Online citations, reference lists, and bibliographies.
← Back to Search

Complexity Affects Regional Cerebral Blood Flow Change During Sequential Finger Movements

N. Sadato, G. Campbell, V. Ibáñez, M. Deiber, M. Hallett
Published 1996 · Psychology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Brain regions activated with complex sequential finger movements were localized by measuring regional cerebral blood flow (rCBF) with positron emission tomography. Whereas the total number and frequency of finger movements were kept constant, the complexity of auditory cued sequential finger movements of the right hand varied, with sequence length as the independent variable. In four conditions of differing complexity, the bilateral primary sensorimotor area, left ventral premotor cortex, posterior supplementary motor area, right superior part of the cerebellum, and left putamen were consistently and equally activated. This finding suggests an executive role in running sequences, regardless of their length. The right dorsal premotor cortex (Brodmann area 6) and the right precuneus (Brodmann area 7) showed a linear increase of rCBF as sequence complexity increased. This finding is consistent with the hypothesis that these areas function in the storage of motor sequences in spatial working memory and the production of ongoing sequential movement with reference to that of buffered memory. A similar increase in the cerebellar vermis and the left thalamus likewise suggests a role of these subcortical structures in complexity of sequential finger movements. Conversely, the left inferior parietal lobule showed a decrease of rCBF as complexity increased. Because short-term phonological storage is localized to this area, we suggest that the visuospatial working memory system may suppress other systems not in use. Our findings suggest that complex sequential finger movements recruit a discrete set of brain areas, in addition to areas underlying the execution of simple movement sequences.
This paper references
10.1152/JN.1984.51.5.1109
Stimulus rate dependence of regional cerebral blood flow in human striate cortex, demonstrated by positron emission tomography.
P. Fox (1984)
10.1152/JN.1988.60.1.325
Neuronal activity in cortical motor areas related to ipsilateral, contralateral, and bilateral digit movements of the monkey.
J. Tanji (1988)
10.1152/JN.1995.73.1.373
Functional anatomy of the mental representation of upper extremity movements in healthy subjects.
K. Stephan (1995)
10.1093/BRAIN/118.5.1339
Effects of stimulus rate on regional cerebral blood flow after median nerve stimulation.
V. Ibáñez (1995)
10.1097/00004647-199601000-00003
Frequency-Dependent Changes of Regional Cerebral Blood Flow during Finger Movements
N. Sadato (1996)
10.1523/JNEUROSCI.14-06-03775.1994
Motor sequence learning: a study with positron emission tomography
I. Jenkins (1994)
10.1523/JNEUROSCI.13-07-02772.1993
Visually guided reaching with the forelimb contralateral to a "blind" hemisphere: a metabolic mapping study in monkeys
H. Savaki (1993)
10.1093/BRAIN/116.1.243
The role of premotor cortex and the supplementary motor area in the temporal control of movement in man.
U. Halsband (1993)
10.1113/jphysiol.1992.sp018910
The activity of monkey thalamic and motor cortical neurones in a skilled, ballistic movement.
E. Butler (1992)
10.1523/JNEUROSCI.14-11-06336.1994
The functional organization of human extrastriate cortex: a PET-rCBF study of selective attention to faces and locations
J. Haxby (1994)
10.1152/JN.1992.68.3.653
A motor area rostral to the supplementary motor area (presupplementary motor area) in the monkey: neuronal activity during a learned motor task.
Y. Matsuzaka (1992)
10.1002/CNE.901990402
Metabolic response of optic centers to visual stimuli in the albino rat: Anatomical and physiological considerations
A. Toga (1981)
10.1002/CNE.902350306
Corticopontine projection in the macaque: The distribution of labelled cortical cells after large injections of horseradish peroxidase in the pontine nuclei
M. Glickstein (1989)
10.1093/BRAIN/103.2.301
A physiological mechanism of bradykinesia.
M. Hallett (1980)
10.1523/JNEUROSCI.13-03-00952.1993
Topographic organization of corticospinal projections from the frontal lobe: motor areas on the lateral surface of the hemisphere
S. He (1993)
10.1002/CNE.903380109
Corticocortical connections of area F3 (SMA‐proper) and area F6 (pre‐SMA) in the macaque monkey
G. Luppino (1993)
10.1152/JN.1985.54.2.348
The role of cerebral cortex in the generation of voluntary saccades: a positron emission tomographic study.
P. Fox (1985)
10.1152/JN.1991.65.6.1392
Regional cerebral blood flow during voluntary arm and hand movements in human subjects.
J. Colebatch (1991)
10.2307/2287608
Applied regression analysis (2. ed.)
