← Back to Search
Superparamagnetic Iron Oxide Nanoparticles For Delivery Of Therapeutic Agents: Opportunities And Challenges
S. Laurent, A. A. Saei, Shahed Behzadi, A. Panahifar, M. Mahmoudi
Published 2014 · Materials Science, Medicine
Download PDFAnalyze on Scholarcy
Introduction: Bearing in mind that many promising drug candidates have the problem of reaching their target site, the concept of advanced drug delivery can play a significant complementary role in shaping modern medicine. Among other nanoscale drug carriers, superparamagnetic iron oxide nanoparticles (SPIONs) have shown great potential in nanomedicine. The intrinsic properties of SPIONs, such as inherent magnetism, broad safety margin and the availability of methods for fabrication and surface engineering, pave the way for diverse biomedical applications. SPIONs can achieve the highest drug targeting efficiency among carriers, since an external magnetic field locally applied to the target organ enhances the accumulation of magnetic nanoparticles in the drug site of action. Moreover, theranostic multifunctional SPIONs make simultaneous delivery and imaging possible. In spite of these favorable qualities, there are some toxicological concerns, such as oxidative stress, unpredictable cellular responses and induction of signaling pathways, alteration in gene expression profiles and potential disturbance in iron homeostasis, that need to be carefully considered. Besides, the protein corona at the surface of the SPIONs may induce few shortcomings such as reduction of SPIONs targeting efficacy. Areas covered: In this review, we will present recent developments of SPIONs as theranostic agents. The article will further address some barriers on drug delivery using SPIONs. Expert opinion: One of the major success determinants in targeted in vivo drug delivery using SPIONs is the adequacy of magnetic gradient. This can be partially achieved by using superconducting magnets, local implantation of magnets and application of magnetic stents. Other issues that must be considered include the pharmacokinetics and in vivo fate of SPIONs, their biodegradability, biocompatibility, potential side effects and the crucial impact of protein corona on either drug release profile or mistargeting. Surface modification of SPIONs can open up the possibility of drug delivery to intracellular organelles, drug delivery across the blood–brain barrier, modifying metabolic diseases and a variety of other multimodal and/or theranostic applications.
This paper references
Integrin-targeting thermally cross-linked superparamagnetic iron oxide nanoparticles for combined cancer imaging and drug delivery.
M. Yu (2010)
Theranostics: combining imaging and therapy.
Sneha S. Kelkar (2011)
Size-Dependent Accumulation of PEGylated Silane-Coated Magnetic Iron Oxide Nanoparticles in Murine Tumors.
E. K. U. Larsen (2009)
Biocompatibility of Fe3O4 nanoparticles evaluated by in vitro cytotoxicity assays using normal, glia and breast cancer cells
B Ankamwar (2010)
EGFRvIII antibody-conjugated iron oxide nanoparticles for magnetic resonance imaging-guided convection-enhanced delivery and targeted therapy of glioblastoma.
C. Hadjipanayis (2010)
Preparation of Water-Dispersible and Biocompatible Iron Oxide Nanoparticles for MRI Agent
Y. Lee (2008)
Magnetic drug-targeting carrier encapsulated with thermosensitive smart polymer: core-shell nanoparticle carrier and drug release response.
J. Zhang (2007)
Surface modified superparamagnetic iron oxide nanoparticles: as a new carrier for bio-magnetically targeted therapy
Sheng Liang (2007)
Evaluation of neck and body metastases to nodes with ferumoxtran 10-enhanced MR imaging: phase III safety and efficacy study.
Y. Anzai (2003)
Optimal design and characterization of superparamagnetic iron oxide nanoparticles coated with polyvinyl alcohol for targeted delivery and imaging.
M. Mahmoudi (2008)
Folic acid-Pluronic F127 magnetic nanoparticle clusters for combined targeting, diagnosis, and therapy applications.
Jia-Jyun Lin (2009)
Tumor-targeted drug delivery and MRI contrast enhancement by chlorotoxin-conjugated iron oxide nanoparticles.
C. Sun (2008)
Recent advances in iron oxide nanocrystal technology for medical imaging.
C. Corot (2006)
Multifunctional Iron Oxide Nanoparticles for Diagnostics, Therapy and Macromolecule Delivery
S. K. Yen (2013)
Zwitterionic-coated "stealth" nanoparticles for biomedical applications: recent advances in countering biomolecular corona formation and uptake by the mononuclear phagocyte system.
