Online citations, reference lists, and bibliographies.
← Back to Search

Impact Of Frailty Markers On Outcomes After Transcatheter Aortic Valve Replacement: Insights From A Japanese Multicenter Registry.

Tetsuro Shimura, M. Yamamoto, S. Kano, A. Kagase, A. Kodama, Y. Koyama, T. Otsuka, S. Kohsaka, N. Tada, F. Yamanaka, T. Naganuma, M. Araki, Shinichi Shirai, K. Mizutani, M. Tabata, H. Ueno, K. Takagi, A. Higashimori, Y. Watanabe, K. Hayashida
Published 2017 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
There are no standardized criteria for measuring patients' frailty. We examined prognosis based on four frailty markers [serum albumin level, grip strength, gait speed, and clinical frailty scale (CFS)] in patients who underwent transcatheter aortic valve replacement (TAVR) between October 2013 and April 2016 and were recorded in the Optimized CathEter vAlvular iNtervention (OCEAN) Japanese multicenter registry. Serum albumin level was assessed by dividing patients into two groups: hypoalbuminemia or non-hypoalbuminemia according to their serum albumin level. Clinical outcomes including all-cause, cardiovascular and non-cardiovascular mortality rates after TAVR were compared. During the follow-up period cumulative all-cause, cardiovascular and non-cardiovascular mortality rates were significantly higher in the hypoalbuminemia group than in the non-hypoalbuminemia group. This result remained unchanged even after a propensity-matched model was used in terms of cumulative all-cause and non-cardiovascular mortality; however, differences in cardiovascular mortality rates were attenuated. To consider the impact of grip strength patients were divided into a low or high peak grip strength group based on classification and regression tree (CART) survival analysis. The clinical outcomes for each sex were compared between the two groups. In both sexes the cumulative 1-year mortality rates were significantly different between the two groups. To investigate gait speed patients were classified into two gait speed groups (low or high gait speed group) based on CART survival analysis. Clinical outcomes were compared between the two groups. The cumulative 1-year mortality rate was significantly different between the two gait speed groups. The effect of CFS on prognosis after TAVR was assessed. Patients were categorized into five groups based on the following CFS scores: CFS1-3, CFS4, CFS5, CFS6, and CFS ≥7. We evaluated the relationship between the CFS score and other indicators of frailty markers. We also assessed the mid-term mortality among the five groups. The CFS score had a significant correlation with other frailty markers. The cumulative 1-year mortality increased with an increasing CFS score. In the Cox regression multivariable analysis, the CFS score was an independent predictive factor of an increased late cumulative mortality risk. In conclusion, the results suggest that serum albumin level, grip strength, gait speed, and CFS score are all useful indicators when considering the optimal indications and risk stratification for TAVR.
This paper references
10.1016/j.jtcvs.2014.05.014
2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.
R. Nishimura (2014)
10.1503/cmaj.050051
A global clinical measure of fitness and frailty in elderly people
K. Rockwood (2005)
10.1016/J.ACCREVIEW.2005.02.073
Risk stratification for in-hospital mortality in acutely decompensated heart failure. Classification and regression tree analysis
G. Fonarow (2005)
10.1016/j.amjcard.2016.11.019
Prognostic Value of Hypoalbuminemia After Transcatheter Aortic Valve Implantation (from the Japanese Multicenter OCEAN-TAVI Registry).
M. Yamamoto (2017)
10.1016/j.jcin.2017.06.055
Sex-Specific Grip Strength After Transcatheter Aortic Valve Replacement in Elderly Patients.
A. Kagase (2018)
10.1161/CIRCINTERVENTIONS.117.005088
Gait Speed Can Predict Advanced Clinical Outcomes in Patients Who Undergo Transcatheter Aortic Valve Replacement: Insights From a Japanese Multicenter Registry
S. Kano (2017)
10.1161/CIR.0000000000000503
2017 AHA/ACC Focused Update of the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
R. Nishimura (2017)
10.1016/j.jacc.2012.09.001
Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document.
A. Kappetein (2012)
10.1034/j.1600-0579.2003.00207.x
Handgrip Strength and Cause‐Specific and Total Mortality in Older Disabled Women: Exploring the Mechanism
T. Rantanen (2003)
10.1016/J.AMJMED.2006.04.018
Grip strength predicts cause-specific mortality in middle-aged and elderly persons.
H. Sasaki (2007)
10.1016/j.jacc.2017.03.011
2017 AHA/ACC Focused Update of the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
R. Nishimura (2017)
10.1016/j.jacc.2014.02.536
2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.
R. Nishimura (2014)
10.1016/j.jamda.2012.02.002
Predicting cause-specific mortality of older men living in the Veterans home by handgrip strength and walking speed: a 3-year, prospective cohort study in Taiwan.
Ping-Jen Chen (2012)
10.1016/j.amepre.2015.10.022
Associations of Relative Handgrip Strength and Cardiovascular Disease Biomarkers in U.S. Adults, 2011-2012.
Hannah G Lawman (2016)
10.4244/EIJY14M08_03
Impact of frailty on short- and long-term morbidity and mortality after transcatheter aortic valve implantation: risk assessment by Katz Index of activities of daily living.
M. Puls (2014)
Gender-specific grip strength after transcatheter aortic valve replacement in elderly patients. JACC Cardiovasc Interv 2017
A Kagase (2017)
10.1161/CIRCULATIONAHA.116.025630
Impact of the Clinical Frailty Scale on Outcomes After Transcatheter Aortic Valve Replacement
Tetsuro Shimura (2017)
10.1161/CIR.0000000000000031
2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.
R. Nishimura (2014)
10.1001/JAMA.293.5.572
Risk stratification for in-hospital mortality in acutely decompensated heart failure: classification and regression tree analysis.
G. Fonarow (2005)
10.1016/j.jacc.2010.06.039
Gait speed as an incremental predictor of mortality and major morbidity in elderly patients undergoing cardiac surgery.
J. Afilalo (2010)
10.1016/j.jcin.2012.06.011
The impact of frailty status on survival after transcatheter aortic valve replacement in older adults with severe aortic stenosis: a single-center experience.
P. Green (2012)



