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Endocrine Pharmacology Research In India: Scientific Progress In Last Five Years
K. Srinivasan, S. S. Sharma
Published 2018 · Medicine
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During the last five years, significant scientific effort has been made in the field of endocrine pharmacology by Indian researchers. Endocrine disorders like diabetes and disorders of the reproductive systems and melatonin are the major areas of research interest of the Indian scientists. Though the researchers have investigated both natural products and synthetic compounds, the reported studies have focused primarily on plant extracts to substantiate their use scientifically based on their folklore use. Diabetes is fast gaining the status of a potential pidemic in India with approximately 69 million people in the world. Various pharmacological investigations on herbal and synthetic compounds have been carried out for the treatment of diabetes and its complications. Saroglitazar , novel PPARα/γ agonist is t he first indigenously developed synthetic antidiabetic drug by an Indian pharmaceutical company as approved for the treatment of type 2 diabetes in June 2013. The potential of certain cell based therapies and nanoformulations were also investigated for different diabetes treatment. The scientific rationale for the use of various herbs on male and female reproduction with respect to aphrodiasic, fertility and antifertility properties has been explored. In addition to role of melatonin in chronobiology , it has been reported to possess multiple pharmacological actions such as antioxidant, anti-inflammatory and neuroprotective actions. Only few Indian scientists have studied on endocrine pharmacology related to adrenal, tyroid and parathyroid gland disorders. In addition, the effects of some endocrine disruptors, toxic chemicals and heavy metals on endocrine systems were also studied. In this review , e have compiled the research articles on scientific progress made in the field of endocrine pharmacology from India between years 2012-2017.
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Radioprotective potential of melatonin against 60Co γ-ray-induced testicular injury in male C57BL/6 mice
S. Khan (2015)
Efficacy of a Novel Fenugreek Seed Extract (Trigonella foenum-graecum, FurocystTM) in Polycystic Ovary Syndrome (PCOS)
A. Swaroop (2015)
Modulatory effects of morin on hyperglycemia by attenuating the hepatic key enzymes of carbohydrate metabolism and β-cell function in streptozotocin-induced diabetic rats.
P. Vanitha (2014)
Effect of ethanol extract of Portulaca oleracea L on ovulation and estrous cycle in female albino rats
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Relationships between the islets blood flow, nitric oxide, insulin, and cytosolic calcium in rat pancreatic islets: effects of DPP-IV inhibitor vildagliptin.
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Antifertility efficacy of Drynaria quercifolia (L.) J. Smith on female Wister albino rats.
B. Das (2014)
Melatonin prevents dexamethasone‐induced testicular oxidative stress and germ cell apoptosis in golden hamster, Mesocricetus auratus
Arun Mukherjee (2015)
Protective effects of Eugenia jambolana extract versus N‐acetyl cysteine against cisplatin‐induced damage in rat testis
H. Anand (2015)
SNEDDS curcumin formulation leads to enhanced protection from pain and functional deficits associated with diabetic neuropathy: an insight into its mechanism for neuroprotection.
Rayanta P Joshi (2013)
Effect of polybrominated diphenyl ether (BDE-209) on testicular steroidogenesis and spermatogenesis through altered thyroid status in adult mice.
D. Sarkar (2016)
Dose‐dependent effects of ethanol extract of Salvia haematodes Wall roots on reproductive function and copulatory behaviour in male rats
F. Bansode (2015)
Saroglitazar, a novel PPARalpha/gamma agonist with predominant PP
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Melatonin protects against isoproterenol‐induced alterations in cardiac mitochondrial energy‐metabolizing enzymes, apoptotic proteins, and assists in complete recovery from myocardial injury in rats
D. Mukherjee (2012)
Pharmacological characterization of ZYDPLA1, a novel long‐acting dipeptidyl peptidase‐4 inhibitor
M. Jain (2015)
Glutamate Excitotoxicity and Oxidative Stress in Epilepsy: Modulatory Role of Melatonin.
