Advances On Research In Protein-Enriched Cow’s Milk: A Review From Omics Perspective
Jay Ronel V. Conejos, Hong-Gu Lee
Published 2018 · Biology
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With deep knowledge and numerous researches about DNA in addition to recent advances in molecular biology and omics analysis methodology, manipulation of DNA transcription becomes possible that may eventually affect protein expression. Possible posttranscriptional modifications such as phosphorylation of proteins could also greatly affect protein expression. There are vast evidences showing that synthesis of milk protein is strongly regulated by several factors such as insulin, amino acids and their specific amino acid transporters as well as various energy sources through transcriptional and posttranscriptional pathways with insulin-mTOR pathway serving as the central point. Available latest data suggest the possibility of nutrigenomic interventions to manipulate milk protein synthesis by supplying amino acids and different energy sources. This could greatly contribute to major progress in understanding milk protein synthesis. With improvement of ‘omics’ tools, utilization of these tools in our future studies would help us fully understand the mechanism behind. This could lead to possible control and manipulation of milk protein synthesis in mammary gland.
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