Online citations, reference lists, and bibliographies.
← Back to Search

Decreased Levels Of IL-1 Alpha And Beta In Psoriatic Lesional Skin.

H. Takematsu, Y. Ohmoto, H. Tagami
Published 1990 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Interleukin 1 (IL-1), which mediates a wide range of biological activities, is thought to play an important role in many inflammatory and immunologic diseases. Normal human epidermal keratinocytes constitutively produce IL-1. Based on our previous data indicating decreased IL-1 activity in psoriatic scale extracts, in the present study, we measured immunoreactive IL-1 alpha and beta levels in the suction blister fluids as well as in the psoriatic scale extracts using enzyme immunoassay for IL-1 alpha and beta. The results showed that although similarly low levels of IL-1 alpha were detectable in the suction blister fluid from normal and psoriatic lesional skin, and that no IL-1 beta was found in most of the blister fluids, indicating that IL-1 alpha is major IL-1 species produced by human skin. As compared to those in the blister fluids, IL-1 alpha levels in the horny tissue extracts were found to be much higher, and they were significantly higher in the orthokeratotic stratum corneum extracts than in the psoriatic scale extracts. However, gel filtration of the orthokeratotic horny tissue extracts demonstrated that constituents for immunoreactive IL-1 alpha and beta were quite variable depending upon the source of the horny tissues. The present study has confirmed that IL-1 levels in the psoriatic scale extracts are decreased when compared with those in the orthokeratotic horny tissue possibly due to an increased epidermal proliferation activity associated with its high turnover rate. The role of IL-1 psoriatic lesions remains unknown.
This paper references
10.1007/BF00372613
Interleukin 2, soluble interleukin 2 receptor, and interferon-γ in the suction blister fluids from psoriatic skin
H. Takematsu (2004)
10.1111/1523-1747.EP12284020
All-trans retinoic acid stimulates growth of adult human keratinocytes cultured in growth factor-deficient medium, inhibits production of thrombospondin and fibronectin, and reduces adhesion.
J. Varani (1989)
10.1016/0167-5699(86)90124-6
There is more than one interleukin 1.
J. Oppenheim (1986)
10.1111/1523-1747.EP12469041
Expression of mRNA homologous to interleukin 1 in human epidermal cells.
T. Bell (1987)
10.1159/000248361
Interleukin 1 alpha and beta in psoriatic skin: enzymoimmunoassay, immunoblot studies and effect of systemic retinoids.
D. Gruaz (1989)
Membrane IL-1: IL-1 alpha precursor binds to the plasma membrane via a lectin-like interaction.
D. Brody (1989)
Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta.
P. Gray (1986)
Interleukin 1 is present in normal human epidermis.
C. Hauser (1986)
Subcellular localization of human monocyte interleukin 1: evidence for an inactive precursor molecule and a possible mechanism for IL 1 release.
O. Bakouche (1987)
10.1002/EJI.1830171024
In vitro production of human interleukin lα and interleukin 1β by peripheral blood mononuclear cells examined by sensitive sandwich enzyme immunoassay
K. Tanaka (1987)
Characterization of lymphocyte-activating factor (LAF) produced by a macrophage cell line, P388D1. II. Biochemical characterization of LAF induced by activated T cells and LPS.
S. Mizel (1978)
Membrane-associated IL 1-like activity on rat dendritic cells.
L. Nagelkerken (1986)
10.1172/JCI112141
Presence of epidermal-derived thymocyte activating factor/interleukin 1 in normal human stratum corneum.
L. Gahring (1985)
10.1159/000249347
Interleukin-1-like activity in horny layer extracts: decreased activity in scale extracts of psoriasis and sterile pustular dermatoses.
H. Takematsu (1986)
10.1084/JEM.164.6.2095
Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1 alpha and beta mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical to interleukin 1
T. Kupper (1986)
10.1038/315641A0
Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs
Carl J. March (1985)
10.1073/PNAS.81.24.7907
Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.
P. Auron (1984)
10.5555/URI:PII:0022202X88911487
Epidermis and lymphocyte interactions during an allergic patch test reaction. Increased activity of ETAF/IL-1, epidermal derived lymphocyte chemotactic factor and mixed skin lymphocyte reactivity in persons with type IV allergy.
C. Larsen (1988)
Regulation of interleukin 1 gene expression by adherence and lipopolysaccharide.
R. Fuhlbrigge (1987)
Recombinant human interleukin 1 alpha: purification and biological characterization.
U. Gubler (1986)
Psoriatic skin lesions contain biologically active amounts of an interleukin 1-like compound.
R. D. Camp (1986)
10.1111/1523-1747.EP12284068
In situ localization of interleukin-1 in normal and psoriatic skin.
L. Romero (1989)
10.1073/PNAS.82.4.1204
Identification of a membrane-associated interleukin 1 in macrophages.
E. Kurt-Jones (1985)
10.1038/324266A0
The cell surface receptors for interleukin-1α and interleukin-1β are identical
S. Dower (1986)
10.1111/1523-1747.EP12277378
Effects of recombinant interleukin 1 and interleukin 2 on human keratinocytes.
V. Morhenn (1989)
10.1111/1523-1747.EP12465135
Keratinocyte membrane-associated epidermal cell-derived thymocyte-activating factor (ETAF).
D. Goldminz (1987)
10.1159/000247852
Granulocyte-macrophage colony-stimulating factor in psoriasis.
H. Takematsu (1990)
10.1111/j.1365-2133.1988.tb02430.x
Immunohistological detection of interleukin 1‐like molecules and tumour necrosis factor in human epidermis before and after UVB‐irradiation in vivo
A. Oxholm (1988)
10.1073/PNAS.84.7.1940
A major factor contributing to epidermal proliferation in inflammatory skin diseases appears to be interleukin 1 or a related protein.
H. Ristow (1987)
10.1111/j.1749-6632.1989.tb24038.x
Production of IL‐6 by Keratinocytes
T. Kupper (1989)
Intracellular localization of human monocyte associated interleukin 1 (IL 1) activity and release of biologically active IL 1 from monocytes by trypsin and plasmin.
K. Matsushima (1986)
10.1111/1523-1747.EP12696825
Localization and characterization of the interleukin 1 immunoreactive pool (IL-1 alpha and beta forms) in normal human epidermis.
L. Didierjean (1989)
Interleukin 1 alpha and interleukin 1 beta bind to the same receptor on T cells.
P. Kilian (1986)
10.1172/JCI113792
Interleukin 1 binds to specific receptors on human keratinocytes and induces granulocyte macrophage colony-stimulating factor mRNA and protein. A potential autocrine role for interleukin 1 in epidermis.
T. Kupper (1988)
10.1111/1523-1747.EP12462081
Identification and characterization of chemoattractants for epidermal cells.
N. Martinet (1988)
10.1073/PNAS.86.4.1273
Regulation of interleukin 1 and its receptor in human keratinocytes.
R. A. Blanton (1989)
10.1111/1523-1747.EP12276763
Elevated plasma interleukin-1 levels in humans following ultraviolet light therapy for psoriasis.
N. Konnikov (1989)
The four biochemically distinct species of human interleukin 1 all exhibit similar biologic activities.
D. Wood (1985)
10.1111/1523-1747.EP12517658
Characteristics of an epidermal cell thymocyte-activating factor (ETAF) produced by human epidermal cells and a human squamous cell carcinoma cell line.
T. Luger (1983)



