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Monitoring Endothelial And Tissue Responses To Cobalt Ferrite Nanoparticles And Hybrid Hydrogels

F. Finetti, E. Terzuoli, S. Donnini, M. Uva, M. Ziche, L. Morbidelli
Published 2016 · Chemistry, Medicine

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Iron oxide nanoparticles (NPs) have been proposed for many biomedical applications as in vivo imaging and drug delivery in cancer treatment, but their toxicity is an ongoing concern. When NPs are intravenously administered, the endothelium represents the first barrier to tissue diffusion/penetration. However, there is little information about the biological effects of NPs on endothelial cells. In this work we showed that cobalt-ferrite (CoFe2O4) NPs affect endothelial cell integrity by increasing permeability, oxidative stress, inflammatory profile and by inducing cytoskeletal modifications. To overcome these problems, NPs have be loaded into biocompatible gels to form nanocomposite hybrid material (polysaccharide hydrogels containing magnetic NPs) that can be further conjugated with anticancer drugs to allow their release close to the target. The organic part of hybrid biomaterials is a carboxymethylcellulose (CMC) polymer, while the inorganic part consists of CoFe2O4 NPs coated with (3-aminopropyl)trimethoxysilane. The biological activity of these hybrid hydrogels was evaluated in vitro and in vivo. Our findings showed that hybrid hydrogels, instead of NPs alone, were not toxic on endothelial, stromal and epithelial cells, safe and biodegradable in vivo. In conclusion, biohydrogels with paramagnetic NPs as cross-linkers can be further exploited for antitumor drug loading and delivery systems.
This paper references
10.1016/j.actbio.2014.11.009
Corrigendum to "Superparamagnetic iron oxide nanoparticles impair endothelial integrity and inhibit nitric oxide production" [Acta Biomater. 10 (2014) 4896-4911].
Ksenia Astanina (2015)
10.2217/NNM-2016-0281
Nanoparticles and the immune system: challenges and opportunities.
S. Grabbe (2016)
10.1016/j.msec.2012.09.003
The role of cobalt ferrite magnetic nanoparticles in medical science.
S. Amiri (2013)
10.1124/jpet.114.218404
Protective Effects of Novel Metal-Nonoates on the Cellular Components of the Vascular System
M. Monti (2014)
10.1016/j.actbio.2013.02.017
In vitro and in vivo evaluation of biodegradable embolic microspheres with tunable anticancer drug release.
Lihui Weng (2013)
10.2147/IJN.S26355
Subtle cytotoxicity and genotoxicity differences in superparamagnetic iron oxide nanoparticles coated with various functional groups
Seong Cheol Hong (2011)
10.3390/POLYM4021157
Hybrid Magnetic Hydrogel: A Potential System for Controlled Drug Delivery by Means of Alternating Magnetic Fields
G. Giani (2012)
10.3390/POLYM4031517
Polysaccharide-Based Hydrogels: The Key Role of Water in Affecting Mechanical Properties
D. Pasqui (2012)
10.2147/IJN.S49948
Biodistribution, kinetics, and biological fate of SPION microbubbles in the rat
Åsa Barrefelt (2013)
10.1016/J.JMMM.2006.11.157
Cobalt ferrite nanoparticles: The control of the particle size and surface state and their effects on magnetic properties
Giovanni Baldi (2007)
10.1007/S00396-008-1949-0
Nanocomposite polymer hydrogels
Patrick J. Schexnailder (2009)
10.1016/j.ijpharm.2009.04.031
Facile fabrication of well-defined hydrogel beads with magnetic nanocomposite shells.
H. Liu (2009)
10.1186/s40959-016-0010-6
Targeting endothelial cell metabolism for cardio-protection from the toxicity of antitumor agents
L. Morbidelli (2016)
10.2147/IJN.S596
Drug delivery and nanoparticles: Applications and hazards
W. D. de Jong (2008)
10.1002/CPHC.200700359
Embedding magnetic nanoparticles into polysaccharide-based hydrogels for magnetically assisted bioseparation.
Y. Liang (2007)
10.1016/j.actbio.2014.07.027
Superparamagnetic iron oxide nanoparticles impair endothelial integrity and inhibit nitric oxide production.
Ksenia Astanina (2014)
10.1016/J.MATLET.2010.10.053
Metal oxide nanoparticles as cross-linkers in polymeric hybrid hydrogels
D. Pasqui (2011)
10.3390/gels1010024
On the Mechanism of Drug Release from Polysaccharide Hydrogels Cross-Linked with Magnetite Nanoparticles by Applying Alternating Magnetic Fields: the Case of DOXO Delivery
M. Uva (2015)
10.2147/IJN.S10458
Toxic effects of iron oxide nanoparticles on human umbilical vein endothelial cells
X. Wu (2010)
10.1021/la305048m
Multifunctional carboxymethyl cellulose-based magnetic nanovector as a theragnostic system for folate receptor targeted chemotherapy, imaging, and hyperthermia against cancer.
B. Sivakumar (2013)
10.1016/j.yjmcc.2009.11.002
deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification.
M. Monti (2010)
10.1038/nrc1782
Paradoxical roles of the immune system during cancer development
K. E. D. Visser (2006)
10.1096/fj.06-7581com
EP2 prostanoid receptor promotes squamous cell carcinoma growth through epidermal growth factor receptor transactivation and iNOS and ERK1/2 pathways
S. Donnini (2007)
10.7150/thno.11544
Magnetic Nanoparticles in Cancer Theranostics
O. Gobbo (2015)
10.1021/cr068445e
Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications.
S. Laurent (2008)
10.4236/JBNB.2014.52014
Influence of Alternating and Static Magnetic Fields on Drug Release from Hybrid Hydrogels Containing Magnetic Nanoparticles
M. Uva (2014)
10.1016/j.actbio.2012.09.006
Biohydrogels with magnetic nanoparticles as crosslinker: characteristics and potential use for controlled antitumor drug-delivery.
R. Barbucci (2012)
10.1021/JP900798R
Superparamagnetic Iron Oxide Nanoparticles with Rigid Cross-linked Polyethylene Glycol Fumarate Coating for Application in Imaging and Drug Delivery
M. Mahmoudi (2009)
10.1039/C1SM05174A
A novel strategy for engineering hydrogels with ferromagnetic nanoparticles as crosslinkers of the polymer chains. Potential applications as a targeted drug delivery system
R. Barbucci (2011)



