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New Treatment Options For Advanced Pancreatic Cancer

G. Middleton, P. Ghaneh, Eithne Costello, W. Greenhalf, J. Neoptolemos
Published 2008 · Medicine

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Pancreatic cancer has a very high mortality rate and affects approximately 230,000 individuals worldwide. Gemcitabine has become established as the standard therapy for advanced pancreatic cancer; however, the survival advantage is small. Adjuvant chemotherapy using either 5-fluorouracil or gemcitabine is now established in pancreatic cancer as an alternative therapy. Combinations of gemcitabine with either platin agents or capecitabine may be advantageous. Anti-EGFR and anti-VEGF agents have been unsuccessful but multiple tyrosine kinase inhibitors are under investigation. Of the increasing number of immunological agents, the GV1001 antitelomerase vaccine holds some interest. Targeted agents against important mitogenic pathways, including MEK/ERK, Src, PI3K/Akt, mTOR, Hedgehog and NF-κB, as well as agents targeting histone deacetylase, poly(ADP-ribose) polymerase, heat shock protein 90 and other agents such as β-lapachone, hold considerable interest for further development. However, the probability of individual success is low.
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GV1001 is a novel vaccine peptide derived from the human telomerase reverse transcriptase (hTERT) corresponding to amino acids 611‐626 of hTERT (6). It is a 16‐amino acid peptide with the following sequence; Glu‐Ala‐Arg‐Pro‐Ala‐ Leu‐Leu‐Thr‐Ser‐Arg‐Leu‐Arg‐Phe‐Ile‐Pro‐Lys (7). Since hTERT is a well‐
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Alisol B acetate induces apoptosis of SGC7901 cells via mitochondrial and phosphatidylinositol 3-kinases/Akt signaling pathways.
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