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Mucoadhesive Nanomedicines: Characterization And Modulation Of Mucoadhesion At The Nanoscale
J. das Neves, M. Bahia, Mansoor M. Amiji, B. Sarmento
Published 2011 · Materials Science, Medicine
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Introduction: The benefits of mucoadhesive systems are related to the increased in situ residence and intimate contact of the delivery vehicle with the mucosa. The recent emergence of nanomedicine and the properties of nanoparticulate systems have created new challenges in understanding the nature and mechanisms of nanoscale mucoadhesion and in the development of methodologies for measuring its mucoadhesive potential. Even when usually regarded as an advantageous property, mucoadhesion can be an inconvenience for nanosystems, and strategies have been developed for minimizing interactions with the mucosal tissues/fluids. Areas covered: This article summarizes the basic concepts of mucoadhesion at the nanoscale, different techniques used for measuring the mucoadhesive potential of nanosystems and strategies for increasing/decreasing mucoadhesive interactions. Expert opinion: The mucoadhesion behavior of materials in bulk and at the nanoscale can significantly differ. Advances in the methodology used for studying the mucoadhesion phenomenon have contributed to its better understanding and, more importantly, the development of strategies to increase/decrease mucoadhesion. However, development of new methodologies for studying mucoadhesion at the nanoscale and the refinement of existing methodologies are still required. Also, a substantial amount of information is still lacking, particularly related to formulation issues, on how to translate lessons learnt at the bench top to the bed side.
This paper references
Pharmaceutical and Medical Aspects of Bioadhesive Systems for Drug Administration
D. Duchěne (1988)
The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles.
J. Suk (2009)
Synthetic polymers alter the structure of cervical mucus.
R. Willits (2001)
Thiomers: preparation and in vitro evaluation of a mucoadhesive nanoparticulate drug delivery system.
A. Bernkop-Schnürch (2006)
Vaginal distribution of Replens and K-Y Jelly using three imaging techniques.
C. Mauck (2008)
Nanoparticles based on N-trimethylchitosan: evaluation of absorption properties using in vitro (Caco-2 cells) and ex vivo (excised rat jejunum) models.
G. Sandri (2007)
Rheological synergy in aqueous mixtures of pectin and mucin
P. Sriamornsak (2008)
Gastrointestinal distribution and in vivo gene transfection studies with nanoparticles-in-microsphere oral system (NiMOS).
M. Bhavsar (2007)
On the Definition of Adhesion
R. Good (1976)
Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus
S. Lai (2007)
Synthesis and in vitro characterization of a novel PAA–ATP conjugate
H. Hoyer (2011)
The effect of a PEG versus a chitosan coating on the interaction of drug colloidal carriers with the ocular mucosa.
A. M. de Campos (2003)
Low molecular weight heparin nanoparticles: mucoadhesion and behaviour in Caco-2 cells
A. Lamprecht (2006)
Methods for the Preparation and Manufacture of Polymeric Nanoparticles
C. Vauthier (2008)
Nasal mucosal temperature during respiration.
J. Lindemann (2002)
Real-time multiple-particle tracking: applications to drug and gene delivery.
Junghae Suh (2005)
Pharmaceutical applications of mucoadhesion for the non‐oral routes
K. Edsman (2005)
Mucoadhesion of poly(2-hydroxyethyl methacrylate) is improved when linear poly(ethylene oxide) chains are added to the polymer network
A. D. Ascentiis (1995)
Studies on the uptake of tomato lectin nanoparticles in everted gut sacs.
B. Carreño-Gómez (1999)
PEGylation of nanoparticles improves their cytoplasmic transport
Junghae Suh (2007)
Controlled surface modification with poly(ethylene)glycol enhances diffusion of PLGA nanoparticles in human cervical mucus.
Yen Cu (2009)
Oral gene delivery with chitosan–DNA nanoparticles generates immunologic protection in a murine model of peanut allergy
K. Roy (1999)
Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier.
