Online citations, reference lists, and bibliographies.
← Back to Search

Why Is The Nanoscale Special (or Not)? Fundamental Properties And How It Relates To The Design Of Nano-enabled Drug Delivery Systems

Daniel P Otto, M. D. de Villiers
Published 2013 · Materials Science

Cite This
Download PDF
Analyze on Scholarcy
Share
Abstract Nanoscience studies describe natural phenomena at the submicron scale. Below a critical nanoscale limit, the physical, chemical, and biological properties of materials show a marked departure in their behavior compared to the bulk. At the nanoscale, energy conversion is dominated by phonons, whereas at larger scales, electrons determine the process. The surface-to-volume ratio at the nanoscale is immense, and interfacial interactions are markedly more important than at the macroscopic level, where the majority of the material is shielded from the surface. These properties render the nanoparticles to be significantly different from their larger counterparts. Nano-enabled drug delivery systems have resulted from multidisciplinary cooperation aimed at improving drug delivery. Significant improvements in the thermodynamic and delivery properties are seen due to nanotechnology. Hybrid nanodelivery systems, i.e., membranes with nanopores that can gate stimuli-responsive drug release could be a future development. Nanotechnology will improve current drug delivery and create novel future delivery systems. The fundamental properties and challenges of nanodelivery systems are discussed in this review.
This paper references
10.1109/JPROC.2006.879787
Nanoscale Thermal Transport and Microrefrigerators on a Chip
A. Shakouri (2006)
10.1007/s10439-005-9001-8
Metal Nanoshells
L. Hirsch (2005)
10.1021/JA045271E
Not ions alone: barriers to ion permeation in nanopores and channels.
O. Beckstein (2004)
10.1021/JP013365U
Nanoscale Mechanisms of Evaporation, Condensation and Nucleation in Confined Geometries
N. Maeda (2002)
10.1038/35102651
Biophysics: Water at the nanoscale
M. Sansom (2001)
10.1016/S0169-409X(01)00116-8
Mathematical modeling of bioerodible, polymeric drug delivery systems.
J. Siepmann (2001)
10.1021/IE50260A018
Dependence of Reaction Velocity upon surface and Agitation
A. Hixson (1931)
10.1002/CHIN.200708238
Gold Nanostructures: Engineering Their Plasmonic Properties for Biomedical Applications
Min Hu (2007)
Drug-loaded nanoparticles – preparation methods and drug targeting issues
E. Alleman (1993)
10.1007/BF00651970
Structure in aqueous solutions of nonpolar solutes from the standpoint of scaled-particle theory
F. H. Stillinger (1973)
10.1103/PHYSREVLETT.90.057401
Optical properties of gold nanorings.
J. Aizpurua (2003)
The physics of macro-, micro- and nanomaterials
G Guisbiers (2005)
Coexistence curves from Gibbs ensemble Monte Carlo simulations
I Brovchenko (1958)
10.1021/ja110801g
Controlled nucleation from solution using polymer microgels.
Ying Diao (2011)
10.1039/B502142C
Size matters: why nanomaterials are different.
E. Roduner (2006)
The Nobel Prize in Chemistry , 2000 : Conductive polymers
A. MacDiarmid
10.1039/B600460C
Release mechanisms for polyelectrolyte capsules.
B. D. De Geest (2007)
10.1063/1.1336569
Thermodynamic implications of confinement for a waterlike fluid
Thomas M Truskett (2001)
10.1002/POLB.21021
Calorimetric glass transition temperature and absolute heat capacity of polystyrene ultrathin films
Yung P. Koh (2006)
10.1103/PHYSREVLETT.95.035501
Single impurity effect on the melting of nanoclusters.
C. Mottet (2005)
10.1016/S0927-7757(02)00079-1
Wetting of nanoparticles and nanoparticle arrays
C. Powell (2002)
10.1016/J.IJPHARM.2005.08.008
Ibuprofen-loaded nanoparticles prepared by a co-precipitation method and their release properties.
B. Jiang (2005)
10.1063/1.479489
Melting thermodynamics of organic nanocrystals
Q. Jiang (1999)
Vapor pressure and solubility of small particles
VF Smolen (1967)
10.1021/NL020287T
Melting Temperature, Brillouin Shift, and Density of States of Nanocrystals
K. Shrivastava (2002)
10.1016/S0370-1573(02)00558-6
Thermal conduction in classical low-dimensional lattices
S. Lepri (2003)
10.1016/0378-5173(95)00033-F
The effect of particle size and shape on the surface specific dissolution rate of microsized practically insoluble drugs
M. Mosharraf (1995)
10.1023/A:1010003718481
Particularities of Heat Conduction in Nanostructures
Gang Chen (2000)
A SIMPLE EQUATION FOR SOLUTE RELEASE PART 1. FICKIAN AND NONFICKIAN RELEASE FROM NONSWELLABLE DEVICES IN THE FORM OF SLABS, SPHERES, CYLINDERS OR DISKS
P. L. Ritger (1987)
10.1016/S0928-4931(02)00266-7
Size effects on the phase diagrams of nanoparticles of various shapes
M. Wautelet (2003)
10.2147/NANO.2006.1.2.181
Chitosan and lactic acid-grafted chitosan nanoparticles as carriers for prolonged drug delivery
N. Bhattarai (2006)
10.1166/JNN.2006.426
Characterization of polymeric micelles for pulmonary delivery of beclomethasone dipropionate.
Nazar Noureen Gaber (2006)
10.1063/1.458411
Thermodynamic aspects of the vitrification of toluene, and xylene isomers, and the fragility of liquid hydrocarbons
C. Alba (1990)
10.1021/nn900299z
Pore-filling nanoporous templates from degradable block copolymers for nanoscale drug delivery.
Kuan-Hsin Lo (2009)
10.1088/0957-4484/17/13/030
Super-hydrophobic surfaces from a simple coating method: a bionic nanoengineering approach
Y. Liu (2006)
10.1021/nn201277a
Water boiling inside carbon nanotubes: toward efficient drug release.
V. Chaban (2011)
Coexistence curves from Gibbs ensemble Monte Carlo simulations
I Brovchenko (1958)
Drug release and release mechanism of prednisolone loaded Solid Lipid Nanoparticles
A. Z. Mühlen (1998)
10.1063/1.1590956
Molecular dynamics investigation of water permeation through nanopores
R. Allen (2003)
A review on electronic properties of individual and conducting polymer nanotubes and nanowires
YZ Long (2010)
10.1021/CM9601188
Vitrification and Crystallization of Organic Liquids Confined to Nanoscale Pores
C. Jackson (1996)
10.1016/S0375-9601(97)00070-4
Capillary condensation within nanopores of various geometries
F. Celestini (1997)
10.1002/ADMA.200501726
Conducting-Polymer Nanotubes for Controlled Drug Release.
M. Abidian (2006)
10.1021/JP035778W
Modeling of pH-Switchable Ion Transport and Selectivity in Nanopore Membranes with Fixed Charges
P. Ramírez (2003)
10.1063/1.1631919
Water in nanopores. I. Coexistence curves from Gibbs ensemble Monte Carlo simulations.
I. Brovchenko (2004)
10.3109/03639049209043684
Uptake capacity and adsorption isotherms of doxorubicin on polymeric nanoparticles: effect of methods of preparation
N. Bapat (1992)
10.1016/J.SNB.2005.03.095
Phase evolution induced by polypyrrole in iron oxide–polypyrrole nanocomposite
Dragoş-Viorel Brezoi (2005)
10.1557/MRS2001.232
Semiconducting and Metallic Polymers: The Fourth Generation of Polymeric Materials
A. Heeger (2001)
10.1021/LA026140Z
Experimental Confirmation of Different Mechanisms of Evaporation from Ink-Bottle Type Pores: Equilibrium, Pore Blocking, and Cavitation
P. Ravikovitch (2002)
10.1023/A:1020631200627
Thermal characteristics in a nanometer scale
I. Hatta (2002)
10.1016/J.MEE.2006.01.113
Porous silicon as drug carrier for controlled delivery of doxorubicin anticancer agent
L. Vaccari (2006)
10.1016/J.CARBON.2010.05.053
Increasing the electrical conductivity of carbon nanotube/polymer composites by using weak nanotube–polymer interactions
Y. Zeng (2010)
10.1016/J.JCIS.2005.05.045
The role of adsorption compression in nanocapillarity.
