Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

The Prospects And Predicaments Of Intravenous Rt-PA In Childhood Ischemic Stroke

R. Behrouz
Published 2014 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
One of the biggest conundrums in acute treatment of childhood arterial ischemic stroke is administration of intravenous recombinant tissue plasminogen activator. Although the benefit of this treatment is well-established in adults, the same effectiveness in children has not been demonstrated. Diversity of underlying causes of ischemic stroke in children and delay and uncertainty in diagnosis are some of the complexities that make intravenous thrombolysis elusive in this population. Physiological, pharmacological and developmental factors may also play roles in variable effect of intravenous recombinant tissue plasminogen activator in children. Current studies are aimed to determine the safety and efficacy of intravenous thrombolysis in carefully-selected children who would benefit the most from this procedure.
This paper references
10.1016/j.jstrokecerebrovasdis.2011.02.010
Stroke in a child safely treated with intravenous tissue plasminogen activator and edaravone, a free radical scavenger.
Haruhisa Baba (2012)
This article raises the question whether thrombolytic activity is pharmacologically possible in children
Cerebral perfusion abnormalities in children with autism and mental retardation: a segmental quantitative SPECT study.
Gupta Sk (2009)
10.1542/peds.2005-2676
Mimics of Childhood Stroke: Characteristics of a Prospective Cohort
R. Shellhaas (2006)
10.1177/088307380001500813
Successful Treatment for Stroke in a Child Using Recombinant Tissue Plasminogen Activator
S. Thirumalai (2000)
10.1016/j.ejpn.2013.03.007
Safe use of alteplase in a 10 months old infant with cardio-embolic stroke.
Z. rener-Primec (2013)
10.1177/0883073807303998
Successful Intravenous Thrombolysis for Acute Stroke in a Child
G. Ortiz (2007)
10.1046/j.1540-8167.2001.00723.x
Use of Tissue Plasminogen Activator in a Stroke After Radiofrequency Ablation of a Left‐Sided Accessory Pathway
B. Cannon (2001)
10.1007/S00115-006-2246-0
[Thrombolysis for ischemic stroke: an update].
M. Koehrmann (2007)
10.2174/1874440001206010103
Brain Development in Childhood
Y. Taki (2012)
10.1017/S1481803500010824
Successful treatment of pediatric stroke with recombinant tissue plasminogen activator (rt-PA): a case report and review of the literature.
S. Cremer (2008)
10.1016/j.pediatrneurol.2007.10.006
Ischemic stroke and excellent recovery after administration of intravenous tissue plasminogen activator.
S. V. Jain (2008)
10.1177/088307380001500508
Neurologic Outcome in Survivors of Childhood Arterial Ischemic Stroke and Sinovenous Thrombosis
G. DeVeber (2000)
10.1159/000203076
Thrombolysis in Acute Childhood Stroke: Design and Challenges of the Thrombolysis in Pediatric Stroke Clinical Trial
C. Amlie-Lefond (2009)
10.1097/PEC.0b013e318244788f
Thrombolytic Therapy for Acute Stroke in a Teenager
A. Muñiz (2012)
10.1161/STROKEAHA.108.519066
Delay to Diagnosis in Acute Pediatric Arterial Ischemic Stroke
M. Rafay (2009)
10.1159/000331930
Successful Intravenous rt-PA Thrombolysis for a Childhood Cardioembolic Stroke with Emery-Dreifuss Muscular Dystrophy
K. Tanaka (2011)
10.1177/08830738060210070701
Administration of Intravenous Tissue Plasminogen Activator in a Pediatric Patient With Acute Ischemic Stroke
Marwan I Shuayto (2006)
10.1097/MNM.0b013e3282f1bb8e
Regional cerebral blood flow in childhood autism: a SPET study with SPM evaluation
L. Burroni (2008)
10.1161/STROKEAHA.108.189696
Management of stroke in infants and children: a scientific statement from a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young.
E. Roach (2008)
in children : data from the nationwide inpatient sample
C Amlie-Lefond (2007)
10.1212/WNL.57.1.157
Successful use of rt-PA in pediatric stroke
M. Carlson (2001)
10.1016/j.braindev.2004.07.010
Regional cerebral blood flow in children with ADHD: changes with age
Ö. Öner (2005)
10.4414/smw.2011.13281
Delayed diagnosis of acute ischemic stroke in children - a registry-based study in Switzerland.
Charlotte Martin (2011)
10.1161/STROKEAHA.106.473983
Thrombolysis for Ischemic Stroke in Children: Data From the Nationwide Inpatient Sample
N. Janjua (2007)
10.1007/s00234-011-0946-z
Perfusion-weighted MR imaging in persistent hemiplegic migraine
I. Mourand (2011)
10.1007/s00247-010-1826-0
Pediatric hemiplegic migraine: susceptibility weighted and MR perfusion imaging abnormality
D. Altınok (2010)
10.3109/02699052.2012.661117
Quality-of-life and psychosocial outcome following childhood arterial ischaemic stroke
F. O’Keeffe (2012)
Guidelines from the American Heart Association providing recommendations and the level of evidence for treatment strategies in childhood stroke
10.1161/STROKEAHA.108.000014
Management of stroke in infants and children: A scientific statement from a special writing group of the american heart association stroke council and the council on cardiovascular disease in the young (Stroke (2008) 39 (2644-2691))
E. Roach (2009)
10.1111/j.1469-8749.2008.03012.x
Delays in investigation and management of acute arterial ischaemic stroke in children
Catherine McGlennan (2008)
10.1542/PEDS.109.1.116
Report of the National Institute of Neurological Disorders and Stroke workshop on perinatal and childhood stroke.
J. Lynch (2002)
10.1016/j.braindev.2008.03.014
Plasticity and injury in the developing brain
M. Johnston (2009)
10.1016/j.jstrokecerebrovasdis.2011.02.008
Ulnar nerve palsy-like motor and sensory loss caused by a small cortical infarct.
T. Ueno (2012)
10.1016/S1474-4422(09)70106-1
Use of alteplase in childhood arterial ischaemic stroke: a multicentre, observational, cohort study
Catherine M. Amlie-Lefond (2009)
•• Perhaps the largest multicenter study looking at childhood stroke
10.1016/j.ejrad.2011.11.044
Perfusion CT in childhood stroke--initial observations and review of the literature.
D. Zebedin (2013)
Cerebral perfusion abnormalities in children with autism and mental retardation: a segmental quantitative SPECT study.
S. Gupta (2009)
10.1160/TH05-01-0047
Developmental haemostasis. Impact for clinical haemostasis laboratories.
P. Monagle (2006)
10.1182/blood.v80.8.1998.bloodjournal8081998
Maturation of the hemostatic system during childhood.
M. Andrew (1992)
10.1177/088307380101600410
Thrombolytic Therapy in an Adolescent Ischemic Stroke
E. Noser (2001)
10.1097/PEC.0b013e31821dc6e8
Successful intravenous thrombolysis in a 14-year-old boy with ischemic stroke.
Isabel Sampaio (2011)
This article outlines some of the causes of delay in diagnosis of childhood stroke



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar