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Risk-adapted Treatment And Follow-up Management In Childhood-onset Craniopharyngioma

Hermann L. Müller
Published 2016 · Medicine

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ABSTRACT Craniopharyngiomas are rare embryonic malformations of the sellar/parasellar region with low histological grade. Here, we review findings on the diagnosis, treatment, clinical course, follow-up, and prognosis of craniopharyngioma patients. Clinical manifestations develop from increased intracranial pressure, anterior visual pathway damage, and hypothalamic/pituitary deficiencies. If the tumor is favorably localized (no anatomical involvement with the hypothalamic and optical structures) therapy of choice is complete resection, meticulously performed to preserve hypothalamic and optic functions. In patients with unfavorable tumor involvement, optimal therapy is limited hypothalamus-sparing surgical strategy, followed by judicious irradiation dosage to minimize recurrences and progression. Surgical lesions and/or anatomical involvement of posterior hypothalamic areas result in serious sequelae, mainly hypothalamic syndrome. Craniopharyngioma is a chronic disease and must be managed as such, providing ongoing care of pediatric and adult patients by experienced multidisciplinary teams in the context of multicenter trials.
This paper references
10.1007/s00401-006-0184-3
Nuclear β-catenin accumulation associates with epithelial morphogenesis in craniopharyngiomas
R. Buslei (2006)
10.7759/cureus.259
Deep Brain Stimulation for Obesity
Allen L Ho (2015)
Combined proton and photon irradiation for craniopharyngioma: long-term results of the early cohort D ow nl oa de d by [ U ni ve rs ity o f C al if or ni a, S an D ie go
MM Fitzek (2006)
10.1210/JCEM.87.8.8751
Melatonin secretion and increased daytime sleepiness in childhood craniopharyngioma patients.
H. Müller (2002)
• Review on the broad range of neuroendocrine disorders in patients with childhood-onset craniopharyngioma
H L Muller (2014)
• Review on the risk-adapted surgical treatment strategies
10.3389/fendo.2011.00100
Different Approaches in Radiation Therapy of Craniopharyngioma
R. Kortmann (2011)
10.1530/EJE-14-1029
Hydrocephalus and hypothalamic involvement in pediatric patients with craniopharyngioma or cysts of Rathke's pouch: impact on long-term prognosis.
A. M. Daubenbüchel (2015)
10.1515/jpem-2014-0338
Hypothalamic obesity after treatment for craniopharyngioma: the importance of the home environment
R. W. Meijneke (2015)
10.1007/s12020-015-0683-x
Magnetic resonance imaging as predictor of functional outcome in craniopharyngiomas
Pietro Mortini (2015)
Grading system for imaging on hypothalamic lesions after initial surgery of craniopharyngioma with high prediction sensitivity for the development of hypothalamic obesity
10.1515/jpem-2014-0415
Eating behavior, weight problems and eating disorders in 101 long-term survivors of childhood-onset craniopharyngioma
A. Hoffmann (2015)
10.1210/er.2009-0033
Mortality in patients with pituitary disease.
M. Sherlock (2010)
10.1007/s00381-010-1330-8
Craniopharyngiomas in children: how radical should the surgeon be?
J. Šteňo (2010)
10.1097/MED.0000000000000214
Craniopharyngioma and hypothalamic injury: latest insights into consequent eating disorders and obesity
H. Müller (2016)
10.1515/jpem-2014-0337
Effects of T3 treatment on brown adipose tissue and energy expenditure in a patient with craniopharyngioma and hypothalamic obesity
H. V. van Santen (2015)
10.1530/EJE-13-0832
Food intake regulating hormones in adult craniopharyngioma patients.
J. Roemmler-Zehrer (2014)
• Study on circadian rhythms and melatonin patters in craniopharyngioma patients
Craniopharyngioma. Handbook of clinical neurology
HL Muller (2014)
10.3171/ped.2006.104.2.5
Phase II trial of conformal radiation therapy for pediatric patients with craniopharyngioma and correlation of surgical factors and radiation dosimetry with change in cognitive function.
T. Merchant (2006)
10.1055/S-0031-1273915
Unusual manifestation of B-cell acute lymphoblastic leukemia in a 16-year-old boy with gastric ulcer caused by blast infiltration
M. Mueller (2011)
10.1111/jpc.12190
Childhood craniopharyngioma: 20‐year institutional experience in Western Australia
S. Rath (2013)
10.3390/jcm4030389
Neuroendocrine Disorders in Pediatric Craniopharyngioma Patients
A. M. Daubenbüchel (2015)
Craniopharyngiomas: Comprehensive diagnosis, treatment and outcome
James George Evans (2015)
Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group.
J. Tomlinson (2001)
10.1016/j.ijrobp.2014.05.051
Proton beam therapy versus conformal photon radiation therapy for childhood craniopharyngioma: multi-institutional analysis of outcomes, cyst dynamics, and toxicity.
A. Bishop (2014)
10.1227/NEU.0b013e31821a872d
Surgical Management of Craniopharyngiomas in Children: Meta-analysis and Comparison of Transcranial and Transsphenoidal Approaches
R. Elliott (2011)
10.1530/EJE-12-0997
GLP-1 analogues as a new treatment option for hypothalamic obesity in adults: report of nine cases.
F. Zoicas (2013)
• Maximum and radical removal through the extended transsphenoidal approach achieved high rate of total removal and good visual outcomes in 42 craniopharyngioma patients ana
• This study reports on equivalent survival and disease control outcomes in proton beam therapy and conventional intensity modulated radiation therapy. Long-term toxicities still have to be analyzed
10.3171/2014.8.FOCUS14366
National treatment trends, complications, and predictors of in-hospital charges for the surgical management of craniopharyngiomas in adults from 2007 to 2011.
Hasan A. Zaidi (2014)
10.1210/JC.2003-031751
Longitudinal study on growth and body mass index before and after diagnosis of childhood craniopharyngioma.
H. Müller (2004)
10.3389/fendo.2011.00070
Diagnostics, Treatment, and Follow-Up in Craniopharyngioma
H. Müller (2011)
10.1055/S-2004-832358
Differential diagnosis of suprasellar tumors in children.
M. Warmuth-Metz (2004)
10.1016/j.wneu.2014.03.029
How to achieve the best possible outcomes in the management of retroinfundibular craniopharyngiomas?
S. Raza (2014)
• Study on effects of structured rehabilitation programs on longterm weight development in patients with childhood-onset craniopharyngioma
10.1515/jpem-2015-0167
Comparison of energy expenditure, body composition, metabolic disorders, and energy intake between obese children with a history of craniopharyngioma and children with multifactorial obesity
Ilanit Bomer (2015)
10.1159/000055967
Radical Surgery in a Neonate with Craniopharyngioma
J. Müller-Scholden (2000)
[Surgery for craniopharyngioma].
E. Ashkenazi (1990)
10.3389/fnsys.2015.00090
Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry
Daniel C. Castro (2015)
10.1186/s40478-015-0211-5
Identification of targets for rational pharmacological therapy in childhood craniopharyngioma
J. Gump (2015)
10.1016/j.radonc.2014.11.035
Long-term disease control and toxicity outcomes following surgery and intensity modulated radiation therapy (IMRT) in pediatric craniopharyngioma.
Brad J. Greenfield (2015)
10.4149/BLL_2014_008
Gastric stimulation in treatment in type 2 diabetes mellitus.
Pavel Zonča (2014)
Long-term outcomes and complications in patients with craniopharyngioma: the British Columbia Cancer Agency experience. International journal of radiation oncology, biology, physics
AC Lo (2014)
Surgical strategies in childhood craniopharyngioma. Frontiers in endocrinology
J Flitsch (2011)
10.1586/14737175.2014.875470
Childhood craniopharyngioma: treatment strategies and outcomes
H. Müller (2014)
10.1055/S-2003-42722
Perioperative dexamethasone treatment in childhood craniopharyngioma--influence on short-term and long-term weight gain.
H. Müller (2003)
10.1038/ng.2868
Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas
P. Brastianos (2014)
10.1097/00006123-199711000-00031
Craniopharyngiomas in two consanguineous siblings: case report.
A. L. Boch (1997)
10.3171/2014.8.GKS141411
Gamma Knife surgery for craniopharyngioma: report on a 20-year experience.
C. Lee (2014)
10.3171/JNS.1996.84.1.0124
Use of bleomycin in intratumoral chemotherapy for cystic craniopharyngioma. Case report.
S. Cavalheiro (1996)
10.1016/j.metabol.2009.06.031
Changes of peripheral alpha-melanocyte-stimulating hormone in childhood obesity.
C. Roth (2010)
10.1038/nrendo.2013.125
Paediatrics: Surgical strategy and quality of life in craniopharyngioma
H. Müller (2013)
10.1515/jpem-2014-0416
Childhood craniopharyngioma – current status and recent perspectives in diagnostics and treatment
Hermann L. Müller (2015)
On the benefits and risks of proton therapy in pediatric craniopharyngioma. International journal of radiation oncology, biology, physics 82:e281-287
C Beltran (2012)
10.1111/cen.12568
Intracystic interferon therapy in childhood craniopharyngioma: who, when and how?
S. Bailey (2015)
10.1515/jpem-2014-0419
Endocrine aspects and sequel in patients with craniopharyngioma
E. Erfurth (2015)
10.1007/s11060-011-0540-6
Incidence of craniopharyngioma in Denmark (n = 189) and estimated world incidence of craniopharyngioma in children and adults
E. H. Nielsen (2011)
10.1515/jpem-2014-0425
Carbohydrate-lipid profile and use of metformin with micronized fenofibrate in reducing metabolic consequences of craniopharyngioma treatment in children: single institution experience
M. Kalina (2015)
10.1016/j.ecl.2014.10.013
Health-related quality of life in pituitary diseases.
Iris Crespo (2015)
• Study on morbidity and mortality in childhood-onset craniopharyngioma showing that hypothalamic obesity is a significant complication of craniopharymngioma associated with increased mortality
Brain-derived neurotrophic factor and its relation to leptin in obese children before and after weight loss. Metabolism
CL Roth (2013)
10.3171/2014.12.JNS141591
Long-term quality of life after endonasal endoscopic resection of adult craniopharyngiomas.
K. Patel (2015)
10.1016/j.ijrobp.2008.05.010
Surveillance of craniopharyngioma cyst growth in children treated with proton radiotherapy.
K. Winkfield (2009)
Fractionated Proton Radiation Treatment for Pediatric Craniopharyngioma: Preliminary Report
Q. T. Luu (2006)
• Comparison of different treatment strategies (gross total vs. limited resection) in two prospective multicenter studies
Craniopharyngioma. Endocrine reviews 35:513-543 *Review on the broad range of neuroendocrine disorders in patients with childhood-onset craniopharyngioma
HL Muller (2014)
A 2013 Surgery for craniopharyngioma
M Buchfelder (2013)
Craniopharyngioma. Journal of neurosurgery
FA Boop (2007)
Childhood craniopharyngioma: hypothalamus D ow nl oa de d by [ U ni ve rs ity o f C al if or ni a, S an D ie go
E Elowe-Gruau (2013)
10.1016/j.ijrobp.2010.11.027
Dosimetric comparison of three-dimensional conformal proton radiotherapy, intensity-modulated proton therapy, and intensity-modulated radiotherapy for treatment of pediatric craniopharyngiomas.
Nicholas S. Boehling (2012)
10.1007/s11060-015-1885-z
A systematic review of cognitive performance in patients with childhood craniopharyngioma
J. Özyurt (2015)
10.3171/JNS.2007.106.1.1
Stereotactic radiosurgery--an organized neurosurgery-sanctioned definition.
G. Barnett (2007)
10.1016/j.pediatrneurol.2013.09.003
A review of childhood and adolescent craniopharyngiomas with particular attention to hypothalamic obesity.
Amy Rosenfeld (2014)
10.1055/S-2007-985848
First experiences with laparoscopic adjustable gastric banding (LAGB) in the treatment of patients with childhood craniopharyngioma and morbid obesity.
H. Müller (2007)
Tabarin A 2013 Is bariatric surgery really inefficient in hypothalamic obesity? Clinical endocrinology
B Gatta (2013)
• Functional magnetic resonance imaging study in childhoodonset craniopharyngioma patients observing remote effects of hypothalamic lesions in the prefrontal cortex
•• First report on BRAF mutations as typical molecular finding in papillary craniopharyngioma
The classification of tumours of the central nervous system.