G. Aranovich (2005)
10.1088/0953-8984/13/19/312
Ballistic energy transfer in dielectric Ar crystals
A. Cenian (2001)
10.1007/s11095-007-9298-0
Effects of Carrier on Disposition and Antitumor Activity of Intraperitoneal Paclitaxel
Max Tsai (2007)
Study of the drug release mechanism from yrphostin AG-1295-loaded nanospheres by in situ and external sink methods
M Chorny (2002)
10.1166/JNN.2006.408
Polymeric nanoparticles as drug controlled release systems: a new formulation strategy for drugs with small or large molecular weight.
E. Leo (2006)
10.1007/S003400100666
The color of finely dispersed nanoparticles
M. Quinten (2001)
Diffusion control of porous membrane by modifying pore properties
MC Berg
10.1021/J100208A003
An emulsion technique for the study of marginal glass formation in molecular liquids
D. Macfarlane (1982)
10.1016/0378-5173(82)90038-2
Calculations of drug release rates from particles
R. H. Guy (1982)
10.3109/03639045.2010.504209
A formulation comparison between micro- and nanosuspensions: the importance of particle size for absorption of a model compound, following repeated oral administration to rats during early development
K. Sigfridsson (2011)
10.1098/rsif.2010.0120.focus
Applications of conducting polymers and their issues in biomedical engineering
R. Ravichandran (2010)
10.1080/02652040410001729278
Nanoparticle-coated microparticles: preparation and characterization
R. Beck (2004)
10.1016/0378-5173(90)90228-V
Physicochemical aspects of drug release: X. Investigation of the applicability of the cube root law for characterization of the dissolution rate of fine particulate materials
E. K. Anderberg (1990)
10.1103/PHYSREVLETT.91.106102
Higher surface energy of free nanoparticles.
K. K. Nanda (2003)
10.1016/S0378-5173(03)00225-4
Drug complexation, in vitro release and cellular entry of dendrimers and hyperbranched polymers.
P. Kolhe (2003)
10.1023/A:1021457911533
A New Mathematical Model Quantifying Drug Release from Bioerodible Microparticles Using Monte Carlo Simulations
J. Siepmann (2004)
10.1021/JA02086A003
The rate of solution of solid substances in their own solutions
A. A. Noyes (1897)
10.2478/BF02475591
On the size dependence of surface tension in the temperature range from melting point to critical point
N. Sdobnyakov (2005)
10.1021/ja200328s
pH-Triggered controlled drug release from mesoporous silica nanoparticles via intracelluar dissolution of ZnO nanolids.
Faheem Muhammad (2011)
10.1021/LA9701079
Adsorption and condensation in pores
C. Aharoni (1998)
10.1039/B212437H
Gold and silver nanoparticles: a class of chromophores with colors tunable in the range from 400 to 750 nm.
Y. Sun (2003)
10.1016/j.ejps.2010.09.008
PLGA:poloxamer blend micro- and nanoparticles as controlled release systems for synthetic proangiogenic factors.
Yolanda Parajó (2010)
10.1021/BI036231A
Real-time probing of membrane transport in living microbial cells using single nanoparticle optics and living cell imaging.
X. N. Xu (2004)
10.1016/J.COCIS.2006.05.001
Layer-by-layer engineered capsules and their applications
A. Johnston (2006)
10.1088/0957-4484/17/8/036
Size, shape and stress effects on the melting temperature of nano-polyhedral grains on a substrate
G. Guisbiers (2006)
10.1002/JPS.2600690814
Solubility and partitioning I: Solubility of nonelectrolytes in water.
S. Yalkowsky (1980)
Particle shape coefficients
H. Heywood (1954)
10.1016/J.MICROMESO.2010.10.042
Effect of textural properties on the drug delivery behaviour of nanoporous TiO2 matrices
M. Signoretto (2011)
10.1016/S0168-3659(00)00367-9
Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation.
H. M. Redhead (2001)
Controlling
T Asefa
10.1016/J.JCONREL.2006.11.011
Turbidimetric measurement and prediction of dissolution rates of poorly soluble drug nanocrystals.