Karina Pombo García (2014)
Dual-aptamer-based delivery vehicle of doxorubicin to both PSMA (+) and PSMA (-) prostate cancers.
Kyoungin Min (2011)
Nanoparticles of Magnetic Ferric Oxides Encapsulated with Poly(D,L Laticde-Co Glycolide) and Their Applications to Magnetic Resonance Imaging Contrast Agent.
S. J. Lee (2003)
Conjugation of functionalized SPIONs SPIONs for delivery of therapeutic agents Expert Opin. Drug Deliv
W Jiang (2012)
Solvent-Free Atom Transfer Radical Polymerization in the Synthesis of Fe2O3@Polystyrene Core−Shell Nanoparticles
Y. Wang (2003)
Multifunctional magnetic nanoparticles for targeted delivery.
A. Kumar (2010)
Chlorotoxin labeled magnetic nanovectors for targeted gene delivery to glioma.
Forrest M Kievit (2010)
Image-guided prostate cancer therapy using aptamer-functionalized thermally cross-linked superparamagnetic iron oxide nanoparticles.
M. Yu (2011)
Development of Magnetic Nanostructured Silica-Based Materials as Potential Vectors for Drug-Delivery Applications
M. Arruebo (2006)
Multifunctional nanomedicine platform for cancer specific delivery of siRNA by superparamagnetic iron oxide nanoparticles-dendrimer complexes.
O. Taratula (2011)
Magnetite-Loaded Polymeric Micelles as Ultrasensitive Magnetic-Resonance Probes†
Hua Ai (2005)
Preparation of Water-Dispersible and Biocompatible Iron Oxide Nanoparticles for MRI Agent
Yun Tack Lee (2006)
Interview: An architectural journey: from trees, dendrons/dendrimers to nanomedicine. Interview by Hannah Stanwix.
D. Tomalia (2012)
Gold nanoparticles can induce the formation of protein-based aggregates at physiological pH.
Dongmao Zhang (2009)
Targeting and retention of magnetic targeted carriers (MTCs) enhancing intra-arterial chemotherapy
S. Goodwin (1999)
Development of magnetically targeted drug delivery system using superconducting magnet
S. Takeda (2007)
Thermally cross-linked superparamagnetic iron oxide nanoparticles: synthesis and application as a dual imaging probe for cancer in vivo.
Haerim Lee (2007)
Magnetic nanocarriers of doxorubicin coated with poly(ethylene glycol) and folic acid: relation between coating structure, surface properties, colloidal stability, and cancer cell targeting.
Karine Kaaki (2012)
Fe2O3 polystyrene core-shell nanoparticles
Tumor remission in Yoshida sarcoma-bearing rts by selective targeting of magnetic albumin microspheres containing doxorubicin.
K. Widder (1981)
Magnetically responsive microspheres and other carriers for the biophysical targeting of antitumor agents.
K. Widder (1979)
Magnetically vectored nanocapsules for tumor penetration and remotely switchable on-demand drug release.
S. D. Kong (2010)
Exocytosis of nanoparticles from cells: role in cellular retention and toxicity.
Ramin Sakhtianchi (2013)
Adsorption of a Protein Monolayer via Hydrophobic Interactions Prevents Nanoparticle Aggregation under Harsh Environmental Conditions.
S. Domínguez-Medina (2013)
A new approach for the in vitro identification of the cytotoxicity of superparamagnetic iron oxide nanoparticles.
M. Mahmoudi (2010)
Effects of PEG length and iron oxide nanoparticles size on reduced protein adsorption and non-specific uptake by macrophage cells.
F. Ni (2012)
Superparamagnetic iron oxide nanotheranostics for targeted cancer cell imaging and pH-dependent intracellular drug release.
P. Zou (2010)
PEGylation of SPIONs by polycondensation reactions: a new strategy to improve colloidal stability in biological media
W. R. Viali (2013)
Novel magnetic iron oxide nanoparticles coated with poly(ethylene imine)-g-poly(ethylene glycol) for potential biomedical application: synthesis, stability, cytotoxicity and MR imaging.
C. Schweiger (2011)
Dextran stabilized iron oxide nanoparticles: synthesis, characterization and in vitro studies.
