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Synthesis, Biological Evaluation, Quantitative-SAR And Docking Studies Of Novel Chalcone Derivatives As Antibacterial And Antioxidant Agents

Mohammad Sayed Alam, S. M. Mostafizur Rahman, Dong-Ung Lee

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AbstractIn the present study, a series of chalcone derivatives including 17 new compounds were synthesised; their antibacterial activities against eleven bacteria, and their free radical-scavenging activities using DPPH were evaluated. All compounds showed significant antibacterial activities against both Grampositive and Gram-negative bacteria. In particular, compound IIIf strongly inhibited Staphylococcus aureus (JMC 2151) and Enterococcus faecalis (CARS 2011-012) with MIC values of 6.25 μg mL