M. T. Crisp (2007)
10.1016/0032-3861(96)00439-9
Synthesis, processing and material properties of conjugated polymers
W. J. Feast (1996)
10.1080/10587250008026186
Electrical and Optical Properties of Conducting Polymer and Carbons in Nano-Scale Periodic Structure and their Intercalation Effects
K. Yoshino (2000)
10.1115/1.2822665
Nonlocal and Nonequilibrium Heat Conduction in the Vicinity of Nanoparticles
G. Chen (1996)
10.1080/02652040600946886
Biodegradable micro- and nanoparticles as long-term delivery vehicles for gentamicin
C. Lecároz (2006)
10.1166/JNN.2005.175
Nanophononics: phonon engineering in nanostructures and nanodevices.
A. Balandin (2005)
10.1103/PHYSREVE.63.031801
Molecular weight dependence of reductions in the glass transition temperature of thin, freely standing polymer films.
K. Dalnoki-Veress (2001)
10.1016/J.PHYSB.2005.06.035
Size effect on melting temperature of nanosolids
Weihong Qi (2005)
10.1016/J.ORGEL.2009.09.018
Length-scale effects on electrical and thermal transport in polyaniline thin films
Jiezhu Jin (2010)
10.1016/J.JCONREL.2005.10.027
Electrochemically controlled release of dexamethasone from conducting polymer polypyrrole coated electrode.
Reecha Wadhwa (2006)
10.1021/nn901181c
Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release.
Jian You (2010)
10.1088/0957-4484/15/9/014
Mathematical modelling on the controlled-release of indomethacin-encapsulated poly(lactic acid-co-ethylene oxide) nanospheres
Y. S. Jo (2004)
10.1006/JCIS.2001.7837
The Thermodynamic Relations between the Melting Point and the Size of Crystals
Yongqiang Xue (2001)
10.1063/1.1524305
Nanoscale thermal transport
D. Cahill (2003)
10.1016/J.IJPHARM.2006.01.030
Experimental determination of the diffusion boundary layer width of micron and submicron particles.
C. Galli (2006)
10.1023/B:JOFL.0000031817.35049.1f
Using Solution-Phase Nanoparticles, Surface-Confined Nanoparticle Arrays and Single Nanoparticles as Biological Sensing Platforms
A. Haes (2004)
10.1016/S0167-577X(02)00667-5
Melting enthalpy depression of nanocrystals
Q. Jiang (2002)
10.1088/0957-4484/16/8/051
Melting point oscillation of a solid over the whole range of sizes
C. Sun (2005)
10.1016/J.EJPB.2006.06.001
Incorporation of camptothecin into N-phthaloyl chitosan-g-mPEG self-assembly micellar system.
P. Opanasopit (2006)
10.1016/S0040-6090(99)00537-4
Finite size effect on glass transition temperatures
Q. Jiang (1999)
10.1021/LA070050I
Inhibiting surface crystallization of amorphous indomethacin by nanocoating.
T. Wu (2007)
10.1016/J.JCONREL.2004.11.018
Release kinetics of hydrophobic and hydrophilic model drugs from pluronic F127/poly(lactic acid) nanoparticles.
X. Xiong (2005)
10.1063/1.1699711
Second‐Order Transition Temperatures and Related Properties of Polystyrene. I. Influence of Molecular Weight
T. Fox (1950)
10.1016/S0168-3659(03)00328-6
Polymer degradation and in vitro release of a model protein from poly(D,L-lactide-co-glycolide) nano- and microparticles.
J. Panyam (2003)
10.1016/S0168-3659(98)00116-3
PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug.
T. Govender (1999)
10.1039/DC9898800203
Charge transfer in conducting polymers. Striving toward intrinsic properties
A. Heeger (1989)
10.1002/JPS.2600631207
Solubility of nonelectrolytes in polar solvents II: solubility of aliphatic alcohols in water.
G. Amidon (1974)
10.1016/J.IJPHARM.2007.05.066
Effect of the microencapsulation of nanoparticles on the reduction of burst release.
