Online citations, reference lists, and bibliographies.
← Back to Search

Characterization And Analysis Of The Outcome Of Adults With Acute Myeloid Leukemia Treated In A Brazilian University Hospital Over Three Decades.

J. T. S. Souto Filho, R. D. Portugal, M. Loureiro, W. Pulcheri, M. Nucci
Published 2011 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
We evaluated the outcome of 227 patients with acute myeloid leukemia during three decades (period 1 - 1980's, N = 89; period 2 - 1990's, N = 73; period 3 - 2000's, N = 65) at a single institution. Major differences between the three groups included a higher median age, rates of multilineage dysplasia and co-morbidities, and a lower rate of clinical manifestations of advanced leukemia in recent years. The proportion of patients who received induction remission chemotherapy was 66, 75, and 85% for periods 1, 2, and 3, respectively (P = 0.04). The median survival was 40, 77, and 112 days, and the 5-year overall survival was 7, 13, and 22%, respectively (P = 0.01). The median disease-free survival was 266, 278, and 386 days (P = 0.049). Survival expectation for patients with acute myeloid leukemia has substantially improved during this 30-year period, due to a combination of lower tumor burden and a more efficient use of chemotherapy and supportive care.
This paper references
Conventional chemotherapy for acute myeloid leukemia: a Brazilian experience.
K. Pagnano (2000)
Acute myelogenous leukemia with an 8;21 translocation. A report on 148 cases from the Groupe Français de Cytogénétique Hématologique.
Groupe Français de Cytogénétique Hématologique (1990)
Clinical characterization of acute myeloid leukemia with myelodysplasia-related changes as defined by the 2008 WHO classification system.
O. Weinberg (2009)
Prognosis of Acute Myeloid Leukemia in the General Population: Data from Southern Switzerland
E. Lerch (2009)
Results of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high‐risk myelodysplastic syndrome:
H. Kantarjian (2006)
De novo acute myeloid leukemia in adults younger than 60 years of age: Socioeconomic aspects and treatment results in a Brazilian university center
E. M. Fagundes (2006)
Prediction of survival during induction therapy in patients with newly diagnosed acute myeloblastic leukemia.
E. Estey (1989)
The treatment of acute myeloid leukemia in Brazil: progress and obstacles.
W. Pulcheri (1995)
Outcomes and quality of care in acute myeloid leukemia over 40 years
S. Alibhai (2009)
Improvements in survival of adults diagnosed with acute myeloblastic leukemia in the early 21st century
D. Pulte (2008)
Prediction of fatal intracranial hemorrhage in patients with acute myeloid leukemia.
C. Chen (2009)
Acute myeloid leukaemia
E. Estey (2006)
Leucemia Mielóide Agura: perfil de duas décadas do Serviço de Hematologia do Hospital das Clínicas de Porto Alegre - RS
R. Bittencourt (2003)
Prognostic variables in newly diagnosed children and adolescents with acute myeloid leukemia: Children's Cancer Group Study 213
R. Wells (2002)
Guidelines on the management of acute myeloid leukaemia in adults
D. Milligan (2006)
Pretreatment prognostic factors and treatment outcome in elderly patients with de novo acute myeloid leukemia.
C. Chen (2005)
Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group.
J. Bennett (1985)
Improved patient survival for acute myeloid leukemia: a population-based study of 9729 patients diagnosed in Sweden between 1973 and 2005.
Å. Derolf (2009)
Estimated number of cases, regional distribution and survival of patients diagnosed with acute myeloid leukemia between 1996 and 2000 in Rio Grande do Sul, Brazil
Marcelo Capra (2007)
População em números absolutos e percentuais, por ano, segundo grupos de idade - 1940/2000
Prefeitura do Rio de Janeiro (2011)
Treatment, long-term outcome and prognostic variables in 214 unselected AML patients in Sweden
M. Åström (2000)
Myeloid leukaemia treatment and survival--the South Australian experience, 1977 to 2002.
C. Luke (2006)
Acute leukemias in Piauí: comparison with features observed in other regions of Brazil.
M. F. Rego (2003)
Remission rate and survival in acute myeloid leukemia: Impact of selection and chemotherapy
A. Wåhlin (1991)
Acute myeloid leukemia in elderly patients: experience of a single center.
C. Rodrigues (2003)
Cytogenetics in acute leukemia
K. Mrózek (2004)
Long-term follow-up of the clinical efficacy of chemotherapy for acute myeloid leukemia at a single institute
Tamami Seo (2001)
Improved patient survival for acute myeloid leukemia: A population-based study of 9,729 patients diagnosed in Sweden 1973-2005 Running title: Survival in acute myeloid leukemia
M. Björkholm (2008)
Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis.
C. Thiede (2002)
Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia.
B. Cheson (2003)
Temporal trends in the proportion cured among adults diagnosed with acute myeloid leukaemia in Sweden 1973–2001, a population‐based study
T. Andersson (2010)
Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet.
H. Doehner (2010)
The clinical significance of cytogenetic abnormalities in acute myeloid leukaemia.
D. Grimwade (2001)
Trends in leukemia incidence and survival in the United States (1973–1998)
Y. Xie (2003)
Drug therapy for acute myeloid leukemia.
M. Tallman (2005)

This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar