)
10.1159/000495519
Validity of Commonly Used Heart Rate Variability Markers of Autonomic Nervous System Function
B. Thomas (2019)
10.1016/j.explore.2019.12.009
Association between chocolate consumption frequency and heart rate variability indices.
R. Latif (2019)
10.1088/1757-899X/469/1/012050
Multiple linear regression model analysis in predicting fasting blood glucose level in healthy subjects
A. Aishah (2019)
Exploring leptin from endothelial activation to subclinical organ damage in young black and white adults: the African-PREDICT study
B. O. Ahiante (2019)
10.1007/s11517-018-1913-1
Cardiac autonomic modulation in response to a glucose stimulus
Gilberto Perpiñan (2018)
10.1055/s-0043-122236
Leptin and its Relation to Autonomic Activity, Endothelial Cell Activation and Blood Pressure in a Young Black and White Population: The African-PREDICT study.
B. O. Ahiante (2017)
The efficacy of Bikram yoga in stressed and sedentary adults
Zoe L. Hewett (2017)
Semantic Scholar Logo Some data provided by SemanticScholar