Cancer Incidence Rates And Trends Among Children And Adolescents In The United States, 2001–2009
David A Siegel, Jessica Blythe King, Eric W Tai, Natasha D. Buchanan, Umed Ajani, Jun Li
Published 2014 · Medicine
Download PDFAnalyze on Scholarcy
OBJECTIVES: Cancer continues to be the leading disease-related cause of death among children and adolescents in the United States. More current information is needed to describe recent cancer trends and identify demographic and geographic variations. METHODS: We analyzed data from the National Program of Cancer Registries and Surveillance, Epidemiology, and End Results statewide registries representing 94.2% of the US population to identify cancers diagnosed among persons aged 0 to 19 years during 2001–2009. Age-adjusted rates and annual percentage change for trends were calculated. Data were stratified by age, gender, race, ethnicity, and geography. RESULTS: We identified 120 137 childhood and adolescent cancer cases during 2001–2009 with an age-adjusted incidence rate of 171.01 per million. The overall rate of all cancers combined remained stable over time (annual percent change [APC], 0.3%; 95% confidence interval [CI], −0.1 to 0.7). There was an increase in the overall cancer trend among African American children and adolescents (APC, 1.3%; 95% CI, 0.2 to 2.5). An increasing trend for thyroid cancer was observed among both genders (APC, 4.9%; 95% CI, 3.2 to 6.6) and specifically among adolescents and those in the Northeast, South, and West regions of the United States. Renal carcinoma incidence was increasing significantly overall (APC, 5.4%; 95% CI, 2.8 to 8.1). Extracranial and extragonadal germ cell tumors and melanoma were both significantly decreasing. CONCLUSIONS: This study reports the novel finding that renal carcinoma rates are increasing among children and adolescents. This study confirms that thyroid cancer rates are increasing and further describes rising cancer rates among African Americans.
This paper references
A pooled analysis of case-control studies of thyroid cancer¶ III. Oral contraceptives, menopausal replacement therapy and other female hormones
Carlo la Vecchia (1999)
Pediatric melanoma: risk factor and survival analysis of the surveillance, epidemiology and end results database.
John J. Strouse (2005)
Annual Report to the Nation on the status of cancer, 1975-2008, featuring cancers associated with excess weight and lack of sufficient physical activity.
Christie R. Eheman (2012)
The chronic disease of childhood obesity: the sleeping giant has awakened.
Ronald J. Sokol (2000)
Renal cell carcinoma in the pediatric population: Results from the California Cancer Registry.
Jonathan L. Silberstein (2009)
Epidemiology and risk factors of kidney cancer.
Vladimír Janout (2004)
Copyright © 2014 by the American Academy of Pediatrics
Grove Village (2014)
Trends in childhood brain tumor incidence, 1973–2009
Roberta Mckean-Cowdin (2013)
Survival variability by race and ethnicity in childhood acute lymphoblastic leukemia.
Nina S Kadan-Lottick (2003)
Childhood and adolescent cancer survival in the US by race and ethnicity for the diagnostic period 1975-1999.
Amy M. Linabery (2008)
Population-based study of renal cell carcinoma in children in Germany, 1980-2005: more frequently localized tumors and underlying disorders compared with adult counterparts. Cancer
B Selle (2006)
N Dubrawsky (1989)
International Classification of 10 SIEGEL et al at Univ of Louisiana
E Steliarova-Foucher (2014)
How representative are the surveillance, epidemiology, and end results (SEER) Program cancer data of the United States?
Ray M Merrill (2004)
SEER Cancer Statistics Review National Cancer Institute . Available at: http://seer.cancer.gov/ csr
N Howlader (1975)
Cancer incidence among children and adolescents in the United States Available at: www.pediatrics.org/cgi/content/ full
J Li (1470)
Childhood cancer risk from conventional radiographic examinations for selected referral criteria: results from a large cohort study.
Gaël P Hammer (2011)
Trends in childhood cancer incidence and mortality in urban Shanghai, 1973-2005.
Ping-ping Bao (2010)
Childhood and adolescent cancer statistics ,
RM Merrill (2014)
Nonradiation risk factors for thyroid cancer in the US Radiologic Technologists Study.
Cari L. Meinhold (2010)
Renal tumors in the second decade of life: results from the California Cancer Registry.
Julia E. Grabowski (2009)
A Cohort Study of Childhood Cancer Incidence after Postnatal Diagnostic X-Ray Exposure
Gaël P Hammer (2009)
Do Polybrominated Diphenyl Ethers (PBDEs) Increase the Risk of Thyroid Cancer?
Yawei Zhang (2008)
Childhood cancer incidence: is it really going up?