S. L. Easo (2013)
Magnetically Vectored Delivery of Cancer Drug Using Remotely On–Off Switchable NanoCapsules
S. D. Kong (2013)
Optimizing the properties of the protein corona surrounding nanoparticles for tuning payload release.
Anna Cifuentes-Rius (2013)
Electrochemical biosensors for glucose based on metal nanoparticles
A. A. Saei (2013)
HSA coated iron oxide nanoparticles as drug delivery vehicles for cancer therapy.
Qimeng Quan (2011)
Toxicity evaluations of superparamagnetic iron oxide nanoparticles: cell "vision" versus physicochemical properties of nanoparticles.
M. Mahmoudi (2011)
Polyethyleneimine functionalized iron oxide nanoparticles as agents for DNA delivery and transfection
S. C. McBain (2007)
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.
A. Gupta (2005)
Superparamagnetic iron oxide--loaded poly(lactic acid)-D-alpha-tocopherol polyethylene glycol 1000 succinate copolymer nanoparticles as MRI contrast agent.
Chandrasekharan Prashant (2010)
Conjugation of Functionalized SPIONs with Transferrin for Targeting and Imaging Brain Glial Tumors in Rat Model
W. Jiang (2012)
Variation of protein corona composition of gold nanoparticles following plasmonic heating.
M. Mahmoudi (2014)
Thermoresponsive core-shell magnetic nanoparticles for combined modalities of cancer therapy.
S. Purushotham (2009)
Superparamagnetic iron oxide--Loaded poly (lactic acid)-d-a-tocopherol polyethylene glycol 1000 succinate copolymer nanoparticles as MRI contrast agent
C Prashant (2010)
Irreversible changes in protein conformation due to interaction with superparamagnetic iron oxide nanoparticles.
M. Mahmoudi (2011)
Development of multifunctional hyaluronan-coated nanoparticles for imaging and drug delivery to cancer cells.
M. El-Dakdouki (2012)
Bio-functionalization of magnetite nanoparticles using an aminophosphonic acid coupling agent: new, ultradispersed, iron-oxide folate nanoconjugates for cancer-specific targeting.
M. Das (2008)
In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals.
Y. Huh (2005)
Superparamagnetic iron oxide nanoparticles alter expression of obesity and T2D-associated risk genes in human adipocytes
S. Sharifi (2013)
Progress in the preparation of magnetic nanoparticles for applications in biomedicine
A. G. Roca (2009)
Targeted therapy for human hepatic carcinoma cells using folate-functionalized polymeric micelles loaded with superparamagnetic iron oxide and sorafenib in vitro
L. Zhang (2013)
Preclinical experiences with magnetic drug targeting: tolerance and efficacy.
A. Lübbe (1996)
Synthesis of β-cyclodextrin conjugated superparamagnetic iron oxide nanoparticles for selective binding and detection of cholesterol crystals.
Hongguang Li (2012)
Clinical experiences with magnetic drug targeting: a phase I study with 4'-epidoxorubicin in 14 patients with advanced solid tumors.
A. Lübbe (1996)
Superparamagnetic iron oxide and drug complex-embedded acoustic droplets for ultrasound targeted theranosis.
C. Wang (2013)
Preparation and in vitro evaluation of folate-receptor-targeted SPION-polymer micelle hybrids for MRI contrast enhancement in cancer imaging.
S. Mahajan (2013)
Hyperthermia using magnetite cationic liposomes for hamster osteosarcoma
Fumiko Matsuoka (2004)
Multifunctional SPIO/DOX-loaded wormlike polymer vesicles for cancer therapy and MR imaging.
Xiaoqiang Yang (2010)
Thiolation of Maghemite Nanoparticles by Dimercaptosuccinic Acid
Intra-operative ex vivo photoacoustic nodal staging in a rat model using a clinical superparamagnetic iron oxide nanoparticle dispersion.
Diederik J. Grootendorst (2013)
In vivo hepatocyte MR imaging using lactose functionalized magnetoliposomes.
A. Ketkar-Atre (2014)
Targeted drug delivery to tumors: myths, reality and possibility.
Y. Bae (2011)
Brain cancer diagnosis and therapy with nanoplatforms.
Y. Koo (2006)
Effect of surface charge of magnetite nanoparticles on their internalization into breast cancer and umbilical vein endothelial cells.
Tetsuya Osaka (2009)
Plasma concentration gradient influences the protein corona decoration on nanoparticles
Mahdi Ghavami (2013)
Time-dependent changes in opsonin amount associated on nanoparticles alter their hepatic uptake characteristics.
