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Salicylic Acid As A Peeling Agent: A Comprehensive Review
Published 2015 · Medicine
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Salicylic acid has been used to treat various skin disorders for more than 2,000 years. The ability of salicylic acid to exfoliate the stratum corneum makes it a good agent for peeling. In particular, the comedolytic property of salicylic acid makes it a useful peeling agent for patients with acne. Once considered as a keratolytic agent, the role of salicylic acid as a desmolytic agent, because of its ability to disrupt cellular junctions rather than breaking or lysing intercellular keratin filaments, is now recognized and is discussed here. Salicylic acid as a peeling agent has a number of indications, including acne vulgaris, melasma, photodamage, freckles, and lentigines. The efficacy and safety of salicylic acid peeling in Fitzpatrick skin types I–III as well as in skin types V and VI have been well documented in the literature. This paper reviews the available data and literature on salicylic acid as a peeling agent and its possible indications. Its properties, efficacy and safety, the peeling procedure, and possible side effects are discussed in detail. An account of salicylism is also included.
This paper references
THE PERCUTANEOUS ABSORPTION OF SALICYLIC ACID
H. Takahashi (1976)
Agents used for treatment of hyperkeratosis
BH Adam (2013)
Salicylic acid revisited.
A. Lin (1998)
Traditional topical treatment of acne.
N. Hjorth (1980)
Salicylic Acid Peels for the Treatment of Acne Vulgaris in Asian Patients
H. Lee (2003)
The effect of various ointment bases on the percutaneous absorption of salicylates. I. Effect of type of ointment base.
M. E. Stolar (1960)
THE PHARMACOLOGICAL BASIS OF THERAPEUTICS
J. H. Gaddum (1941)
Dermatopharmacology of salicylic acid. II. Epidermal antihyperplastic effect of salicylic acid in animals.
E. Weirich (1975)
Salicylic acid: an alternative to alpha-hydroxy acids
AM Kligman (1997)
An explanation for the keratolytic effect of salicylic acid
R Marks (1975)
Studies on the effect of salicylic acid on normal skin
M. Davies (1976)
Chemical peeling with salicylic acid in polyethylene glycol vehicle suppresses skin tumour development in hairless mice
T. Dainichi (2003)
Distribution and keratolytic effect of salicylic acid and urea in human skin.
M. Lodén (1995)
Effective over-the-counter acne treatments.
W. Bowe (2008)
On ointments containing salicylic acid.
S. A. Kvorning (1954)
N. Schürer (2006)
Salicylic acid in the dermatologic armamentarium
ZD Draelos (1997)
Two cases of fatal salicylate poisoning after topical application of an antifungal solution.
Lindsey Cp (1968)
Detection of the action of salicylic acid on the normal stratum corneum
D. L. Roberts (1980)
Comparative study of the effect of 50% pyruvic and 30% salicylic peels on the skin lipid film in patients with acne vulgaris
B. Marczyk (2014)
An institutional survey of tinea capitis in Harare, Zimbabwe and a trial of miconazole cream versus Whitfield's ointment in its treatment
S. Wright (1986)
The Fitzpatrick Skin Type Classification Scale
Rediscovering the cutaneous benefits of salicylic acid
ZD Draelos (1997)
R. B. Aronsohn (1984)
TWO CASES OF FATAL SALICYLATE POISONING AFTER TOPICAL APPLICATION OF AN ANTIFUNGAL SOLUTION
C. Lindsey (1968)
Salicylic Acid Peels for the Treatment of Photoaging
D. Kligman (1998)
Contact allergy to salicylic acid
C. Goh (1986)
New formulation of chemical peeling agent: 30% salicylic acid in polyethylene glycol. Absorption and distribution of 14C-salicylic acid in polyethylene glycol applied topically to skin of hairless mice.
S. Ueda (2002)
Chemical peels Cosmetic Dermatology: Principles and Practice
L Baumann (2009)
Pharmacotherapy update: current therapies and research for common dermatologic conditions. The many roles of topical salicylic acid
J. Del Rosso (2005)
Atlas of cosmetic dermatology
Zoe Kececioght Draelos (2000)
Chemexfoliation and Superficial Skin Resurfacing
P. Bourelly (2005)
The safety and efficacy of salicylic acid chemical peels in darker racial-ethnic groups.
P. Grimes (1999)
Relative bioavailability of salicylic acid following dermal application of a 30% salicylic acid skin peel preparation.
W. Fung (2008)
Applications of hydroxy acids: classification, mechanisms, and photoactivity
A. Kornhauser (2010)
Salicylic acid: not a beta-hydroxy acid
RJ Yu (1997)
Goodman and Gilman's The Pharmacological Basis of Therapeutics
K. Newhouse (1996)
Facts and Comparisons
Sister Mary Berenice (1951)
The Fitzpatrick Skin Type Classification Scale Available from
Skin Inc (2007)
Color atlas of chemical peels
A. Tosti (2006)
Salicylic acid as a peeling agent
Lipids are covalently attached to rigid corneocyte protein envelopes existing predominantly as beta-sheets: a solid-state nuclear magnetic resonance study.
N. D. Lazo (1995)
Refractory hypoglycemia secondary to topical salicylate intoxication.
R. Raschke (1991)
Chemical and mechanical skin resurfacing
GD Monheit (2003)
Chemical peels In: Wolverton SE, editor. Comprehensive Dermatologic Drug Therapy
M Kinsley (2013)
Dermatopharmacology of salicylic acid. III. Topical contra-inflammatory effect of salicylic acid and other drugs in animal experiments.