S. Vishnoi (2016)
Folate-decorated PLGA nanoparticles as a rationally designed vehicle for the oral delivery of insulin.
S. Jain (2012)
Modulatory effects of naringin on hepatic key enzymes of carbohydrate metabolism in high-fat diet/low-dose streptozotocin-induced diabetes in rats.
L. Pari (2017)
Effect of Naltrexone on photoperiodic regulation of testicular steroidogenesis in adult golden hamster, Mesocricetus auratus.
Arun Mukherjee (2016)
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Oral dydrogesterone treatment during early pregnancy to prevent recurrent pregnancy loss and its role in modulation of cytokine production: a double-blind, randomized, parallel, placebo-controlled trial.
A. Kumar (2014)
Resveratrol ameliorates cardiac oxidative stress in diabetes through deacetylation of NFkB-p65 and histone 3.
P. Bagul (2015)
Neurorestorative effects of eugenol, a spice bioactive: Evidence in cell model and its efficacy as an intervention molecule to abrogate brain oxidative dysfunctions in the streptozotocin diabetic rat
S. N. Prasad (2016)
Lactational exposure of phthalate causes long-term disruption in testicular architecture by altering tight junctional and apoptotic protein expression in Sertoli cells of first filial generation pubertal Wistar rats
S. Sekaran (2015)
Rosmarinic acid modulates the antioxidant status and protects pancreatic tissues from glucolipotoxicity mediated oxidative stress in high-fat diet: streptozotocin-induced diabetic rats.
Jayanthy Govindaraj (2015)
Treatment with exendin-4 improves the antidiabetic efficacy and reverses hepatic steatosis in glucokinase activator treated db/db mice.
N. Dhanesha (2013)
Protective effect of Caralluma fimbriata against high-fat diet induced testicular oxidative stress in rats.
Sudhakara Gujjala (2016)
Effect of aqueous leaf extract of Dalbergia sissoo Roxb. on spermatogenesis and fertility in male mice
H. P. Verma (2014)
Combined therapy of insulin-producing cells and haematopoietic stem cells offers better diabetic control than only haematopoietic stem cells’ infusion for patients with insulin-dependent diabetes
S. Dave (2014)
Novel therapy for insulin-dependent diabetes mellitus: infusion of in vitro-generated insulin-secreting cells
S. Dave (2013)
Reversal of diabetes-induced behavioral and neurochemical deficits by cinnamaldehyde.
Akshay Jawale (2016)
Catechin induced modulation in the activities of thyroid hormone synthesizing enzymes leading to hypothyroidism
A. Chandra (2012)
Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats.
A. Rathinam (2016)
Melatonin protects against isoproterenol-induced alterations in cardiac mitochondrial energy-metabolizing enzymes, apoptotic
S Datta (2012)
Surface engineered and ligand anchored nanobioconjugate: an effective therapeutic approach for oral insulin delivery in experimental diabetic rats.
R. Sharma (2015)
Excess aldosterone-induced changes in insulin signaling molecules and glucose oxidation in gastrocnemius muscle of adult male rat
J. Selvaraj (2012)
Antifertility activity of Thevetia peruviana (Pers.) K. Schum leaf in female Sprague-Dawley rat
Jhuma Samanta (2016)
Gastro-protective and Anti-stress Efficacies of Monomethyl Fumarate and a Fumaria indica Extract in Chronically Stressed Rats
A. Shakya (2015)
Protective roles of nanomelatonin in cerebral ischemia-reperfusion of aged brain: Matrixmetalloproteinases as regulators
S. Sarkar (2017)
Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia.
P. Bhattacharya (2014)
Therapeutic approaches of melatonin in microwave radiations-induced oxidative stress-mediated toxicity on male fertility pattern of Wistar rats
Ramovatar Meena (2014)
Dose-Dependent Adverse Effects of Salinomycin on Male Reproductive Organs and Fertility in Mice
O. O. Ojo (2013)
Myoinositol ameliorates high-fat diet and streptozotocin-induced diabetes in rats through promoting insulin receptor signaling.
