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Biomaterial-based Scaffolds – Current Status And Future Directions

Tarun Garg, Amit K. Goyal
Published 2014 · Medicine, Materials Science
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Introduction: Biomaterial-based scaffold formulations (three-dimensional Porous matrix, nano-fibre mesh, hydrogels and microspheres) are the major components that are used to deliver the bioactive molecules into the body organs through different routes for an effective treatment of various diseases. Areas covered: Various fabrication techniques such as freeze-drying, polymerisation, spray drying, gas foaming, supercritical fluid technology, etc., are successfully used for fabrication of scaffold formulations. Due to their unique characteristics, these formulations are widely used against various diseases such as tuberculosis, bone defects, cartilage repair, skin diseases, cardiovascular diseases, periodontal diseases, wound dressing, etc. Expert opinion: The study of biomaterial-based scaffold formulations is exhilarating with novel approaches to drug/cell/gene delivery being developed all the time. At present, there is a huge extent of research being performed worldwide on all aspects of tissue engineering/drug or gene delivery. In the future, the main focus will be on the development of more patient compliant, sustained and controlled delivery systems against various diseases by modification of polymers, manufacturing technologies as well as carrier systems.
This paper references
10.1002/jbm.b.31756
Nano Ag loaded PVA nano-fibrous mats for skin applications.
Thi-Hiep Nguyen (2011)
Directed polymerization shrinkage versus a horizontal incremental filling technique: interfacial adaptation in vivo in Class II cavities.
Jan W V van Dijken (1998)
10.1615/CRITREVTHERDRUGCARRIERSYST.2013007259
Stimuli-sensitive hydrogels: an excellent carrier for drug and cell delivery.
Tarun Garg (2013)
10.3791/3624
Constructing a collagen hydrogel for the delivery of stem cell-loaded chitosan microspheres.
David O. Zamora (2012)
10.1021/la3040853
Characterization of the structural morphology of chemically modified silica prepared by surface polymerization of a mixture of long and short alkyl chains using 13C and 29Si NMR spectroscopy.
Hafeez O Fatunmbi (2013)
10.3109/10717544.2012.762434
Eudragit-coated aceclofenac-loaded pectin microspheres in chronopharmacological treatment of rheumatoid arthritis
Thiruganesh Ramasamy (2013)
10.3109/03639045.2012.756511
Preparation of novel porous starch microsphere foam for loading and release of poorly water soluble drug
Tongying Jiang (2014)
10.1177/0885328213499272
Encapsulation of simvastatin in PLGA microspheres loaded into hydrogel loaded BCP porous spongy scaffold as a controlled drug delivery system for bone tissue regeneration
Subrata Deb Nath (2014)
10.1080/026520400288319
Controlled delivery of drugs from a novel injectable in situ formed biodegradable PLGA microsphere system.
R A Jain (2000)
10.1163/156856209X412209
Nitroxyl Radical Incorporated Electrospun Biodegradable Poly(ester Amide) Nanofiber Membranes
Lei Li (2009)
10.1007/s10856-012-4689-0
Hyaluronic acid/mildly crosslinked alginate hydrogel as an injectable tissue adhesion barrier
Seung Yeon Na (2012)
10.3109/10837450.2013.784334
Naltrexone-loaded poly[La–(Glc–Leu)] polymeric microspheres for the treatment of alcohol dependence: in vitro characterization and in vivo biocompatibility assessment
Kunal P. Pagar (2014)
10.1016/j.jconrel.2003.10.021
Stabilization of oligonucleotide-polyethylenimine complexes by freeze-drying: physicochemical and biological characterization.
Carola Brus (2004)
10.1021/bm9004645
Mechanistic implication for cross-linking in sterculia-based hydrogels and their use in GIT drug delivery.
Baljit Singh (2009)
10.1371/journal.pone.0060473
BMP2 Genetically Engineered MSCs and EPCs Promote Vascularized Bone Regeneration in Rat Critical-Sized Calvarial Bone Defects
Xiaoning He (2013)
10.1016/j.ijpharm.2005.12.038
A fibrin encapsulated liposomes-in-chitosan matrix (FLCM) for delivering water-soluble drugs. Influences of the surface properties of liposomes and the crosslinked fibrin network.
Tze-Wen Chung (2006)
10.1007/s10856-012-4610-x
Fabrication and evaluation of electrospun collagen/poly(N-isopropyl acrylamide)/chitosan mat as blood-contacting biomaterials for drug delivery
Saravanabhavan Shanmuga Sundar (2012)
10.3109/02652048.2013.805838
Novel PLA microspheres with hydrophilic and bioadhesive surfaces for the controlled delivery of fenretinide
Mirella Falconi (2014)
10.1007/s13318-011-0070-9
Formulation and evaluation of micro hydrogel of Moxifloxacin hydrochloride
Basavaraj K. Nanjwade (2011)
10.1021/bc070006e
Dual-surface-modified bacteriophage MS2 as an ideal scaffold for a viral capsid-based drug delivery system.