Y. Wang (2008)
Gliadin Nanoparticles as Carriers for the Oral Administration of Lipophilic Drugs. Relationships Between Bioadhesion and Pharmacokinetics
M. A. Arangoa (2004)
Mucoadhesion of Latexes. I. Analytical Methods and Kinetic Studies
C. Durrer (2004)
An extensive but practical review of the most commonly used methods for obtaining polymeric nanoparticles
C Vauthier (2009)
Triple therapy-based targeted nanoparticles for the treatment of Helicobacter pylori.
S. Ramteke (2008)
In vitro evaluation of the mucoadhesive properties of polysaccharide-based nanoparticulate oral drug delivery systems.
Siwar Chayed (2007)
The basics and underlying mechanisms of mucoadhesion.
J. Smart (2005)
Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systems.
H. Takeuchi (2005)
Label-free detection with the resonant mirror biosensor.
M. Zourob (2009)
Mucoadhesion of colloidal particulate systems in the gastro-intestinal tract
G. Ponchel (1997)
The PEGylation strategy for obtaining non-adhesive nanoparticles is investigated and nicely discussed in this paper
Increased oral bioavailability of paclitaxel by its encapsulation through complex formation with cyclodextrins in poly(anhydride) nanoparticles.
M. Agüeros (2010)
Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses
S. Lai (2009)
Developments in the area of bioadhesive drug delivery systems
C. Lehr (2002)
Barrier properties of gastrointestinal mucus to nanoparticle transport.
Jason S. Crater (2010)
Adhesion of polyether-modified poly(acrylic acid) to mucin.
John J. Cleary (2004)
Movements of HIV-virions in human cervical mucus.
H. Boukari (2009)
Mucoadhesive effect of thiolated PEG stearate and its modified NLC for ocular drug delivery.
Jie Shen (2009)
An interesting paper that explores how the formulation of nanoparticle-based dosage forms can significantly impact the mucoadhesive behavior of nanoparticulates
Normal oral, rectal, tympanic and axillary body temperature in adult men and women: a systematic literature review.
Märtha Sund-Levander (2002)
Direct measurement of interactions between stimulation-responsive drug delivery vehicles and artificial mucin layers by colloid probe atomic force microscopy.
Motoyuki Iijima (2008)
Cyclodextrin-insulin complex encapsulated polymethacrylic acid based nanoparticles for oral insulin delivery.
S. Sajeesh (2006)
Enhanced Viscoelasticity of Human Cystic Fibrotic Sputum Correlates with Increasing Microheterogeneity in Particle Transport*
M. Dawson (2003)
Mucoadhesive drug delivery systems (Review)
E. A. Kharenko (2009)
An atomic force microscopy investigation of bioadhesive polymer adsorption onto human buccal cells.
Divyesh R. Patel (2000)
Barrier properties of mucus.
Richard A. Cone (2009)
Engineering strategies to enhance nanoparticle-mediated oral delivery
Yvonne J. Yamanaka (2008)
Preparation of Ulex europaeus lectin-gliadin nanoparticle conjugates and their interaction with gastrointestinal mucus.
I. Ezpeleta (1999)
An investigation into the role of mucus thickness on mucoadhesion in the gastrointestinal tract of pig.
F. J. O. Varum (2010)
The use of Eudragit RS 100/cyclodextrin nanoparticles for the transmucosal administration of glutathione.
A. Lopedota (2009)
Lectin-mediated Drug Delivery: Discrimination Between Cytoadhesion and Cytoinvasion and Evidence for Lysosomal Accumulation of Wheat Germ Agglutinin in the Caco-2 Model
M. Wirth (2002)
Bioadhesion: new possibilities for drug administration?
J. Woodley (2001)
The role of mucoadhesion of trimethyl chitosan and PEGylated trimethyl chitosan nanocomplexes in insulin uptake.
Anchalee Jintapattanakit (2009)
Improved intestinal absorption of calcitonin by mucoadhesive delivery of novel pectin-liposome nanocomplexes.