R. O. Barnard (1982)
10.3171/PED-07/10/318
Neuroradiological findings of bleomycin leakage in cystic craniopharyngioma. Report of three cases.
L. Lafay-Cousin (2007)
10.1111/j.1467-789X.2012.01004.x
Hypothalamic obesity in children
A. Bereket (2012)
Quality of life in patients with hypopituitarism. Current opinion in endocrinology, diabetes, and obesity
I Crespo (2015)
10.1016/j.nlm.2014.03.007
Remote effects of hypothalamic lesions in the prefrontal cortex of craniopharygioma patients
J. Özyurt (2014)
10.1016/B978-0-444-59602-4.00019-8
Surgical approach to pituitary tumors.
D. Solari (2014)
10.1016/j.jpeds.2013.12.010
Neuropsychological outcome in patients with childhood craniopharyngioma and hypothalamic involvement.
J. Özyurt (2014)
10.1159/000368798
Longitudinal Changes in Body Mass Index in Children with Craniopharyngioma
M. J. Khan (2014)
10.1007/s12020-015-0800-x
Preoperative staging in childhood craniopharyngioma: standardization as a first step towards improved outcome
H. Müller (2015)
10.3171/jns.1998.89.4.0547
The descriptive epidemiology of craniopharyngioma.
G. Bunin (1997)
Radical surgery in a neonate with craniopharyngioma. report of a case.
J. Müller-Scholden (2000)
10.1002/path.1562
Possible linkage between specific histological structures and aberrant reactivation of the Wnt pathway in adamantinomatous craniopharyngioma
K. Kato (2004)
The first report on impact of initial hydrocephalus and hypothalamic involvement on long-term prognosis in childhood craniopharyngioma
•• First report on incidence and clinical course of diencephalic syndrome before and after diagnosis of childhood-onset craniopharyngioma
• The role of intracystic therapy in the form of interferon alpha is discussed; including when to use this therapeutic option and practical details of its use
• First published transcriptome for adamentinomatous craniopharyngioma and identification of targets for rational therapy
• New surgical endoscopic approaches and improvement of long-term quality of life
10.6065/apem.2013.18.4.161
Pathophysiology and clinical characteristics of hypothalamic obesity in children and adolescents
Ja Hye Kim (2013)
10.1530/EJE-11-0158
Post-operative hypothalamic lesions and obesity in childhood craniopharyngioma: results of the multinational prospective trial KRANIOPHARYNGEOM 2000 after 3-year follow-up.
H. Müller (2011)
10.1586/14737175.2015.1100078
Craniopharyngioma: long-term consequences of a chronic disease
H. Müller (2015)
10.1007/s11060-014-1600-5
The ophthalmic natural history of paediatric craniopharyngioma: a long-term review
E. Drimtzias (2014)
10.3389/fendo.2012.00039
Intracystic Therapies for Cystic Craniopharyngioma in Childhood
U. Bartels (2012)
Craniopharyngioma. Handbook of clinical neurology
HL Muller (2014)
• Review on the broad range of neuroendocrine disorders in patients with childhood-onset craniopharyngioma
Resting energy expenditure is lower in craniopharyngioma patients compared to children with multifactorial obesity regardless of the amount of fat-free mass
This study highlights the therapeutic dilemma in recurrent craniopharyngioma after irradiation. The authors recommend an attempt at gross-total resection in such cases
10.1007/s007010200058
Craniopharyngioma in a Mother and Daughter
A. L. Green (2002)
10.1016/j.ijrobp.2011.01.005
On the benefits and risks of proton therapy in pediatric craniopharyngioma.
C. Beltran (2012)
10.1210/JC.2002-021797
Obesity in patients with craniopharyngioma: assessment of food intake and movement counts indicating physical activity.
K. Harz (2003)
10.1159/000338695
Functional Neuroimaging in Craniopharyngioma: A Useful Tool to Better Understand Hypothalamic Obesity?
C. Roth (2012)
10.1530/EJE-13-0280
Clinical characteristics and effects of GH replacement therapy in adults with childhood-onset craniopharyngioma compared with those in adults with other causes of childhood-onset hypothalamic-pituitary dysfunction.