Ernest W Kovacs (2007)
10.1016/0039-9140(96)01964-9
Simple solvent extraction technique for elimination of matrix interferences in the determination of methylmercury in environmental and biological samples by ethylation-gas chromatography-cold vapor atomic fluorescence spectrometry.
Liyuan Liang (1996)
10.1016/j.colsurfb.2011.10.052
Cross-linked hyaluronic acid-based flexible cell delivery system: application for chondrogenic differentiation.
Hyung-Don Hwang (2012)
Biomaterial-based scaffolds --current status and future directions
(2014)
10.1159/000348359
Delivery of Mesenchymal Stem Cells in Chitosan/Collagen Microbeads for Orthopedic Tissue Repair
Limin Wang (2013)
10.1016/j.jdermsci.2012.02.002
Mesenchymal stem cells delivered in a microsphere-based engineered skin contribute to cutaneous wound healing and sweat gland repair.
Sha Huang (2012)
10.1021/ja040226s
Silver(I)-imidazole cyclophane gem-diol complexes encapsulated by electrospun tecophilic nanofibers: formation of nanosilver particles and antimicrobial activity.
Abdulkareem Melaiye (2005)
10.1002/jbm.b.32888
Development of poly(butylene succinate) microspheres for delivery of levodopa in the treatment of Parkinson's disease.
Krithika Mohanraj (2013)
10.1021/ja051977c
Direct fabrication and harvesting of monodisperse, shape-specific nanobiomaterials.
Jason P. Rolland (2005)
10.1016/J.ACTBIO.2007.09.011
Novel fabrication techniques to produce microspheres by thermally induced phase separation for tissue engineering and drug delivery.
Jonny James Blaker (2008)
10.1007/s10856-010-4127-0
Development of porous HAp and β-TCP scaffolds by starch consolidation with foaming method and drug-chitosan bilayered scaffold based drug delivery system
Biswanath Kundu (2010)
10.1089/ten.TEA.2012.0455
Scaffold-based delivery of a clinically relevant anti-angiogenic drug promotes the formation of in vivo stable cartilage.
Matteo Centola (2013)
10.1002/jsfa.5757
Application of molecularly imprinted hydrogel for the preparation of lactose-free milk.
Farzin Hadizadeh (2013)
10.1016/j.biomaterials.2013.05.048
Co-encapsulation of anti-BMP2 monoclonal antibody and mesenchymal stem cells in alginate microspheres for bone tissue engineering.
Alireza Moshaverinia (2013)
10.1126/scitranslmed.3004890
Engineering Complex Tissues
Anthony J. Atala (2012)
10.1002/term.1683
Chondrogenic potential of injectable κ-carrageenan hydrogel with encapsulated adipose stem cells for cartilage tissue-engineering applications.
Elena Geta Popa (2015)
Microengineered hydrogels for tissue engineering. Biomaterials
A Khademhosseini (2007)
Mechanistic implication for cross-linking in sterculiabased hydrogels and their use in GIT drug delivery. Biomacromolecules
B Singh (2009)
10.1016/j.ijpharm.2013.03.021
Development and evaluation of a novel phytosome-loaded chitosan microsphere system for curcumin delivery.
Ji-fen Zhang (2013)
10.1126/science.1169494
Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties
April M Kloxin (2009)
10.1016/S0168-3659(03)00274-8
Porous chitosan scaffold containing microspheres loaded with transforming growth factor-beta1: implications for cartilage tissue engineering.
Sung Eun Kim (2003)
10.1517/17425247.5.1.105
Cell-penetrating peptides for drug delivery across membrane barriers
Camilla Foged (2008)
10.2174/187221112802652606
Pharmaceutical polymeric nanoparticles prepared by the double emulsion- solvent evaporation technique.
Elizabeth Piñón-Segundo (2012)
10.1208/s12249-008-9085-1
Variables Influencing Drug Release from Layered Matrix System Comprising Hydroxypropyl Methylcellulose
Thawatchai Phaechamud (2008)
10.1097/SCS.0b013e31824f6647
Degree of Swelling of the Medial Rectus Muscle on CT Images to Differentiate Old From New Medial Orbital Wall Fracture
Kun Hwang (2012)
10.1021/la701366f
Radiation-induced synthesis and cryo-TEM characterization of silver nanoshells on linoleate spherical micelles.
