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The 15-Country Collaborative Study Of Cancer Risk Among Radiation Workers In The Nuclear Industry: Estimates Of Radiation-Related Cancer Risks

E. Cardis, M. Vrijheid, M. Blettner, E. Gilbert, M. Hakama, C. Hill, G. Howe, J. Kaldor, C. Muirhead, M. Schubauer-Berigan, T. Yoshimura, F. Bermann, G. Cowper, J. Fix, C. Hacker, B. Heinmiller, M. Marshall, I. Thierry-chef, D. Utterback, Y. Ahn, E. Amoros, P. Ashmore, A. Auvinen, J-M Bae, J. Bernar, A. Biau, E. Combalot, P. Deboodt, A. Sacristan, M. Eklöf, H. Engels, G. Engholm, G. Gulis, R. Habib, K. Holan, H. Hyvonen, A. Kerekes, J. Kurtinaitis, H. Malker, M. Martuzzi, A. Mastauskas, A. Monnet, M. Moser, M. Pearce, D. B. Richardson, F. Rodríguez-Artalejo, A. Rogel, H. Tardy, M. Telle-Lamberton, I. Turai, M. Usel, K. Veress
Published 2007 · Medicine

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Abstract Cardis, E., Vrijheid, M., Blettner, M., Gilbert, E., Hakama, M., Hill, C., Howe, G., Kaldor, J., Muirhead, C. R., Schubauer-Berigan, M., Yoshimura, T., Bermann, F., Cowper, G., Fix, J., Hacker, C., Heinmiller, B., Marshall, M., Thierry-Chef, I., Utterback, D., Ahn, Y-O., Amoros, E., Ashmore, P., Auvinen, A., Bae, J-M., Bernar, J. S., Biau, A., Combalot, E., Deboodt, P., Diez Sacristan, A., Eklöf, M., Engels, H., Engholm, G., Gulis, G., Habib, R. R., Holan, K., Hyvonen, H., Kerekes, A., Kurtinaitis, J., Malker, H., Martuzzi, M., Mastauskas, A., Monnet, A., Moser, M., Pearce, M. S., Richardson, D. B., Rodriguez-Artalejo, F., Rogel, A., Tardy, H., Telle-Lamberton, M., Turai, I., Usel, M. and Veress, K. The 15-Country Collaborative Study of Cancer Risk among Radiation Workers in the Nuclear Industry: Estimates of Radiation-Related Cancer Risks. Radiat. Res. 167, 396– 416 (2007). A 15-Country collaborative cohort study was conducted to provide direct estimates of cancer risk following protracted low doses of ionizing radiation. Analyses included 407,391 nuclear industry workers monitored individually for external radiation and 5.2 million person-years of follow-up. A significant association was seen between radiation dose and all-cause mortality [excess relative risk (ERR) 0.42 per Sv, 90% CI 0.07, 0.79; 18,993 deaths]. This was mainly attributable to a dose-related increase in all cancer mortality (ERR/Sv 0.97, 90% CI 0.28, 1.77; 5233 deaths). Among 31 specific types of malignancies studied, a significant association was found for lung cancer (ERR/Sv 1.86, 90% CI 0.49, 3.63; 1457 deaths) and a borderline significant (P = 0.06) association for multiple myeloma (ERR/Sv 6.15, 90% CI <0, 20.6; 83 deaths) and ill-defined and secondary cancers (ERR/Sv 1.96, 90% CI −0.26, 5.90; 328 deaths). Stratification on duration of employment had a large effect on the ERR/Sv, reflecting a strong healthy worker survivor effect in these cohorts. This is the largest analytical epidemiological study of the effects of low-dose protracted exposures to ionizing radiation to date. Further studies will be important to better assess the role of tobacco and other occupational exposures in our risk estimates.
This paper references
10.2307/3579020
Effects of low doses and low dose rates of external ionizing radiation: cancer mortality among nuclear industry workers in three countries.
E. Cardis (1995)
10.1667/RR3170
Analysis of Mortality among Canadian Nuclear Power Industry Workers after Chronic Low-Dose Exposure to Ionizing Radiation
L. Zablotska (2004)
Tobacco smoke and involuntary smoking.
