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Polydopamine Coating Promotes Early Osteogenesis In 3D Printing Porous Ti6Al4V Scaffolds

L. Li, Yi-Xuan Li, Longfei Yang, Fei Yu, Kaijia Zhang, Jing Jin, Jianping Shi, Liya Zhu, Huixin Liang, X. Wang, Q. Jiang
Published 2019 · Materials Science

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Background: Titanium implants are widely used in orthopedic and dental for more than 30 years. Its stable physicochemical properties and mechanical strength are indeed appropriate for implantation. However, the Bioinertia oxidized layer and higher elastic modulus often lead to the early implantation failure. Methods: In this study, we proposed a simple design of porous structure to minimize the disparity between scaffold and natural bone tissue, and introduced a one-step reaction to form a polydopamine (PDA) layer on the surface of titanium for the purpose of improving osteogenesis as well. The porous scaffolds with pore size of 400 µm and porosity of 44.66% were made by additive manufacturing. The cell behavior was tested by seeding MC3T3-E1 cells on Ti6Al4V films for 15 days. The biomechanical properties were then analyzed by finite element (FE) method and the in vivo osteogenesis effect was accordingly evaluated by implanting the scaffolds for 5 weeks in rabbits. Results: According to the achieved results, it was revealed that the immersion for 40 min with dopamine could significantly improve the cell adhesion. The proposed method for design of porous structure can avoid the stress shielding effect and bone growth inside the PDA coating scaffolds, which were observed at the early stage of bone healing process. Conclusions: It can be concluded that the proposed PDA coating method is effective in promoting early osteogenesis, as well as being easy to operate, and can be helpful in the future clinical application of titanium implants.
This paper references
Covalent Immobilization of Collagen on Titanium through Polydopamine Coating to Improve Cellular Performances of MC3T3-E1 Cells.
X. Yu (2013)
Bone regeneration in the presence of a synthetic hydroxyapatite/silica oxide-based and a xenogenic hydroxyapatite-based bone substitute material.
A. Kruse (2011)
Osteostatin-coated porous titanium can improve early bone regeneration of cortical bone defects in rats.
J. van der Stok (2015)
Single-molecule mechanics of mussel adhesion
H. Lee (2006)
The synergistic effect of hierarchical micro/nano-topography and bioactive ions for enhanced osseointegration.
W. Zhang (2013)
A Porous Scaffold Design Method for Bone Tissue Engineering Using Triply Periodic Minimal Surfaces
Jianping Shi (2018)
Evaluation of an artificial vertebral body fabricated by a tantalum-coated porous titanium scaffold for lumbar vertebral defect repair in rabbits
Faqi Wang (2018)
Current progress in inorganic artificial biomaterials
Z. Li (2011)
Biocompatibility of Advanced Manufactured Titanium Implants—A Review
A. T. Sidambe (2014)
Additively manufactured biodegradable porous magnesium.
Y. Li (2018)
Potential Use of Porous Titanium–Niobium Alloy in Orthopedic Implants: Preparation and Experimental Study of Its Biocompatibility In Vitro
J. Xu (2013)
Poly(dopamine)-assisted immobilization of Arg-Gly-Asp peptides, hydroxyapatite, and bone morphogenic protein-2 on titanium to improve the osteogenesis of bone marrow stem cells.
Chih-Yuan Chien (2013)
Failure of a properly positioned tantalum rod for treatment of early femoral head necrosis and conversion to total hip arthroplasty
Wael Samir Osman (2015)
Mussel-inspired bioactive ceramics with improved bioactivity, cell proliferation, differentiation and bone-related gene expression of MC3T3 cells.
Mengchi Xu (2013)
Porous titanium scaffolds fabricated using a rapid prototyping and powder metallurgy technique.
Garrett Ryan (2008)
Metallic implant biomaterials
Q. Chen (2015)
Highly aligned porous Ti scaffold coated with bone morphogenetic protein-loaded silica/chitosan hybrid for enhanced bone regeneration.
Hyun-Do Jung (2014)
A 2003 update of bone physiology and Wolff's Law for clinicians.
H. Frost (2004)
Dopamine-assisted immobilization of hydroxyapatite nanoparticles and RGD peptides to improve the osteoconductivity of titanium.
Chih-Yuan Chien (2013)
Three-dimensional scaffolds for tissue engineering applications: role of porosity and pore size.
Qiu Li Loh (2013)
Covalent immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces.
Fabíola Costa (2011)
Evaluation of the osteogenesis and osseointegration of titanium alloys coated with graphene: an in vivo study
Kewen Li (2018)
3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration.
J. Inzana (2014)
Rapid prototyped porous titanium coated with calcium phosphate as a scaffold for bone tissue engineering.