J Attia (2007)
10.1002/jbm.a.34434
Electrospinning collagen/chitosan/poly(L-lactic acid-co-ε-caprolactone) to form a vascular graft: mechanical and biological characterization.
Anlin Yin (2013)
10.1016/j.jconrel.2004.11.014
In vivo anti-tumor effect of dual release of cisplatin and adriamycin from biodegradable gelatin hydrogel.
Mitsunaga Konishi (2005)
10.1155/2013/549623
Thermal Stability Analysis under Embankment with Asphalt Pavement and Cement Pavement in Permafrost Regions
Zhang Jun-wei (2013)
10.1691/PH.2012.1152
Synthesis, characterization, drug-loading capacity and safety of novel pH-independent amphiphilic amino acid copolymer micelles.
Jihui Tang (2012)
10.3109/03639045.2011.628676
Hydrogels containing rutin intended for cutaneous administration: efficacy in wound healing in rats
Juliana Sousa de Almeida (2012)
10.1166/JNN.2013.6058
Supramolecular hydrogel based on graphene oxides for controlled release system.
Qian-Yi Cheng (2013)
10.1166/JBN.2010.1135
High entrapment efficiency of chitosan/polylactic acid/tripolyphotspate nanosized microcapsules for rapamycin by an emulsion-evaporation approach.
Jing Yu Fu (2010)
10.1089/ten.TEA.2009.0404
Adipose-derived stem cell delivery into collagen gels using chitosan microspheres.
Shanmugasundaram Natesan (2010)
10.1002/jbmr.1558
Therapeutic effect of local administration of low-dose simvastatin-conjugated gelatin hydrogel for fracture healing.
Tomoaki Fukui (2012)
10.1002/nbm.1735
MRI studies of cryoinjury infarction in pig hearts: ii. Effects of intrapericardial delivery of adipose-derived stem cells (ADSC) embedded in agarose gel.
Yao-Joe Yang (2012)
10.3892/mmr.2013.1673
Determination of the density of human nuclear cataract lenses
Ke Xu (2013)
10.1006/jcis.2000.7303
Rheological Properties and Orientational Distributions of Dilute Ferromagnetic Spherocylinder Particle Dispersions.
Akira Satoh (2001)
10.1510/icvts.2008.192831
Development of novel drug-eluting biodegradable nano-fiber for prevention of postoperative pulmonary venous obstruction.
Masato Mutsuga (2009)
10.1080/10611860802473345
Design and evaluation of matrices of Eudragit with polycarbophil and carbopol for colon-specific delivery.
Laila Fatima Ali Asghar (2008)
10.3109/03639045.2013.794828
Study on the release of fenofibrate nanosuspension in vitro and its correlation with in situ intestinal and in vivo absorption kinetics in rats
Yuanlong Xu (2014)
Stabilization of oligonucleotidepolyethylenimine complexes by freezedrying: physicochemical and biological characterization
C Brus (2004)
10.1007/s10856-012-4806-0
Novel macro-microporous gelatin scaffold fabricated by particulate leaching for soft tissue reconstruction with adipose-derived stem cells
Manraj Phull (2012)
10.3109/02652049809006834
Microencapsulation of ketorolac tromethamine by means of a coacervation-phase separation technique induced by the addition of non-solvent.
L Genç (1998)
10.1016/j.jconrel.2005.11.016
Dual release of proteins from porous polymeric scaffolds.
Julien Sohier (2006)
10.1517/17425247.2013.739156
Injectable hydrogel therapies and their delivery strategies for treating myocardial infarction
Todd D Johnson (2013)
10.1016/j.joca.2013.07.016
Transplantation of autologous endothelial progenitor cells in porous PLGA scaffolds create a microenvironment for the regeneration of hyaline cartilage in rabbits.
NJ. Chang (2013)
10.1016/j.carres.2011.04.040
Electrospun nano-fiber mats containing cationic cellulose derivatives and poly (vinyl alcohol) with antibacterial activity.
Baoquan Jia (2011)
10.1002/btpr.1761
Hydrolytically degradable poly(ethylene glycol) hydrogel scaffolds as a cell delivery vehicle: characterization of PC12 cell response.
Silviya Petrova Zustiak (2013)
10.1016/j.actbio.2013.02.008
Controlled delivery of mesenchymal stem cells and growth factors using a nanofiber scaffold for tendon repair.
Cionne N. Manning (2013)
10.1016/j.actbio.2006.12.006
Cell adhesion and mechanical properties of a flexible scaffold for cardiac tissue engineering.
L Araida Hidalgo-Bastida (2007)
10.1006/jcis.2002.8451
Rheological properties and orientational distributions of dilute ferromagnetic spherocylinder particle dispersions. Part II. Analysis for the two typical magnetic field directions.