Kevin C J Yuen (2013)
10.1016/j.wneu.2014.10.002
Optic chiasm distortions caused by craniopharyngiomas: clinical and magnetic resonance imaging correlation and influence on visual outcome.
R. Prieto (2015)
Childhood craniopharyngioma. Pituitary
HL Muller (2013)
10.1007/s00381-009-0978-4
Neurosurgical treatment strategies in childhood craniopharyngiomas: is less more?
T. Schubert (2009)
10.1093/neuonc/nov044
Survival, hypothalamic obesity, and neuropsychological/psychosocial status after childhood-onset craniopharyngioma: newly reported long-term outcomes.
A. Sterkenburg (2015)
10.1530/EJE-15-0709
History before diagnosis in childhood craniopharyngioma: associations with initial presentation and long-term prognosis.
A. Hoffmann (2015)
10.1371/journal.pone.0076562
Prevalence of Neurobehavioral, Social, and Emotional Dysfunction in Patients Treated for Childhood Craniopharyngioma: A Systematic Literature Review
G. Zada (2013)
10.3171/2010.1.FOCUS09310
Craniopharyngiomas: intratumoral chemotherapy with interferon-alpha: a multicenter preliminary study with 60 cases.
S. Cavalheiro (2010)
10.1055/s-0034-1387747
[Childhood craniopharyngioma with hypothalamic obesity - no long-term weight reduction due to rehabilitation programs].
A. Sterkenburg (2014)
10.1016/j.wneu.2014.07.023
The role of the endoscopic endonasal route in the management of craniopharyngiomas.
L. Cavallo (2014)
10.1515/jpem-2014-0417
Surgery for pediatric craniopharyngiomas: is less more?
J. Flitsch (2015)
10.1016/j.metabol.2012.08.001
Brain-derived neurotrophic factor and its relation to leptin in obese children before and after weight loss.
C. Roth (2013)
10.1530/EJE-13-1025
Sleep-wake and melatonin pattern in craniopharyngioma patients.
L. Pickering (2014)
10.1210/jc.2011-0174
Consequences of craniopharyngioma surgery in children.
H. Müller (2011)
10.1055/S-2001-16855
Obesity after childhood craniopharyngioma--German multicenter study on pre-operative risk factors and quality of life.
H. Müller (2001)
10.1530/EJE-15-0422
Nonalcoholic fatty liver disease and fatigue in long-term survivors of childhood-onset craniopharyngioma.
A. Hoffmann (2015)
10.1515/jpem-2014-0445
The importance of interdisciplinary communication with patients about complex, chronic illnesses: our experiences as parents of a child with a craniopharyngioma
D. Nemergut (2015)
10.1093/jnci/djv310
Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy.
P. Brastianos (2016)
10.1016/j.clineuro.2014.07.014
Outcome and mid-term prognosis after maximum and radical removal of craniopharyngiomas with the priority to the extended transsphenoidal approach—A single center experience
Yoshikazu Ogawa (2014)
Report favoring expanded endonasal approaches for subchiasmatic, infundibular, and retroinfundibular craniopharyngioma in order to achieve best oncologic and quality of life outcomes
Craniopharyngioma. Endocr Rev. 2014;35:513–543
HL Muller (2014)
First report on eating behavior and eating disorders in a large cohort of 101 long-term survivors of childhood-onset craniopharyngioma
10.3171/2013.5.JNS131047
Craniopharyngiomas and the hypothalamus.
Juraj Štěňo (2013)
10.1515/jpem-2014-0512
Hypothalamic obesity in children: pathophysiology to clinical management
B. Haliloǧlu (2015)
10.1111/cen.12031
Is bariatric surgery really inefficient in hypothalamic obesity?
B. Gatta (2013)
10.1007/s11102-012-0418-4
Pathology and pathogenesis of craniopharyngiomas
Sarah J. Larkin (2012)
10.1007/s00381-012-1787-8
Management of craniopharyngioma: the Liverpool experience following the introduction of the CCLG guidelines. Introducing a new risk assessment grading system
C. Mallucci (2012)
10.1159/000113019
Childhood Craniopharyngioma
H. Müller (2008)
10.3171/2013.11.PEDS1320
Comparative effectiveness of treatment options for pediatric craniopharyngiomas.