Nartaya Thirawong (2008)
Anti-Helicobacter pylori effect of mucoadhesive nanoparticles bearing amoxicillin in experimental gerbils model
R. Umamaheshwari (2008)
Adhesion of nanoparticles.
J. Carrillo (2010)
Barrier Properties of Gastrointestinal Mucus to Nanoparticle Transport
Jason S. Crater and (2010)
Disruption of the mucus barrier by topically applied exogenous particles.
Shayna L McGill (2010)
A pH-sensitive microsphere system for the colon delivery das Neves
A Lamprecht (2005)
Performance of an in vitro mucoadhesion testing method for vaginal semisolids: influence of different testing conditions and instrumental parameters.
J. das Neves (2008)
Mathematical modeling of molecular diffusion through mucus.
Yen Cu (2009)
The importance of gel properties for mucoadhesion measurements: a multivariate data analysis approach
H. Hägerström (2004)
Mucoadhesive DL-Lactide/Glycolide Copolymer Nanospheres Coated with Chitosan to Improve Oral Delivery of Elcatonin
Y. Kawashima (2000)
Making polymeric micro- and nanoparticles of complex shapes
J. Champion (2007)
Mucoadhesion: a review of characterization techniques
M. Davidovich-Pinhas (2010)
Mucoadhesive properties of carbopol or chitosan-coated liposomes and their effectiveness in the oral administration of calcitonin to rats.
H. Takeuchi (2003)
Mucoadhesion dependence of pharmaceutical polymers on mucosa characteristics.
D. Accili (2004)
Engineering design and molecular dynamics of mucoadhesive drug delivery systems as targeting agents.
Laura Serra (2009)
An overview of the biophysical applications of atomic force microscopy.
N. Santos (2004)
Chapter 4 – Mucus
R. Cone (2005)
A mucoadhesive nanoparticulate system for the simultaneous delivery of macromolecules and permeation enhancers to the intestinal mucosa.
Abdallah Makhlof (2011)
Mucoadhesion of Latexes. II. Adsorption Isotherms and Desorption Studies
C. Durrer (2004)
Interactions between drug delivery particles and mucin in solution and at interfaces.
O. Svensson (2008)
Quartz crystal microbalance: a useful tool for studying thin polymer films and complex biomolecular systems at the solution-surface interface. Biomacromolecules
KA Marx (2003)
Human Immunodeficiency Virus Type 1 Is Trapped by Acidic but Not by Neutralized Human Cervicovaginal Mucus
S. Lai (2009)
Deposition, retention, and clearance of inhaled particles.
M. Lippmann (1980)
Bioadhesion by Means of Specific Binding of Tomato Lectin
C. Lehr (2004)
Chitosan and its derivatives: potential excipients for peroral peptide delivery systems.
A. Bernkop-Schnürch (2000)
Measurement of gastrointestinal pH profiles in normal ambulant human subjects.
D. F. Evans (1988)
The Oral Absorption of Micro- and Nanoparticulates: Neither Exceptional Nor Unusual
A. Florence (2004)
Effect of size, surface charge, and hydrophobicity on the translocation of polystyrene microspheres through gastrointestinal mucin
D. A. Norris (1997)
A pH-sensitive microsphere system for the colon delivery of tacrolimus containing nanoparticles.
A. Lamprecht (2005)
Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery.
Lichen Yin (2009)
Hydrogels as mucoadhesive and bioadhesive materials: a review.
N. Peppas (1996)
Wheat germ agglutinin-grafted lipid nanoparticles: preparation and in vitro evaluation of the association with Caco-2 monolayers.
Ying Liu (2010)
Diffusion of macromolecules and virus-like particles in human cervical mucus.
S. S. Olmsted (2001)
Corneal temperature in patients with dry eye evaluated by infrared radiation thermometry.
H. Fujishima (1996)
A pHsensitive microsphere system for the colon delivery das Neves , Bahia , Amiji & Sarmento Expert Opin
H Yamamoto (2011)
Mucoadhesive microdiscs engineered for ophthalmic drug delivery: effect of particle geometry and formulation on preocular residence time.
