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FORMULATION AND IN-VITRO CHARACTERIZATION OF BIODEGRADABLE ISONIAZID NANOPARTICLES IN COW URINE

V. S. Babu
Published 2017 · Chemistry

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Scientific community believes that Nanotechnology offers new ways to address residual scientific concerns for Mycobacterium Tuberculosis (TB). Nanoparticles one of the great colloidal drug delivery as controlled drug deliver as well as site specific delivery. Nanoparticles acquire an exclusive stability then compared to other novel drug delivery system. This phenomenon may be help to targeting organs. Isoniazid Nanoparticles were Prepared by using of biodegradable polymer mostly compatibility to the human system. The present study was carried to prepare Isoniazid nanoparticles showed significant advancement of this technology is that the using of nanoparticles as drug carriers are had high stability and carrier capacity the sustained drug release from the matrix, such properties of nanoparticles enables improvement of drug bioavailability and reduction of the dosing frequency. The aim of the present study was to develop and evaluate nanoparticulate drug delivery system of highly cow urine soluble drug Isoniazid by using sodium alginate polymer were prepared by two techniques i.e. cross-linking method and solvent evaporation method. Sodium alginate gel was prepared using cow urine. Sodium alginate was used as a poly anionic natural polymer. The nanoparticles were prepared using different ratios of sodium alginate and isoniazid in the ratio of (1:1,1:2and1:3). The encapsulation efficiency was also studied to find out the percentage drug entrapped in the prepared isoniazid Nanoparticles. The result of ratio 1:1 (isoniazid:aliginate) showed a good encapsulation efficiency of 89.5%.Isoniazid nanoparicle was confirmed by FT-IR,DSC and quantitated by prepared nanoparticle appeared spherical with a dense drug core in transmission electron microscope studies., mean diameter of nanoparticle was 560.3 nm, and the zeta potential was -0.4mev. The drug loading decreased WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES SJIF Impact Factor 6.647 Volume 6, Issue 5, 626-658 Research Article ISSN 2278 – 4357 Article Received on 23 Feb. 2017, Revised on 16 March 2017, Accepted on 05 April 2017 DOI: 10.20959/wjpps20175-8964 *Corresponding Author Vothani Sarath Babu Academic Consultant, S.V.U.College of Pharmaceutical Sciences, Sri Venkateswara University, Tirupati, A. P., INDIA.
This paper references
10.2174/187152308786847816
Biodegradable Polymer Based Particulate Carrier(s) for the Delivery of Proteins and Peptides
N. Mishra (2008)
10.1023/A:1012126301290
The Mechanism of Uptake of Biodegradable Microparticles in Caco-2 Cells Is Size Dependent
M. P. Desai (2004)
C . Cudworth . Thearapatic Apllication of implantable drug delivery systems
K Lawerence. (1998)
Mark , Saltzman . Polymeric implante for cancer chemotherapy and Drug delivery Reviews
C Becker. (1997)
Clinical pharmacokinetics of antitubercular drugs
M. R. Holdiness (2001)
10.1186/1477-3155-9-55
Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines
A. Mahapatro (2011)
10.1002/JPS.20765
Biowaiver monographs for immediate release solid oral dosage forms: isoniazid.
C. Becker (2007)
Design and in vitro characterization of Amoxicillin loaded sepia nanoparticles
S. Ramesh (2010)
Chittoor to provided good Laboratory Facilities. I would like to thanks to our college (SVCOP) Principal Prof. K. Bhaskar Reddy to motivation and support of my research work
Nagar
A Novel Approach To Formulation Of Anticancer Drugs Innanoparticles. The University Of Michigan
Xinyi Gu (2008)
PEG-ylated nanoparticles for biological and pharmaceutical application
Z. Pangi (2003)
Thearapatic Apllication of implantable drug delivery systems
KD Alekha (1998)
The pharmacological basis of therapeutics Antimicrobial Agents In Hardmann
W. A. Petri (2001)
Çalış Etodolac Loaded Poly (Lactide- Co-Glycolide) Nanoparticles and In Vitro Characterization.Hacettepe University
Yasemin Çırpanlı (2009)
The in vitro release profiles for a system of haloperidolloaded PLGA nanoparticles
A. Budhian (2008)
Biodegradable polymeric nanoparticles as www.wjpps.com Vol 6, Issue 5, 2017
K. S. Soppimath (2001)
10.1128/AAC.48.8.2951-2957.2004
Isoniazid Pharmacokinetics-Pharmacodynamics in an Aerosol Infection Model of Tuberculosis
R. Jayaram (2004)
Sp . Wate , Nj . Duragkar , Mr . Tajne And Ss . Jadhav . Study Of Analgesic Activity Of Cow Urine And Its Distillate By RatTail Immersion Method
Sovan Lal Pal (2012)
10.1016/J.JCONREL.2005.04.013
Using different structure types of microemulsions for the preparation of poly(alkylcyanoacrylate) nanoparticles by interfacial polymerization.
K. Krauel (2005)
10.37285/ijpsn.2009.2.2.4
Chitosan Based Nanoparticles in Drug Delivery
J. Patel (2011)
Nanoparticles in colloidal drug delivery systems
J. Kreutter (1994)
10.1016/S0168-3659(00)00339-4
Biodegradable polymeric nanoparticles as drug delivery devices.
K. Soppimath (2001)
10.1163/156856206775997322
Synthesis and characterization of PLGA nanoparticles
C. Astete (2006)
Polymeric implante for cancer chemotherapy and Drug delivery Reviews
K Lawerence. (1997)
Nanoparticle: An overview of preparation and characterization
S. Pal (2011)
Chitosan Based Nanoparticles
J. K Patel (2009)
The pharmacological basis of therapeutics Antimicrobial Agents In Hardmann. MacGraw Hill Medical Publishing division
W A Petri (2001)
10.1023/A:1018908421434
Biodegradable Nanoparticles Containing Doxorubicin-PLGA Conjugate for Sustained Release
H. Yoo (2004)
DIFFERENT TECHNIQUES FOR PREPARATION OF POLYMERIC NANOPARTICLES-A
H. K. Yadav (2012)
Sema Çalış Etodolac Loaded Poly ( Lactide - Co - Glycolide ) Nanoparticles and In Vitro Characterization
Cecile Robineau Yasemin Çırpanlı (2012)
Synthesis and characterization of PLGA nanoparticles.Journal of Biomaterials
C. E. Astete (2006)
I express my great thanks to our college Sri Venkateswara College of Pharmacy
A novel approach to formulation of anticancer drugs in nanoparticles
X. Gu (2008)
Study of Analgesic Activity of Cow Urine and Its Distillate by Rat-Tail Immersion Method
S. Pawar (2012)



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