P. J. Antony (2017)
5HT3 receptor antagonist (ondansetron) reverses depressive behavior evoked by chronic unpredictable stress in mice: Modulation of hypothalamic–pituitary–adrenocortical and brain serotonergic system
Deepali Gupta (2014)
Biphasic action of iodine in excess at different doses on ovary in adult rats.
D. Mahapatra (2017)
Fisetin, a tetra hydroxy flavone recuperates antioxidant status and protects hepatocellular ultrastructure from hyperglycemia mediated oxidative stress in streptozotocin induced experimental diabetes in rats.
G. S. Prasath (2013)
Cypermethrin-induced reproductive toxicity in the rat is prevented by resveratrol
Poonam Sharma (2014)
Therapeutic exploration of betulinic acid in chemically induced hypothyroidism
M. Afzal (2013)
Second generation anti-epileptic drugs adversely affect reproductive functions in young non-epileptic female rats
S. Kumar (2014)
Impact of arsenic(V) on testicular oxidative stress and sperm functional attributes in Swiss albino mice
P. R. Guvvala (2016)
Protective effects of Ficus carica leaves on glucose and lipids levels, carbohydrate metabolism enzymes and β-cells in type 2 diabetic rats
Santiagu Stephen Irudayaraj (2017)
Lactucaxanthin - a potential anti-diabetic carotenoid from lettuce (Lactuca sativa) inhibits α-amylase and α-glucosidase activity in vitro and in diabetic rats.
Sowmya Shree Gopal (2017)
A novel GPR40 agonist, CNX-011-67, suppresses glucagon secretion in pancreatic islets under chronic glucolipotoxic conditions in vitro
M. K. Verma (2014)
Contraceptive studies of isolated fractions of Cuminum cyminum in male albino rats
P. Saxena (2015)
Melatonin supplementation in rat ameliorates ovariectomy-induced oxidative stress
D. Baxi (2013)
Catecholamine Stress Hormones Regulate Cellular Iron Homeostasis by a Posttranscriptional Mechanism Mediated by Iron Regulatory Protein
Nisha Tapryal (2015)
A P (2016) Potential Dual Role of Eugenol in Inhibiting Advanced Glycation End Products in Diabetes: Proteomic and Mechanistic Insights
V S (2016)
Protection of testis through antioxidant action of Mallotus roxburghianus in alloxan-induced diabetic rat model.
V. K. Roy (2015)
Activation of GPR40 attenuates chronic inflammation induced impact on pancreatic β-cells health and function
M. K. Verma (2014)
Corrective role of Eugenia jambolana on testicular impairment in streptozotocin‐induced diabetic male albino rat: An approach through genomic and proteomic study
A. Ghosh (2014)
Dietary Zinc Deficiency Effects Dorso-lateral and Ventral Prostate of Wistar Rats: Histological, Biochemical and Trace Element Study
S. Joshi (2014)
amino]4-methyl-1,3-thiazole-5-carboxylic acid exhibits antidiabetic potential and raises insulin sensitivity via amelioration of oxidative enzymes and inflammatory
R Wadhwa (2017)
Effect of Mucuna pruriens (Linn.) on sexual behavior and sperm parameters in streptozotocin-induced diabetic male rat.
S. Suresh (2012)
Antihyperlipidemic Effect of Fisetin, a Bioflavonoid of Strawberries, Studied in Streptozotocin‐Induced Diabetic Rats
G. S. Prasath (2014)
Sodium valproate ameliorates diabetes-induced fibrosis and renal damage by the inhibition of histone deacetylases in diabetic rat.