A. S. Hasan (2007)
10.1016/S1369-7021(04)00614-5
Water on the nanoscale
C. Sealy (2004)
10.1016/0378-5173(88)90216-5
Physicochemical aspects of drug release. VII. The effect of surfactant concentration and drug particle size on solubility and dissolution rate of felodipine, a sparingly soluble drug
E. K. Anderberg (1988)
10.1063/1.94549
Scaling relations in the equation of state, thermal expansion, and melting of metals
F. Guinea (1984)
10.1016/J.PROGPOLYMSCI.2009.09.003
Carbon nanotube–polymer composites: Chemistry, processing, mechanical and electrical properties
Z. Špitalský (2010)
Polymeric colloidal systems containing ethionamide: preparation and physico-chemical characterization.
E. Lopes (2000)
10.1021/JP012233Y
A Hydrophobic Gating Mechanism for Nanopores
O. Beckstein (2001)
10.1021/AR9702278
Nucleation of First-Order Phase Transitions
D. Oxtoby (1998)
10.1023/A:1021532311219
Melting enthalpy depression of nanocrystals based on surface effect
L. Liang (2002)
10.1142/7579
An Introduction to Interfaces & Colloids: The Bridge to Nanoscience
J. Berg (2009)
10.1021/LA0267490
Correlation between saturation pressures and dimensions of nanoparticles. Are the fundamental equations really fair
V. K. Dobruskin (2003)
10.1039/B406006G
Physical chemistry of encapsulation and release
G. Sukhorukov (2004)
10.1016/J.PROGPOLYMSCI.2007.05.012
Conducting polymers in biomedical engineering
N. Guimard (2007)
10.1039/C0CE00394H
Polymorphism control of nanosized glycine crystals on engineered surfaces
Kyooneon Kim (2011)
Medical nanotechnology: shortening clinical trials and regulatory pathways?
M. Ferrari (2005)
10.1021/JP0470703
Activation Barrier Scaling for the Spontaneous Evaporation of Confined Water
A. Luzar (2004)
10.1007/s12045-011-0109-x
There’s plenty of room at the bottom
R. Feynman (2011)
10.1021/JP048762U
Melting of Nanostructured Drugs Embedded into a Polymeric Matrix
P. Bergese (2004)
10.1021/LA011345D
Effect of Anionic Starburst Dendrimers on the Crystallization of CaCO3 in Aqueous Solution: Size Control of Spherical Vaterite Particles
K. Naka (2002)
10.1080/00018739300101484
Low-dimensional systems: quantum size effects and electronic properties of semiconductor microcrystallites (zero-dimensional systems) and some quasi-two-dimensional systems
A. Yoffe (1993)
10.1016/J.IJPHARM.2004.07.019
The role of solid nanoparticle technology in the parenteral delivery of poorly water-soluble drugs.
J. Kipp (2004)
10.1039/B804266G
Stabilization of the amorphous state of pharmaceuticals in nanopores
G. Rengarajan (2008)
10.1021/JA049724R
Polymorph selectivity under nanoscopic confinement.
Jeong-Myeong Ha (2004)
10.1002/PSSA.200673223
Confinement effects on optical phonons in spherical, rod-, and tetrapod-shaped nanocrystals detected by Raman spectroscopy
C. Nobile (2007)
10.1021/am800038z
Maximum conductivity of packed nanoparticles and their polymer composites.
D. Untereker (2009)
10.2217/17435889.1.2.201
Biomedical applications of plasmon resonant metal nanoparticles.
Hongwei Liao (2006)
10.1016/S0921-4526(00)00564-0
Glass transition thermodynamics of organic nanoparticles
Z. Zhang (2001)
10.1002/SMLL.200400010
Nanoscience and nanotechnology: a personal view of a chemist.
V. Balzani (2005)
10.1016/S0303-2647(02)00010-2
From molecular biology to nanotechnology and nanomedicine.
K. Bogunia-Kubik (2002)
Water in nanopores
J. Köfinger (2009)
10.1016/J.SUSC.2006.09.037
Solubility of fractal nanoparticles
A. Mihranyan (2007)
10.1021/BM060200O
Study on drug release behaviors of poly-alpha,beta-[n-(2-hydroxyethyl)-L-aspartamide]-g-poly(epsilon-caprolactone) nano- and microparticles.
Zhi-Mei Miao (2006)
10.1016/J.COMPSCITECH.2007.10.056
Effect of nanotube waviness on the electrical conductivity of carbon nanotube-based composites
Chunyu Li (2008)
10.1016/j.ijpharm.2009.09.004
Comparison of anti-tumor efficacy of paclitaxel delivered in nano- and microparticles.