Logan G Spector (2009)
SEER) Program. National Cancer Institute SEER*Stat Software, version 8.1.2. Bethesda, MD: National Cancer Institute; 2013. Available at: www.seer.cancer.gov/seerstat
Childhood and adolescent cancer statistics, 2014.
Elizabeth E Ward (2014)
J Adolesc Young Adult Oncol
Pediatric Thyroid Carcinoma Incidence and Temporal Trends in the USA (1973–2007): Race or Shifting Diagnostic Paradigm?
Laurens Holmes (2012)
Perchlorate versus other environmental sodium/iodide symporter inhibitors: potential thyroid-related health effects.
Bert De Groef (2006)
Quality of race, Hispanic ethnicity, and immigrant status in population-based cancer registry data: implications for health disparity studies
Limin X. Clegg (2006)
Incidence of Childhood and Adolescent Melanoma in the United States: 1973–2009
Jeannette R. Wong (2013)
The second expert report, Food, Nutrition, Physical Activity and the Prevention of Cancer: A Global Perspective
Liisa M. Valsta (2007)
Estimated risks of radiation-induced fatal cancer from pediatric CT.
David J. Brenner (2001)
Population-based study of renal cell carcinoma in children in Germany, 1980–2005: more frequently localized tumors and underlying disorders compared with adult
B Selle (2006)
Metabolic factors and risk of thyroid cancer in the Metabolic syndrome and Cancer project (Me-Can)
Martin Almquist (2011)
Treatment outcomes in black and white children with cancer: results from the SEER database and St Jude Children's Research Hospital, 1992 through 2007.
Ching-Hon Pui (2012)
International Classification of Childhood Cancer, third edition.
Eva Steliarova-Foucher (2005)
Impact of enhanced detection on the increase in thyroid cancer incidence in the United States: review of incidence trends by socioeconomic status within the surveillance, epidemiology, and end results registry, 1980-2008.
Nan Li (2013)
Epidemiology and risk factors for kidney cancer
Wong-Ho Chow (2010)
Childhood Cancer Incidence Trends in Association With US Folic Acid Fortification (1986–2008)
Amy M. Linabery (2012)
Examination of the Increase in Thyroid Cancer Incidence Among Younger Women in the United States by Age, Race, Geography, and Tumor Size, 1999-2007.
Dawn M. Holman (2011)
Melanoma incidence rises for children and adolescents: an epidemiologic review of pediatric melanoma in the United States.
Mary T. Austin (2013)
Annual Report to the Nation on the Status of Cancer, 1975–2009, Featuring the Burden and Trends in Human Papillomavirus (HPV)–Associated Cancers and HPV Vaccination Coverage Levels
Ahmedin Jemal (2013)
Trends in childhood cancer incidence in the U.S. (1992-2004).
Amy M. Linabery (2008)
Population-based study of renal cell carcinoma in children in Germany, 1980-2005: more frequently localized tumors and underlying disorders compared with adult counterparts.
Barbara Selle (2006)
Food, Nutrition, Physical Activity, and the Prevention of Cancer : a Global Perspective : 食物、栄養、身体活動とがんの予防 : 世界的展望(前篇)
廣畑 富雄 (2012)
Dental x-rays and the risk of thyroid cancer: A case-control study
Anjum Memon (2010)
Time trends of cancer incidence in European children (1978-1997): report from the Automated Childhood Cancer Information System project.
Peter Kaatsch (2006)
Misclassification of race/ethnicity in a Population-based Cancer Registry (United States)
Scarlett Lin Gomez (2006)
Germ Cell Tumors
Thomas A. Olson (2016)
Principles and Practice of Pediatric Oncology
Beatriz E. Amendola (1990)
Childhood and adolescent cancer statistics
E Ward (2014)
Medical exposure to radiation and thyroid cancer.
S. B. H. Schonfeld (2011)
Cancer Incidence Among Children and Adolescents in the United States, 2001–2003
Jun Li (2008)
Cancer statistics, 2014.
Rebecca L Siegel (2014)
International Classification of 10 SIEGEL et al by guest on September 24, 2017 http://pediatrics.aappublications.org/ Downloaded from Childhood Cancer, Third Edition. Cancer
E Steliarova-Foucher (2005)
Increase in the incidence of differentiated thyroid carcinoma in children, adolescents, and young adults: a population-based study.
Lucas Bonachi Vergamini (2014)
Annual Report to the Nation on the Status of Cancer, 1975–2007, Featuring Tumors of the Brain and Other Nervous System
Betsy A. Kohler (2011)
Annual Summary of Vital Statistics: 2007
Melonie Heron (2010)
, 1975 - 2008 , featuring cancers associated with excess weight and lack of suf fi cient physical activity
L Holmes (2012)
Centers of Disease Control and Prevention. 10 leading causes of death by age group, United States – 2008
Cancer incidence among children and adolescents in the United States, 2001-2003. Pediatrics
J Li (2008)
Annual Report to the Nation on the status of cancer, 1975-2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer.