This paper is referenced by
10.1111/j.1365-2133.1991.tb04949.x
Determination of released CD4 and CD8 antigens in the suction‐blister fluid and horny‐tissue extract in patients with psoriasis
H. Takematsu (1991)
10.2336/NISHINIHONHIFU.57.921
Interleukin 8: Roles in psoriasis.
T. Kojima (1995)
10.1007/978-3-642-27606-4
Treatment of dry skin syndrome
M. Lodén (2012)
10.1620/TJEM.172.243
Lack of correlation between interleukin 6 and interleukin 1 levels in psoriatic lesional skin.
H. Takematsu (1994)
10.1002/EJI.1830250623
Enhanced production of biologically active interleukin‐1α and interleukin‐1β by psoriatic epidermal cells ex vivo: evidence of increased cytosolic interleukin‐1β levels and facilitated interleukin‐1 release
R. Debets (1995)
10.1016/J.DET.2004.03.010
Current concepts in the immunopathogenesis of psoriasis.
M. A. Lowes (2004)
10.4110/IN.2002.2.4.189
Psoriasis as a T-cell-mediated Immunologic Disease
W. Lew (2002)
10.1684/ejd.2010.0845
Differential cytokine secretion of cultured bone marrow stromal cells from patients with psoriasis and healthy volunteers.
K. Zhang (2010)
10.1111/j.1365-4362.1993.tb00950.x
WOUND HEALING
H. Hammar (1993)
10.2340/00015555-2709
Minimally-invasive Sampling of Interleukin-1α and Interleukin-1 Receptor Antagonist from the Skin: A Systematic Review of In vivo Studies in Humans.
Denise Falcone (2017)
10.3109/02844319409022010
Evaluation of cytokines in donor site wound fluids.
I. Ono (1994)
10.1111/j.1468-2494.2011.00644.x
Corneobiology and Corneotherapy – a final chapter
A. Kligman (2011)
10.1111/1523-1747.EP12340143
Elevation of interleukin 1 receptor antagonist in the stratum corneum of sun-exposed and ultraviolet B-irradiated human skin.
T. Hirao (1996)
10.1080/000155500750042907
Inflammatory mediators in normal, sensitive and diseased skin types.
D. Reilly (2000)
Semantic Scholar Logo Some data provided by SemanticScholar