Masayuki Aoshima (2002)
10.1016/j.jconrel.2012.04.013
Optimising the self-assembly of siRNA loaded PEG-PCL-lPEI nano-carriers employing different preparation techniques.
Thomas Endres (2012)
10.1016/j.ijpharm.2012.10.014
Polymeric nanoparticles augment the ocular hypotensive effect of melatonin in rabbits.
Teresa Musumeci (2013)
10.1080/10717540701203067
Design and Development of a Novel Controlled Release PLGA Alginate-Pectinate Polyspheric Drug Delivery System
Joe L Sweet (2007)
10.1111/j.1525-1594.2011.01274.x
Repair of bone defect in femoral condyle using microencapsulated chitosan, nanohydroxyapatite/collagen and poly(L-lactide)-based microsphere-scaffold delivery system.
Xufeng Niu (2011)
10.1208/s12249-010-9544-3
Evaluation of Mucoadhesive Hydrogels Loaded with Diclofenac Sodium–Chitosan Microspheres for Rectal Administration
Eman Sadder El-Leithy (2010)
10.1111/j.1469-7580.2008.00974.x
Mesenchymal stem cell interaction with a non-woven hyaluronan-based scaffold suitable for tissue repair.
Gianandrea Pasquinelli (2008)
10.1002/jbm.a.31194
Polyurethane biomaterials for fabricating 3D porous scaffolds and supporting vascular cells.
Stéphanie Grenier (2007)
10.1016/j.jconrel.2009.02.021
Controlled release of insulin from pH/temperature-sensitive injectable pentablock copolymer hydrogel.
Dai Phu Huynh (2009)
10.1211/0022357011778197
Interpretation of mucoadhesive properties of polymer gel preparations using a tensile strength method.
Helene Hägerström (2001)
10.2174/15672018113109990054
Development and in vitro evaluation of diclofenac sodium loaded mucoadhesive microsphere with natural gum for sustained delivery.
Md Lutful Amin (2013)
10.1517/17425247.2012.652614
Production methodologies of polymeric and hydrogel particles for drug delivery applications
Ana Catarina Lima (2012)
10.1016/J.BIOMATERIALS.2007.07.021
Microengineered hydrogels for tissue engineering.
Ali Khademhosseini (2007)
Therapeutic applications of anti-CD4 antibodies.
Daniel Olive (1993)
10.1016/j.biomaterials.2013.02.002
Repair of the injured spinal cord by transplantation of neural stem cells in a hyaluronan-based hydrogel.
Andrea J. Mothe (2013)
10.1016/j.msec.2013.04.021
Bactericidal property and biocompatibility of gentamicin-loaded mesoporous carbonated hydroxyapatite microspheres.
Ya-Jun Guo (2013)
10.1016/j.ijpharm.2013.07.022
Poly(ester amide) blend microspheres for oral insulin delivery.
Pan He (2013)
10.1016/j.biomaterials.2011.05.033
Enhanced MSC chondrogenesis following delivery of TGF-β3 from alginate microspheres within hyaluronic acid hydrogels in vitro and in vivo.
Liming Bian (2011)
10.3109/03639045.2012.762655
Development and physico-mechanical characterization of carrageenan and poloxamer-based lyophilized matrix as a potential buccal drug delivery system
Farnoosh Kianfar (2014)
10.2144/000112493
Localized delivery of DNA to the cells by viral collagen-loaded silica colloidal crystals.
Harshini Sarojini (2007)
10.1371/journal.pone.0051991
Intramyocardial Delivery of Mesenchymal Stem Cell-Seeded Hydrogel Preserves Cardiac Function and Attenuates Ventricular Remodeling after Myocardial Infarction
Eva Mathieu (2012)
10.1080/03639040601015521
Sustained-release from Layered Matrix System Comprising Chitosan and Xanthan Gum
Thawatchai Phaechamud (2007)
10.1016/j.bbrc.2005.05.051
In vivo bone formation by human marrow stromal cells in biodegradable scaffolds that release dexamethasone and ascorbate-2-phosphate.
Hyongbum Henry Kim (2005)
10.4103/0250-474X.40333
Design and In Vitro Characterization of Buccoadhesive Drug Delivery System of Insulin
Jasjeet Kaur Sahni (2008)
10.1016/S0168-3659(01)00498-9
Enhanced bone formation by controlled growth factor delivery from chitosan-based biomaterials.
Jue-Yeon Lee (2002)
10.1007/s10856-013-5001-7
In vitro study of dual drug-eluting stents with locally focused sirolimus and atorvastatin release
Svea Petersen (2013)
10.1021/nn300106t
Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery.
