Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

NO Donors With Anticancer Activity

A. Janczuk, Q. Jia, M. Xian, Z. Wen, P. Wang, T. Cai
Published 2002 · Chemistry

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Nitric oxide (NO) radicals, endogenously produced from L-arginine or supplied by NO-releasing donors, are involved in numerous physiological and pathological processes. Although there has been rapid growth in NO research, cancer research still remains in its infancy. A few reports suggest that NO has some anticancer properties, yet others implicate NO in tumour promotion. This article will focus on the anticancer activity of NO donors that have been claimed in patents between 1998 and 2001.
This paper references
10.1111/j.1525-1373.2000.22525.x
Nitric oxide donors.
T. Yamamoto (2000)
Peroxynitrite Oxidation of Sulfhydryls
Rafael Radil (1991)
cells through cGMP-independent mechanism
Griffith Feldman Pl (1996)
10.1053/EJSO.1999.0917
The actions and interactions of nitric oxide in solid tumours.
P. Brennan (2000)
Nitriglycerin-mediated vasorelaxation is modulated by endothelial calcium-activated potassium channels
L BANG (1999)
10.1021/JM00115A013
Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects.
C. M. Maragos (1991)
Relationship between the structure of taxol and other taxanes on induction of tumor necrosis factor-alpha gene expression and cytotoxicity.
C. Burkhart (1994)
10.1021/cen-v071n051.p026
The surprising life of nitric oxide
P. Feldman (1993)
10.1093/CARCIN/22.8.1207
Nitroglycerin: a NO donor inhibits TPA-mediated tumor promotion in murine skin.
P. Trikha (2001)
10.1016/S0024-3205(99)80006-X
Biotransformation and cytotoxic properties of NO-donors on MCF7 and U251 cell lines.
A. Adami (1998)
Nitric oxide synthesis contributes to IL-2-induced antitumor responses against intraperitoneal Meth A tumor.
C. Y. Yim (1995)
10.1046/J.1523-1755.2000.00808.X
Nitric oxide modulates expression of matrix metalloproteinase-9 in rat mesangial cells.
W. Eberhardt (2000)
10.1097/00005537-200111000-00004
Nitric Oxide Improves Cisplatin Cytotoxicity in Head and Neck Squamous Cell Carcinoma
B. Azizzadeh (2001)
10.1139/Y02-007
Role of nitric oxide in tumour progression with special reference to a murine breast cancer model.
L. Jadeski (2002)
Nitric oxide: physiology, pathophysiology, and pharmacology.
S. Moncada (1991)
10.2174/1568008013341811
Immunoregulatory effects of L-arginine and therapeutical implications.
M. Potenza (2001)
10.1016/S0887-2333(01)00006-6
In vitro cytotoxicity of glyco-S-nitrosothiols. a novel class of nitric oxide donors.
H. Babich (2001)
Rationale for development of platinum analogs.
J. Burchenal (1979)
10.1023/A:1020537506008
Endothelium-Derived Relaxing Factor: Discovery, Early Studies, and Identification as Nitric Oxide
R. Furchgott (1999)
10.1517/13543776.10.5.559
Nitric oxide donors - current trends in therapeutic applications
J. Lehmann (2000)
10.1016/S1470-2045(00)00256-4
Role of nitric oxide in carcinogenesis and tumour progression.
P. Lala (2001)
10.1046/j.1365-2613.1998.00081.x
Pharmacological reactivity of neoplastic and non‐neoplastic associated neovasculature to vasoconstrictors
Andrade (1998)
Nitric oxide inhibits ornithine decarboxylase by Snitrosylation
PM BAYER (1999)
Role of nitric oxide in macrophage antimicrobial activity
C NATHAN (1991)
10.1002/(SICI)1521-3773(19990712)38:13/14<1882::AID-ANIE1882>3.0.CO;2-V
Nitric oxide: a unique endogenous signaling molecule in vascular biology.
L. Ignarro (1999)
10.1006/EXCR.1997.3675
Nitric oxide and cGMP regulate endothelial permeability and F-actin distribution in hydrogen peroxide-treated endothelial cells.
S. M. Liu (1997)
10.1016/S0891-5849(00)00251-3
Diazeniumdiolates: pro- and antioxidant applications of the "NONOates".
A. Fitzhugh (2000)
10.1007/BF00046364
Vascular and interstitial barriers to delivery of therapeutic agents in tumors
R. Jain (2004)
10.1016/0092-8674(94)90266-6
Nitric oxide synthases: Roles, tolls, and controls
C. Nathan (1994)
CHAKRABORTY C: Role of nitric oxide in carcinogenesis and tumor progression
PK LALA (2001)
10.1006/BBRC.1998.8409
Structural significance of the benzoyl group at the C-3'-N position of paclitaxel for nitric oxide and tumor necrosis factor production by murine macrophages.
T. Kirikae (1998)
The role of p53 in cell-cycle control and apoptosis: implications for cancer.
C. J. Leonard (1995)
10.1006/BBRC.1999.1210
Nitric oxide inhibits ornithine decarboxylase by S-nitrosylation.
P. M. Bauer (1999)
Patents Papers of special note have been highlighted as either of interest (•) or of considerable interest (••) to readers
(2001)
10.1172/JCI112642
Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.
J. C. Drapier (1986)
10.1203/00006450-199501000-00010
Nitric Oxide-Induced Cytotoxicity: Involvement of Cellular Resistance to Oxidative Stress and the Role of Glutathione in Protection
M. W. Walker (1995)
Nitric oxide/nucleophile complexes inhibit the in vitro proliferation of A375 melanoma cells via nitric oxide release.
C. M. Maragos (1993)
10.1073/PNAS.92.16.7162
Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.
E. Bonfoco (1995)
Enhancement of fas-mediated cytotoxicity to tumour via treatment of NO
Changes in energy metabolism and X-ray sensitivity in murine tumours by the nitric oxide donor SIN-1.
P. Wood (1996)
10.1007/BF00690207
P53, cell cycle control and apoptosis: Implications for cancer
M. Kastan (2004)
10.1016/0163-7258(92)90051-Z
Multistage carcinogenesis in mouse skin.
J. DiGiovanni (1992)
10.1002/(SICI)1097-0142(20000115)88:2<381::AID-CNCR20>3.0.CO;2-M
Antitumor activity of a novel glyco‐nitric oxide conjugate in ovarian carcinoma
G. Cantuaria (2000)
10.1002/(SICI)1097-0215(19990209)80:4<617::AID-IJC22>3.0.CO;2-C
Hypoxia‐mediated stimulation of carcinoma cell invasiveness via upregulation of urokinase receptor expression
C. Graham (1999)
10.1016/0952-7915(91)90079-G
Role of nitric oxide synthesis in macrophage antimicrobial activity.
C. Nathan (1991)
10.1016/S0008-6363(99)00116-9
Nitroglycerin-mediated vasorelaxation is modulated by endothelial calcium-activated potassium channels.
L. Bang (1999)
10.1006/EXCR.1995.1266
Effects of the disintegrin eristostatin on individual steps of hematogenous metastasis.
V. Morris (1995)
Cisplatin and nitric oxide have synergistic antitumor activity in cP resistant human melanoma cells
PG BRAUNSCHWEIGER (1996)
Nitric oxide donor SNAP induces apoptosis in smooth muscle Jia, Janczuk, Cai, Xian, Wen & Wang Expert Opin
E NISHIO (1996)
Role of nitric oxide in carcinogenesis and tumor progression
Lala Pk (2001)
10.1016/S0960-894X(99)00363-7
Targeting nitric oxide to cancer cells: cytotoxicity studies of glyco-S-nitrosothiols.
Y. Hou (1999)
10.1042/bj3570593
Nitric oxide synthases: structure, function and inhibition.
W. K. Alderton (2001)
10.1016/0960-894X(96)00484-2
Glyco-S-nitrosothiols, a novel class of NO donor compounds
J. Ramirez (1996)
10.1023/A:1005960822365
Role of nitric oxide in tumor progression: Lessons from experimental tumors
P. Lala (2004)
The hypoxic cell: a target for selective cancer therapy--eighteenth Bruce F. Cain Memorial Award lecture.
J. Brown (1999)
10.1016/S0006-2952(97)00573-X
Differential inhibitory effects of three nitric oxide donors on ornithine decarboxylase activity in human colon carcinoma cells.
F. Blachier (1998)
10.1016/S0076-6879(99)01088-5
Glyco-S-nitrosothiols: sugar-SNAP, a new type of nitric oxide donor.
Y. Hou (1999)
10.1016/S0065-230X(01)82004-2
Nitric oxide-induced apoptosis in tumor cells.
V. Umansky (2001)
10.1016/0306-4522(94)00491-M
Nitric oxide induces necrotic but not apoptotic cell death in oligodendrocytes
B. Mitrovic (1995)
10.1006/BBRC.1994.2304
Exogenous nitric oxide inhibits proliferation of cultured vascular endothelial cells.
W. Yang (1994)
10.1023/A:1005963400984
Significance of nitric oxide in carcinogenesis, tumor progression and cancer therapy
P. Lala (2004)
10.1006/NIOX.1999.0232
Gas-phase oxidation of nitric oxide: chemical kinetics and rate constant.