S. Khan (2015)
Discovery of biaryl-4-carbonitriles as antihyperglycemic agents that may act through AMPK-p38 MAPK pathway
A. Goel (2014)
Protective effects of 5,7,4'-trihydroxy-6,3'dimethoxy-flavone 5-O-α-l-rhamnopyranoside, isolated from Annona squamosa leaves in thyrotoxicosis and in hepatic lipid peroxidation in rats.
S. Panda (2015)
Protective effect of melatonin on propoxur-induced impairment of memory and oxidative
A KTripathi (2014)
The exaptation of endocrine pharmacology
S. Kalra (2012)
Melatonin actions on ovaprim (synthetic GnRH and domperidone)-induced oocyte maturation in carp.
Mahammed Moniruzzaman (2016)
Evaluation of anti‐diabetic activity of glycyrrhizin‐loaded nanoparticles in nicotinamide‐streptozotocin‐induced diabetic rats
R. Rani (2017)
Effect of Letrozole, a selective aromatase inhibitor, on testicular activities in adult mice: Both in vivo and in vitro study.
R. Verma (2017)
Therapeutic potential of pterostilbene against pancreatic beta‐cell apoptosis mediated through Nrf2
E. Bhakkiyalakshmi (2014)
Melatonin pre-treatment mitigates SHSY-5Y cells against oxaliplatin induced mitochondrial stress and apoptotic cell death
Mohammad Waseem (2017)
Selenium nanoparticles involve HSP-70 and SIRT1 in preventing the progression of type 1 diabetic nephropathy.
G. S. Kumar (2014)
Persistent hexavalent chromium exposure impaired the pubertal development and ovarian histoarchitecture in wistar rat offspring
J. B. Samuel (2014)
Androgenic and Spermatogenic Activity of Alkylamide‐Rich Ethanol Solution Extract of Anacyclus pyrethrum DC
V. Sharma (2013)
Syzygium cumini ameliorates insulin resistance and beta-cell dysfunction via modulation of PPAR, dyslipidemia, oxidative
D SArya (2012)
Cytotoxic and Genotoxic Effects of Titanium Dioxide Nanoparticles in Testicular Cells of Male Wistar Rat
Ramovatar Meena (2014)
Bisphenol A Induces Oxidative Stress in Bone Marrow Cells, Lymphocytes, and Reproductive Organs of Holtzman Rats
Dinesh Tiwari (2017)
Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation, function and glucose homeostasis through modulation of p38/ERK MAPK and apoptotic pathways: study in juvenile diabetic rat.
S. Khan (2014)
Hypoglycemic and beta-cells regenerative ef
G RGandhi (2012)
3-Bromo-7-nitroindazole attenuates brain ischemic injury in diabetic stroke via inhibition of endoplasmic reticulum stress pathway involving CHOP.
K. Srinivasan (2012)
Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management
Arun Chaudhury (2017)
Design, synthesis and characterization of zinc-morin, a metal flavonol complex and evaluation of its antidiabetic potential in HFD-STZ induced type 2 diabetes in rats.
V. Sendrayaperumal (2014)
A (2016) Hypoglycemic activity of 6bromoembelin and vilangin in high-fat diet fedstreptozotocin-induced type 2 diabetic rats and molecular docking studies
N Al-Dhabi (2016)
Anxiolytic, antidepressant, and antistress activities of the aqueous extract of Cinnamomum tamala Nees and Eberm in rats
Gayaprasad Upadhyay (2016)
Baicalin and chrysin mixture imparts cyto-protection against methylglyoxal induced cytotoxicity and diabetic tubular injury by modulating RAGE, oxidative stress and inflammation.
J. Singh (2017)
Male reproductive toxicity of CrVI: In-utero exposure to CrVI at the critical window of testis differentiation represses the expression of Sertoli cell tight junction proteins and hormone receptors in adult F1 progeny rats.
K. Kumar (2017)
Diosmin Modulates the NF-kB Signal Transduction Pathways and Downregulation of Various Oxidative Stress Markers in Alloxan-Induced Diabetic Nephropathy
S. Ahmed (2016)
Synthesis, molecular docking and anti-diabetic evaluation of 2,4-thiazolidinedione based amide derivatives.
