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Nanoparticle-based Drug Delivery Systems: Promising Approaches Against Infections
Shweta Ranghar, Parul Sirohi, P. Verma, Vishnu Agarwal
Published 2013 · Medicine
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Despite the fact that many new drugs and technologies have been developed to combat the infectious diseases, these have continued to be global health challenges. The use of conventional antimicrobial agents against these infections is always associated with problems such as the development of multiple drug resistance and adverse side effects. In addition, the inefficient traditional drug delivery system results in inadequate therapeutic index, low bioavailability of drugs and many other limitations. In this regard, antimicrobial nanoparticles and nanosized drug delivery carriers have emerged as potent effective agents against the infections. Nanoparticles have unique properties owing to their ultra small and controllable size such as high surface area, enhanced reactivity, and functionalizable structure. This review focused on different classes of antimicrobial nanoparticles, including metal, metal oxide and others along with their mechanism of action and their potential use against the infections. The review also focused on the development of nanoparticle systems for antimicrobial drug delivery and use of these systems for delivery of various antimicrobial agents, giving an overview about modern nanoparticle based therapeutic strategies against the infections.
This paper references
Trends and developments in liposome drug delivery systems.
T. Lian (2001)
Applications of nanobiotechnology in clin
KK Jain (2011)
Antibiotic resistance in bacteria.
S. Amyes (1992)
Synthesis and characterization of zinc/iron oxide composite nanoparticles and their antibacterial properties
T. Gordon (2011)
Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery.
E. Souto (2004)
PEGylated peptide-based dendritic nanoparticulate systems for delivery of artemether
D. Bhadra (2005)
Dendrimer−Silver Complexes and Nanocomposites as Antimicrobial Agents
L. Balogh (2001)
Hollow silica nanocontainers as drug delivery vehicles.
Jaemoon Yang (2008)
Solid lipid nanoparticles (SLN) as ocular delivery system for tobramycin.
R. Cavalli (2002)
Microwave‐Assisted Synthesis of Nanocrystalline MgO and Its Use as a Bacteriocide
S. Makhluf (2005)
The use of nanoparticles in anti-microbial materials and their characterization.
E. Weir (2008)
Polymers for the sustained release of proteins and other macromolecules
R. Langer (1976)
SLN and NLC for topical delivery of ketoconazole
E. Souto (2005)
Disinfection of surfaces by photocatalytic oxidation with titanium dioxide and UVA light.
K. P. Kühn (2003)
Effective drug delivery, in vitro and in vivo, by carbon-based nanovectors noncovalently loaded with unmodified Paclitaxel.
J. Berlin (2010)
Oral nanoparticle-based antituberculosis drug delivery to the brain in an experimental model.
R. Pandey (2006)
Botrytis cinerea and Penicillium expansum
A Lipovsky (2011)
Nitric oxide-containing nanoparticles as an antimicrobial agent and enhancer of wound healing.
R. Weller (2009)
Receptor Mediated Targeting of Lectin Conjugated Gliadin Nanoparticles in the Treatment of Helicobacter pylori
R. Umamaheshwari (2003)
Antibacterial and antifungal activity of a soda-lime glass containing copper nanoparticles.
L. Esteban-Tejeda (2009)
Size-dependent bacterial growth inhibition and mechanism of antibacterial activity of zinc oxide nanoparticles.
Krishna R. Raghupathi (2011)
Development of nanoparticles for antimicrobial drug delivery.
L. Zhang (2010)
Preparation, Characterization and Antibacterial Properties of Silver-Chitosan Nanocomposites Using Different Molecular Weight Grades of Chitosan
S. Honary (2011)
Antibacterial Activity and Mechanism of Action of Zinc Oxide Nanoparticles against Campylobacter jejuni
Y. Xie (2011)
Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science.
C. Niemeyer (2001)
Cancer nanotechnology: opportunities and challenges
M. Ferrari (2005)
′CASCADE′- AND ′NONSKID-CHAIN-LIKE′ SYNTHESES OF MOLECULAR CAVITY TOPOLOGIES
E. Buhleier (1978)
Antimicrobial reactive oxygen and nitrogen species: concepts and controversies
F. Fang (2004)
Nitric oxide-containing nanoparticles
RB Weller (2008)
Intracellular Delivery of Saquinavir in Biodegradable Polymeric Nanoparticles for HIV/AIDS
Lipa K Shah (2006)
Anti-microbial activities of aerosolized transition metal oxide nanoparticles.