E. Weirich (1976)
[On the therapy of acne].
T. Krajewski (1961)
Evidence and considerations in the application of chemical peels in skin disorders and aesthetic resurfacing.
M. Rendon (2010)
Salicylic acid ointment peeling of the hands and forearms. Effective nonsurgical removal of pigmented lesions and actinic damage.
J. Swinehart (1992)
Update on chemical peels.
Jon E Mendelsohn (2002)
Histologic changes in the skin of hairless mice following peeling with salicylic acid.
S. Imayama (2000)
The chemistry of salicylic acid
W. Brackett (1997)
Analgesic antipyretic and anti-inflammatory agents
A Burke (2006)
Agents used for treatment of hyperkeratosis. In: Wolverton SE, editor. Comprehensive Dermatologic Drug Therapy
Bh Adam (2013)
Am J Cosmet Surg
Rb Aronsohn (1984)
Standard guidelines of care for chemical peels.
Niti Khunger (2008)
Allergic contact dermatitis to colophony included in the formulation of flexible collodion BP, the vehicle of a salicylic and lactic acid wart paint.
J. Lachapelle (1990)
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Exploring the Use of Amine Modified Mesoporous Magnesium Carbonate for the Delivery of Salicylic Acid in Topical Formulations: In Vitro Cytotoxicity and Drug Release Studies
Maria Vall (2019)
Synthesis, molecular docking and ADMET study of ionic liquid as anticancer inhibitors of DNA and COX-2, TOPII enzymes
Sefa Celik (2019)
Efficacy and safety of Jessner’s solution peel in comparison with salicylic acid 30% peel in the management of patients with acne vulgaris and postacne hyperpigmentation with skin of color: a randomized, double‐blinded, split‐face, controlled trial
K. N. How (2020)
The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study
K. Kantikosum (2019)
A toddler case of keratosis follicularis squamosa (Dohi) successfully treated with salicylic acid ointment
Y. Nakamura (2019)
Salicylic Acid for Face (Facial Salicylic Acid Peel)
Mercedes es Flórez White (2020)
Light and Temperature Effects on Metabolite Concentration in Selected Herbs and Microgreens
B. Høyen (2017)
Animal, Herb, and Microbial Toxins for Structural and Pharmacological Study of Acid-Sensing Ion Channels
D. Osmakov (2020)
Considerations on the Use of Organic Substances in Chemical Peels: A Systematic Review
Soimita Emiliana Măgerusan (2020)
Licochalcone A in Combination with Salicylic Acid as Fluid Based and Hydroxy-Complex 10% Cream for the Treatment of Mild Acne: A Multicenter Prospective Trial
F. Dall'oglio (2019)
Caractérisation moléculaire et enzymatique d’une HCT impliquée dans la biosynthèse de dérivés d’acide caféoyl-quinique chez Ipomoea batatas
Léonor Duriot (2016)
Clinical evidence for washing and cleansers in acne vulgaris: a systematic review*
T. Stringer (2018)
Comparative study of buffered 50% glycolic acid (pH 3.0) + 0.5% salicylic acid solution vs Jessner's solution in patients with acne vulgaris
Jeong In Jae (2018)
AN OVERVIEW OF DANDRUFF AND NOVEL FORMULATIONS AS A TREATMENT STRATEGY
M. Narshana (2018)
Chemical peeling for acne and melasma: current status and innovations.
C. Conforti (2019)
Thermogravimetry–mass spectrometry investigations of montmorillonite interlayer water perturbations caused by aromatic acid adsorbates
Audrey L. Ingram (2016)
Therapeutic response and safety of the topical, sequential use of antiseptic, keratolytic, and pentamidine creams (3-PACK) on Leishmania (Viannia) braziliensis-infected mice
Betsy Yaneth Muñoz (2019)
Superficial Chemical Peels
Beth Haney (2020)
Practical Introduction to Laser Dermatology
V. Madan (2020)
Preparation, Spectra and Biological Properties of Transition Metals ((III) and (II) Mixed - Ligand Complexes with 5-Chlorosalicylic Acid and L-Valine
Shatha M. H. Obaid (2019)
Rapid skin optical clearing enhancement with salicylic acid for imaging blood vessels in vivo.
Hua-Bin He (2020)
Jessner’s Peel for Extra-Facial Areas
S. Wilson (2020)
ON salicylic acid ( CAS 69-727 ) Submission
Identification of pre- and pro-haptens with a β-galactosidase-expressing E. coli culture system for skin sensitization.
M. Nepal (2019)
Synergistic efficacy of salicylic acid with a penetration enhancer on human skin monitored by OCT and diffuse reflectance spectroscopy
Q. Zhao (2016)
Chemisches Peeling in der Dermatologie
Wolfgang G Philipp-Dormston (2019)
New comonomers in malic acid polyesters
J. Telegdi (2017)
Salicylic Acid Peeling for Extra-Facial Areas
Vanesa Piquero (2020)
Superficial Chemical Peels and Microdermabrasion
R. Miest (2019)
Aesthetic Procedures: Nurse Practitioner's Guide to Cosmetic Dermatology
Beth Haney (2019)
Behavioral and physiological responses of Daphnia magna to salicylic acid
A. Szabelak (2020)
Examination of the influence of inorganic salts on the extraction of salicylic acid from aqueous solutions
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