← Back to Search
Investigation Of The Parameters Affecting The Release Of Flurbiprofen From Chitosan Microspheres
Müşerref Günseli Yüksel Tilkan, Nurten Karacan Özdemir
Published 2018 · Chemistry
Download PDFAnalyze on Scholarcy
Flurbiprofen (FLB), a NSAID, widely used for preventing pain generally for arthritis or dental problems. In this study, FLB loaded chitosan microspheres were prepared by ionotropic gelation method. In this method, microspheres were formed by dropping chitosan solutions containing FLB into sodium alginate solutions including sodium tripolyphosphate (TPP). A variety of formulation parameters like drug:polymer ratio, drug concentration, polymer’s molecular weight, polymer concentration, pH and the concentration of TPP solutions, drying method and stirring time were analyzed. The dissolution studies were performed in a shaking water bath in pH 7.4 phosphate buffer saline (PBS) at 37 °C. Laser diffractometer was used for particle size analysis, and scanning electron microscope (SEM) was used for morphological properties. Drug loading and loading efficiency were calculated by using UV spectrophotometer. The particles obtained were spherical with 0.7-1.3 mm size range, and the loading efficiency was approximately 21-79%. The dissolution studies conducted revealed that drug:polimer ratio and the polymer type and concentration affected the drug release from microspheres. It was observed that increasing the polymer concentration, polymer’s molecular weight and TPP concentration decreased the FLB release from microspheres, which was according to Higuchi kinetics.
This paper references
Chitosan--as a biomaterial.
T. Chandy (1990)
Fabrication, characterization and cytotoxicity studies of ionically cross-linked docetaxel loaded chitosan nanoparticles.
Ankit Jain (2016)
Design and characterisation of doxorubicin-releasing chitosan microspheres for anti-cancer chemoembolisation
Jung Min Park (2012)
Controlled release of vancomycin from biodegradable microcapsules.
Y. Ozalp (2001)
Preparation and characterization of chitosan microspheres as drug carrier for prednisolone sodium phosphate as model for anti-inflammatory drugs
A. Berthold (1996)
Oxaliplatin-chitosan nanoparticles induced intrinsic apoptotic signaling pathway: a "smart" drug delivery system to breast cancer cell therapy.
R. Vivek (2014)
Stomach-Specific Controlled Release Gellan Beads of Acid-Soluble Drug Prepared by Ionotropic Gelation Method
Mrunalini Narkar (2010)
A novel approach to prepare tripolyphosphate/chitosan complex beads for controlled release drug delivery.
X. Shu (2000)
Efficient resveratrol production by immobilized β-glucosidase on cross-linked chitosan microsphere modified by l-lysine
Jie Zhang (2014)
Crosslinked chitosan nanoparticle formulations for delivery from pressurized metered dose inhalers.
Ketan Sharma (2012)
Preparation of chitosan microspheres by ionotropic gelation under a high voltage electrostatic field for protein delivery.
Lihua Ma (2010)
Development and in vitro/in vivo evaluation of Zn-pectinate microparticles reinforced with chitosan for the colonic delivery of progesterone
Hytham H Gadalla (2016)
Alternative approach to the preparation of chitosan beads
C. Aral (1998)
The effect of cross-linking of chitosan microspheres with genipin on protein release
Youling Yuan (2007)
Novel pH-sensitive citrate cross-linked chitosan film for drug controlled release.
X. Shu (2001)
Design of a controlled release osmotic pump system of ibuprofen
N. Özdemir (1997)
Biodegradable drug delivery systems
D. A. Wood (1980)
Preparation and Evaluation Of Drug-Containing Chitosan Beads
R. Bodmeier (1989)
Controlling chitosan-based encapsulation for protein and vaccine delivery.
B. Koppolu (2014)
Biodegradable polymers—an overview†
Sindhu Doppalapudi (2014)
Electrospinning of chitosan dissolved in concentrated acetic acid solution.
X. Geng (2005)
Enhancement of dissolution and bioavailibity of flurbiprofen by low molecular weight chitosans. Pharmazie
M Anraku (2010)
Kinetic study of chitosan-tripolyphosphate complex reaction and acid-resistive properties of the chitosan-tripolyphosphate gel beads prepared by in-liquid curing method
F. Mi (1999)
Preparation and characterization of chitosan microparticles intended for controlled drug delivery.