Zhipeng Wang (2010)
Nanoconjugated vancomycin: new opportunities for the development of anti-VRSA agents.
S. P. Chakraborty (2010)
ANTIFUNGAL ACTIVITY OF ZINC OXIDE NANOPARTICLES AGAINST DERMATOPHYTIC LESIONS OF CATTLE
Eman M. El-Diasty (2013)
CD Kaur (2007)
Photocatalytic antibacterial effect of TiO(2) film formed on Ti and TiAg exposed to Lactobacillus acidophilus.
Jung-Yoon Choi (2007)
Comparative studies on the efficacy of AmBisome and Fungizone in a mouse model of disseminated aspergillosis.
K. Takemoto (2004)
Antimicrobial efficiency of titanium dioxide‐coated surfaces
P. Murányi (2010)
Iron and oxidative stress in bacteria.
D. Touati (2000)
Selfassembled nanoparticle drug delivery systems from galactosylated polysaccharide–doxorubicin conjugate
Y Gu (1978)
Chitosan as antimicrobial agent: applications and mode of action.
E. Rabea (2003)
Biogenic synthesis of silver nanoparticles and their synergistic effect with antibiotics: a study against gram-positive and gram-negative bacteria.
A. M. Fayaz (2010)
Carbon nanotubes for biomedical applications
N. Sinha (2005)
Synthesis, characterization, and evaluation of antimicrobial and cytotoxic effect of silver and titanium nanoparticles.
F. Martinez-Gutierrez (2010)
Liposome-encapsulated aminoglycosides in pre-clinical and clinical studies.
R. Schiffelers (2001)
Dendrimers: emerging polymers for drug-delivery systems.
B. Nanjwade (2009)
Titania-silver and alumina-silver composite nanoparticles: novel, versatile synthesis, reaction mechanism and potential antimicrobial application.
T. Bala (2011)
Selective toxicity of zinc oxide nanoparticles to prokaryotic and eukaryotic systems.
K. M. Reddy (2007)
Eradication of mucoid Pseudomonas aeruginosa with fluid liposome-encapsulated tobramycin in an animal model of chronic pulmonary infection.
C. Beaulac (1996)
Iron Loading and Disease Surveillance
E. Weinberg (1999)
Characterisation of copper oxide
D Hu (2007)
Anti-biofilm efficacy of nitric oxide-releasing silica nanoparticles.
Evan M. Hetrick (2009)
Alginate nanoparticles as antituberculosis drug carriers: formulation development, pharmacokinetics and therapeutic potential.
Zahoor Ahmad (2006)
Vancomycin bound biogenic gold nanoparticles: A different perspective for development of anti VRSA agents
A. M. Fayaz (2011)
Antibacterial activities of zinc oxide nanoparticles against Escherichia coli O157:H7
Y. Liu (2009)
Lymphatic targeting of zidovudine using surface-engineered liposomes.
C. D. Kaur (2008)
EPR Study of Visible Light-Induced ROS Generation by Nanoparticles of ZnO
A. Lipovsky (2009)
Preparation and characterization of solid lipid nanoparticles containing cyclosporine by the emulsification-diffusion method
Z. Urbán-Morlán (2010)
Comparison of the aqueous solubilization of practically insoluble niclosamide by polyamidoamine (PAMAM) dendrimers and cyclodextrins.
B. Devarakonda (2005)
Efficacy and Pharmacokinetics of Intravenous Nanocapsule Formulations of Halofantrine in Plasmodium berghei-Infected Mice
V. Mosqueira (2004)
Silver nanoparticles as a new generation of antimicrobials.
M. Rai (2009)
Cancer nanotechnology: opportunities
M. Ferrari (2011)
Understanding structure-stability relationships of Candida antartica lipase B in ionic liquids.
