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Reactivation Of Hepatitis B Virus Following Anti-Tumor Necrosis Factor-α Therapy
S. J. Jang, Y. Jung, S. H. Kim, S. Kim, O. S. Kwon, Y. S. Kim, D. J. Choi, J. Kim
Published 2013 · Medicine
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Anti-tumor necrosis factor (TNF)-α therapy is being increasingly used to treat several rheumatic diseases and inflammatory bowel diseases. However, treatment with anti-TNF-α therapy of patients with a concurrent hepatitis B virus (HBV) or hepatitis C virus (HCV) infection can promote viral reactivation and potentially fatal liver failure. The medical records of 176 patients who had been treated with an anti-TNF-α therapy at single center from January 2010 to December 2012 were retrospectively analyzed. Of the 176 patients, the hepatitis B surface antigen (HBsAg) status of 114 (64.8%) were tested at the baseline. Five (4.4%) of them were HBsAgpositive, and 109 (95.6%) were negative. Only 10 of the HBsAg-negative patients (9.2%) were checked for hepatitis B core antigen. Ninety-one patients were checked for anti-HCV, and two (2.2%) were positive. After their anti-TNF-α therapy, HBV reactivation was confirmed in two patients. The reactivation of HBV after the anti-TNF-α therapy was observed in the HBsAg-positive patients.
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