Susumu Nagayama (2007)
Efficient γ-amino-proline-derived cell penetrating peptide-superparamagnetic iron oxide nanoparticle conjugates via aniline-catalyzed oxime chemistry as bimodal imaging nanoagents.
S. Cavalli (2012)
Image-guided breast tumor therapy using a small interfering RNA nanodrug.
M. Kumar (2010)
Validation of High Gradient Magnetic Field Based Drug Delivery to Magnetizable Implants Under Flow
Z. G. Forbes (2008)
Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubes.
H. Karlsson (2008)
cRGD-functionalized, DOX-conjugated, and ⁶⁴Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging.
Xiaoqiang Yang (2011)
Noninvasive monitoring of stem cell transfer for muscle disorders
G. Walter (2004)
Methotrexate-immobilized poly(ethylene glycol) magnetic nanoparticles for MR imaging and drug delivery.
N. Kohler (2006)
Superparamagnetic iron oxide nanoparticles: amplifying ROS stress to improve anticancer drug efficacy. Theranostics
G Huang (2013)
Efficient internalization of peptide-conjugated SPIONs in dendritic cells for tumor targeting.
D. Kim (2012)
'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption.
Impact of surface coating and particle size on the uptake of small and ultrasmall superparamagnetic iron oxide nanoparticles by macrophages
S. Saito (2012)
Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface.
A. Salvati (2013)
The influence of protein adsorption on nanoparticle association with cultured endothelial cells.
Morton Ehrenberg (2009)
Preparation and magnetic resonance imaging effect of polyvinylpyrrolidone-coated iron oxide nanoparticles.
H. Lee (2006)
Chemical modification of chitosan as a gene carrier in vitro and in vivo
T. Kim (2007)
Solvent-free atom transfer radical polymerization in the synthesis of SPIONs for delivery of therapeutic agents Expert Opin. Drug Deliv
Y Wang (2003)
Conjugation of functionalized SPIONs SPIONs for delivery of therapeutic agents
W Jiang (2012)
Inhibition of tumor-cell invasion with chlorotoxin-bound superparamagnetic nanoparticles.
O. Veiseh (2009)
Superparamagnetic iron oxide: pharmacokinetics and toxicity.
R. Weissleder (1989)
Dendronized iron oxide nanoparticles for multimodal imaging.
G. Lamanna (2011)
Preventing protein adsorption and macrophage uptake of gold nanoparticles via a hydrophobic shield.
T. Larson (2012)
Size-controlled synthesis of superparamagnetic iron oxide nanoparticles and their surface coating by gold for biomedical applications
H. Maleki (2012)
Evaluation of uptake and transport of cationic and anionic ultrasmall iron oxide nanoparticles by human colon cells
Blanka Halamoda Kenzaoui (2012)
Magnetic Iron Oxide Nanoparticles: Synthesis and Surface Functionalization Strategies
W. Wu (2008)
Superparamagnetic Iron Oxide Nanoparticles with Rigid Cross-linked Polyethylene Glycol Fumarate Coating for Application in Imaging and Drug Delivery
M. Mahmoudi (2009)
Pre-coating with serum albumin reduces receptor-mediated hepatic disposition of polystyrene nanosphere: implications for rational design of nanoparticles.
K. Ogawara (2004)
Iron/iron oxide core-shell nanoclusters for biomedical applications
Y. Qiang (2006)
Decorporation of Biohazards Utilizing Nanoscale Magnetic Carrier Systems
A. Rosengart (2005)
Mathematical modelling of magnetically targeted drug delivery
A. Grief (2005)
Synthesis and Characterization of Spherical Magnetite/Biodegradable Polymer Composite Particles.
S. A. Gómez-Lopera (2001)
Magnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles.
S. Laurent (2011)
Multi-functional magnetic nanoparticles for magnetic resonance imaging and cancer therapy.
Murali M Yallapu (2011)
Controlled PEGylation of Monodisperse Fe3O4 Nanoparticles for Reduced Non‐Specific Uptake by Macrophage Cells
J. Xie (2007)
Therapeutic benefits from nanoparticles: the potential significance of nanoscience in diseases with compromise to the blood brain barrier.
S. Krol (2013)
Superhigh-magnetization nanocarrier as a doxorubicin delivery platform for magnetic targeting therapy.