N. Draper (1981)
10.1016/0006-8993(69)90141-3
Cortico-cortical connections in the rhesus monkey.
D. Pandya (1969)
10.1073/PNAS.80.13.4179
Frequency-dependent activation of glucose utilization in the superior cervical ganglion by electrical stimulation of cervical sympathetic trunk.
P. Yarowsky (1983)
10.1038/jcbfm.1990.88
The Relationship between Global and Local Changes in PET Scans
Karl J. Friston (1990)
10.1038/363583A0
The scratchpad of the mind
M. Raichle (1993)
10.1093/BRAIN/116.6.1387
Both primary motor cortex and supplementary motor area play an important role in complex finger movement.
H. Shibasaki (1993)
10.1212/WNL.43.11.2311
Functional magnetic resonance imaging of complex human movements
S. Rao (1993)
10.1126/SCIENCE.8342027
Functional magnetic resonance imaging of motor cortex: hemispheric asymmetry and handedness.
S. G. Kim (1993)
10.1152/JN.1980.43.1.118
Supplementary motor area and other cortical areas in organization of voluntary movements in man.
P. Roland (1980)
10.1111/j.1460-9568.1989.tb00769.x
Changes in Regional Cerebral Oxidative Metabolism Induced by Tactile Learning and Recognition in Man
P. Roland (1989)
10.1038/371413A0
Role for supplementary motor area cells in planning several movements ahead
J. Tanji (1994)
10.1038/jcbfm.1989.97
Localisation in PET Images: Direct Fitting of the Intercommissural (AC—PC) Line
Karl J. Friston (1989)
10.1038/323217A0
Role of the cerebellum in the visual guidance of movement
J. Stein (1986)
10.1007/978-1-4615-8579-4
Higher Cortical Functions in Man
A. R. Luria (1980)
10.1126/SCIENCE.7973661
Coding of visual space by premotor neurons.
M. Graziano (1994)
10.1016/0006-8993(68)90213-8
Pontine relay from cerebral cortex to cerebellar cortex and nucleus interpositus.
N. Tsukahara (1968)
10.1002/ANA.410370114
Regional cerebral blood flow changes in motor cortical areas after transient anesthesia of the forearm
N. Sadato (1995)
10.1038/368633A0
Brain regions associated with acquisition and retrieval of verbal episodic memory
T. Shallice (1994)
10.1152/JN.1991.66.3.705
Neuronal activity in the primate premotor, supplementary, and precentral motor cortex during visually guided and internally determined sequential movements.
H. Mushiake (1991)
10.1097/00001756-199309150-00002
Activation of precentral and mesial motor areas during the execution of elementary proximal and distal arm movements: a PET study.
M. Matelli (1993)
10.1038/jcbfm.1991.122
Comparing Functional (PET) Images: The Assessment of Significant Change
Karl J. Friston (1991)
10.1038/363623A0
Spatial working memory in humans as revealed by PET
J. Jonides (1993)
10.1073/PNAS.82.21.7462
Functional mapping of the human cerebellum with positron emission tomography.
P. Fox (1985)
10.1073/PNAS.88.5.1621
Dissociation of object and spatial visual processing pathways in human extrastriate cortex.
J. Haxby (1991)
10.1146/ANNUREV.NE.09.030186.002041
Parallel organization of functionally segregated circuits linking basal ganglia and cortex.
G. E. Alexander (1986)
10.1126/SCIENCE.493986
Activation of the supplementary motor area during voluntary movement in man suggests it works as a supramotor area.
J. M. Orgogozo (1979)
10.1126/SCIENCE.1621084
Distributed neural network underlying musical sight-reading and keyboard performance.
J. Sergent (1992)
10.1097/00001756-199009000-00016
Motor learning in man: a positron emission tomographic study.
R. Seitz (1990)
10.1523/JNEUROSCI.11-03-00667.1991
The origin of corticospinal projections from the premotor areas in the frontal lobe
R. Dum (1991)
10.1016/0959-4388(93)90167-W
Basal ganglia intrinsic circuits and their role in behavior
J. Mink (1993)
10.2307/2063815
Nonparametric Statistical Methods
M. Hollander (1973)
10.1016/S0009-9260(05)80985-7
Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268
M. J. Torrens (1990)



This paper is referenced by
10.1007/978-3-662-57723-3_2
Grundlagen der Händigkeit
Theresa Allweiss (2019)
10.1016/S0926-6410(01)00104-5
The role of lateral premotor-cerebellar-parietal circuits in motor sequence control: a parametric fMRI study.