M. Naim (2017)
Molecular cues to the anti-implantation effect of nano-puerarin in rats.
G. Saraswat (2016)
Impact of buserelin acetate or hCG administration on day 12 post-ovulation on subsequent luteal profile and conception rate in buffalo (Bubalus bubalis).
A. K. Pandey (2013)
Expression analysis of Sox9 genes during annual reproductive cycles in gonads and after nanodelivery of LHRH in Clarias batrachus.
I. Bhat (2016)
Efficacy of FurosapTM, a novel Trigonella foenum-graecum seed extract, in Enhancing Testosterone Level and Improving Sperm Profile in Male Volunteers
Anuj Maheshwari (2017)
Effect of Excess Iodine on Oxidative Stress Markers, Steroidogenic—Enzyme Activities, Testicular Morphology, and Functions in Adult Male Rats
A. Chakraborty (2015)
Effect of cadmium chloride on secretion of 17β-estradiol by the ovarian follicles of common carp, Cyprinus carpio.
S. Das (2013)
Study on The Reproductive Organs and Fertility of The Male Mice following Administration of Metronidazole
Mrinalini Kumari (2013)
Parthenolide, an NF-kappaB Inhibitor
A K (2017)
Diabetic nephropathy: New insights into established therapeutic paradigms and novel molecular targets.
D. Sharma (2017)
Natural male contraceptive: phytochemical investigation and anti-spermatogenic activity of Pistia stratiotes Linn.
K. Singh (2014)
Aphrodisiac and spermatogenic potential of alkaloidal fraction of Hygrophila spinosa T. Ander in rats.
N. Vyas (2016)
Impact of low molecular weight phthalates in inducing reproductive malfunctions in male mice: Special emphasis on Sertoli cell functions.
N. Kumar (2015)
Antithyroid effects of naringin, hesperidin and rutin in l-T4 induced hyperthyroid rats: possible mediation through 5'DI activity.
S. Panda (2014)
Effect of tamoxifen on spermatogenesis and testicular steroidogenesis.
R. Verma (2017)
Make in India
Ameya Patil (2014)
Levosimendan reduces myocardial damage and improves cardiodynamics in streptozotocin induced diabetic cardiomyopathy via SERCA2a/NCX1 pathway.
M. Akhtar (2016)
Genistein ameliorates cardiac inflammation and oxidative stress in streptozotocin-induced diabetic cardiomyopathy in rats
S. K. Gupta (2015)
Insulin sensitization via partial agonism of PPARγ and glucose uptake through translocation and activation of GLUT4 in PI3K/p-Akt signaling pathway by embelin in type 2 diabetic rats.
G. R. Gandhi (2013)
Modulation of neuro-inflammatory condition, acetylcholinesterase and antioxidant levels by genistein attenuates diabetes associated cognitive decline in mice.
M. S. Rajput (2017)
Effect of mesenchymal stem cells transplantation on glycaemic profile & their localization in streptozotocin induced diabetic Wistar rats
S. Bhansali (2015)
Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study
Swati Dongre (2015)
Garlic activates SIRT-3 to prevent cardiac oxidative stress and mitochondrial dysfunction in diabetes.
M. R. Sultana (2016)
Syzygium cumini ameliorates insulin resistance and β-cell dysfunction via modulation of PPAR, dyslipidemia, oxidative stress, and TNF-α in type 2 diabetic rats.
A. Sharma (2012)
Melatonin protects against lipid‐induced mitochondrial dysfunction in hepatocytes and inhibits stellate cell activation during hepatic fibrosis in mice
Nabanita Das (2017)
Fisetin Imparts Neuroprotection in Experimental Diabetic Neuropathy by Modulating Nrf2 and NF-κB Pathways
Reddemma Sandireddy (2015)
Melatonin alleviates hyperthyroidism induced oxidative stress and neuronal cell death in hippocampus of aged female golden hamster, Mesocricetus auratus
G. Rao (2016)
Repositioning of Drugs in Cardiometabolic Disorders: Importance and Current Scenario.