J. A. Ko (2002)
Ibuprofen-loaded porous microspheres suppressed the progression of monosodium iodoacetate-induced osteoarthritis in a rat model.
Jang won Park (2016)
Development of novel formulations for Chagas' disease: Optimization of benznidazole chitosan microparticles based on artificial neural networks.
D. Leonardi (2009)
Chitosan and Its Use as a Pharmaceutical Excipient
L. Ilium (1998)
Sunitinib loaded chitosan nanoparticles formulation and its evaluation.
Jayapal John Joseph (2016)
Natural polymers as drug delivery systems
S. Bogdansky (1990)
Design and characterization of doxorubicin-releasing chitosan microspheres for anti-cancer chemoembolization
JM Park (2012)
Chitosan decreases total cholesterol in women: a randomized, double-blind, placebo-controlled trial
H. Bokura (2003)
Modulation of surface charge, particle size and morphological properties of chitosan-TPP nanoparticles intended for gene delivery.
Quan Gan (2005)
Drug release from chitosan beads
L. C. Wan (1994)
Application of chitosan microparticles for treatment of metritis and in vivo evaluation of broad spectrum antimicrobial activity in cow uteri.
Soo Jin Jeon (2016)
Effect of Experimental Parameters on Alginate/Chitosan Microparticles for BCG Encapsulation
Liliana Aranha Caetano (2016)
Controlled release of indomethacin by chitosan-polyelectrolyte complex: optimization and in vivo/in vitro evaluation
S. Shiraishi (1993)
Preparation of a prolonged release tablet of aspirin with chitosan.
Y. Kawashima (1985)
Controlled drug release properties of ionically cross-linked chitosan beads: the influence of anion structure.
X. Shu (2002)
Enhancement of dissolution and bioavailability of flurbiprofen by low molecular weight chitosans.
Makoto Anraku (2010)
Implantable Controlled Release Drug Delivery Systems: A Review
M. P. Danckwerts (1991)
Intra-articular delivery of sinomenium encapsulated by chitosan microspheres and photo-crosslinked GelMA hydrogel ameliorates osteoarthritis by effectively regulating autophagy.
Pengfei Chen (2016)
Development of chitosan nanoparticles as drug delivery system for a prototype capsid inhibitor.
Meiyan Xue (2015)
In vitro cytotoxicity and in vivo efficacy of 5-fluorouracil-loaded enteric-coated PEG-crosslinked chitosan microspheres in colorectal cancer therapy in rats.
Kuntal Ganguly (2015)
Development and in vitro evaluation of novel floating chitosan microcapsules for oral use: comparison with non-floating chitosan microspheres.
I. El-Gibaly (2002)
Microencapsulated chitosan nanoparticles for pulmonary protein delivery: in vivo evaluation of insulin-loaded formulations.
S. Al-Qadi (2012)
Albumin Nanospheres as Carriers for Passive Drug Targeting: An Optimized Manufacturing Technique
B. Müller (2004)
Low molecular weight chitosan inhibits obesity induced by feeding a high‐fat diet long‐term in mice
M. Sumiyoshi (2006)
Novel method for the preparation of controlled-release theophylline granules coated with a polyelectrolyte complex of sodium polyphosphate-chitosan.
Y. Kawashima (1985)
Chitosan–Pluronic nanoparticles as oral delivery of anticancer gemcitabine: preparation and in vitro study
H. Hosseinzadeh (2012)
Chitosan-based gastrointestinal delivery systems.
Radi Hejazi (2003)
Recent advances in the use of microspheres for targeted therapy.
S. Davis (1985)
Spherical agglomerates of water-insoluble drugs.
R. Bodmeier (1989)
This paper is referenced by
Effects of processing conditions on properties and morphology of chitosan/lovastatin particles
Dam Xuan Thang (2019)
New approaches to tumor therapy with siRNA-decorated and chitosan-modified PLGA nanoparticles
Behiye Şenel (2019)
Application of sodium alginate extracted from a Tunisian brown algae Padina pavonica for essential oil encapsulation: Microspheres preparation, characterization and in vitro release study.
Adel Faidi (2019)