M. Lopez-Heredia (2008)
Nanostructured glass–ceramic coatings for orthopaedic applications
Guocheng Wang (2011)
Enhanced bone regeneration of cortical segmental bone defects using porous titanium scaffolds incorporated with colloidal gelatin gels for time- and dose-controlled delivery of dual growth factors.
J. van der Stok (2013)
Anodic Oxidation of Titanium: From Technical Aspects to Biomedical Applications
M. V. Diamanti (2011)
In vitro effects of mussel-inspired polydopamine coating on Ti6Al4V alloy
J. H. Lee (2012)
Oligonucleotide-RGD peptide conjugates for surface modification of titanium implants and improvement of osteoblast adhesion.
J. Michael (2009)
Biomedical interfaces: titanium surface technology for implants and cell carriers.
M. Schuler (2006)
Mussel-Inspired Surface Chemistry for Multifunctional Coatings
H. Lee (2007)
Surface functionalization of TiO2 nanotubes with bone morphogenetic protein 2 and its synergistic effect on the differentiation of mesenchymal stem cells.
Min Lai (2011)
Bioinspired Titanium Drug Eluting Platforms Based on a Poly-β-cyclodextrin-Chitosan Layer-by-Layer Self-Assembly Targeting Infections.
Alexandra Pérez-Anes (2015)
Cellular materials as porous scaffolds for tissue engineering
T. Freyman (2001)
Rapid prototyping: porous titanium alloy scaffolds produced by selective laser melting for bone tissue engineering.
P. Warnke (2009)
Mussel-inspired dopamine- and plant-based cardanol-containing polymer coatings for multifunctional filtration membranes.
Yongseok Choi (2014)
Immobilization of Bone Morphogenetic Protein on DOPA- or Dopamine-Treated Titanium Surfaces to Enhance Osseointegration
Jeonghwa Kang (2013)
Bio-inspired strategy for on-surface synthesis of silver nanoparticles for metal/organic hybrid nanomaterials and LDI-MS substrates.
Seonki Hong (2011)
Mussel-Inspired Polydopamine Coating as a Universal Route to Hydroxyapatite Crystallization
Jungki Ryu (2010)
Effective immobilization of BMP-2 mediated by polydopamine coating on biodegradable nanofibers for enhanced in vivo bone formation.
Hyeong-jin Cho (2014)
A TPMS-based method for modeling porous scaffolds for bionic bone tissue engineering
Jianping Shi (2018)
Mechanical evaluation of porous titanium (Ti6Al4V) structures with electron beam melting (EBM).
J. Parthasarathy (2010)
Role of material surfaces in regulating bone and cartilage cell response.
B. Boyan (1996)
Pore throat size and connectivity determine bone and tissue ingrowth into porous implants: three-dimensional micro-CT based structural analyses of porous bioactive titanium implants.
B. Otsuki (2006)
A mussel-inspired polydopamine coating as a versatile platform for the in situ synthesis of graphene-based nanocomposites.
Liangqia Guo (2012)
Design and fabrication of graduated porous Ti-based alloy implants for biomedical applications
Jianping Shi (2017)
In vitro and in vivo study of additive manufactured porous Ti6Al4V scaffolds for repairing bone defects
G. Li (2016)
Mussel-inspired bioceramics with self-assembled Ca-P/polydopamine composite nanolayer: preparation, formation mechanism, improved cellular bioactivity and osteogenic differentiation of bone marrow stromal cells.
C. Wu (2014)
Mechanical testing of metals . Ductility testing . Compression test for porous and cellular metals
A Kruse
Facile Conjugation of Biomolecules onto Surfaces via Mussel Adhesive Protein Inspired Coatings.
H. Lee (2009)
3D finite element analysis of porous Ti-based alloy prostheses
Ile Mircheski (2016)
Bone regeneration performance of surface-treated porous titanium.
S. Amin Yavari (2014)
Polydopamine--a nature-inspired polymer coating for biomedical science.
Martin E. Lynge (2011)
Polydopamine coating promotes early osteogenesis in 3D printing porous Ti6Al4V scaffolds.
L. Li (2019)
Reasons for failures of oral implants.
B. Chrcanovic (2014)
Localized delivery of growth factors for bone repair.
V. Luginbuehl (2004)
Antibacterial activity and increased bone marrow stem cell functions of Zn-incorporated TiO2 coatings on titanium.
H. Hu (2012)
Clinical applications of bone graft substitutes.
S. Khan (2000)
Consolidation des fractures
J. Meyrueis (2006)
Biomimetic CaP coating incorporated with parathyroid hormone improves the osseointegration of titanium implant
X. Yu (2012)
Mussel-inspired dendritic polymers as universal multifunctional coatings.
Q. Wei (2014)
Surface modification of titanium substrate with a novel covalently-bound copolymer thin film for improving its platelet compatibility
Ching-Hsiung Shen (2015)
Poly(dopamine) coating of scaffolds for articular cartilage tissue engineering.
Wei-Bor Tsai (2011)
3D printing individualized heel cup for improving the self-reported pain of plantar fasciitis
L. Li (2018)

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