Menglin Chen (2012)
10.1007/s12272-012-0312-7
Design and in vitro and in vivo characterization of mucoadhesive matrix pellets of metformin hydrochloride for oral controlled release: A technical note
Pradum Pundlikrao Ige (2012)
10.1088/1748-6041/8/3/035004
A comparison of fibrin, agarose and gellan gum hydrogels as carriers of stem cells and growth factor delivery microspheres for cartilage regeneration.
Mark Ahearne (2013)
10.1016/j.jconrel.2012.11.005
Polymeric hydrogels for oral insulin delivery.
Kiran Chaturvedi (2013)
10.1016/j.jconrel.2010.05.026
Facile control of porous structures of polymer microspheres using an osmotic agent for pulmonary delivery.
Jangwook Lee (2010)
10.1039/b804234a
Stop-flow lithography to generate cell-laden microgel particles.
Priyadarshi Panda (2008)
10.1002/ccd.21781
Intracoronary delivery of mesenchymal stem cells at high flow rates after myocardial infarction improves distal coronary blood flow and decreases mortality in pigs.
Raúl Llano (2009)
10.1016/j.jconrel.2008.10.021
Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering.
Xiaoqin Wang (2009)
10.1073/pnas.1210182109
Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function
Ioannis K. Zervantonakis (2012)
10.1097/00002480-199642060-00008
A One Stage Versus Two Stage Surgical Technique: Tissue Reaction to a Percutaneous Device Provided With Titanium Fiber Mesh Applicable for Peritoneal Dialysis
Y C Paquay (1996)
10.1016/j.biomaterials.2008.12.030
The reversal of hyperglycaemia in diabetic mice using PLGA scaffolds seeded with islet-like cells derived from human embryonic stem cells.
Gen-hong Mao (2009)
10.1016/j.actbio.2013.07.023
Dental mesenchymal stem cells encapsulated in an alginate hydrogel co-delivery microencapsulation system for cartilage regeneration.
Alireza Moshaverinia (2013)
10.1089/ten.tea.2010.0707
Expansion and delivery of adipose-derived mesenchymal stem cells on three microcarriers for soft tissue regeneration.
Yalei Zhou (2011)
10.1166/JNN.2011.3243
Electrospun nano composites of poly(vinyl pyrrolidone)/ nano-silver for antibacterial materials.
Suyeon Hwang (2011)
10.1021/nn202833n
Template-free synthesis and encapsulation technique for layer-by-layer polymer nanocarrier fabrication.
Aisha Qi (2011)
10.1021/bm300733n
Co-delivery of adipose-derived stem cells and growth factor-loaded microspheres in RGD-grafted N-methacrylate glycol chitosan gels for focal chondral repair.
Abby Sukarto (2012)
10.1186/scrt182
Encapsulation and 3D culture of human adipose-derived stem cells in an in-situ crosslinked hybrid hydrogel composed of PEG-based hyperbranched copolymer and hyaluronic acid
Waqar Hassan (2012)
10.1080/10717540902861267
Chitosan glutamate hydrogels with local anesthetic activity for buccal application
Rosario Pignatello (2009)
10.1007/978-1-62703-363-3_23
Formulation of selected renal cells for implantation into a kidney.
Craig Halberstadt (2013)
10.1163/156856208784089634
Nano-fiber scaffold science and tissue engineering. Foreword.
Dietmar Werner Hutmacher (2008)
10.1016/j.actbio.2011.04.008
Direct deposited porous scaffolds of calcium phosphate cement with alginate for drug delivery and bone tissue engineering.
Gil-Su Lee (2011)
10.1002/jsfa.4340
Effect of heat treatment on quality, thermal and pasting properties of sweet potato starch during yearlong storage.
Wenzhong Hu (2011)
10.1016/j.jconrel.2009.12.030
Controlled drug release from biodegradable thermoresponsive physical hydrogel nanofibers.
Xian Jun Loh (2010)
10.1016/j.jconrel.2010.07.098
Hydrogels of collagen-inspired telechelic triblock copolymers for the sustained release of proteins.
Henrique Teles (2010)
10.1016/S0142-9612(00)00122-8
A biodegradable polymer scaffold for delivery of osteotropic factors.
Kyumin Whang (2000)
10.1016/j.jbiosc.2013.01.011
Biodegradable porous sheet-like scaffolds for soft-tissue engineering using a combined particulate leaching of salt particles and magnetic sugar particles.
Chengzhi Hu (2013)
10.1038/ki.1996.436
Polymerization of normal and intact beta 2-microglobulin as the amyloidogenic protein in dialysis-amyloidosis.
Josep M Campistol (1996)
10.1002/bmc.2791
Storage stability studies for tributyltin determination in human urine samples using headspace solid-phase microextraction and gas chromatography mass spectrometry.