M. Alavanja (2004)
10.1667/RR3259
Lung Cancer in Mayak Workers
E. Gilbert (2004)
10.1136/bmj.293.6551.845
Mortality of workers at the Sellafield plant of British Nuclear Fuels.
P. Smith (1986)
10.1667/RR0554.1
The 15-Country Collaborative Study of Cancer Risk among Radiation Workers in the Nuclear Industry: Design, Epidemiological Methods and Descriptive Results
M. Vrijheid (2007)
10.1378/CHEST.121.5_SUPPL.121S
COPD: epidemiology, prevalence, morbidity and mortality, and disease heterogeneity.
D. Mannino (2002)
10.5453/jhps.32.173
First Analysis of Mortality of Nuclear Industry Workers in Japan, 1986-1992
EpidemiologicalStudyGroupofNuclearWorkers (1997)
10.1093/OXFORDJOURNALS.AJE.A113083
A Mantel-Haenszel statistic for testing the association between a polychotomous exposure and a rare outcome.
T. Hakulinen (1981)
10.1136/bmj.297.6651.757
Mortality of employees of the Atomic Weapons Establishment, 1951-82.
V. Beral (1988)
10.1136/oem.2005.019760
Age at exposure to ionising radiation and cancer mortality among Hanford workers: follow up through 1994
S. Wing (2005)
10.1002/AJIM.10332
Plutonium-related work and cause-specific mortality at the United States Department of Energy Hanford Site.
S. Wing (2004)
10.1016/S0140-6736(94)91706-X
Direct estimates of cancer mortality due to low doses of ionising radiation: an international study*1
Iarcstudygrouponcancerriskam (1994)
10.1093/RPD/NCI327
Radiation exposure and cause specific mortality among nuclear workers in Belgium (1969-1994).
H. Engels (2005)
10.1111/j.1467-842X.2005.tb00760.x
Mortality rates among nuclear industry workers at Lucas Heights Science and Technology Centre
R. R. Habib (2005)
10.1056/NEJM198101223040404
Radiation-induced myelomatosis.
J. Cuzick (1981)
10.1093/OXFORDJOURNALS.AJE.A009682
First analysis of mortality and occupational radiation exposure based on the National Dose Registry of Canada.
J. P. Ashmore (1998)
10.1093/OXFORDJOURNALS.AJE.A114523
Mortality among plutonium and other radiation workers at a plutonium weapons facility.
G. Wilkinson (1987)
10.1097/00004032-199505000-00004
Accounting for bias in dose estimates in analyses of data from nuclear worker mortality studies.
E. Gilbert (1995)
and E
S. Wing (1984)
10.26616/nioshpub2005131
An epidemiologic study of mortality and radiation-related risk of cancer among workers at the Idaho National Engineering and Environmental Laboratory, a U. S. Department of Energy facility : NIOSH Occupational Energy Research Program final report
M. Schubauer-Berigan (2005)
10.1136/oem.53.4.225
Relations between age at occupational exposure to ionising radiation and cancer risk.
A. Stewart (1996)
10.1136/oem.60.3.227
Confounding and confounders
R. McNamee (2003)
10.1289/EHP.99107649
Radiation and mortality of workers at Oak Ridge National Laboratory: positive associations for doses received at older ages.
D. Richardson (1999)
10.1136/oem.44.3.149
Further assessment of the effects of occupational radiation exposure in the United Kingdom Atomic Energy Authority mortality study.
H. Inskip (1987)
International Collaborative Study of Cancer Risk Among Nuclear Industry Workers, II—Protocol
E. Cardis (1992)
10.6028/nbs.hb.47
[RECOMMENDATIONS of the International Commission on Radiological Protection].
R. Sievert (1955)
10.1088/0952-4746/19/1/002
Occupational radiation exposure and mortality: second analysis of the National Registry for Radiation Workers.
C. Muirhead (1999)
10.1097/00004032-198901000-00001
Mortality of workers at the Hanford site: 1945-1981.
E. Gilbert (1989)
10.1088/0952-4746/13/2/001
Further analysis, incorporating assessment of the robustness of risks of cancer mortality in the National Registry for Radiation Workers
M. Little (1993)
The effect of record linkage errors on risk estimates in cohort mortality studies
A. Dewanji Krewski (2005)
10.1002/SIM.4780080205
Issues in analysing the effects of occupational exposure to low levels of radiation.