Parmeshwar B. Katare (2016)
Biphasic effect of Syzygium aromaticum flower bud on reproductive physiology of male mice
R. Mishra (2016)
CNX-011-67, a novel GPR40 agonist, enhances glucose responsiveness, insulin secretion and islet insulin content in n-STZ rats and in islets from type 2 diabetic patients
V. Sunil (2014)
Diabetes mellitus and its complications in India
R. Unnikrishnan (2016)
Endocrine disrupting pesticides impair the neuroendocrine regulation of reproductive behaviors and secondary sexual characters of red munia (Amandava amandava)
S. Pandey (2017)
Melatonin Reduces Ulcerative Colitis-Associated Local and Systemic Damage in Mice: Investigation on Possible Mechanisms
P. Trivedi (2013)
Antifertility efficacy of Coccinia indica in male mice and its possible mechanisms of action on spermatogenesis.
H. P. Verma (2017)
Immunogenicity and Contraceptive Efficacy of Escherichia coli‐Expressed Recombinant Porcine Zona Pellucida Proteins
N. Gupta (2013)
Aqueous extract of tamarind seeds selectively increases glucose transporter-2, glucose transporter-4, and islets' intracellular calcium levels and stimulates β-cell proliferation resulting in improved glucose homeostasis in rats with streptozotocin-induced diabetes mellitus.
S. Sole (2012)
Antifertility effect of hydroalcoholic leaves extract of Michelia champaca L.: an ethnomedicine used by Bhatra women in Chhattisgarh state of India.
Seema Taprial (2013)
Modulation of Steroidogenic Pathway in Rat Granulosa Cells with Subclinical Cd Exposure and Insulin Resistance: An Impact on Female Fertility
Muskaan Belani (2014)
Observational Study of Effects of Saroglitazar on Glycaemic and Lipid Parameters on Indian Patients with Type 2 Diabetes
S. Chatterjee (2015)
Role of cortisol and superoxide dismutase in psychological stress induced anovulation.
Manika Kala (2016)
Evaluation of ameliorative potential of supranutritional selenium on enrofloxacin-induced testicular toxicity.
Soya Rungsung (2016)
Alterations in Hippocampal Oxidative Stress, Expression of AMPA Receptor GluR2 Subunit and Associated Spatial Memory Loss by Bacopa monnieri Extract (CDRI-08) in Streptozotocin-Induced Diabetes Mellitus Type 2 Mice
S. Pandey (2015)
Development of quercetin nanoformulation and in vivo evaluation using streptozotocin induced diabetic rat model
Deepak Chitkara (2012)
Effect of Boerhaavia diffusa in experimental prostatic hyperplasia in rats
B. Vyas (2013)
2-[(4-Chlorobenzyl) amino]-4-methyl-1,3-thiazole-5-carboxylic acid exhibits antidiabetic potential and raises insulin sensitivity via amelioration of oxidative enzymes and inflammatory cytokines in streptozotocin-induced diabetic rats.
Yam Nath Paudel (2017)
Chromium picolinate attenuates hyperglycemia-induced oxidative stress in streptozotocin-induced diabetic rats.
B. Sundaram (2013)
Elucidation of hypoglycemic action and toxicity studies of insulin-like protein from Costus igneus.
Manasi R Hardikar (2016)
Effect of triptolide on reproduction of female lesser bandicoot rat, Bandicota bengalensis
P. Dhar (2014)
Anti - inflammatory action of Tamarind seeds reduces hyperglycemic excursion by repressing pancreatic beta - cell damage and normalizing SREBP - 1 c concentration
S SoleS (2013)
Zinc protects cyclophosphamide-induced testicular damage in rat: involvement of metallothionein, tesmin and Nrf2.
