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Gelatin Nanoparticles As A Delivery System For Proteins

Reena Kaintura, Purnima Sharma, Samaer Singh, K. Rawat, P. Solanki
Published 2015 · Materials Science

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In this study, solvent worse method with further modification was used to produce biodegradable hydrophilic gelatin nanoparticles (GNPs) for delivery of proteins (BSA/HSA). The GNPs were characterized by High resolution transmission electron microscopy; scanning electron microscopy and Fourier transform infrared spectroscopy. Zeta potential showed positive value at acidic pH and negative value at basic pH. The GNPs size obtained as particles with a typical size 5-40 nm were produced. The maximum loading of BSA and HAS found as 10% and encapsulation efficiency obtained as 90% (w/w) of BSA and 80% (w/w) of HSA. The release profile for BSA/HSA have been entrapped well with the GNPs, since a controlled release of the protein is observed within 6 days in case of BSA and biphasic release was observed within 16 day for HSA.
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