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The Presence Of Helicobacter Pylori In Postmenopausal Women Is Not A Factor To The Decrease Of Bone Mineral Density.

A. Kakehasi, Cláudia M C Mendes, L. Coelho, L. Castro, A. Barbosa
Published 2007 · Medicine

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BACKGROUND Osteoporosis affects approximately 30% of postmenopausal women. Gastrectomy, pernicious anemia, and more recently Helicobacter pylori infection, have all been implicated in the pathogenesis of osteoporosis. A reduced parietal cell mass is a common feature in these conditions. AIM To study a possible relationship between chronic gastritis, parietal cell density of the oxyntic mucosa and bone mineral density in postmenopausal women, as chronic gastritis, Helicobacter pylori infection and osteoporosis are frequently observed in the elderly. METHODS Fifty postmenopausal women (61.7 +/- 7 years) were submitted to gastroduodenal endoscopy and bone densitometry by dual energy X-ray absorptiometry. Glandular atrophy was evaluated objectively by the determination of parietal cell density. Helicobacter pylori infection was evaluated by histology, urease test and breath test with 13C. RESULTS Thirty-two patients (64%) presented chronic multifocal gastritis, and 20 of them (40%) showed signs of gastric mucosa atrophy. Lumbar spine osteoporosis was found in 18 patients (36%). The parietal cell density in patients with and without osteoporosis was 948 +/- 188 and 804 +/- 203 cells/mm(2), respectively. Ten osteoporotic patients (55%) and 24 non-osteoporotic patients (75%) were infected by Helicobacter pylori. CONCLUSION Postmenopausal women with osteoporosis presented a well-preserved parietal cell density in comparison with their counterparts without osteoporosis. Helicobacter pylori infection was not different between the two groups. We concluded that neither atrophic chronic gastritis nor Helicobacter pylori seem to be a reliable risk factor to osteoporosis in postmenopausal women.
This paper references
10.5555/uri:pii:0039606047901645
The postgastrectomy syndrome.
D. Adlersberg (1947)
10.1097/00002281-199505000-00017
Metabolic bone disease in gastrointestinal, hepatobiliary, and pancreatic disorders and total parenteral nutrition.
M. Honasoge (1995)
The relationship between the acid output of the stomach following "maximal" histamine stimulation and the parietal cell mass.
Card Wi (1960)
Osteoporosis in Patients with Inflammatory Bowel Disease
Maladie de Crohn (2005)
A silver nitrate stain for alpha-2 cells in human pancreatic islets.
L. Grimelius (1968)
10.3109/00365529309090245
Gastrectomy causes bone loss in the rat: is lack of gastric acid responsible?
P. Persson (1993)
Guidelines for diagnosis and management of osteoporosis. The European Foundation for Osteoporosis and Bone Disease.
J. Kanis (1997)
10.1053/GAST.2003.50106
AGA technical review on osteoporosis in gastrointestinal diseases.
Charles N. Bernstein (2003)
10.1073/pnas.86.8.2834
Gastrin releases a blood calcium-lowering peptide from the acid-producing part of the rat stomach.
P. Persson (1989)
Postgastrectomy syndrome. A clinical study based upon 100 patients.
F. Rejman (1970)
10.1016/S0739-5930(08)70376-3
Prevalence of Helicobacter pylori Infection in Male Patients with Osteoporosis and Controls
R. B. Stein (2006)
The quantitative relationship between parietal cells and gastric acidity.
L. Tongen (1950)
10.1136/gut.32.11.1303
Osteopenia and osteomalacia after gastrectomy: interrelations between biochemical markers of bone remodelling, vitamin D metabolites, and bone histomorphometry.
S. Bisballe (1991)
The quantitative relationship between parietal cells and gastric acidity.
Tongen La (1950)
10.3109/00365529309103125
Effect of Helicobacter pylori eradication on antral gastrin- and somatostatin-immunoreactive cell density and gastrin and somatostatin concentrations.
D. Queiroz (1993)
10.1210/endo-96-5-1217
The importance of the stomach in gastrin-induced hypocalcemia in the rat.