T. de Diego (2005)
soda-lime glass containing copper nanoparticles. Nanotechnology
FC Fang (2009)
The Bacteria Fight Back
G. Taubes (2008)
Changing patterns of infectious disease
Trish Berglund (1986)
The antibacterial and antifungal activity of a soda-lime glass containing silver nanoparticles.
L. Esteban-Tejeda (2009)
Antimicrobial sensitivity of Escherichia coli to alumina nanoparticles.
I. Sadiq (2009)
The increasing use of silver-based products as antimicrobial agents: a useful development or a cause for concern?
I. Chopra (2007)
Antibacterial activity and mechanism of action of zinc oxide nanoparticles
Y e10394. Xie (2010)
Self-assembled nanoparticle drug delivery systems from galactosylated polysaccharide-doxorubicin conjugate loaded doxorubicin.
Yu Cao (2010)
Characterisation of copper oxide nanoparticles for antimicrobial applications.
G. Ren (2009)
Photocatalytic antibacterial effect of TiO2 film formed on Ti and TiAg exposed
JY Choi (2007)
Development of multifunctional nanoparticles for targeted drug delivery and noninvasive imaging of therapeutic effect.
H. K. Sajja (2009)
Glyconanobiotics: Novel carbohydrated nanoparticle antibiotics for MRSA and Bacillus anthracis.
Sampath C Abeylath (2008)
H. Gold (1996)
Dendrimers and dendritic polymers in drug delivery.
E. Gillies (2005)
IVAN BOHA (2007)
Antibacterial and antifungal activity
TL Esteban (2003)
Effective Drug Delivery
J. South Med (1995)
改善されたアップコンバージョン蛍光とMR緩和でのNaYF 4 :Yb, Er/NaGdF 4 ナノ結晶のシード媒介合成
Guo Hai (2010)
Bactericidal effect of iron oxide nanoparticles on Staphylococcus aureus
N. Tran (2010)
Mesoporous silica nanoparticle based nano drug delivery systems: synthesis, controlled drug release and delivery, pharmacokinetics and biocompatibility
Q. He (2011)
PLGA-lecithin-PEG core-shell nanoparticles for controlled drug delivery.
J. M. Chan (2009)
Bactericidal effect of silver nanoparticles against multidrug-resistant bacteria
H. H. Lara (2010)
Solid lipid nanoparticles (SLN) as carriers for the topical delivery of econazole nitrate: in‐vitro characterization, ex‐vivo and in‐vivo studies
V. Sanna (2007)
Polyamidoamine (PAMAM) dendrimers as biocompatible carriers of quinolone antimicrobials: an in vitro study.
Y. Cheng (2007)
Strain specificity in antimicrobial activity of silver and copper nanoparticles.
J. Ruparelia (2008)
Polymeric carriers for amphotericin B: in vitro activity, toxicity and therapeutic efficacy against systemic candidiasis in neutropenic mice.
M. S. Espuelas (2003)
Antibiotic-conjugated polyacrylate nanoparticles: new opportunities for development of anti-MRSA agents.
E. Turos (2007)
Preparation and antibacterial activity of chitosan nanoparticles.
Lifeng Qi (2004)
New ways to treat bacterial infections.
P. Taylor (2002)
Antifungal activity of zinc oxide nanoparticles against Botrytis cinerea and Penicillium expansum.
L. He (2011)
Bactericidal Performance of Visible-Light Responsive Titania Photocatalyst with Silver Nanostructures
M. Wong (2010)
Effect of abiotic factors on the antibacterial activity of chitosan against waterborne pathogens.
Y. Chung (2003)
Eradication of mucoid
Nano Lett (2001)
H. Morton (1948)
antibacterial activity of chitosan nanoparticles
EI Rabea (2004)
action, side effects and drug interactions
Z Wang (2000)
Applications of nanobiotechnology in clinical diagnostics.
K. Jain (2007)
Targeted delivery of arjunglucoside I using surface hydrophilic and hydrophobic nanocarriers to combat experimental leishmaniasis
R. Tyagi (2005)
Polymeric particles in vaccine delivery.
