Online citations, reference lists, and bibliographies.
← Back to Search

Monitoring Endothelial And Tissue Responses To Cobalt Ferrite Nanoparticles And Hybrid Hydrogels

F. Finetti, E. Terzuoli, S. Donnini, M. Uva, M. Ziche, L. Morbidelli
Published 2016 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Iron oxide nanoparticles (NPs) have been proposed for many biomedical applications as in vivo imaging and drug delivery in cancer treatment, but their toxicity is an ongoing concern. When NPs are intravenously administered, the endothelium represents the first barrier to tissue diffusion/penetration. However, there is little information about the biological effects of NPs on endothelial cells. In this work we showed that cobalt-ferrite (CoFe2O4) NPs affect endothelial cell integrity by increasing permeability, oxidative stress, inflammatory profile and by inducing cytoskeletal modifications. To overcome these problems, NPs have be loaded into biocompatible gels to form nanocomposite hybrid material (polysaccharide hydrogels containing magnetic NPs) that can be further conjugated with anticancer drugs to allow their release close to the target. The organic part of hybrid biomaterials is a carboxymethylcellulose (CMC) polymer, while the inorganic part consists of CoFe2O4 NPs coated with (3-aminopropyl)trimethoxysilane. The biological activity of these hybrid hydrogels was evaluated in vitro and in vivo. Our findings showed that hybrid hydrogels, instead of NPs alone, were not toxic on endothelial, stromal and epithelial cells, safe and biodegradable in vivo. In conclusion, biohydrogels with paramagnetic NPs as cross-linkers can be further exploited for antitumor drug loading and delivery systems.
This paper references
Corrigendum to "Superparamagnetic iron oxide nanoparticles impair endothelial integrity and inhibit nitric oxide production" [Acta Biomater. 10 (2014) 4896-4911].
Ksenia Astanina (2015)
Nanoparticles and the immune system: challenges and opportunities.
S. Grabbe (2016)
The role of cobalt ferrite magnetic nanoparticles in medical science.
S. Amiri (2013)
Protective Effects of Novel Metal-Nonoates on the Cellular Components of the Vascular System
M. Monti (2014)
In vitro and in vivo evaluation of biodegradable embolic microspheres with tunable anticancer drug release.
Lihui Weng (2013)
Subtle cytotoxicity and genotoxicity differences in superparamagnetic iron oxide nanoparticles coated with various functional groups
Seong Cheol Hong (2011)
Hybrid Magnetic Hydrogel: A Potential System for Controlled Drug Delivery by Means of Alternating Magnetic Fields
G. Giani (2012)
Polysaccharide-Based Hydrogels: The Key Role of Water in Affecting Mechanical Properties
D. Pasqui (2012)
Biodistribution, kinetics, and biological fate of SPION microbubbles in the rat
Åsa Barrefelt (2013)
Cobalt ferrite nanoparticles: The control of the particle size and surface state and their effects on magnetic properties
Giovanni Baldi (2007)
Nanocomposite polymer hydrogels
Patrick J. Schexnailder (2009)
Facile fabrication of well-defined hydrogel beads with magnetic nanocomposite shells.
H. Liu (2009)
Targeting endothelial cell metabolism for cardio-protection from the toxicity of antitumor agents
L. Morbidelli (2016)
Drug delivery and nanoparticles: Applications and hazards
W. D. de Jong (2008)
Embedding magnetic nanoparticles into polysaccharide-based hydrogels for magnetically assisted bioseparation.
Y. Liang (2007)
Superparamagnetic iron oxide nanoparticles impair endothelial integrity and inhibit nitric oxide production.
Ksenia Astanina (2014)
Metal oxide nanoparticles as cross-linkers in polymeric hybrid hydrogels
D. Pasqui (2011)
On the Mechanism of Drug Release from Polysaccharide Hydrogels Cross-Linked with Magnetite Nanoparticles by Applying Alternating Magnetic Fields: the Case of DOXO Delivery
M. Uva (2015)
Toxic effects of iron oxide nanoparticles on human umbilical vein endothelial cells
X. Wu (2010)
Multifunctional carboxymethyl cellulose-based magnetic nanovector as a theragnostic system for folate receptor targeted chemotherapy, imaging, and hyperthermia against cancer.
B. Sivakumar (2013)
deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification.
M. Monti (2010)
Paradoxical roles of the immune system during cancer development
K. E. D. Visser (2006)
EP2 prostanoid receptor promotes squamous cell carcinoma growth through epidermal growth factor receptor transactivation and iNOS and ERK1/2 pathways
S. Donnini (2007)
Magnetic Nanoparticles in Cancer Theranostics
O. Gobbo (2015)
Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications.
S. Laurent (2008)
Influence of Alternating and Static Magnetic Fields on Drug Release from Hybrid Hydrogels Containing Magnetic Nanoparticles
M. Uva (2014)
Biohydrogels with magnetic nanoparticles as crosslinker: characteristics and potential use for controlled antitumor drug-delivery.
R. Barbucci (2012)
Superparamagnetic Iron Oxide Nanoparticles with Rigid Cross-linked Polyethylene Glycol Fumarate Coating for Application in Imaging and Drug Delivery
M. Mahmoudi (2009)
A novel strategy for engineering hydrogels with ferromagnetic nanoparticles as crosslinkers of the polymer chains. Potential applications as a targeted drug delivery system
R. Barbucci (2011)