J. Schulak (1975)
[What are the gastric modifications induced by acute and chronic Helicobacter pylori infection?].
D. Lamarque (2003)
The presence of Helicobacter pylori in postmenopausal women is not a factor to the decrease of bone mineral density
AM Kakehasi
10.1172/JCI111254
An evaluation of the importance of gastric acid secretion in the absorption of dietary calcium.
G. Bo-Linn (1984)
10.1093/oxfordjournals.aje.a115204
Epidemiology of vertebral fractures in women.
L. J. Melton (1989)
Long-term follow-up after Billroth I and II partial gastrectomy. Gastrointestinal tract function and changes in bone metabolism.
M. Pääkkönen (1984)
Long-term sequelae of Helicobacter pylori gastritis
Z. Xin (2001)
The relationship between the acid output of the stomach following "maximal" histamine stimulation and the parietal cell mass.
W. Card (1960)
10.7326/0003-4819-66-5-917
The absorption of calcium carbonate.
P. Ivanovich (1967)
10.1359/JBMR.1998.13.5.763
A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men.
B. Riggs (1998)
Osteoporosis, metabolic aberrations, and increased risk for vertebral fractures after partial gastrectomy.
D. Mellström (1993)
The presence of Helicobacter pylori in postmenopausal women is not a factor to the decrease of bone mineral density
Barbosa AJA
10.1007/BF03000061
The effects of gastrectomy in animals
A. Ivy (1940)
10.1136/gut.36.5.710
Osteoporosis in treated adult coeliac disease.
X. McFarlane (1995)
10.14341/OSTEO201614-5
The diagnosis of osteoporosis.
J. Kanis (1994)
Parietal cell/endocrine cell ratio in the oxyntic mucosa of some species of mammals
RC Ferreira (1999)
10.7326/0003-4819-118-9-199305010-00001
Factors Associated with Appendicular Bone Mass in Older Women
D. Bauer (1993)
10.1016/0022-4804(77)90140-8
Evidence for a role of the stomach in serum calcium regulation.
E. Kaplan (1977)
10.1016/S8756-3282(98)00150-1
Secondary osteoporosis and the risk of vertebral deformities in women.
L. J. Melton (1999)
10.1590/S0004-28032005000400003
Avaliação da densidade mineral óssea em pacientes com doença inflamatória intestinal
F. Lora (2005)
10.1007/BF01623782
Guidelines for diagnosis and management of osteoporosis
J. Kanis (2005)
10.1016/0026-0495(76)90023-8
The importance of the stomach in mediating histamine-induced hypocalcemia in the rat.
E. Kaplan (1976)
The presence of Helicobacter pylori in postmenopausal women is not a factor to the decrease of bone mineral density
Mendes CMC
10.1046/J.1365-2265.2000.0977C.X
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
J. Kanis (2000)
10.1056/NEJM198507113130202
Calcium absorption and achlorhydria.
R. Recker (1985)
10.1016/S8756-3282(09)80004-5
Epidemiology of osteoporosis.
J. Kanis (1992)
10.1016/0167-0115(90)90068-8
Evidence that gastrin enhances 45Ca uptake into bone through release of a gastric hormone
R. Håkanson (1990)
The presence of Helicobacter pylori in postmenopausal women is not a factor to the decrease of bone mineral density
LP Castro
10.1016/S0016-5085(08)81239-5
Increassed parietal cell density in patients with perfurated duodenal ulcer: Comparison with non-complicated duodenal ulcer patients
A. Barbosa (2001)
Quelles sont les modifications gastriques induites par l'infection aiguë et chronique par Helicobacter pylori ?
D. Lamarque (2003)
10.1016/S0002-9610(97)00123-2
High prevalence of bone disorders after gastrectomy.
T. Zittel (1997)
10.3181/00379727-168-41237
The Mechanism of Action and Target Organ of Gastrin-Induced Hypocalcemia
L. Limlomwongse (1981)
10.1007/S11894-001-0082-8
Osteopenia and osteoporosis in gastrointestinal diseases: Diagnosis and treatment
J. Southerland (2001)
Helicobacter pylori seropositivity is increased in osteoporosis
H Nielsen (2001)



This paper is referenced by
10.2147/TCRM.S80647
Risk factors for osteoporosis in Japan: is it associated with Helicobacter pylori?