M. Hua (2011)
Crucial role of protein corona for specific targeting of nanoparticles. Nanomedicine 2014;In press
M Mahmoudi (2014)
Difference between Toxicities of Iron Oxide Magnetic Nanoparticles with Various Surface-Functional Groups against Human Normal Fibroblasts and Fibrosarcoma Cells
Won Jun Yang (2013)
Multifunctional superparamagnetic nanocarriers with folate-mediated and pH-responsive targeting properties for anticancer drug delivery.
M. Guo (2011)
An RGD-Modified MRI-Visible Polymeric Vector for Targeted siRNA Delivery to Hepatocellular Carcinoma in Nude Mice
Chun Wu (2013)
Cytotoxicity of Uncoated and Polyvinyl Alcohol Coated Superparamagnetic Iron Oxide Nanoparticles
M. Mahmoudi (2009)
Iron oxide nanoparticles for targeted cancer imaging and diagnostics.
Joshua E. Rosen (2012)
Folate receptor targeted, carboxymethyl chitosan functionalized iron oxide nanoparticles: a novel ultradispersed nanoconjugates for bimodal imaging.
D. Bhattacharya (2011)
Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications.
S. Laurent (2008)
Enhanced cellular uptake of aminosilane-coated superparamagnetic iron oxide nanoparticles in mammalian cell lines
X. Zhu (2012)
Positive hyaluronan/PEI/DNA complexes as a target-specific intracellular delivery to malignant breast cancer
Xiyang Sun (2009)
Binding of blood proteins to carbon nanotubes reduces cytotoxicity
C. Ge (2011)
Protein corona significantly reduces active targeting yield.
Vahid Mirshafiee (2013)
Superparamagnetic iron oxide nanoparticles with rigid crosslinked polyethylene glycol fumarate coating for application in imaging and drug delivery
M Mahmoudi (2009)
Nanoimmunoliposome delivery of superparamagnetic iron oxide markedly enhances targeting and uptake in human cancer cells in vitro and in vivo.
Chengli Yang (2008)
Selective targeting capability acquired with a protein corona adsorbed on the surface of DOTAP/ DNA nanoparticles
G Caracciolo (2013)
On designing stable magnetic vectors as carriers for malaria DNA vaccine.
F. Al-Deen (2013)
Exploiting the protein corona around gold nanorods for loading and triggered release.
J. Kah (2012)
Nanoparticles enhance brain delivery of blood–brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging
R. Koffie (2011)
Pluronic/chitosan shell cross-linked nanocapsules encapsulating magnetic nanoparticles
K. H. Bae (2008)
Cytotoxicity and Cell Cycle Effects of Bare and Poly(vinyl alcohol)‐Coated Iron Oxide Nanoparticles in Mouse Fibroblasts
M. Mahmoudi (2009)
Citric-acid-coated magnetite nanoparticles for biological applications
M. Răcuciu (2006)
Interaction of stable colloidal nanoparticles with cellular membranes.
M. Mahmoudi (2014)
Nanocapsules with specific targeting and release properties using miniemulsion polymerization
K. Landfester (2013)
Analysis of magnetic drug carrier particle capture by a magnetizable intravascular stent—2: Parametric study with multi-wire two-dimensional model
H. Chen (2005)
Selective targeting capability acquired with a protein corona adsorbed on the surface of 1,2-dioleoyl-3-trimethylammonium propane/DNA nanoparticles.
G. Caracciolo (2013)
Biocompatibility of Fe(3)O(4) nanoparticles evaluated by in vitro cytotoxicity assays using normal, glia and breast cancer cells.
B. Ankamwar (2010)
Physical-chemical aspects of protein corona: relevance to in vitro and in vivo biological impacts of nanoparticles.
M. Monopoli (2011)
Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats.
M. Longmire (2008)
Erratum: Chemotherapy targeting by DNA capture in viral protein particles (Nanomedicine (2012) 7:3 (335-352))
H. Agadjanian (2012)
Superparamagnetic nanoparticles for biomedical applications
Margarethe Hoffman-Amtenbrink (2009)
What the cell "sees" in bionanoscience.
Dorota Walczyk (2010)
Folate-conjugated iron oxide nanoparticles for solid tumor targeting as potential specific magnetic hyperthermia mediators: synthesis, physicochemical characterization, and in vitro experiments.