A. Rice-Ficht (2010)
Enhanced activity of liposomal polymyxin B against Pseudomonas aeruginosa in a rat model of lung infection.
Abdelwahab Omri (2002)
Selected antimicrobial agents: mechanisms of action, side effects and drug interactions.
C. Walker (1996)
This paper is referenced by
Engineering of Ceramics Nanoparticles in Medicine and Environmental Applications: Recent Review
Aseel Hadi (2019)
Novel and revisited approaches in nanoparticle systems for buccal drug delivery.
A. S. Macedo (2020)
Encapsulation and Application of Metal Nanoparticles in Pharma
A. D’souza (2017)
Encapsulation of lethal, functional and therapeutic medicinal nanoparticles and quantum dots for the improved diagnosis and treatment of infection
D. K. Sarker (2017)
Nanoantibiotics: A Novel Rational Approach to Antibiotic Resistant Infections.
A. Engin (2019)
A new methodology for simultaneous comparison and optimization between nanoparticles and their drug conjugates against various multidrug-resistant bacterial strains
A. J. Shaikh (2019)
An assessment of the future impact of alternative technologies on antibiotics markets
E. Nwokoro (2016)
Nano-antibiotics: Nano Encapsulation of Natural and Synthetic Antimicrobials to Combat Multi Drug Resistant Pathogens
Bushra Jamil (2016)
Biomedical Applications of Calcium Oxide Nanoparticles-A Spectroscopic Study
S. Abraham (2018)
Are antibiotic-functionalized nanoparticles a promising tool in antimicrobial therapies?
J. F. A. de Oliveira (2017)
Broadening the spectrum of small-molecule antibacterials by metallic nanoparticles to overcome microbial resistance.
M. Rai (2017)
Free radical-releasing systems for targeting biofilms.
V. Fasiku (2020)
Nanovehículos para el tratamiento de la infección bacteriana I
Raquel Olmeda Pérez (2017)
Current Trends in the Preparation of Nanoparticles for Drug Delivery
I. Bhat (2017)
An investigation into the uptake of gold nanoparticles by isolated cells and whole vessels and their influence on function
T. Mohamed (2014)
Nanoparticles: Antimicrobial Applications and Its Prospects
K. M. Varier (2019)
Nanopharmaceuticals: Principles and Applications Vol. 1
V. K. Yata (2020)
Synthesis of an oleic acid based pH‐responsive lipid and its application in nanodelivery of vancomycin
Danford Mhule (2018)
The antimicrobial activity of nanoparticles: present situation and prospects for the future
L. Wang (2017)
Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”
P. Baptista (2018)
Silica Nanoparticles Containing Gadolinium Complex as Potential Alternative to Anticancer Radiotherapy
D. Soares (2015)
Relationship between the process variables and physicochemical features of liquid-core nanocapsules produced via nanoprecipitation
J. D. Echeverri (2019)
Nanotechnology in Skin, Soft Tissue, and Bone Infections
M. Rai (2020)
Lipid-based nanoparticles as novel drug delivery systems for antimicrobial agents
A. Rassouli (2019)
Phytosynthesis of Silver Nanoparticles Using Perilla frutescens Leaf Extract: Characterization and Evaluation of Antibacterial, Antioxidant, and Anticancer Activities
N. V. Reddy (2021)
Novel lipid nanostructures for delivery of natural agents with antioxidant, antiinflammatory and antistroke potential: perspectives and outcomes
H. Ahmad (2017)
Smart Biopolymeric Nanocarriers for Drug Delivery Applications
Preetam Bala (2020)
Recent advances on antimicrobial wound dressing: A review.
D. Simões (2018)
An overview of electrospun membranes loaded with bioactive molecules for improving the wound healing process
S. Miguel (2019)
Chitosan nanoparticles in drug therapy of infectious and inflammatory diseases
P. Rajitha (2016)
Liposomes vs Phytosomes: Principles, Methodologies, and Therapeutic Applications with Emphasis on CNS Disorders
H. Ahmad (2021)
Silica Nanoparticles Containing Gadolinium Complex as Potential Alternative to Anticancer Radiotherapy
Daniel Crístian Ferreira Soares (2015)See more