K. Maremanda (2014)
Antifertility activity of Artemisia vulgaris leaves on female Wistar rats.
Afsar Shaik (2014)
Dose-Dependent Effect of Deltamethrin in Testis, Liver, and Kidney of Wistar Rats
Poonam Sharma (2014)
NF-kappaB Inhibition Resolves Cognitive Deficits
A K (2016)
Garlic and Resveratrol
R Adela (2016)
In Silico and In Vitro Investigation of the Piperine's Male Contraceptive Effect: Docking and Molecular Dynamics Simulation Studies in Androgen-Binding Protein and Androgen Receptor.
G. Chinta (2015)
Amelioration of diabetes-induced neurobehavioral and neurochemical changes by melatonin and nicotinamide: Implication of oxidative stress–PARP pathway
Ashok Jangra (2013)
Fisetin improves glucose homeostasis through the inhibition of gluconeogenic enzymes in hepatic tissues of streptozotocin induced diabetic rats.
G. S. Prasath (2014)
Efficacy of Teriparatide in Patients with Hypoparathyroidism: A Prospective, Open-label Study
V. Upreti (2017)
Insulin sensitizing and cardioprotective effects of Esculetin and Telmisartan combination by attenuating Ang II mediated vascular reactivity and cardiac fibrosis.
A. Kadakol (2015)
Antidiabetic and antihyperlipidemic activities of a novel polyherbal formulation in high fat diet/streptozotocin induced diabetic rat model
N. Subhasree (2015)
Reproductive toxicity of lead, cadmium, and phthalate exposure in men
N. Pant (2014)
Renoprotective and antioxidative effects of methanolic Paederia foetida leaf extract on experimental diabetic nephropathy in rats.
M. Borgohain (2017)
Melatonin attenuates 60 Co gamma-ray-induced hematopoietic, immunological and gastrointestinal injuries
N KChaudhury (2017)
Garlic activates SIR
S Anwar Mohammed (2016)
Cypermethrin induced reproductive toxicity in male Wistar rats: protective role of Tribulus terrestris.
Poonam Sharma (2013)
Antidiabetic potential of polyherbal formulation DB14201: Preclinical development, safety and efficacy studies.
Geetha Krishnan Gopalakrishna Pillai (2017)
Protective effects of melatonin against metabolic and reproductive disturbances in polycystic ovary syndrome in rats
S. Pai (2014)
Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis‐associated colon carcinogenesis
P.P. Trivedi (2016)
In vitro toxicity and antidiabetic activity of a newly developed polyherbal formulation (MAC-ST/001) in streptozotocin-induced diabetic Wistar rats
D. Yadav (2012)
Hypoglycemic activity of 6-bromoembelin and vilangin in high-fat diet fed-streptozotocin-induced type 2 diabetic rats and molecular docking studies.
A. Stalin (2016)
Chitosan-Nanoconjugated Hormone Nanoparticles for Sustained Surge of Gonadotropins and Enhanced Reproductive Output in Female Fish
M. A. Rather (2013)
Rufinamide Improves Functional and Behavioral Deficits via Blockade of Tetrodotoxin-Resistant Sodium Channels in Diabetic Neuropathy.
S. Kharatmal (2015)
Recovery of lead-induced suppressed reproduction in male rats by testosterone.
M. Reshma Anjum (2015)
Selective Inhibition of PTP1B by Vitalboside A from Syzygium cumini Enhances Insulin Sensitivity and Attenuates Lipid Accumulation Via Partial Agonism to PPARγ: In Vitro and In Silico Investigation
G. Thiyagarajan (2016)
Adenosine Monophosphate-Activated Protein Kinase Abates Hyperglycaemia-Induced Neuronal Injury in Experimental Models of Diabetic Neuropathy: Effects on Mitochondrial Biogenesis, Autophagy and Neuroinflammation
Veera Ganesh Yerra (2016)
Role of pterostilbene in attenuating immune mediated devastation of pancreatic beta cells via Nrf2 signaling cascade.