Y. Choy (2008)
Shape Induced Inhibition of Phagocytosis of Polymer Particles
J. Champion (2008)
Comparison of the mucoadhesive properties of various polymers.
V. Grabovac (2005)
Pharmaceutical and medical aspects of Mucoadhesive nanomedicines: characterization and modulation of mucoadhesion at the nanoscale
D Duchene (2011)
Force measurements with the atomic force microscope: Technique, interpretation and applications
Hans-Jürgen Butt (2005)
Fluorescent bionanoprobes to characterize cytoadhesion and cytoinvasion.
Christian Fillafer (2008)
Altering Mucus Rheology to “Solidify” Human Mucus at the Nanoscale
S. Lai (2009)
Quantification of the bioadhesive properties of protein-coated PVM/MA nanoparticles.
P. Arbós (2002)
Interactions between chitosan-modified particles and mucin-coated surfaces.
O. Svensson (2008)
Mucoadhesion of Hydroxypropylmethacrylate Nanoparticles to Rat Intestinal Ileal Segments in Vitro
C. Pimienta (2004)
The Impact of Vehicles on the Mucoadhesive Properties of Orally Administrated Nanoparticles: a Case Study with Chitosan-4-Thiobutylamidine Conjugate
D. Sakloetsakun (2010)
Novel polyelectrolyte complexes based on poly(methacrylic acid)-bis(2-aminopropyl)poly(ethylene glycol) for oral protein delivery
S. Sajeesh (2007)
DNA diffusion in mucus: effect of size, topology of DNAs, and transfection reagents.
H. Shen (2006)
Embryonic Chicken Trachea as a New In Vitro Model for the Investigation of Mucociliary Particle Clearance in the Airways
A. Henning (2008)
Characterization of chitosan hydrochloride--mucin rheological interaction: influence of polymer concentration and polymer:mucin weight ratio.
S. Rossi (2001)
In vitro study of lectin-latex conjugates for specific bioadhesion
J. M. Irache (1994)
A rheological examination of the mucoadhesive/mucus interaction: the effect of mucoadhesive type and concentration.
F. Madsen (1998)
Thiomers: a new generation of mucoadhesive polymers.
A. Bernkop-Schnürch (2005)
Insulin-Loaded Nanoparticles Based on N-Trimethyl Chitosan: In Vitro (Caco-2 Model) and Ex Vivo (Excised Rat Jejunum, Duodenum, and Ileum) Evaluation of Penetration Enhancement Properties
G. Sandri (2010)
Design of nanoparticles composed of graft copolymers for oral peptide delivery.
S. Sakuma (2001)
Mucin Interactions with Functionalized Polystyrene Latexes
C. Durrer (1995)
Quantitative and microautoradiographic study on mouse intestinal distribution of polycyanoacrylate nanoparticles
J. Kreuter (1989)
This paper describes the interesting association of an ex vivo embryonic chicken trachea model with a powerful particle tracking technique for studying mucociliary clearance
A Henning (2010)
The receptor-mediated endocytosis of nonspherical particles.
P. Decuzzi (2008)
Alginate/Chitosan Nanoparticles are Effective for Oral Insulin Delivery
B. Sarmento (2007)
Influence of particle size and material properties on mucociliary clearance from the airways.
A. Henning (2010)
Porcine gastric mucin (PGM) at the water/poly(dimethylsiloxane) (PDMS) interface: influence of pH and ionic strength on its conformation, adsorption, and aqueous lubrication properties.
S. Lee (2005)
Mucoadhesives in the gastrointestinal tract: revisiting the literature for novel applications.
Dimitra Dodou (2005)
Analysis of the meal‐dependent intragastric performance of a gastric‐retentive tablet assessed by magnetic resonance imaging
A. Steingoetter (2003)
Relationship between corneal temperature and finger temperature.