D. Asaoka (2015)
10.4082/kjfm.2015.36.5.239
Helicobacter pylori: A Possible Risk Factor for Bone Health
Y. H. Chung (2015)
10.1155/2014/340765
The Relationship between H. pylori Infection and Osteoporosis in Japan
D. Asaoka (2014)
10.1155/2014/814756
Association between Helicobacter pylori Infection and Risk of Osteoporosis in Elderly Taiwanese Women with Upper Gastrointestinal Diseases: A Retrospective Patient Record Review
Shih-Chun Lin (2014)
10.1136/bmjopen-2018-027356
Relationship between Helicobacter pylori infection and osteoporosis: a systematic review and meta-analysis
Taiwu Wang (2019)
10.3109/00365520903434117
Hypochlorhydric stomach: a risk condition for calcium malabsorption and osteoporosis?
P. Sipponen (2010)
10.1007/s00223-018-0473-6
Atrophic Gastritis as a Risk Factor for Bone Loss in Premenopausal Women in Their 40s: A Retrospective Cohort Study
A-Sol Kim (2018)
10.1007/s10620-019-05775-4
Bone of Contention: Helicobacter pylori and Osteoporosis—Is There an Association?
K. Papamichael (2019)
10.1111/j.1523-5378.2007.00533.x
Extragastric Manifestations of Helicobacter pylori Infection – Other Helicobacters
U. Bohr (2007)
10.1186/s12876-018-0780-4
Relationship between Helicobacter pylori infection and bone mineral density: a retrospective cross-sectional study
Bo-Lin Pan (2018)
10.1007/s00774-015-0703-1
Association between Helicobacter pylori infection and osteoporosis: a systematic review and meta-analysis
S. Upala (2015)
10.1371/journal.pone.0101852
Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women
Hye Won Kim (2014)
Contribución de Latinoamérica al estudio del Helicobacter pylori
A. Ramos (2009)
inflammation can affect the impact of H.pylori on BMD changes and confound the results.
Behzad Heidari (2015)
10.1111/j.1523-5378.2008.00634.x
Extragastric Manifestations of Helicobacter pylori Infection: Other Helicobacters
H. Moyaert (2008)
10.1589/JPTS.23.61
Helicobacter Pylori Seropositivity in Patients with Postmenopausal Osteoporosis
N. Akkaya (2011)
10.1007/s10620-008-0417-5
Chronic Gastritis and Bone Mineral Density in Women
Adriana Maria Kakehasi (2008)
10.1371/journal.pone.0162645
Analysis of Patients with Helicobacter pylori Infection and the Subsequent Risk of Developing Osteoporosis after Eradication Therapy: A Nationwide Population-Based Cohort Study
Hong-Mo Shih (2016)
10.1159/000479317
Decrease of Estradiol and Several Lifestyle Factors, but Not Helicobacter pylori Infection, Are Significant Risks for Osteopenia in Japanese Females
D. Chinda (2017)
10.1007/s00774-015-0688-9
Chlamydia pneumoniae and Helicobacter pylori IgG seropositivities are not predictors of osteoporosis-associated bone loss: a prospective cohort study
M. R. Kalantarhormozi (2015)
10.1371/journal.pone.0175365
Analysis of the associations among Helicobacter pylori infection, adiponectin, leptin, and 10-year fracture risk using the fracture risk assessment tool: A cross-sectional community-based study
L. Chen (2017)
10.2478/plua-2014-0004
Evaluation of the Number of Gastric Mucoid Epitheliocytes and Parietal Cells in Relation to the Amount of Helicobacteria in the Fundic Gland Region of Domestic Dogs (Canis Familiaris)
Dace Bērziņa (2014)
Helicobacter pylori infection and osteoporosis in elderly patients
Behzad Heidari (2015)
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