Sudhir S Chakravarthi (2010)
10.1016/J.ADDR.2005.09.014
Targeted drug delivery with dendrimers: comparison of the release kinetics of covalently conjugated drug and non-covalent drug inclusion complex.
A. Patri (2005)
10.1021/JP107631M
Amorphous Ibuprofen Confined in Nanostructured Silica Materials: A Dynamical Approach
A. Brás (2011)
10.1021/BM050174E
Controlled drug release from porous polyelectrolyte multilayers.
M. C. Berg (2006)
10.1039/B607437E
Thermally-induced glass formation from hydrogel nanoparticles.
D. Missirlis (2006)
Solubility. XII. Regular solutions
JH Hildebrandt (1929)
10.1016/S0168-3659(99)00012-7
Lidocaine loaded biodegradable nanospheres. II. Modelling of drug release.
M. Polakovič (1999)
10.1016/S0378-5173(00)00375-6
Defining the drug incorporation properties of PLA-PEG nanoparticles.
T. Govender (2000)
10.1115/1.1447938
Ballistic-Diffusive Equations for Transient Heat Conduction From Nano to Macroscales
G. Chen (2002)
10.1016/J.SAA.2004.10.035
A study on the sizes and concentrations of gold nanoparticles by spectra of absorption, resonance Rayleigh scattering and resonance non-linear scattering.
Y. Q. He (2005)
10.4135/9781412994231.N87
National Nanotechnology Initiative
M. Roco (2012)
10.1201/9781315217178-6
There's Plenty of Room at the Bottom: An Invitation to Enter a New Field of Physics
R. P. Feynman (2011)
10.1115/1.2352781
In-Plane and Out-Of-Plane Thermal Conductivity of Silicon Thin Films Predicted by Molecular Dynamics
C. J. Gomes (2006)
10.1016/S0939-6411(00)00143-0
Development and characterization of CyA-loaded poly(lactic acid)-poly(ethylene glycol)PEG micro- and nanoparticles. Comparison with conventional PLA particulate carriers.
R. Gref (2001)
10.1016/J.CES.2005.03.030
A conceptually simple derivation of the Kelvin equation (short communication)
K. Galvin (2005)
10.1016/J.DISAMONTH.2005.08.004
Nanostructure-mediated drug delivery.
G. Hughes (2005)
10.1177/153303460400300104
Nanoshell-Enabled Photonics-Based Imaging and Therapy of Cancer
C. Loo (2004)
10.1039/B401097C
Size-effects in the dissolution of hydroxyapatite: an understanding of biological demineralization
R. Tang (2004)
10.1002/ADFM.200700330
Selective Nucleation of Organic Single Crystals from Vapor Phase on Nanoscopically Rough Surfaces
S. Mannsfeld (2007)
10.1088/0022-3727/33/20/318
Modelling for size-dependent and dimension-dependent melting of nanocrystals
Zhensong Zhang (2000)
10.1115/1.2911450
Challenges in Microscale Conductive and Radiative Heat Transfer
C. L. Tien (1994)
10.1016/J.JPBA.2005.05.014
A new approach in the prediction of the dissolution behavior of suspended particles by means of their particle size distribution.
A. Tinke (2005)
10.1103/PhysRevLett.89.175502
Intermittent permeation of cylindrical nanopores by water.
R. Allen (2002)
10.1103/PHYSREVLETT.90.065502
Dynamics of capillary drying in water.
Kevin Leung (2003)
Nanoscale drug delivery behavior of nanoporous TiO 2 matrices
VV Chaban (2011)
10.1007/S10450-009-9176-7
Controlling adsorption and release of drug and small molecules by organic functionalization of mesoporous materials
T. Asefa (2009)
10.1016/S0928-4931(01)00410-6
Electric and elastic properties of conductive polymeric nanocomposites on macro- and nanoscales
M. Knite (2002)
10.1016/J.POLYMER.2011.06.046
Modeling and characterization of the electrical conductivity of carbon nanotube-based polymer composites
T. Takeda (2011)
10.1103/PHYSREVB.71.165412
Electronic transport in single polyaniline and polypyrrole microtubes
Y. Long (2005)
10.1016/J.ELECOM.2008.11.052
Electrochemically controlled release based on nanoporous conducting polymers
Xiliang Luo (2009)
10.1021/LA951007A
The Solid−Liquid Interface in Capillary Condensation. Sorption of Water by Active Carbons†
C. Aharoni (1997)
10.1002/adma.200901656
Preparation, bioactivity, and drug release of hierarchical nanoporous bioactive glass ultrathin fibers.