F. Girardin (1999)
Cystic fibrosis sputum: a barrier to the transport of nanospheres.
N. Sanders (2000)
Chitosan-NAC nanoparticles as a vehicle for nasal absorption enhancement of insulin.
X. Wang (2009)
Effectiveness of submicron-sized, chitosan-coated liposomes in oral administration of peptide drugs.
H. Takeuchi (2005)
Efficacy and Mechanism of Action of Chitosan Nanocapsules for Oral Peptide Delivery
C. Prego (2006)
Mucoadhesion of polystyrene nanoparticles having surface hydrophilic polymeric chains in the gastrointestinal tract.
S. Sakuma (1999)
Mucoadhesion mechanism of chitosan and thiolated chitosan-poly(isobutyl cyanoacrylate) core-shell nanoparticles.
I. Bravo-Osuna (2007)
Transport of Polymeric Nanoparticle Gene Carriers in Gastric Mucus
M. Dawson (2004)
Mucin structure, aggregation, physiological functions and biomedical applications
R. Bansil (2006)
Development and In Vitro Evaluation of Surface Modified Poly(lactide-co-glycolide) Nanoparticles with Chitosan-4-Thiobutylamidine
V. Grabovac (2007)
Bioadhesive properties and biodistribution of cyclodextrin-poly(anhydride) nanoparticles.
M. Agüeros (2009)
Lectin-mediated drug delivery: the second generation of bioadhesives.
C. Lehr (2000)
Human cervical mucus and its interaction with sperm: a fine-structural view.
A. I. Yudin (1989)
Micro- and macrorheology of mucus.
S. Lai (2009)
Quartz crystal microbalance: a useful tool for studying thin polymer films and complex biomolecular systems at the solution-surface interface.
K. Marx (2003)
Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier
Benjamin C Tang (2009)
In vivo determination of the time and location of mucoadhesive drug delivery systems disintegration in the gastrointestinal tract.
C. Kremser (2008)
Soluble N-(2-hydroxypropyl) methacrylamide copolymers as a potential oral, controlled-release, drug delivery system. I. Bioadhesion to the rat intestine in vitro
J. F. Bridges (1988)
Differential Adhesion of Normal and Inflamed Rat Colonic Mucosa by Charged Liposomes
T. Jubeh (2004)
Surface-modified PLGA nanosphere with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctions.
H. Yamamoto (2005)
G. Strous (1992)
Oral bioavailability of insulin contained in polysaccharide nanoparticles.
B. Sarmento (2007)
Preparation and in vitro evaluation of mucoadhesion and permeation enhancement of thiolated chitosan-pHEMA core-shell nanoparticles.
Firooze Aghaei Moghaddam (2009)
Paclitaxel incorporated in hydrophobically derivatized hyperbranched polyglycerols for intravesical bladder cancer therapy
C. Mugabe (2009)
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues.
S. Lai (2009)
Surface energy and the contact of elastic solids
K. L. Johnson (1971)
A comparison of different in vitro methods for measuring mucoadhesive performance
S. Tamburić (1997)
Pharmaceutical and medical aspects of Mucoadhesive nanomedicines: characterization and modulation of mucoadhesion at the nanoscale 1100 Expert Opin
D Duchene (2011)
Effect of various poloxamer coatings on in vitro adhesion of isohexylcyanoacrylate nanospheres to rat ileal segments under liquid flow
C. Pimienta (1992)
This paper is referenced by
Chitosan-Based Nanomedicine for Rosmarinic Acid Ocular Delivery
S. Silva (2014)
Intestinal uptake of barley protein-based nanoparticles for β-carotene delivery
Guangyu Liu (2019)
The Potential of Silk and Silk-Like Proteins as Natural Mucoadhesive Biopolymers for Controlled Drug Delivery
A. Brooks (2015)
Synthesis and characterization of novel carboxymethyl Assam Bora rice starch for the controlled release of cationic anticancer drug based on electrostatic interactions
S. Mohapatra (2017)
Interactions of microbicide nanoparticles with a simulated vaginal fluid.