Fabio Sonvico (2005)
Brain Iron Toxicity: Differential Responses of Astrocytes, Neurons, and Endothelial Cells
Julie A. Gaasch (2007)
Protein corona affects the relaxivity and MRI contrast efficiency of magnetic nanoparticles.
H. Amiri (2013)
A simplified method for synthesis of Fe3O4@PAA nanoparticles and its application for the removal of basic dyes
Yinyin Xu (2012)
Chlorotoxin bound magnetic nanovector tailored for cancer cell targeting, imaging, and siRNA delivery.
O. Veiseh (2010)
Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy.
M. Mahmoudi (2011)
Silica nanocapsules of fluorescent conjugated polymers and superparamagnetic nanocrystals for dual-mode cellular imaging.
Happy Tan (2011)
Targeted delivery of anticancer drugs with intravenously administered magnetic liposomes in osteosarcoma-bearing hamsters.
T. Kubo (2000)
Methotrexate-modified superparamagnetic nanoparticles and their intracellular uptake into human cancer cells.
N. Kohler (2005)
Combined ultrasmall superparamagnetic particles of iron oxide-enhanced and diffusion-weighted magnetic resonance imaging reliably detect pelvic lymph node metastases in normal-sized nodes of bladder and prostate cancer patients.
H. Thoeny (2009)
Antibiofouling polymer-coated superparamagnetic iron oxide nanoparticles as potential magnetic resonance contrast agents for in vivo cancer imaging.
Haerim Lee (2006)
Targeting of primary breast cancers and metastases in a transgenic mouse model using rationally designed multifunctional SPIONs.
Forrest M Kievit (2012)
Colloidal stability of carboxylated iron oxide nanomagnets for biomedical use
Etelka Tombácz (2014)
Magnetic and MR relaxation properties of avidin-biotin conjugated superparamagnetic nanoparticles
J. Park (2008)
MRI-visible polymeric vector bearing CD3 single chain antibody for gene delivery to T cells for immunosuppression.
Gui-Hua Chen (2009)
Superparamagnetic Iron Oxide Nanoparticles: Amplifying ROS Stress to Improve Anticancer Drug Efficacy
G. Huang (2013)
Rotavirus capsid surface protein VP4-coated Fe3O4 nanoparticles as a theranostic platform for cellular imaging and drug delivery. Biomaterials
W Chen (2012)
Superparamagnetic Iron Oxide Nanoparticle–Aptamer Bioconjugates for Combined Prostate Cancer Imaging and Therapy
A. Wang (2008)
Magnetic resonance imaging tracking of stem cells in vivo using iron oxide nanoparticles as a tool for the advancement of clinical regenerative medicine.
M. Mahmoudi (2011)
Fluorescent, superparamagnetic nanospheres for drug storage, targeting, and imaging: a multifunctional nanocarrier system for cancer diagnosis and treatment.
Hoonsung Cho (2010)
Renal clearance of quantum dots
H. Choi (2007)
Targeting Breast Cancer Cells and Their Metastases Through Luteinizing Hormone Releasing Hormone (LHRH) Receptors Using Magnetic Nanoparticles
C. Leuschner (2005)
Magnetic colloids as drug vehicles.
J. D. Durán (2008)
Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors.
E. K. U. Larsen (2012)
Rotavirus capsid surface protein VP4-coated Fe(3)O(4) nanoparticles as a theranostic platform for cellular imaging and drug delivery.
W. Chen (2012)
Multifunctional doxorubicin loaded superparamagnetic iron oxide nanoparticles for chemotherapy and magnetic resonance imaging in liver cancer.
Jin Hee Maeng (2010)
Multifunctional stable and pH-responsive polymer vesicles formed by heterofunctional triblock copolymer for targeted anticancer drug delivery and ultrasensitive MR imaging.
Xiaoqiang Yang (2010)
Development of superparamagnetic nanoparticles for MRI: effect of particle size, charge and surface nature on biodistribution.
C. Chouly (1996)
Crucial role of the protein corona for the specific targeting of nanoparticles.
M. Mahmoudi (2015)
Specific targeting of tumor angiogenesis by RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a clinical 1.5-T magnetic resonance scanner.
Chunfu Zhang (2007)
Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats.
Tapan Jain (2008)
An RGDmodified MRI-visible polymeric vector for targeted siRNA delivery to hepatocellular carcinoma in nude mice
C Wu (2013)
This paper is referenced by
Superparamagnetic iron oxide nanoparticles conjugated with folic acid for dual target-specific drug delivery and MRI in cancer theranostics.