Y. Hong (2010)
10.1016/S0168-3659(00)00339-4
Biodegradable polymeric nanoparticles as drug delivery devices.
K. Soppimath (2001)
10.1016/J.MICROMESO.2007.12.003
Role of mesoporous silicates on carbamazepine dissolution rate enhancement
V. Ambrogi (2008)
10.1039/b914956m
Semiconducting polymers: the Third Generation.
A. Heeger (2010)
10.1021/LA011203J
Effect of the Energy of Adsorption at the Pore Wall Surface on Capillary Condensation
C. Aharoni (2002)
10.1016/S1359-6446(03)02874-5
Controlled release technologies for drug delivery.
D. Brayden (2003)
10.1016/J.ACTAMAT.2005.07.014
Phase diagram versus diagram of solubility: What is the difference for nanosystems?
A. Shirinyan (2005)
10.1016/S0958-1669(03)00068-5
Nanotechnology: convergence with modern biology and medicine.
M. Roco (2003)
10.1016/0378-5173(86)90131-6
Evaluation of carrier capacity and release characteristics for poly( butyl 2-cyanoacrylate) nanoparticles
L. Illum (1986)
10.1016/S0168-3659(02)00210-9
Study of the drug release mechanism from tyrphostin AG-1295-loaded nanospheres by in situ and external sink methods.
M. Chorny (2002)
10.1016/j.addr.2006.09.010
Particulate nanomedicines.
S. Moghimi (2006)
Controlling adsorption of drug and small molecules by organic functionalization of mesoporous materials
T Asefa (2009)
10.1021/JA060367P
A new class of silica cross-linked micellar core-shell nanoparticles.
Q. Huo (2006)
10.1063/1.2199469
Size-dependent melting behavior of Zn nanowire arrays
X. Wang (2006)
10.1002/ANIE.199001381
Starburst Dendrimers: Molecular‐Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter
D. Tomalia (1990)
10.1103/PHYSREVA.13.2287
Size effect on the melting temperature of gold particles
Pa Buffat (1976)
10.1142/S0217979206035849
MICROSCOPIC QUANTUM MECHANICAL FOUNDATION OF FOURIER'S LAW
M. Michel (2006)
10.1002/ADFM.200500878
Shape change and color gamut in gold nanorods, dumbbells, and dog bones
X. Xu (2006)
10.1021/MA60044A030
Glass Transition of the Polymer Microphase
Jan Barěs (1975)
10.1016/S1748-0132(07)70016-6
Au nanoparticles target cancer
P. Jain (2007)
10.1016/S1748-0132(07)70018-X
Nanostructuring expands thermal limits
W. Kim (2007)
10.1016/0168-3659(87)90035-6
A simple equation for description of solute release II. Fickian and anomalous release from swellable devices
P. L. Ritger (1987)
10.1016/S1748-0132(07)70017-8
Generating heat with metal nanoparticles
A. Govorov (2007)
10.1103/PHYSREVLETT.96.095504
Salt permeation and exclusion in hydroxylated and functionalized silica pores.
Kevin Leung (2006)
10.1002/JPS.2600521210
MECHANISM OF SUSTAINED-ACTION MEDICATION. THEORETICAL ANALYSIS OF RATE OF RELEASE OF SOLID DRUGS DISPERSED IN SOLID MATRICES.
T. Higuchi (1963)
10.1002/1521-3773(20011203)40:23<4330::AID-ANIE4330>3.0.CO;2-W
Organic Nanoparticles in the Aqueous Phase-Theory, Experiment, and Use.
D. Horn (2001)
10.1016/J.IJPHARM.2005.05.027
Nano-encapsulation of azole antifungals: potential applications to improve oral drug delivery.
