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Mucoadhesive Nanomedicines: Characterization And Modulation Of Mucoadhesion At The Nanoscale

J. das Neves, M. Bahia, Mansoor M. Amiji, B. Sarmento
Published 2011 · Materials Science, Medicine

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Introduction: The benefits of mucoadhesive systems are related to the increased in situ residence and intimate contact of the delivery vehicle with the mucosa. The recent emergence of nanomedicine and the properties of nanoparticulate systems have created new challenges in understanding the nature and mechanisms of nanoscale mucoadhesion and in the development of methodologies for measuring its mucoadhesive potential. Even when usually regarded as an advantageous property, mucoadhesion can be an inconvenience for nanosystems, and strategies have been developed for minimizing interactions with the mucosal tissues/fluids. Areas covered: This article summarizes the basic concepts of mucoadhesion at the nanoscale, different techniques used for measuring the mucoadhesive potential of nanosystems and strategies for increasing/decreasing mucoadhesive interactions. Expert opinion: The mucoadhesion behavior of materials in bulk and at the nanoscale can significantly differ. Advances in the methodology used for studying the mucoadhesion phenomenon have contributed to its better understanding and, more importantly, the development of strategies to increase/decrease mucoadhesion. However, development of new methodologies for studying mucoadhesion at the nanoscale and the refinement of existing methodologies are still required. Also, a substantial amount of information is still lacking, particularly related to formulation issues, on how to translate lessons learnt at the bench top to the bed side.
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F. Bonyadi (2016)
10.1016/j.colsurfb.2015.11.044
Mucoadhesive acrylated block copolymers micelles for the delivery of hydrophobic drugs.
Tal Eshel-Green (2016)
10.1007/s12639-017-0973-8
Assessment of spiramycin-loaded chitosan nanoparticles treatment on acute and chronic toxoplasmosis in mice
Samia E. Etewa (2017)
10.1016/j.ejpb.2019.09.004
Impact of polyethylene glycol polymers on the physicochemical properties and mucoadhesivity of itraconazole nanoparticles.
Ricardo Machado Cruz (2019)
10.1016/j.colsurfb.2015.10.036
Mucoadhesive thermo-responsive chitosan-g-poly(N-isopropylacrylamide) polymeric micelles via a one-pot gamma-radiation-assisted pathway.
A. Sosnik (2015)
10.1016/j.carbpol.2018.08.142
Chitosan functionalized poly (ε-caprolactone) nanoparticles for amphotericin B delivery.
Rossana Gabriela Del Jesus Vásquez Marcano (2018)
10.1016/S1773-2247(14)50085-8
Mucosal nanosystems for improved topical drug delivery: vaginal route of administration
Željka Vanić (2014)
10.1007/978-1-4614-9524-6_3
Mucus as a Barrier for Biopharmaceuticals and Drug Delivery Systems
H. Zhang (2014)
10.1002/9781119414018.ch5
Characterization of Bioadhesion, Mucin‐interactions and Mucosal Permeability of Pharmaceutical Nano‐ and Microsystems
E. Hagesaether (2021)
10.1016/j.ijpharm.2016.04.019
PEGDA hydrogels as a replacement for animal tissues in mucoadhesion testing.
Tal Eshel-Green (2016)
10.1016/j.biomaterials.2014.10.026
Novel protease inhibitor-loaded Nanoparticle-in-Microparticle Delivery System leads to a dramatic improvement of the oral pharmacokinetics in dogs.
Julieta C. Imperiale (2015)
10.1002/mabi.201600534
Innovative Methods and Applications in Mucoadhesion Research.
A. Mackie (2017)
10.1016/J.PROGPOLYMSCI.2014.07.010
Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: A review
A. Sosnik (2014)
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