Z. Ali (2014)
10.1097/MOP.0b013e3282495a22
Craniopharyngioma: modern concepts in pathogenesis and treatment
M. Garrè (2007)
10.1210/jc.2010-0993
Reduced energy expenditure and impaired feeding-related signals but not high energy intake reinforces hypothalamic obesity in adults with childhood onset craniopharyngioma.
H. Holmer (2010)
10.1007/s10552-005-9012-7
Melatonin Treatment in Obese Patients with Childhood Craniopharyngioma and Increased Daytime Sleepiness
H. Müller (2005)
Craniopharyngiomas and the hypothalamus. Journal of neurosurgery
J Steno (2013)
10.1016/S0140-6736(00)04006-X
Association between premature mortality and hypopituitarism
J. Tomlinson (2001)
10.3171/2010.2.FOCUS09304
Craniopharyngioma Clinical Status Scale: a standardized metric of preoperative function and posttreatment outcome.
R. Elliott (2010)
10.1016/j.ijrobp.2014.01.019
Long-term outcomes and complications in patients with craniopharyngioma: the British Columbia Cancer Agency experience.
A. Lo (2014)
Changes of peripheral alphamelanocyte-stimulating hormone in childhood
CL Roth (2010)
Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. Nature genetics 46:161-165 **First report on BRAF mutations as typical molecular finding in papillary craniopharyngioma
PK Brastianos (2014)
10.1159/000357783
Patterns of Care for Craniopharyngioma: Survey of Members of the American Association of Neurological Surgeons
Todd C Hankinson (2013)
10.1016/B978-0-12-416706-3.00027-1
Craniopharyngioma – Pediatric Management
Hermann L. Müller (2015)
10.1530/EJE-12-1082
Autonomic nervous system balance in children and adolescents with craniopharyngioma and hypothalamic obesity.
M. Cohen (2013)
10.1111/cen.12523
Specific behaviour, mood and personality traits may contribute to obesity in patients with craniopharyngioma
J. Roemmler-Zehrer (2015)
10.1002/oby.21067
Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity
C. Roth (2015)
10.3389/fendo.2011.00078
Effects of Methylphenidate on Weight Gain and Food Intake in Hypothalamic Obesity
Clinton T. Elfers (2011)
10.1210/jc.2012-2069
Xanthogranuloma, Rathke's cyst, and childhood craniopharyngioma: results of prospective multinational studies of children and adolescents with rare sellar malformations.
H. Müller (2012)
10.3171/2010.1.FOCUS09303
Magnetic resonance imaging-graded hypothalamic compression in surgically treated adult craniopharyngiomas determining postoperative obesity.
J. V. Van Gompel (2010)
10.1007/s11102-012-0429-1
Radiotherapy for craniopharyngioma
A. Aggarwal (2012)
10.1055/s-0031-1273743
Ectopic craniopharyngioma.
Uwe Kordes (2011)
Craniopharyngioma – Pediatric Management. In: Craniopharyngiomas – Comprehensive Diagnosis, Treatment and Outcome
HL Müller (2015)
Brain-derived neurotrophic factor and its relation to leptin in obese children before and after weight loss. Metabolism: clinical and experimental 62:226-234
CL Roth (2013)
Health-related quality of life in pituitary diseases. Endocrinology and metabolism clinics
I Crespo (2015)
• Obesity at presentation, rather than panhypopituitarism either at or after presentation, predicts the risk for long-term obesity in childhood craniopharyngioma
Childhood craniopharyngioma. Recent advances in diagnosis, treatment and follow-up
HL Muller (2008)
10.1007/s00401-012-0957-9
Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma
C. Andoniadou (2012)
10.1016/J.IJROBP.2005.09.034
Combined proton and photon irradiation for craniopharyngioma: long-term results of the early cohort of patients treated at Harvard Cyclotron Laboratory and Massachusetts General Hospital.
M. Fitzek (2006)
10.1055/s-0031-1284420
Long-term follow-up of morbidly obese patients with childhood craniopharyngioma after laparoscopic adjustable gastric banding (LAGB).
