Online citations, reference lists, and bibliographies.
← Back to Search

In Vitro Performance Testing Of Nanoparticulate Drug Products For Parenteral Administration

Elena Fecioru, M. Klein, J. Kraemer, M. Wacker
Published 2019 · Chemistry

Cite This
Download PDF
Analyze on Scholarcy
Share
The parenteral administration route is most effective for the delivery of drug substances with poor oral bioavailability. Nanoparticulate drug delivery systems were developed with the specific purpose of overcoming the obstacles met by conventional drug therapy for parenteral administration in case of drug targeting or passing biobarriers. Today, in vitro performance tests are a prerequisite for formulation development and quality control of nanoparticulate dosage forms, focusing on drug release and stability of the release rate in particular if the release should extend to days. As a consequence of the diverse technologies of these novel dosage forms, at present there is no standardized in vitro release test available. With a focus on parenterally administered formulations, this review describes published methods used for in vitro drug release testing of nanoparticulate drug products. Some of the techniques may be applicable to nanoparticulate dosage forms for oral application.
This paper references
10.1208/s12249-008-9146-5
5-Fluorouracil-Loaded BSA Nanoparticles: Formulation Optimization and In Vitro Release Study
A. Maghsoudi (2008)
10.2165/00003088-200342050-00002
Pharmacokinetics of Pegylated Liposomal Doxorubicin
A. Gabizon (2003)
10.1016/j.ejpb.2009.09.003
Drug delivery to the brain using surfactant-coated poly(lactide-co-glycolide) nanoparticles: influence of the formulation parameters.
S. Gelperina (2010)
10.1007/s11095-005-9397-8
Methods to Assess in Vitro Drug Release from Injectable Polymeric Particulate Systems
Susan Dsouza (2005)
Nanoparticle Preparation Process Using Novel Microjet Reactor Technology for Enhancing Dissolution Rates of Poorly Water Soluble Drugs
A. E. Türeli (2015)
Progress in Nanomedicine: Approved and Investigational Nanodrugs.
C. Ventola (2017)
10.14227/DT180311P15
Simulated Biological Fluids with Possible Application in Dissolution Testing
M. Marques (2011)
10.1007/s11095-012-0795-4
Development of a New Method to Assess Nanocrystal Dissolution Based on Light Scattering
K. Anhalt (2012)
A REVIEW ON PARENTRAL IMPLANTS
Tejashree A. Ghadge (2014)
10.1155/2014/304757
A Review of In Vitro Drug Release Test Methods for Nano-Sized Dosage Forms
Susan D'Souza (2014)
10.1007/s13346-012-0064-4
Drug release from nanomedicines: selection of appropriate encapsulation and release methodology
S. J. Wallace (2012)
10.14227/DT250418P8
In Vitro Release Test Methods for Drug Formulations for Parenteral Applications
V. Gray (2018)
10.1208/s12249-013-9960-2
Dissolution Studies of Poorly Soluble Drug Nanosuspensions in Non-sink Conditions
Peng Liu (2013)
10.1016/j.ejps.2018.05.004
How to measure release from nanosized carriers?
Lisa Nothnagel (2018)
10.22028/D291-23051
Analyzing drug load and release from pharmaceutical nanocarriers for the treatment of inflammatory bowel diseases
A. Guillot (2014)
Critical Quality and Performance Parameters for Modified-Release Parenteral Dosage Form
D. J. Burgess (2005)
10.1007/s11095-014-1569-y
Bridging Laboratory and Large Scale Production: Preparation and In Vitro-Evaluation of Photosensitizer-Loaded Nanocarrier Devices for Targeted Drug Delivery
Susanne Beyer (2014)
10.1016/J.CEP.2011.05.006
Influence of process conditions on the mean size of PLGA nanoparticles
T. Feczkó (2011)
10.1007/s11095-008-9560-0
What is a Suitable Dissolution Method for Drug Nanoparticles?
Desmond Heng (2008)
Physiology of the Cerebrospinal Fluid
H. Davson (1967)
10.1016/j.ijpharm.2010.01.009
A novel USP apparatus 4 based release testing method for dispersed systems.
U. Bhardwaj (2010)
10.1111/j.2042-7158.2012.01482.x
Accelerated in‐vitro release testing methods for extended‐release parenteral dosage forms
Jie Shen (2012)
10.1208/ps010311
A novel in vitro release method for submicron-sized dispersed systems
N. Chidambaram (2008)
10.1371/journal.pone.0032568
Uptake Mechanism of ApoE-Modified Nanoparticles on Brain Capillary Endothelial Cells as a Blood-Brain Barrier Model
S. Wagner (2012)
10.1016/j.ejpb.2018.03.010