This paper is referenced by
10.5603/CJ.a2019.0038
Nutritional risk index is a better predictor of early mortality than conventional nutritional markers after trans-catheter aortic valve replacement: A prospective cohort study.
Silvia Mas-Peiró (2019)
10.1253/circj.cj-19-0096
Current Key Issues in Transcatheter Aortic Valve Replacement Undergoing a Paradigm Shift.
In-Chang Hwang (2019)
10.1007/s00259-019-04523-0
Early effects of transcatheter aortic valve replacement on cardiac sympathetic nervous function assessed by 123I-metaiodobenzylguanidine scintigraphy in patients with severe aortic valve stenosis
Y. Kadoya (2019)
10.1016/j.regg.2019.10.011
Geriatría transversal. Un reto asistencial para el siglo xxi
J. I. González-Montalvo (2020)
10.1080/24748706.2019.1630787
Non-Cardiovascular Comorbidities as Evaluated by Elixhauser Comorbidity Score in Individuals Undergoing TAVR
V. Nagaraja (2019)
10.1016/j.jcct.2018.03.007
Computed tomography-based fat and muscle characteristics are associated with mortality after transcatheter aortic valve replacement.
B. Foldyna (2018)
LITHUANIAN UNIVERSITY OF HEALTH SCIENCES MEDICAL ACADEMY FACULTY OF NURSING DEPARTMENT OF NURSING AND CARE
Sreeja Nair Radhakrishnan (2019)
10.1253/circj.CJ-17-0816
Impact of Frailty Markers for Unplanned Hospital Readmission Following Transcatheter Aortic Valve Implantation.
M. Saji (2018)
10.1161/JAHA.118.010139
Gait Speed and 1‐Year Mortality Following Cardiac Surgery: A Landmark Analysis From the Society of Thoracic Surgeons Adult Cardiac Surgery Database
J. Afilalo (2018)
Current Treatment Strategy Guided by Surgical Risk Score TAVR vs . SAVR or Standard Therapy
In-Chang Hwang (2019)
Semantic Scholar Logo Some data provided by SemanticScholar