H. Tsukahara (1999)
Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide.
R. Radi (1991)
10.1172/JCI119783
Nitric oxide in excitable tissues: physiological roles and disease.
K. S. Christopherson (1997)
10.1007/978-1-59259-002-5_8
Nitric Oxide and Platelet-Mediated Hemostasis
E. Battinelli (2000)
10.2165/00128415-199606230-00027
Nitric oxide
I. Rovira (1995)
10.1042/CS0980507
S-Nitrosothiols: a class of nitric oxide-donor drugs.
H. Al-Sa’doni (2000)
10.1002/jlb.59.6.797
Activation of nitric oxide synthase gene for inhibition of cancer metastasis
K. Xie (1996)
Nitric oxide and platelet-mediated hemostasis. In: Nitric oxide cardiovascular system
E M Battinelli (2000)
10.1084/JEM.169.5.1543
Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells
D. Stuehr (1989)
10.1016/S0891-5849(00)00247-1
Nitric oxide (NO)-related pharmaceuticals: contemporary approaches to therapeutic NO modulation.
D. Janero (2000)
10.1016/S0014-5793(00)01858-5
Structural significance of the acyl group at the C‐10 position and the A ring of the taxane core of paclitaxel for inducing nitric oxide and tumor necrosis factor production by murine macrophages
T. Kirikae (2000)
Nitric Oxide in Cells
J. R. Lancaster (1992)
10.1021/CR000040L
Nitric oxide donors: chemical activities and biological applications.
P. Wang (2002)
10.1016/S0008-6363(00)00103-6
Antioxidants and the bioactivity of endothelium-derived nitric oxide.
D. Tomasian (2000)
10.1002/(SICI)1521-3773(19990712)38:13/14<1870::AID-ANIE1870>3.0.CO;2-8
ENDOTHELIUM-DERIVED RELAXING FACTOR : DISCOVERY, EARLY STUDIES, AND IDENTIFCATION AS NITRIC OXIDE (NOBEL LECTURE)
R. Furchgott (1999)
•• Excellent and very comprehensive review
10.1016/B978-012370420-7/50045-9
Role of Macrophage-Derived Nitric Oxide in Target Cell Injury
J. Albina (2000)
10.1152/ajpgi.1999.276.2.G315
Nitric oxide. I. Physiological chemistry of nitric oxide and its metabolites:implications in inflammation.
M. Grisham (1999)
10.1093/JNCI/93.24.1879
Nitric oxide-mediated regulation of chemosensitivity in cancer cells.
N. E. Matthews (2001)
10.1093/CARCIN/19.5.711
The multifaceted roles of nitric oxide in cancer.
D. Wink (1998)
10.1093/CARCIN/17.5.1171
Nitric oxide synthase activity and expression in human colorectal cancer.
S. Moochhala (1996)
10.1016/0360-3016(88)90002-8
Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy.
R. Gatenby (1988)
Nitric oxide inhibition selectively increases matrix metalloproteinase-9 activation in vitro by rat aortic smooth muscle cells
GR UPCHURCH (2000)
10.1006/BBRC.1996.0563
Nitric oxide donor SNAP induces apoptosis in smooth muscle cells through cGMP-independent mechanism.
E. Nishio (1996)
10.1080/10715769900301161
Endogenous nitric oxide synthesis: biological functions and pathophysiology.
D. Bredt (1999)
10.1182/BLOOD.V93.7.2342.407K09_2342_2352
Nitric-oxide-induced apoptosis in human leukemic lines requires mitochondrial lipid degradation and cytochrome C release.
A. Ushmorov (1999)
Effect of L-arginine on the retention of macrophage tumoricidal activity.
M. Takema (1991)
First discovery of low doses of NO donors for inhibition and prevention of malignant cell phenotypes
10.1002/CHIN.199940254
Current trends in the development of nitric oxide donors.
Y. Hou (1999)
The action and interactions of nitric oxide in solid tumor
PA BRENNAN (2000)



This paper is referenced by
10.1016/J.NIOX.2005.10.005
Photochemistry of the [Fe4(mu3-S)3(NO)7]- complex in the presence of S-nucleophiles: a spectroscopic study.
A. Chmura (2006)
10.1016/J.CCLET.2013.03.006
Synthesis and in vitro biological evaluation of nitric oxide-releasing derivatives of hydroxylcinnamic acids as anti-tumor agents
M. Lu (2013)
10.1016/j.bmcl.2016.04.068
Novel anticancer oridonin derivatives possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: Design, synthesis, biological evaluation and nitric oxide release studies.
