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BMP Signaling Pathways In Cartilage And Bone Formation.

Andrea Hoffmann, Gerhard W. Gross
Published 2001 · Biology, Medicine
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This review focuses on the molecular aspects of osteogenesis and chondrogenesis as they relate to cellular and developmental levels. We discuss BMP (bone morphogenetic protein)-mediated signaling pathways for the patterning of skeletal elements and mechanisms for the induction of cartilage and bone formation. We emphasize BMP-mediated initiation of chondrogenesis and osteogenesis and consider BMP-dependent signaling cascades in mesenchymal progenitor cells during the development of the axial and appendicular skeleton and during growth plate and joint formation. In particular, we discuss BMP-signaling mediators of the Smad and TAK family and the modulation of these signals by cross-talk and integration with other signaling pathways.



This paper is referenced by
10.1016/j.jphotobiol.2010.01.008
Chondrogenic mRNA expression in prechondrogenic cells after blue laser irradiation.
Toshihiro Kushibiki (2010)
10.1007/s00774-008-0879-8
Skeletal metamorphosis in fibrodysplasia ossificans progressiva (FOP)
Frederick S. Kaplan (2008)
Acceleration of bone formation in distraction osteogenesis by bone morphogenetic protein-7
Manuela. Hrit (2006)
10.1371/journal.pone.0165079
The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling
Arne Olav Melleby (2016)
10.1016/S0070-2153(06)78004-8
Anabolic agents and the bone morphogenetic protein pathway.
Ian Ross Garrett (2007)
10.1038/sj.gt.3302201
Gene-based approaches for the repair of articular cartilage
S B Trippel (2004)
Histologische Beurteilung der in vivo Knochenneubildung besiedelter Konstrukte nach osteogener Stimulation und Beimpfung mit vaskulärem endothelialem Wachstumsfaktor (VEGF) im Mausmodell
Ulrich Lenze (2012)
10.2220/BIOMEDRES.35.69
Periosteum-derived cells respond to mechanical stretch and activate Wnt and BMP signaling pathways.
Ryohei Ito (2014)
10.1007/978-1-4939-7587-7_2
Growth and Development of Articular Cartilage
Facundo Las Heras (2020)
10.1128/MCB.25.12.5073-5083.2005
Connexin 40, a Target of Transcription Factor Tbx5, Patterns Wrist, Digits, and Sternum
Anne Pizard (2005)
Advances in Brief Oncogenic-Catenin Is Required for Bone Morphogenetic Protein 4 Expression in Human Cancer Cells 1
Jung-sik Kim (2002)
10.1016/j.jff.2019.103616
Aspalathin from Aspalathus linearis (rooibos) reduces osteoclast activity and increases osteoblast activity in vitro
Travers Sagar (2020)
10.1016/j.devcel.2005.02.013
Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes.
Theo P Hill (2005)
10.1016/j.ydbio.2010.05.509
Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base.
Guiyuan He (2010)
10.1289/ehp.10028
Lead Induces Chondrogenesis and Alters Transforming Growth Factor-β and Bone Morphogenetic Protein Signaling in Mesenchymal Cell Populations
Michael J Zuscik (2007)
10.1055/S-0032-1308822
Nontraditional modification to articular cartilage.
Vasili Karas (2012)
10.2200/s00212ed1v01y200910tis003
Articular Cartilage Tissue Engineering
Kyriacos A. Athanasiou (2009)
10.1387/ijdb.14598792
BMP4 promotes chondrocyte proliferation and hypertrophy in the endochondral cranial base.
Lillian Shum (2003)
10.1186/s11658-019-0136-2
miR-29b-3p regulated osteoblast differentiation via regulating IGF-1 secretion of mechanically stimulated osteocytes
Qiangcheng Zeng (2019)
10.1242/dev.02480
Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors
Stephen J. Rodda (2006)
10.1016/j.bbrc.2011.01.071
Mechanism involved in enhancement of osteoblast differentiation by hyaluronic acid.
Michinao Kawano (2011)
10.1007/s10006-013-0398-1
Implants in bone: Part I. A current overview about tissue response, surface modifications and future perspectives
Cornelius von Wilmowsky (2013)
10.1074/jbc.M111.337030
Undersulfation of Heparan Sulfate Restricts Differentiation Potential of Mouse Embryonic Stem Cells*
Maud Forsberg (2012)
Naturopathic Approaches to Preventing and Treating Osteoporosis
Ellen Kamhi (2010)
10.1083/jcb.200402138
CD44 modulates Smad1 activation in the BMP-7 signaling pathway
Richard S. Peterson (2004)
10.1302/0301-620X.91B5.21832
Articular cartilage tissue engineering: today's research, tomorrow's practice?
A. Getgood (2009)
10.1002/dvdy.22565
Mechanisms of digit formation: Human malformation syndromes tell the story.
Sigmar Stricker (2011)
10.21007/ETD.CGHS.2015.0084
Genetic control of survival and weight loss during pneumonic Burkholderia pseudomallei (Bp) infection
Felicia D. Emery (2015)
10.1039/C2JM16490F
MC3T3 preosteoblast differentiation on bone morphogenetic protein-2 peptide ormosils
Colin J. Przybylowski (2012)
Title Simultaneous gene transfer of bone morphogenetic protein ( BMP )-2 and BMP-7 by in vivo electroporation induces rapid bone formation and BMP4 expression
Mariko Kawai ()
10.1016/j.urolonc.2003.12.008
Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs).
Hongwei Cheng (2003)
10.2500/ar.2011.2.0004
Expression of bone morphogenic protein in sinonasal inverted papilloma with new bone formation
Tomoyo Okamoto (2011)
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