Dornadula Sireesh (2017)
Status of stem cell based clinical trials in the treatment for diabetes.
C. Viswanathan (2013)
16,17-Dihydro-17b-hydroxy isomitraphylline alkaloid as an inhibitor of DPP-IV, and its effect on incretin hormone and β-cell proliferation in diabetic rat.
Ashutosh Shukla (2012)
Evaluation of the Effect of Curcumin Capsules on Glyburide Therapy in Patients with Type‐2 Diabetes Mellitus
P. Neerati (2014)
Ameliorating effect of chromium administration on hepatic glucose metabolism in streptozotocin-induced experimental diabetes.
B. Sundaram (2012)
From 'Make in India' to 'Made in India': the saroglitazar story.
S. Ramakrishnan (2015)
Amelioration of testosterone induced benign prostatic hyperplasia by Prunus species.
A. K. Jena (2016)
Anti - inflammatory action of Tamarind seeds reduces hyperglycemic excursion by repressing pancreatic beta - cell damage and normalizing SREBP - 1 c concentration
S SoleS (2013)
Kaikini A A and Sathaye S (2016) Renoprotective effect of diosgenin
V V (2016)
S Ashwini (2017)
Fisetin averts oxidative stress in pancreatic tissues of streptozotocin-induced diabetic rats
G. S. Prasath (2012)
Evaluation of the ef
A K (2014)
Abortifacient potential of methanolic extract of Anthocephalus cadamba stem bark in mice.
Muhammad Vaseem Shaikh (2015)
IN0523 (Urs-12-ene3alpha,24beta-diol) a plant based derivative of boswellic acid protect Cisplatin induced urogenital toxicity
S Arvinda (2017)
Protective Effects of Andrographis paniculata Extract and Pure Andrographolide Against Chronic Stress-Triggered Pathologies in Rats
A. Thakur (2014)
Puerarin, a selective oestrogen receptor modulator, disrupts pregnancy in rats at pre-implantation stage.
P. Saha (2012)
Protective Effect and Potential Mechanism of Ginkgo biloba Extract EGb 761 on STZ‐induced Neuropathic Pain in Rats
R. Taliyan (2012)
Melatonin improves humoral and cell-mediated immune responses of male golden hamster following stress induced by dexamethasone
D. Vishwas (2013)
Melatonin protects against behavioural dysfunctions and dendritic spine damage in 3-nitropropionic acid-induced rat model of Huntington's disease
J. Chakraborty (2014)
Citrus limon extract: possible inhibitory mechanisms affecting testicular functions and fertility in male mice
Nidhi Singh (2016)
In vitro and in vivo evaluation of osteoporosis therapeutic peptide PTH 1-34 loaded pegylated chitosan nanoparticles.
D. Narayanan (2013)
Sodium butyrate reduces insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat: A comparative study with metformin.
S. Khan (2016)
Improved stability and antidiabetic potential of insulin containing folic acid functionalized polymer stabilized multilayered liposomes following oral administration.
A. Agrawal (2014)
Reversible Germ Cell Toxicity of Sulphasalazine and Ampicillin Combination in Male Rats
H. Gupta (2013)
PTH 1-34 loaded thiolated chitosan nanoparticles for osteoporosis: oral bioavailability and anabolic effect on primary osteoblast cells.
D. Narayanan (2014)
Morin activates the Nrf2‐ARE pathway and reduces oxidative stress‐induced DNA damage in pancreatic beta cells
P. Vanitha (2017)
Ellagic acid inhibits non-enzymatic glycation and prevents proteinuria in diabetic rats.
G. Raghu (2016)
Chrysin, a PPAR-γ agonist improves myocardial injury in diabetic rats through inhibiting AGE-RAGE mediated oxidative stress and inflammation.
N. Rani (2016)