S. Xu (2016)
10.1039/B812131A
Bifunctional nanoparticle assemblies: photoluminescent and nitric oxide photodelivering monolayer protected platinum clusters
M. Barone (2008)
10.1016/J.CCLET.2010.10.036
Synthesis and bioactivity of novel nitric oxide-releasing ursolic acid derivatives
L. Chen (2011)
10.1039/B802126K
Nitric oxide photoreleasing multilayer films
L. Valli (2008)
10.1021/OL050541Z
Bis-diazeniumdiolates of dialkyldiamines: enhanced nitric oxide loading of parent diamines.
M. Reynolds (2005)
10.1016/j.ijpharm.2017.05.023
A multifunctional β-cyclodextrin-conjugate photodelivering nitric oxide with fluorescence reporting.
Gábor Benkovics (2017)
10.1016/j.msec.2018.05.073
Triple stimuli-responsive keratin nanoparticles as carriers for drug and potential nitric oxide release.
Y. Li (2018)
10.1039/C1JM13288A
Photoactivated nanomaterials for biomedical release applications
S. Sortino (2012)
10.1002/cphc.200900451
Dual-function multilayers for the photodelivery of nitric oxide and singlet oxygen.
G. Giancane (2009)
10.1002/EJOC.200901207
A Phenolic Antioxidant Releasing Nitric Oxide on Demand
Elisa Vittorino (2010)
10.1039/B713372C
A multifunctional nanoassembly of mesogen-bearing amphiphiles and porphyrins for the simultaneous photodelivery of nitric oxide and singlet oxygen.
E. Caruso (2007)
10.1039/b807353h
Nanostructured molecular films and nanoparticles with photoactivable functionalities.
S. Sortino (2008)
10.1002/chem.200901037
A "dual-function" photocage releasing nitric oxide and an anthrylmethyl cation with a single wavelength light.
Elisa Vittorino (2009)
10.1039/b800132d
Amplified nitric oxide photorelease in DNA proximity.
Fiorella L. Callari (2008)
10.1016/S1773-2247(12)50034-1
Cyclodextrin-based nanoconstructs for photoactivated therapies
A. Mazzaglia (2012)
Rôle du monoxyde d'azote lors d'une pneumonie à pneumocoque. Effet bénéfique du nitroprusside de sodium
Marie-Christine Dumas (2007)
10.1016/j.bmcl.2009.02.005
Porphyrins containing nitric oxide donors: Synthesis and cancer cell-oriented NO release.
W. Liu (2009)
10.1039/B913123J
Bichromophoric multilayer films for the light-controlled generation of nitric oxide and singlet oxygen
Elisa Vittorino (2009)
10.1016/J.BMC.2003.09.003
Synthesis and cytotoxicity of 5-fluorouracil/diazeniumdiolate conjugates.
T. B. Cai (2003)
10.1517/13543776.14.6.849
Recent developments in anticancer nitric oxide donors
T. B. Cai (2004)
10.1016/J.CCLET.2009.11.033
Synthesis and biological evaluation of nitric oxide-releasing matrine derivatives as anticancer agents
Li Qin He (2010)
10.1016/j.ejmech.2018.03.072
Incorporation of nitric oxide donor into 1,3-dioxyxanthones leads to synergistic anticancer activity.
Jie Liu (2018)
10.1039/B809121H
Nitric oxide photocaging platinum nanoparticles with anticancer potential
M. Barone (2008)
10.1039/C2JM34834A
Enzymatically degradable nitric oxide releasing S-nitrosated dextran thiomers for biomedical applications
Vinod B. Damodaran (2012)
10.1016/j.jcis.2011.09.084
Photofunctional multilayer films by assembling naked silver nanoparticles and a tailored nitric oxide photodispenser at water/air interface.
Elisa Vittorino (2012)
10.1016/J.CCLET.2007.11.025
Synthesis and biological evaluation of nitric oxide-releasing sixalkoxyl biphenyl derivatives as anticancer agents
X. W. Kong (2008)
10.1016/j.carbpol.2017.07.020
Novel nitroaniline-cellulose nanohybrids: nitro radical photo-release and its antibacterial action.
Prashant Chauhan (2017)
10.1007/978-3-319-22942-3_8
Phototherapeutic Release of Nitric Oxide with Engineered Nanoconstructs.
Aurore Fraix (2016)
10.1016/j.ejmech.2017.03.027
Design, synthesis and biological evaluation of novel nitric oxide-donating protoberberine derivatives as antitumor agents.
J. Chen (2017)
10.1039/C4RA08250H
A multi-photoresponsive molecular-hybrid for dual-modal photoinactivation of cancer cells
Aurore Fraix (2014)
See more
Semantic Scholar Logo Some data provided by SemanticScholar