R. Pandey (2005)
10.1103/PHYSREVE.56.R6283
Pathway to surface-induced phase transition of a confined fluid
K. Lum (1997)
10.1021/JP1108587
Improving the Adsorption and Release Capacity of Organic-Functionalized Mesoporous Materials to Drug Molecules with Temperature and Synthetic Methods
Rajyalakshmi Vathyam (2011)
10.1002/1521-3765(20020104)8:1<28::AID-CHEM28>3.0.CO;2-B
Size-dependent chemistry: properties of nanocrystals.
C. Rao (2002)
10.1016/S0375-9601(98)00538-6
ON THE SHAPE DEPENDENCE OF THE MELTING TEMPERATURE OF SMALL PARTICLES
M. Wautelet (1998)
10.1016/J.JCONREL.2006.09.013
Indomethacin-loaded polymeric nanocarriers based on amphiphilic polyphosphazenes with poly (N-isopropylacrylamide) and ethyl tryptophan as side groups: Preparation, in vitro and in vivo evaluation.
J. Zhang (2006)
10.1088/0957-4484/17/16/042
Solid solubility limit in alloying nanoparticles.
G. Ouyang (2006)
10.1088/0957-4484/15/12/004
Phase separation in nanoparticles
A. Shirinyan (2004)
10.1016/0378-5173(88)90235-9
Physicochemical aspects of drug release. VIII. The relation between particle size and surface specific dissolution rate in agitated suspensions
M. Bisrat (1988)
10.1016/0378-5173(92)90277-9
Physicochemical aspects of drug release. XV. Investigation of diffusional transport in dissolution of suspended, sparingly soluble drugs
M. Bisrat (1992)
10.1002/APP.31806
Preparation and in vitro drug‐release behavior of 5‐fluorouracil‐loaded poly(hydroxybutyrate‐co‐hydroxyhexanoate) nanoparticles and microparticles
Xiao-yun Lu (2010)
Microscopic quantum mechanical foundation of Fouriers
M Michel (2006)
Phase diagrams versus diagram of solubility: what is the difference for nanosystems ? Acta Mater
AS Shirinyan (2005)
10.1016/J.ACA.2005.10.011
Biosensing and drug delivery by polypyrrole.
S. Geetha (2006)
10.1021/CM061186P
High surface area nanoporous polymers for reversible hydrogen storage
J. Germain (2006)
10.1021/la104351k
Surface design for controlled crystallization: the role of surface chemistry and nanoscale pores in heterogeneous nucleation.
Ying Diao (2011)
10.1038/nature01845
Water-driven structure transformation in nanoparticles at room temperature
H. Zhang (2003)



This paper is referenced by
10.1517/17425247.2015.988135
Differences in physicochemical properties to consider in the design, evaluation and choice between microparticles and nanoparticles for drug delivery
Daniel P Otto (2015)
10.1016/j.ejpb.2019.05.004
Niclosamide repositioning for treating cancer: Challenges and nano-based drug delivery opportunities.
Eduardo José Barbosa (2019)
10.1007/s11051-019-4721-0
Evaluation of acute toxicity and copper accumulation in organs of Wistar rats, 14 days after oral exposure to copper oxide (II) nano- and microparticles
Magno Maciel-Magalhães (2019)
10.1080/09205063.2016.1184120
Preparation of ultrafine poly(methyl methacrylate-co-methacrylic acid) biodegradable nanoparticles loaded with ibuprofen
Hened Saade (2016)
10.1007/s11051-018-4405-1
Unique features of the nano-scale
S. Fonash (2018)
10.1007/978-3-319-48764-9_215
Hybrid Nanoscale Magnetic Composites
Maria A G Soler (2013)
10.1016/J.POWTEC.2014.01.088
Self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles
Schalk J. Strydom (2014)
10.1016/J.SOLIDSTATESCIENCES.2016.12.015
Compressibility and structural behavior of pure and Fe-doped SnO 2 nanocrystals
F. Grinblat (2017)
10.1088/2053-1591/AAE063
Characterization of V-doped SnO 2 nanoparticles at ambient and high pressures
Sergio Ferrari (2018)
10.1155/2016/8384973
Preparation and Loading with Rifampicin of Sub-50 nm Polyethyl cyanoacrylate Nanoparticles by Semicontinuous Heterophase Polymerization
Hened Saade (2016)
Semantic Scholar Logo Some data provided by SemanticScholar