Brenda Kay Edwards (2014)
Building the infrastructure for nationwide cancer surveillance and control – a comparison between The National Program of Cancer Registries (NPCR) and The Surveillance, Epidemiology, and End Results (SEER) Program (United States)
Phyllis A. Wingo (2004)
This paper is referenced by
Cytopathological spectrum of peripheral neuroblastic tumours in fine needle aspiration cytology and categorization as per International Neuroblastoma Pathology Classification.
Abin Koshy (2019)
Health disparities and impact on outcomes in children with primary central nervous system solid tumors.
Mary T. Austin (2016)
Environmental and Economic Strategies for Primary Prevention of Cancer in Early Life
David L. Kriebel (2016)
Long-term outcomes after percutaneous renal cryoablation performed with adjunctive techniques.
Faraz Khan (2018)
Childhood leukaemia incidence and trends in a Middle Eastern country during 1980–2014: a population-based study
Saeed Akhtar (2020)
Survivors of Childhood Cancer and Cancer Treatments
May-Tal Sauerbrun-Cutler (2016)
One Year Follow-up of Outcomes from the Randomized Clinical Trial of the Building on Family Strengths Program
Shervin S. Churchill (2018)
Trends in Thyroid Cancer Incidence in Korean Children (1999-2012) Based on Palpation and Nonpalpation Detection Methods
Yoon Young Cho (2015)
Thyroid Cancer in Children and Adolescents
Mahnaz Kousha (2018)
Thyroid carcinoma in children, adolescents, and young adults in Brazil: A report from 11 population-based cancer registries
Rejane de Souza Reis (2020)
Temporal trends in incidence of childhood cancer in Switzerland, 1985-2014.
Grit Sommer (2019)
[A persistent "conjunctivitis" in a 2-year-old boy].
Névine El Khatib (2017)
Spatial and temporal variations of childhood cancers: Literature review and contribution of the French national registry
Stéphanie Goujon (2018)
Pediatric Differentiated Thyroid Carcinoma in The Netherlands: A Nationwide Follow-Up Study.
Mariëlle S Klein Hesselink (2016)
Pediatric differentiated thyroid carcinoma: The clinicopathological features and the coexistence of Hashimoto's thyroiditis.
Pei-You Ren (2019)
Long-TermQuality of Life inAdult Survivors of Pediatric Differentiated Thyroid Carcinoma
Marloes Nies (2019)
Classic Architecture with Multicentricity and Local Recurrence, and Absence of TERT Promoter Mutations are Correlates of BRAFV600E Harboring Pediatric Papillary Thyroid Carcinomas
Semen Onder (2016)
Pediatric papillary thyroid cancer >1 cm: is total thyroidectomy necessary?
Tate R. Nice (2015)
Cost-effectiveness of Tisagenlecleucel vs Standard Care in High-risk Relapsed Pediatric Acute Lymphoblastic Leukemia in Canada.
Jill Furzer (2020)
Validation of dynamic risk stratification in pediatric differentiated thyroid cancer
Seo Young Sohn (2017)
Characteristics of Follicular Variant Papillary Thyroid Carcinoma in a Pediatric Cohort
Stephanie L Samuels (2018)
Histopathologic variables differentially affect melanoma survival by age at diagnosis.
Kriti Mishra (2019)
Soft tissue sarcoma nomograms and their incorporation into practice.
Dario Callegaro (2017)
The Growing Pediatric Health Gap: Environmental Injustice Threatens Our Future.
L. Drew Rosen (2016)
Foreword: Cancer Prevention Can Start Early and Last a Lifetime
Mary C White (2016)
Progress and Prospects in Pediatric Leukemia.
Pillai Pallavi Madhusoodhan (2016)
Opportunities and challenges in the immunological therapy of pediatric malignancy: a concise snapshot
Francesco Ceppi (2017)
Childhood, adolescent and young adult cancer incidence in Japan in 2009–2011
Kota Katanoda (2017)
Assisted reproductive technology and the risk of pediatric cancer: A population based study and a systematic review and meta analysis.
Daniella Gilboa (2019)
Clinicopathological Features and Treatment Outcomes in Ewing's Sarcoma Patients: A 10-year experience of Alexandria Clinical Oncology Department
Asmaa Nazeer (2017)
Pediatric leukemia: Moving toward more accurate models.
Thomas Milan (2019)
Introductory Chapter: Contemporary Pediatric Hematology and Oncology
Marwa M Zakaria (2019)See more