B. Haslinger (2002)
10.1016/S0304-3940(98)00150-5
Modulation of ipsilateral motor cortex in man during unimanual finger movements of different complexities
M. Tinazzi (1998)
10.1016/j.neuroimage.2003.12.001
Brain activation during manipulation of the myoelectric prosthetic hand: a functional magnetic resonance imaging study
M. Maruishi (2004)
10.1101/419754
Parcellation of motor sequence representations in the human neocortex
Atsushi Yokoi (2018)
10.1016/S1388-2457(02)00417-0
Ipsilateral cortical activation during finger sequences of increasing complexity: representation of movement difficulty or memory load?
F. Hummel (2003)
10.1152/jn.00337.2016
Interactive effect of acute pain and motor learning acquisition on sensorimotor integration and motor learning outcomes.
E. Dancey (2016)
10.1006/nimg.2001.0780
Comparison of Auditory, Somatosensory, and Visually Instructed and Internally Generated Finger Movements: A PET Study
R. Weeks (2001)
10.1016/j.wneu.2010.06.050
A functional magnetic resonance imaging study of factors influencing motor function after surgery for gliomas in the rolandic region.
S. Safavi-Abbasi (2010)
Apprendre un art ensemble : étude longitudinale d’enregistrements simultanés en électroencéphalographie lors de performances musicales
Michaël A. S. Acquadro (2016)
The Role of Subcortical Regions in Speech Production
S. Kim (2012)
10.1093/BRAIN/121.9.1695
The role of the human motor cortex in the control of complex and simple finger movement sequences.
C. Gerloff (1998)
10.1152/JN.01052.2003
How self-initiated memorized movements become automatic: a functional MRI study.
T. Wu (2004)
10.1016/S1388-2457(00)00428-4
Functional dissociation of lower and upper frequency mu rhythms in relation to voluntary limb movement
G. Pfurtscheller (2000)
10.1523/JNEUROSCI.1986-07.2007
Serial Organization of Human Behavior in the Inferior Parietal Cortex
T. Jubault (2007)
10.1007/s00221-005-2337-3
The timing and intensity of transcranial magnetic stimulation, and the scalp site stimulated, as variables influencing motor sequence performance in healthy subjects
B. Gregori (2005)
10.1007/978-3-642-58716-0_31
Functional MRI of the Sensorimotor System
M. Hallett (2000)
10.1162/jocn.2006.18.12.1984
Anatomical Substrates of Visual and Auditory Miniature Second-language Learning
Roger D. Newman-Norlund (2006)
10.1136/jnnp.74.4.471
Preoperative motor system brain mapping using positron emission tomography and statistical parametric mapping: hints on cortical reorganisation
P. Meyer (2003)
10.1016/S1567-4231(09)70160-1
Chapter 12 Imaging
Scott T. Grafton (2003)
10.1016/S0926-6410(00)00059-8
Neuroanatomical discrimination between manipulating and maintaining processes involved in verbal working memory; a functional MRI study.
T. Tsukiura (2001)
10.1016/S0926-6410(03)00198-8
Functional neuroanatomy of interference in overlapping dual tasks: an fMRI study.
T. Schubert (2003)
10.1080/00222895.2012.747482
The Effects of Brain Lateralization on Motor Control and Adaptation
P. Mutha (2012)
10.3389/fnhum.2015.00314
May Functional Imaging be Helpful for Behavioral Assessment in Children? Regions of Motor and Associative Cortico-Subcortical Circuits Can be Differentiated by Laterality and Rostrality
Julia M. August (2015)
10.1016/S0168-0102(97)90507-1
1519 Role of the supplementary motor area and the right premotor cortex in coordination of bimanual finger movements
N. Sadato (1997)
10.1016/j.neuroimage.2012.03.084
Theta burst TMS increases cerebral blood flow in the primary motor cortex during motor performance as assessed by arterial spin labeling (ASL)
A. Orosz (2012)
REHABILITATION OUTCOME FOLLOWING ACUTE STROKE: CONSIDERING IDEOMOTOR APRAXIA
A. J. Wu (2013)
10.1016/J.PNEUROBIO.2007.02.003
The missing link between action and cognition
D. J. Serrien (2007)
10.1093/BRAIN/123.4.790
Essential role of the right superior parietal cortex in Japanese kana mirror reading: An fMRI study.
Y. Dong (2000)
University of Groningen Cervical dystonia
Paulien Maria de ()
10.1017/S0317167100032947
Role of the ipsilateral motor cortex in voluntary movement.
R. Chen (1997)
10.1152/JN.2000.83.1.528
Cortical activity in precision- versus power-grip tasks: an fMRI study.
H. Ehrsson (2000)
See more
Semantic Scholar Logo Some data provided by SemanticScholar