E. Gilbert (1989)
10.11513/JRRSABST.2004.0_48_3
Joint effects of radiation and smoking on lung cancer risk among atomic bomb survivors.
D. Pierce (2003)
Cancer occurrence among radiation workers at Jaslovské Bohunice nuclear power plant.
G. Gulis (2003)
10.1002/AJIM.10306
Cancer mortality among French Atomic Energy Commission workers.
M. Telle-Lamberton (2004)
10.1136/bmj.38499.599861.E0
Risk of cancer after low doses of ionising radiation: retrospective cohort study in 15 countries
E. Cardis (2005)
SOURCES AND EFFECTS OF IONIZING RADIATION : United Nations Scientific Committee on the Effects of Atomic Radiation UNSCEAR 2000 Report to the General Assembly, with Scientific Annexes
岩崎 民子 (2002)
10.1002/(SICI)1097-0274(199901)35:1<21::AID-AJIM4>3.0.CO;2-X
Effects of exposure to external ionizing radiation on cancer mortality in nuclear workers monitored for radiation at Rocketdyne/Atomics International.
B. Ritz (1999)
10.1097/00004032-199306000-00001
Mortality of workers at the Hanford site: 1945-1986.
E. Gilbert (1993)
and G
V. Beral (1951)
Mortality among workers at Oak Ridge National Laboratory.
H. Prichard (1992)
10.1093/AJE/153.4.319
Invited commentary: studies of workers exposed to low doses of radiation.
E. Gilbert (2001)
10.1093/AJE/153.4.309
First analysis of cancer incidence and occupational radiation exposure based on the National Dose Registry of Canada.
W. Sont (2001)
10.2307/3579391
Studies of the mortality of atomic bomb survivors. Report 12, Part I. Cancer: 1950-1990.
D. Pierce (1996)
10.1038/sj.jea.7500416
The effect of censoring on cancer risk estimates based on the Canadian National Dose Registry of occupational radiation exposure
H. Shin (2005)
10.1093/OXFORDJOURNALS.AJE.A115226
The international comparability of cancer mortality data. Results of an international death certificate study.
C. Percy (1989)
and D
S. Win (1994)
1990 Recommendations of the International Commission on Radiological Protection
Icrp (1991)
10.1002/AJIM.20113
Mortality of workers exposed to ionizing radiation at the French National Electricity Company.
A. Rogel (2005)
10.1667/RR3258
Analysis of the Mortality Experience amongst U.S. Nuclear Power Industry Workers after Chronic Low-Dose Exposure to Ionizing Radiation
G. Howe (2004)
10.1667/RR0552.1
The 15-Country Collaborative Study of Cancer Risk among Radiation Workers in the Nuclear Industry: Study of Errors in Dosimetry
I. Thierry-chef (2007)



This paper is referenced by
10.1007/s00066-012-0170-8
Anti-inflammatory effects of low-dose radiotherapy
M. Arenas (2012)
10.1007/s00247-014-2983-3
γ-H2AX foci are increased in lymphocytes in vivo in young children 1 h after very low-dose X-irradiation: a pilot study
B. Halm (2014)
10.1200/JCO.2011.36.2483
Tailored diagnostics: a proposal.
S. B. O’Neill (2011)
10.1097/HP.0b013e3181b08a20
DOES SCIENTIFIC EVIDENCE SUPPORT A CHANGE FROM THE LNT MODEL FOR LOW-DOSE RADIATION RISK EXTRAPOLATION?
D. Averbeck (2009)
Molecular identification of let-336 and analysis of ionizing radiation induced lethal mutations within caenorhabditis elegans eT1(III;V)
Aalton Rylan Fernandes (2011)
10.4172/2161-069X.1000189
Bowel Imaging in IBD Patients: Review of the Literature and Current Recommendations
A Lahat (2014)
10.14260/JEMDS/2017/866
FEASIBILITY AND SAFETY OF FLUOROLESS URETERORENOSCOPY- OUR INSTITUTIONAL EXPERIENCE
Balaji Appiya Ramamoorthy (2017)
Radiation health effect problem at a glance
N. B. Ouchi (2019)
Space Radiation Risk of Radiation Carcinogenesis Risk of Acute Radiation Syndromes Due to Solar Particle Events Risk of Acute or Late Central Nervous System Effects from Radiation Exposure Risk of Degenerative Tissue or Other Health Effects from Radiation Exposure
Janice L Huff (2009)
10.1002/ajim.22391
Life-span carcinogenicity studies on Sprague-Dawley rats exposed to γ-radiation: design of the project and report on the tumor occurrence after post-natal radiation exposure (6 weeks of age) delivered in a single acute exposure.