This paper is referenced by
Magnetogels: Prospects and Main Challenges in Biomedical Applications
Sérgio R S Veloso (2018)
KRIT1 loss-mediated upregulation of NOX1 in stromal cells promotes paracrine pro-angiogenic responses.
F. Finetti (2020)
Carboxymethylcellulose hydrogels cross-linked with magnetite nanoparticles for the removal of organic and inorganic pollutants from water
M. Uva (2017)
A Review on Polysaccharide Based Nanocomposite Hydrogel Systems Fabrication Using Diverse Reinforcing Materials
Nisha Sharma (2020)
PluS Nanoparticles Loaded with Sorafenib: Synthetic Approach and Their Effects on Endothelial Cells
F. Palomba (2019)
Phaseolus vulgaris L. var. Venanzio Grown in Tuscany: Chemical Composition and In Vitro Investigation of Potential Effects on Colorectal Cancer
F. Finetti (2020)
Targeted T1 Magnetic Resonance Imaging Contrast Enhancement with Extraordinarily Small CoFe2O4 Nanoparticles
Dominique Piché (2019)
Exploiting Unique Alignment of Cobalt Ferrite Nanoparticles, Mild Hyperthermia, and Controlled Intrinsic Cobalt Toxicity for Cancer Therapy.
Preethi B Balakrishnan (2020)
Bidimentional In Vitro Angiogenic Assays to Study CCM Pathogenesis: Endothelial Cell Proliferation and Migration.
F. Finetti (2020)
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.
Margherita Brindisi (2019)
Applications of cobalt ferrite nanoparticles in biomedical nanotechnology.
S. Y. Srinivasan (2018)
Nanoparticles as new tools for inhibition of cancer angiogenesis
Nasser Hashemi Goradel (2018)
Effect of Magnesium Substitution on Structural, Magnetic and Biological Activity of Co(1-x)Mg(x)Fe2O4 Nano-colloids
Khuram Shahzad (2020)
Next‐Generation Magnetic Nanocomposites: Cytotoxic and Genotoxic Effects of Coated and Uncoated Ferric Cobalt Boron (FeCoB) Nanoparticles In Vitro
K. Netzer (2018)
pH responsive N-succinyl chitosan/Poly (acrylamide-co-acrylic acid) hydrogels and in vitro release of 5-fluorouracil
Shahid Bashir (2017)
Semantic Scholar Logo Some data provided by SemanticScholar