H. Müller (2011)
10.1038/nrendo.2010.168
Childhood craniopharyngioma—current concepts in diagnosis, therapy and follow-up
H. Müller (2010)
10.1210/jc.2012-3928
Childhood craniopharyngioma: hypothalamus-sparing surgery decreases the risk of obesity.
É. Elowe-Gruau (2013)
10.1155/2010/519607
Increased Daytime Sleepiness in Patients with Childhood Craniopharyngioma and Hypothalamic Tumor Involvement: Review of the Literature and Perspectives
H. Müller (2010)
Pathophysiology and clinical characteristics of hypothalamic obesity in children and adolescents. Annals of pediatric endocrinology & metabolism
JH Kim (2013)
Martinez-Barbera D ow nl oa de d by [ U ni ve rs ity o f C al if or ni a, S an D ie go
C Gaston-Massuet (2011)
10.1210/JC.2002-030003
Octreotide therapy of pediatric hypothalamic obesity: a double-blind, placebo-controlled trial.
R. Lustig (2003)
10.1186/1748-717X-9-203
Long term results after fractionated stereotactic radiotherapy (FSRT) in patients with craniopharyngioma: maximal tumor control with minimal side effects
S. Harrabi (2014)
10.1055/s-0034-1368785
Childhood craniopharyngioma - changes of treatment strategies in the trials KRANIOPHARYNGEOM 2000/2007.
A. Hoffmann (2014)
10.1097/MED.0000000000000169
Quality of life in patients with hypopituitarism
I. Crespo (2015)
10.1159/000120860
Craniopharyngioma: results of survey of the American Society of Pediatric Neurosurgery.
R. Sanford (1994)
10.1210/jc.2014-1680
Diencephalic syndrome in childhood craniopharyngioma--results of German multicenter studies on 485 long-term survivors of childhood craniopharyngioma.
A. Hoffmann (2014)
10.3171/JNS.1996.85.1.0073
Management of childhood craniopharyngioma: can the morbidity of radical surgery be predicted?
C. D. de Vile (1996)
10.1016/B978-0-444-59602-4.00016-2
Chapter 16 - Craniopharyngioma
H. Müller (2014)
Magnetic resonance imaging as predictor of functional outcome in craniopharyngiomas. Endocrine. 2016;51:148–162
P Mortini (2016)
Childhood craniopharyngioma - diagnostic and therapeutic strategies
HL Muller (2003)
Analysis of neuropsychological outcome in long-term survivors of childhood-onset craniopharyngioma with special regard to hypothalamic involvement
•• First report on incidence and risk factors for nonalcoholic fatty liver disease (NAFLD) in childhood-onset craniopharyngioma patients
Craniopharyngioma. In: WHO Classification of Tumours of the Central Nervous System (3rd edition) Eds: Louis DN
EJ Rushing (2007)
Surgical approach to pituitary tumors. Handbook of clinical neurology
D Solari (2014)
10.1002/14651858.CD008890.pub2
Intracystic bleomycin for cystic craniopharyngiomas in children.
Y. Fang (2012)
10.1210/jc.2012-4184
Clinical review: Bariatric surgery following treatment for craniopharyngioma: a systematic review and individual-level data meta-analysis.
M. Bretault (2013)
10.3389/fendo.2011.00096
Surgical Strategies in Childhood Craniopharyngioma
Jörg Flitsch (2011)
10.3171/2014.10.PEDS14384
Recurrent craniopharyngioma after conformal radiation in children and the burden of treatment.
Paul Klimo (2015)
10.1210/jc.2013-2000
Hypothalamic involvement predicts cognitive performance and psychosocial health in long-term survivors of childhood craniopharyngioma.
S. Fjalldal (2013)
10.1073/pnas.1101553108
Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans
C. Gaston-Massuet (2011)
10.1007/s40618-014-0196-0
Analysis of short- and long-term metabolic effects of growth hormone replacement therapy in adult patients with craniopharyngioma and non-functioning pituitary adenoma
E. Profka (2014)
10.1016/j.critrevonc.2013.07.013
Surgical strategies and modern therapeutic options in the treatment of craniopharyngiomas.
P. Mortini (2013)



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