M. Soffritti (2015)
10.1016/j.ejso.2018.06.023
Single centre guidelines for radiological follow-up based on 775 patients treated by cytoreductive surgery and HIPEC for appendiceal pseudomyxoma peritonei.
K. Govaerts (2018)
10.1002/ccd.27660
2018 ACC/HRS/NASCI/SCAI/SCCT Expert Consensus Document on Optimal Use of Ionizing Radiation in Cardiovascular Imaging—Best Practices for Safety and Effectiveness, Part 1: Radiation Physics and Radiation Biology
John W. Hirshfeld (2018)
10.1097/HP.0B013E3182050493
Implications of radiation epidemiologic data for risk assessment and radiation protection.
R. Shore (2011)
10.1016/j.urology.2019.01.070
Modeling the Incidence of Secondary Malignancy Related to Ionizing Radiation Use in the Management of Nephrolithiasis.
Todd Yecies (2019)
10.1667/RR15094.1
Prominent Dose-Rate Effect and Its Age Dependence of Rat Mammary Carcinogenesis Induced by Continuous Gamma-Ray Exposure
T. Imaoka (2018)
10.1007/s10140-013-1142-8
Radiation exposure among patients with the highest CT scan utilization in the emergency department
K. Shah (2013)
10.1177/1559325818796331
Health Impacts of Low-Dose Ionizing Radiation: Current Scientific Debates and Regulatory Issues
A. Vaiserman (2018)
10.1007/s10140-015-1373-y
Significant but reasonable radiation exposure from computed tomography-related medical imaging in the ICU
B. Slovis (2015)
10.1038/nrclinonc.2017.78
Evolution of lymphoma staging and response evaluation: current limitations and future directions
Joel Cunningham (2017)
Radiation Exposure and Associated Cancer Risk With Cardiac Diagnostic Imaging
Anjeli K. Nayar (2013)
10.1038/nrcardio.2009.53
Medical imaging: the radiation issue
A. Einstein (2009)
10.1667/RR1404.1
The Ukrainian-American Study of Leukemia and Related Disorders among Chornobyl Cleanup Workers from Ukraine: III. Radiation Risks
A. Romanenko (2008)
10.4111/kju.2014.55.9.581
Pilot Study of Low-Dose Nonenhanced Computed Tomography With Iterative Reconstruction for Diagnosis of Urinary Stones
S. H. Park (2014)
10.1586/ern.09.98
Radiation-induced gliomas
G. Prasad (2009)
10.4022/jafib.280
Reducing Ionizing Radiation Associated with Atrial Fibrillation Ablation: An Ultrasound-Guided Approach.
N. Bhatia (2010)
significance and radiation exposure in Nagasaki atomic bomb survivors Relationship between monoclonal gammopathy of undetermined
Sabro Momita (2011)
Early and late follow-up of patients with Hodgkin ’ s lymphoma . Recommendations of the Polish Lymphoma Research Group
Poradnia Onkologiczna (2016)
10.1177/0020731416689553
Criticism of Volume 1181 of the New York Academy of Sciences Reaches a New Low
Alison Rosamund Katz (2017)
10.1667/RR13988.1
Cancer Mortality through 2005 among a Pooled Cohort of U.S. Nuclear Workers Exposed to External Ionizing Radiation
M. Schubauer-Berigan (2015)
10.1007/s00402-015-2257-z
The compliance with and knowledge about radiation protection in operating room personnel: a cross-sectional study with a questionnaire
T. Jentzsch (2015)
10.14407/JRP.2015.40.1.025
DIFFERENTIAL EXPRESSION OF RADIATION RESPONSE GENES IN SPLEEN, LUNG, AND LIVER OF RATS FOLLOWING ACUTE OR CHRONIC RADIATION EXPOSURE
H. Jin (2015)
10.1007/s10554-010-9742-9
Low dose dual-source CT angiography of the thoracic aorta
C. Farrelly (2010)
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