George A Zachariadis (2013)
10.2174/156720112803529837
Synthesis and characterization of carboxymethyl chitosan hydrogel: application as pH-sensitive delivery for nateglinide.
Subhash S. Vaghani (2012)
10.1248/CPB.58.195
Novel spray freeze-drying technique using four-fluid nozzle-development of organic solvent system to expand its application to poorly water soluble drugs.
Toshiyuki Niwa (2010)
10.1016/J.JCONREL.2007.08.030
In vitro and in vivo test of PEG/PCL-based hydrogel scaffold for cell delivery application.
Ji sun Park (2007)
10.1177/0885328211402243
Development of a pre-vascularized 3D scaffold-hydrogel composite graft using an arterio-venous loop for tissue engineering applications
Subha Narayan Rath (2012)
10.3109/10717544.2013.855277
Development and characterization of niosomal gel for topical delivery of benzoyl peroxide
Gagan K. Goyal (2015)
10.1016/j.ijpharm.2013.01.040
Vitamin B12 loaded polycaprolactone nanofibers: a novel transdermal route for the water soluble energy supplement delivery.
Kalaipriya Madhaiyan (2013)
10.1021/jp311044a
Diffusion studies of dihydroxybenzene isomers in water-alcohol systems.
Dale J. Codling (2013)
The formulation of flurbiprofen loaded microspheres using hydroxypropylmethycellulose and ethylcellulose.
Muhammad Khurram Shahzad (2013)
10.1016/J.CARRES.2007.07.007
Preparation and properties of a pH/temperature-responsive carboxymethyl chitosan/poly(N-isopropylacrylamide)semi-IPN hydrogel for oral delivery of drugs.
Bao-lin Guo (2007)
10.1016/j.biomaterials.2004.05.014
Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluation.
James A. Cooper (2005)
10.1016/S0168-3659(02)00086-X
Prolonged antifungal effects of clotrimazole-containing mucoadhesive thermosensitive gels on vaginitis.
Jung Yun Chang (2002)
10.1080/10717540500313455
Cross-Linked Guar Gum Hydrogel Discs for Colon-Specific Delivery of Ibuprofen: Formulation and In Vitro Evaluation
A Das (2006)
10.1163/092050609X12597621891620
Degradation Behavior of 3D Porous Polydioxanone-b-Polycaprolactone Scaffolds Fabricated Using the Melt-Molding Particulate-Leaching Method
Se Heang Oh (2011)
10.1002/(SICI)1097-4636(2000)53:1<1::AID-JBM1>3.0.CO;2-R
A novel fabrication method of macroporous biodegradable polymer scaffolds using gas foaming salt as a porogen additive.
Yoonkey Nam (2000)
10.2174/187221112802652633
Single emulsion-solvent evaporation technique and modifications for the preparation of pharmaceutical polymeric nanoparticles.
María Guadalupe Nava-Arzaluz (2012)
10.1517/17425247.2012.633507
In vitro and in vivo evaluation of Assam Bora rice starch-based bioadhesive microsphere as a drug carrier for colon targeting
Mohammad Zaki Ahmad (2012)
10.1002/jbm.a.33079
Hydrophilized 3D porous scaffold for effective plasmid DNA delivery.
Se Heang Oh (2011)
Optimization of process parameters for the continuous ethanol production by Kluyveromyces lactis immobilized cells in hydrogel copolymer carrier.
S F Deriase (2001)
10.1016/j.jcis.2009.01.058
Investigation on surface molecular conformations and pervaporation performance of the poly(vinyl alcohol) (PVA) membrane.
Wei Zhang (2009)
10.1073/pnas.1215498110
Hydrogel drug delivery system with predictable and tunable drug release and degradation rates
Gary W. Ashley (2013)
10.1002/biot.201200131
Tissue scaffold surface patterning for clinical applications.
Brandon G Gerberich (2013)
10.1016/j.actbio.2011.12.008
bFGF-containing electrospun gelatin scaffolds with controlled nano-architectural features for directed angiogenesis.
Ramon B. Montero (2012)
10.1007/s10856-005-4713-8
Nano- and micro-fiber combined scaffolds: A new architecture for bone tissue engineering
Kadriye Tuzlakoglu (2005)
10.3109/21691401.2013.837474
Development and characterization of nanocarriers for topical treatment of psoriasis by using combination therapy
Nupur Parnami (2014)
10.1055/s-0033-1354364
Spray drying as a fast and simple technique for the preparation of extended release dipyridamole (DYP) microparticles in a fixed dose combination (FDC) product with aspirin.