A comparison of two biorelevant in vitro drug release methods for nanotherapeutics based on advanced physiologically‐based pharmacokinetic modelling
Fabian Jung (2018)
10.3762/bjnano.9.98
Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations
J. Jeevanandam (2018)
Evaluation of nanoparticles as drug-delivery systems. III: materials, stability, toxicity, possibilities of targeting, and use.
J. Kreuter (1983)
Biology data book, volume III.
P. L. Altman (1974)
10.1155/2013/374252
Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers
S. Salmaso (2013)
10.1007/s11481-006-9032-4
Nanotechnology: A Focus on Nanoparticles as a Drug Delivery System
J. Kingsley (2006)
Determination of the Dissolution Behavior of Celecoxib-Eudragit E 100-Nanoparticles Using CrossFlow Filtration
J. Schichtel (2017)
10.2174/187221111795471391
Parenteral drug delivery: a review.
Neha Gulati (2011)
10.4314/TJPR.V5I1.14634
Nanoparticles - A Review
V. Mohanraj (2007)
10.1023/A:1018983904537
Significant Transport of Doxorubicin into the Brain with Polysorbate 80-Coated Nanoparticles
A. Gulyaev (2004)
10.1016/J.MATPR.2017.09.189
Challenges in the drug release testing of next-generation nanomedicines – What do we know?
Matthias Wacker (2017)
10.1016/j.ejpb.2010.12.014
Online monitoring of dissolution tests using dedicated potentiometric sensors in biorelevant media.
D. Juenemann (2011)
10.1016/0378-5173(91)90367-W
A collaborative study of the in vitro dissolution of phenacetin crystals comparing the flow through method with the USP Paddle method
M. Nicklasson (1991)
10.1208/s12249-012-9875-3
Using USP I and USP IV for Discriminating Dissolution Rates of Nano- and Microparticle-Loaded Pharmaceutical Strip-Films
Lucas Sievens-Figueroa (2012)
10.3390/pharmaceutics10040233
In Vitro and In Silico Analyses of Nicotine Release from a Gelisphere-Loaded Compressed Polymeric Matrix for Potential Parkinson’s Disease Interventions
Pradeep Kumar (2018)
10.1016/j.jconrel.2012.03.020
Doxil®--the first FDA-approved nano-drug: lessons learned.
Y. Barenholz (2012)
10.1016/j.semcdb.2015.01.002
Anatomy and physiology of the blood-brain barrier.
Yonatan Serlin (2015)
10.1007/s11095-015-1761-8
Solid Phase Extraction as an Innovative Separation Method for Measuring Free and Entrapped Drug in Lipid Nanoparticles
A. Guillot (2015)
10.1111/j.2042-7158.2012.01520.x
Analytical methods for dissolution testing of nanosized drugs
D. Juenemann (2012)
10.5607/en.2014.23.3.246
Increasing the Efficiency of Parkinson's Disease Treatment Using a poly(lactic-co-glycolic acid) (PLGA) Based L-DOPA Delivery System
P. Gambaryan (2014)
10.1016/j.addr.2013.08.008
Drug delivery to the central nervous system by polymeric nanoparticles: what do we know?
J. Kreuter (2014)
First International Scientific Workshop on Nanomedicines
M. Papaluca (2010)
10.1016/j.ejpb.2010.10.012
Biorelevant in vitro dissolution testing of products containing micronized or nanosized fenofibrate with a view to predicting plasma profiles.
D. Juenemann (2011)
10.1016/j.actbio.2017.01.069
Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning.
Guangzhi Yang (2017)
10.1186/s40580-014-0031-5
Felodipine loaded PLGA nanoparticles: preparation, physicochemical characterization and in vivo toxicity study
U. Jana (2014)
10.14227/DT200213P15
In Situ Drug Release Monitoring with a Fiber-Optic System: Overcoming Matrix Interferences Using Derivative Spectrophotometry
Alexis Guillot (2013)
10.1208/pt040107
FIP/AAPS guidelines to dissolution/in vitro release testing of novel/special dosage forms
M. Siewert (2008)
10.1208/s12248-016-9967-1
Nanomedicines in the EU—Regulatory Overview
R. Pita (2016)
10.1007/978-3-319-41129-3_2
Nanoparticles Types, Classification, Characterization, Fabrication Methods and Drug Delivery Applications
Saurabh Bhatia (2016)
10.1016/j.ejpb.2017.02.006
The dispersion releaser technology is an effective method for testing drug release from nanosized drug carriers
C. Janas (2017)
10.1155/2013/136590
In Vitro Release Kinetics of Antituberculosis Drugs from Nanoparticles Assessed Using a Modified Dissolution Apparatus
Yuan Gao (2013)
10.1016/j.ijpharm.2012.04.053
Impact of the experimental conditions on drug release from parenteral depot systems: From negligible to significant.
C. Delplace (2012)



Semantic Scholar Logo Some data provided by SemanticScholar