Yinping Huang (2017)
Acid and reduction stimulated logic "and"-type combinational release mode achieved in DOX-loaded superparamagnetic nanogel.
Meifang Song (2016)
A. N. Chakoli (2019)
Magnetic particle spectroscopy-based bioassays: methods, applications, advances, and future opportunities
K. Wu (2019)
Targeted superparamagnetic iron oxide nanoparticles for early detection of cancer: Possibilities and challenges.
Zahra Bakhtiary (2016)
Nanoparticules lipidiques de type Janus à compartiment superparamagnétique : du procédé de mise en oeuvre aux applications théranostiques
E. Millart (2017)
Synthesis of Nano-Paramagnetic Oleuropein to Induce KRAS Over-Expression: A New Mechanism to Inhibit AGS Cancer Cells
Farhad Barzegar (2019)
Assessment of Magnetic Properties of Nanostructured Silicon Loaded with Superparamagnetic Iron Oxide Nanoparticles
P. Granitzer (2015)
Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems
F. Jiang (2015)
Nanoparticles for tumor targeting
Ting Jiang (2017)
Magnetic particle spectroscopy allows precise quantification of nanoparticles after passage through human brain microvascular endothelial cells.
C. Gräfe (2016)
Toxicity assessment and comparison between two types of iron oxide nanoparticles in Mytilus galloprovincialis.
Chrysa Taze (2016)
Comparison of active, passive and magnetic targeting to tumors of multifunctional paclitaxel/SPIO-loaded nanoparticles for tumor imaging and therapy.
N. Schleich (2014)
Principles and applications of nanomaterial-based hyperthermia in cancer therapy
Jin Kook Kang (2020)
Nanomedical innovation: the SEON-concept for an improved cancer therapy with magnetic nanoparticles.
S. Lyer (2015)
Superparamagnetic iron oxide nanoparticulate system: synthesis, targeting, drug delivery and therapy in cancer.
Sathyadevi Palanisamy (2019)
Application and development of superparamagnetic nanoparticles in sample pretreatment and immunochromatographic assay
Z. Huang (2019)
In vitro toxicity of FemOn, FemOn-SiO2 composite, and SiO2-FemOn core-shell magnetic nanoparticles
Y. Toropova (2017)
Magnetic drug-loaded osteoinductive Fe3O4/CaCO3 hybrid microspheres system: efficient for sustained release of antibiotics
Jingyi Xue (2020)
Magnetic nanoparticles for environmental and biomedical applications: A review
L. Mohammed (2017)
Superparamagnetic Fe3O4 nanoparticles: synthesis by a solvothermal process and functionalization for a magnetic targeted curcumin delivery system
M. Qi (2016)
Folate targeted coated SPIONs as efficient tool for MRI
C. Scialabba (2017)
Zinc Oxide Composites of Doxorubicin in the Form of Coating , Composite Films and Gels with a High Antitumor Activity and Low Toxicity
E. R. Arakelova (2019)
Pegylated and amphiphilic Chitosan coated manganese ferrite nanoparticles for pH-sensitive delivery of methotrexate: Synthesis and characterization.
Z. Karimi (2017)
Novel morphologies of poly(allyamine hydrochloride)–methotrexate nanoassemblies for methotrexate delivery
W. Wang (2018)
Magnetic molecularly imprinted polymer nanoparticles for dispersive micro solid-phase extraction and determination of buprenorphine in human urine samples by HPLC-FL
B. Habibi (2018)
Multifunctional Magnetic Liposomes for Cancer Imaging and Therapeutic Applications
Manashjit Gogoi (2016)
Accurate iron quantification in colloids and nanocomposites by a simple UV-Vis protocol
Miquel Torras (2020)
Processing and characterization of tailor-made superparamagnetic iron oxide nanoparticles (SPIO-NPs) for pharmaceutical applications
M. K. Khalid (2018)
Filling of porous silicon with magnetic materials
P. Granitzer (2016)
Applications of Iron Oxide Nanoparticles in the Magnetic Resonance Imaging for the Cancer Diagnosis
Kanwal Akhtar (2021)
State-of-Art Bio-Assay Systems and Electrochemical Approaches for Nanotoxicity Assessment
R. Shinde (2020)See more