Hadi Hamishehkar (2014)
10.1002/jbm.a.34081
A cellular delivery system fabricated with autologous BMSCs and collagen scaffold enhances angiogenesis and perfusion in ischemic hind limb.
Jinling Wang (2012)
10.1002/jps.22310
A three-dimensional polycaprolactone scaffold combined with a drug delivery system consisting of electrospun nanofibers.
Hyeon Yoon (2011)
10.1590/S1806-83242013000100012
Chemical cleaning agents and bonding to glass-fiber posts.
Ana Paula R Gonçalves (2013)
10.1016/j.joen.2008.02.005
In vivo generation of dental pulp-like tissue by using dental pulp stem cells, a collagen scaffold, and dentin matrix protein 1 after subcutaneous transplantation in mice.
Rebecca Prescott (2008)
10.1016/j.actbio.2013.02.043
Heparin crosslinked chitosan microspheres for the delivery of neural stem cells and growth factors for central nervous system repair.
Nolan B. Skop (2013)
10.1016/j.jconrel.2013.03.027
Supercritical fluid technology based large porous celecoxib-PLGA microparticles do not induce pulmonary fibrosis and sustain drug delivery and efficacy for several weeks following a single dose.
Devender S. Dhanda (2013)
10.1163/092050610X522486
Proliferation of Chondrocytes on a 3-D Modelled Macroporous Poly(Hydroxyethyl Methacrylate)–Gelatin Cryogel
Deepti Singh (2011)
10.1021/am300292v
Flexible and microporous chitosan hydrogel/nano ZnO composite bandages for wound dressing: in vitro and in vivo evaluation.
P. T. Sudheesh Kumar (2012)
10.1111/j.1750-3841.2011.02266.x
Improvement of gel strength and melting point of fish gelatin by addition of coenhancers using response surface methodology.
Jayappa M. Koli (2011)
10.1021/mp100227m
Sustained antibacterial activity from triclosan-loaded nanostructured mesoporous silicon.
Mengjia Wang (2010)
10.1517/17425247.2011.559457
Cell-mediated drug delivery
Elena V Batrakova (2011)
10.1364/OL.37.002925
Microfiber Fabry-Perot interferometer fabricated by taper-drawing technique and its application as a radio frequency interrogated refractive index sensor.
Jiejun Zhang (2012)
10.1016/j.biomaterials.2008.09.046
The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages.
Jingwei Xie (2009)
10.1002/jbm.a.10070
Development of a porous poly(L-lactic acid)/hydroxyapatite/collagen scaffold as a BMP delivery system and its use in healing canine segmental bone defect.
Yunyu Hu (2003)
10.5731/pdajpst.2013.00919
Preparation and Evaluation of Sustained Release Infliximab Microspheres
Kedar Gokhale (2013)
10.1615/CRITREVTHERDRUGCARRIERSYST.V29.I1.10
Scaffold: a novel carrier for cell and drug delivery.
Tarun Garg (2012)
10.1021/ci400100c
Scaffold-Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitors
Sarah R. Langdon (2013)
10.1016/j.jconrel.2011.03.010
Porous hydroxyapatite scaffold with three-dimensional localized drug delivery system using biodegradable microspheres.
Jun Sik Son (2011)
10.1002/cbin.10123
Injectable thermosensitive chitosan/β-glycerophosphate/collagen hydrogel maintains the plasticity of skeletal muscle satellite cells and supports their in vivo viability.
Ke Ding (2013)
10.1021/jp711128s
Phase separation dynamics of aqueous solutions of thermoresponsive polymers studied by a laser T-jump technique.
Yasuyuki Tsuboi (2008)
10.1016/J.IJPHARM.2007.10.007
PLGA/PEG-derivative polymeric matrix for drug delivery system applications: Characterization and cell viability studies.