J. das Neves (2012)
Fabrication of lecithin-gum tragacanth muco-adhesive hybrid nano-carrier system for in-vivo performance of Amphotericin B.
Tooba Jabri (2018)
Insights into gold nanoparticles as a mucoadhesive system
M. Ouellette (2018)
Novel poly(vinyl alcohol)-based amphiphilic nanogels by non-covalent boric acid crosslinking of polymeric micelles.
Hen Moshe (2017)
Mollusk glue inspired mucoadhesives for biomedical applications.
Jinke Xu (2012)
Mucoadhesive nanogels by ionotropic crosslinking of chitosan-g-oligo(NiPAam) polymeric micelles as novel drug nanocarriers.
Maya Menaker Raskin (2016)
Mucoadhesive paclitaxel-loaded chitosan-poly (isobutyl cyanoacrylate) core-shell nanocapsules containing copaiba oil designed for oral drug delivery
Francisco Humberto Xavier-Jr. (2019)
Nanoparticles for the regulation of intestinal inflammation: opportunities and challenges.
Rute Nunes (2019)
Direct Determination of Chitosan-Mucin Interactions Using a Single-Molecule Strategy: Comparison to Alginate-Mucin Interactions
Kristin E. Haugstad (2015)
Toxicity evaluation of poly(anhydride) nanoparticles as carriers for oral administration of drugs
P. Ojer (2013)
Novel mixed vesicles containing lactobacilli biosurfactant for vaginal delivery of an anti‐Candida agent
A. Abruzzo (2018)
The Effects of Nanoparticle Drug Delivery Formulations on the Rheological Properties of Mucus
Nishan Katuwal (2017)
Chitosan nanoparticles: a survey of preparation methods
A. Grenha (2012)
Complexation as an approach to entrap cationic drugs into cationic nanoparticles administered intranasally for Alzheimer's disease management: preparation and detection in rat brain
A. Hanafy (2015)
Gelucire-Based Nanoparticles for Curcumin Targeting to Oral Mucosa: Preparation, Characterization, and Antimicrobial Activity Assessment.
Heba A Hazzah (2015)
Application of Nano Drug Delivery System in Mucoadhesive Polymers
F. Bonyadi (2016)
Mucoadhesive acrylated block copolymers micelles for the delivery of hydrophobic drugs.
Tal Eshel-Green (2016)
Assessment of spiramycin-loaded chitosan nanoparticles treatment on acute and chronic toxoplasmosis in mice
Samia E. Etewa (2017)
Impact of polyethylene glycol polymers on the physicochemical properties and mucoadhesivity of itraconazole nanoparticles.
Ricardo Machado Cruz (2019)
Mucoadhesive thermo-responsive chitosan-g-poly(N-isopropylacrylamide) polymeric micelles via a one-pot gamma-radiation-assisted pathway.
A. Sosnik (2015)
Chitosan functionalized poly (ε-caprolactone) nanoparticles for amphotericin B delivery.
Rossana Gabriela Del Jesus Vásquez Marcano (2018)
Mucosal nanosystems for improved topical drug delivery: vaginal route of administration
Željka Vanić (2014)
Mucus as a Barrier for Biopharmaceuticals and Drug Delivery Systems
H. Zhang (2014)
Characterization of Bioadhesion, Mucin‐interactions and Mucosal Permeability of Pharmaceutical Nano‐ and Microsystems
E. Hagesaether (2021)
PEGDA hydrogels as a replacement for animal tissues in mucoadhesion testing.
Tal Eshel-Green (2016)
Novel protease inhibitor-loaded Nanoparticle-in-Microparticle Delivery System leads to a dramatic improvement of the oral pharmacokinetics in dogs.
Julieta C. Imperiale (2015)
Innovative Methods and Applications in Mucoadhesion Research.
A. Mackie (2017)
Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: A review
A. Sosnik (2014)See more