This paper is referenced by
10.3390/pharmaceutics10030145
Magnetogels: Prospects and Main Challenges in Biomedical Applications
Sérgio R S Veloso (2018)
10.1016/j.cellsig.2020.109527
KRIT1 loss-mediated upregulation of NOX1 in stromal cells promotes paracrine pro-angiogenic responses.
F. Finetti (2020)
10.1016/J.JECE.2017.07.025
Carboxymethylcellulose hydrogels cross-linked with magnetite nanoparticles for the removal of organic and inorganic pollutants from water
M. Uva (2017)
10.37591/jopc.v8i1.3732
A Review on Polysaccharide Based Nanocomposite Hydrogel Systems Fabrication Using Diverse Reinforcing Materials
Nisha Sharma (2020)
10.1021/acsomega.9b01699
PluS Nanoparticles Loaded with Sorafenib: Synthetic Approach and Their Effects on Endothelial Cells
F. Palomba (2019)
10.3390/antiox9121181
Phaseolus vulgaris L. var. Venanzio Grown in Tuscany: Chemical Composition and In Vitro Investigation of Potential Effects on Colorectal Cancer
F. Finetti (2020)
10.1021/acsami.8b17162
Targeted T1 Magnetic Resonance Imaging Contrast Enhancement with Extraordinarily Small CoFe2O4 Nanoparticles
Dominique Piché (2019)
10.1002/adma.202003712
Exploiting Unique Alignment of Cobalt Ferrite Nanoparticles, Mild Hyperthermia, and Controlled Intrinsic Cobalt Toxicity for Cancer Therapy.
Preethi B Balakrishnan (2020)
10.1007/978-1-0716-0640-7_27
Bidimentional In Vitro Angiogenic Assays to Study CCM Pathogenesis: Endothelial Cell Proliferation and Migration.
F. Finetti (2020)
10.1016/j.ejmech.2018.11.004
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.
Margherita Brindisi (2019)
10.2217/nnm-2017-0379
Applications of cobalt ferrite nanoparticles in biomedical nanotechnology.
S. Y. Srinivasan (2018)
10.1002/jcp.26029
Nanoparticles as new tools for inhibition of cancer angiogenesis
Nasser Hashemi Goradel (2018)
10.1007/s10876-020-01862-z
Effect of Magnesium Substitution on Structural, Magnetic and Biological Activity of Co(1-x)Mg(x)Fe2O4 Nano-colloids
Khuram Shahzad (2020)
10.1111/bcpt.12918
Next‐Generation Magnetic Nanocomposites: Cytotoxic and Genotoxic Effects of Coated and Uncoated Ferric Cobalt Boron (FeCoB) Nanoparticles In Vitro
K. Netzer (2018)
10.1371/journal.pone.0179250
pH responsive N-succinyl chitosan/Poly (acrylamide-co-acrylic acid) hydrogels and in vitro release of 5-fluorouracil
Shahid Bashir (2017)
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