Ana Fernández-Carballido (2008)



This paper is referenced by
10.1093/rb/rbaa006
Osteoimmunomodulatory effects of biomaterial modification strategies on macrophage polarization and bone regeneration
Yajuan Xie (2020)
10.3109/21691401.2014.1000493
Enhancing the bioavailability of mebendazole by integrating the principles solid dispersion and nanocrystal techniques, for safe and effective management of human echinococcosis
Sushant Chaudhary (2016)
10.3109/1061186X.2014.994097
Brain delivery of intranasal in situ gel of nanoparticulated polymeric carriers containing antidepressant drug: behavioral and biochemical assessment
Prabhjot Kaur (2015)
10.3109/21691401.2015.1052472
Development, optimization, and characterization of polymeric electrospun nanofiber: a new attempt in sublingual delivery of nicorandil for the management of angina pectoris
Baljeet Singh (2016)
10.3109/10717544.2014.935532
Permeation enhancer strategies in transdermal drug delivery
Harneet Marwah (2016)
10.3109/10717544.2014.935530
Surfactant-based drug delivery systems for treating drug-resistant lung cancer
Prabhjot Kaur (2016)
10.1016/B978-0-323-46143-6.00022-1
Advancement in pulmonary drug delivery systems for treatment of tuberculosis
Amit K. Goyal (2017)
10.3109/21691401.2015.1012260
In situ nasal gel drug delivery: A novel approach for brain targeting through the mucosal membrane
Prabhjot Kaur (2016)
10.3389/fbioe.2020.00742
Hybrid Freeze-Dried Dressings Composed of Epidermal Growth Factor and Recombinant Human-Like Collagen Enhance Cutaneous Wound Healing in Rats
Yating Cheng (2020)
10.1155/2018/7848901
Biomaterial Scaffolds in Regenerative Therapy of the Central Nervous System
Yanchao Wang (2018)
10.3109/21691401.2014.966195
Mucosal vaccination against tuberculosis using Ag85A-loaded immunostimulating complexes
Swati Pabreja (2016)
10.1007/978-981-10-6080-9_4
Nanogels of Natural Polymers
Daniela Pamfil (2018)
10.1016/J.MSEC.2019.110060
Polyacrylate/polyacrylate-PEG biomaterials obtained by high internal phase emulsions (HIPEs) with tailorable drug release and effective mechanical and biological properties.
Marco Corti (2019)
10.1007/s13770-015-0005-7
Three-dimensional culture of mesenchymal stem cells
Jong Kyu Hong (2015)
10.3109/10717544.2014.993486
Development, optimization and evaluation of surfactant-based pulmonary nanolipid carrier system of paclitaxel for the management of drug resistance lung cancer using Box-Behnken design
Prabhjot Kaur (2016)
10.3390/ijms161126050
Application of Wnt Pathway Inhibitor Delivering Scaffold for Inhibiting Fibrosis in Urethra Strictures: In Vitro and in Vivo Study
Kaile Zhang (2015)
10.3109/1061186X.2014.947295
Therapeutic potential of nanocarrier for overcoming to P-glycoprotein
Vimratjeet Kaur (2014)
10.1016/j.ijpharm.2019.02.043
Enzymatic crosslinked gelatin 3D scaffolds for bone tissue engineering.
Mari Carmen Echave (2019)
10.1021/acs.molpharmaceut.5b00016
Development and Characterization of Nanoembedded Microparticles for Pulmonary Delivery of Antitubercular Drugs against Experimental Tuberculosis.
Amit K. Goyal (2015)
10.1016/J.POLYMER.2017.07.047
In vitro biocompatibility of vapour phase polymerised conductive scaffolds for cell lines
Jong Seob Choi (2017)
10.1007/s12565-016-0352-z
A dermal equivalent developed from adipose-derived stem cells and electrospun polycaprolactone matrix: an in vitro and in vivo study
Vahid Bayati (2016)
10.1002/adma.201904329
Advanced Nanotechnology Leading the Way to Multimodal Imaging-Guided Precision Surgical Therapy.
Cong Wang (2019)
10.1517/14712598.2015.1070825
Challenges in engineering osteochondral tissue grafts with hierarchical structures
Ivana Gadjanski (2015)
10.1039/C4RA04248D
Biocompatible multiblock aliphatic polyesters containing ether-linkages: influence of molecular architecture on solid-state properties and hydrolysis rate
Matteo Gigli (2014)
10.3390/ijms20020278
Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms
Minghan Chi (2019)
10.2147/IJN.S193328
Mucoadhesive electrospun nanofibers for drug delivery systems: applications of polymers and the parameters’ roles
Graciela Lizeth Pérez-González (2019)
10.1039/c9ra09385k
The mineralization, drug release and in vivo bone defect repair properties of calcium phosphates/PLA modified tantalum scaffolds
Rong Zhou (2020)
10.18869/acadpub.shefa.5.4.76
The Application of Alginate Scaffold in Neural Tissue Engineering
Maryam Borhani-Haghighi (2018)
10.1016/B978-0-12-800548-4.00008-5
Current Applications for Bioengineered Skin
Sara Guerrero-Aspizua (2016)
10.1016/B978-0-12-803269-5.00004-8
Oxidative Stress and Biomaterials: The Inflammatory Link
Isaac M. Adjei (2016)
10.1039/C7PY01375B
Tailored emulsion-templated porous polymer scaffolds for iPSC-derived human neural precursor cell culture
Ashley R Murphy (2017)
10.1177/0022034518772260
Pulp Regeneration by 3-dimensional Dental Pulp Stem Cell Constructs
Yuki Itoh (2018)
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