← Back to Search
Hydrogels For Peptide Hormones Delivery: Therapeutic And Tissue Engineering Applications
Mohsen Doostmohammadi, A. Ameri, R. Mohammadinejad, Negar Dehghannoudeh, I. Banat, M. Ohadi, Gholamreza Dehghannoudeh
Published 2019 · Chemistry, Medicine
Download PDFAnalyze on Scholarcy
Abstract Peptides are the most abundant biological compounds in the cells that act as enzymes, hormones, structural element, and antibodies. Mostly, peptides have problems to move across the cells because of their size and poor cellular penetration. Therefore, a carrier that could transfer peptides into cells is ideal and would be effective for disease treatment. Until now, plenty of polymers, e.g., polysaccharides, polypeptides, and lipids were used in drug delivery. Hydrogels made from polysaccharides showed significant development in targeted delivery of peptide hormones because of their natural characteristics such as networks, pore sizes, sustainability, and response to external stimuli. The main aim of the present review was therefore, to gather the important usages of the hydrogels as a carrier in peptide hormone delivery and their application in tissue engineering and regenerative medicine.
This paper references
Cross-Linked Hydrogel for Pharmaceutical Applications: A Review
R. Parhi (2017)
Injectable and Thermosensitive Hydrogel Containing Liraglutide as a Long-Acting Antidiabetic System.
Y. Chen (2016)
The use of polyion complex micelles to enhance the oral delivery of salmon calcitonin and transport mechanism across the intestinal epithelial barrier. Biomaterials
N Li (2012)
Current challenges in non-invasive insulin delivery systems: a comparative review.
E. Khafagy (2007)
Protein and peptide parenteral controlled delivery
R. Pawar (2004)
Controlling the degradation of pH/temperature-sensitive injectable hydrogels based on poly(β-amino ester)
D. Huynh (2010)
Exenatide can reduce glucose independent of islet hormones or gastric emptying.
V. Ionut (2008)
Materials and methods for delivery of biological drugs.
A. Zelikin (2016)
Recombinant growth hormone (GH) therapy in GH-deficient adults: a long-term controlled study on daily versus thrice weekly injections.
G. Amato (2000)
Facile hydrophilic surface modification of poly(tetrafluoroethylene) using fluoroalkyl-terminated poly(ethylene glycol)s
Giyoong Tae (2003)
Synthetic Hydrogels and Their Impact on Health and Environment
Ljubiša B. Nikolić (2018)
mPEG-PLA and PLA-PEG-PLA nanoparticles as new carriers for delivery of recombinant human Growth Hormone (rhGH)
R. Ghasemi (2018)
Lipid-based nanocarriers for oral peptide delivery.
Zhigao Niu (2016)
Poly(amino carbonate urethane)-based biodegradable, temperature and pH-sensitive injectable hydrogels for sustained human growth hormone delivery
V. Phan (2016)
Thermo-responsive Temporary Plugging Agent Based on Multiple Phase Transition Supramolecular Gel
Du Guangyan (2017)
A Tripeptidyl Ensemble Perspective of Interactive Control of Growth Hormone Secretion
J. Veldhuis (2003)
Effect of intermittent systemic administration of recombinant parathyroid hormone (1-34) on mandibular fracture healing in rats.
Henry H. Rowshan (2010)
Sustained Release of Exendin 4 Using Injectable and Ionic-Nano-Complex Forming Polymer Hydrogel System for Long-Term Treatment of Type 2 Diabetes Mellitus.
Bo-Bae Seo (2019)
Oral bioavailability of insulin contained in polysaccharide nanoparticles.
B. Sarmento (2007)
Calcitonin-Loaded Thermosensitive Hydrogel for Long-Term Antiosteopenia Therapy.
Yanpeng Liu (2017)
Synthesis and characterization of novel pH-, ionic strength and temperature-sensitive hydrogel for insulin
N Rasool (2010)
Biodegradable and thermoreversible PCLA-PEG-PCLA hydrogel as a barrier for prevention of post-operative adhesion.
Z. Zhang (2011)
Recent advances in protein and Peptide drug delivery: a special emphasis on polymeric nanoparticles.
Ashaben Patel (2014)
Protein and Peptide Drug Delivery: Oral Approaches
J. Shaji (2008)
Recent Advances in Drug Delivery Systems
J. Anderson (1984)
Smart polymers for the controlled delivery of drugs – a concise overview
Honey Priya James (2014)
Time-action profile of an oral enteric insulin formulation in healthy Chinese volunteers.
J. Li (2012)
A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives
Abdul Muheem (2016)
Intestinal absorption of human insulin in pigs using delivery systems based on superporous hydrogel polymers.
F. Dorkoosh (2002)
PEGylation of somatropin (recombinant human growth hormone): impact on its clearance in humans.
R. Webster (2008)
Collagen and hyaluronic acid based polymeric blends as drug delivery systems for the release of physiological concentrations of growth hormone
M. Cascone (1994)
Fear of injections in young adults: prevalence and associations.
Yael Nir (2003)
Sustained release of parathyroid hormone via in situ cross‐linking gelatin hydrogels improves the therapeutic potential of tonsil‐derived mesenchymal stem cells for hypoparathyroidism
Y. S. Park (2018)
Hydrogels for biomedical applications.
A. Hoffman (2002)
Sustained delivery of human growth hormone from a novel gel system: SABER.
F. Okumu (2002)
Making the case: developing innovative adherence solutions for the treatment of tuberculosis
Malvika Verma (2019)
Production of insulin-loaded poly(ethylene glycol)/poly(l-lactide) (PEG/PLA) nanoparticles by gas antisolvent techniques.
N. Elvassore (2001)
Enteric-coated capsules filled with freeze-dried chitosan/poly(gamma-glutamic acid) nanoparticles for oral insulin delivery.
K. Sonaje (2010)
University Park Press
J A Parsons (1976)
Nanotechnology in insulin delivery for management of diabetes.
Fatemah Bahman (2019)
Microencapsulated chitosan nanoparticles for pulmonary protein delivery: in vivo evaluation of insulin-loaded formulations.
S. Al-Qadi (2012)
Silica nanoparticle coated liposomes: a new type of hybrid nanocapsule for proteins.
Vellore J. Mohanraj (2010)
Nanomaterials for Drug Delivery to the Central Nervous System
D. Teleanu (2019)
Therapeutic peptides: Historical perspectives, current development trends, and future directions.
Jolene L. Lau (2018)
Peptide hormones and lipopeptides: from self‐assembly to therapeutic applications
J. Hutchinson (2017)
Fundamentals of chitosan-based hydrogels: elaboration and characterization techniques
R. A. Batista (2019)
Gastrointestinal transit and mucoadhesive characteristics of complexation hydrogels in rats.
T. Goto (2006)
Instability, stabilization, and formulation of liquid protein pharmaceuticals.
W. Wang (1999)
Assessment of poly(methacrylic acid-co-N-vinyl pyrrolidone) as a carrier for the oral delivery of therapeutic proteins using Caco-2 and HT29-MTX cell lines.
D. A. Carr (2010)
Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron–sulfur protein
G. Jafari (2015)
Protein and peptide drug delivery system
D. Rao (2019)
State of the art in PEGylation: the great versatility achieved after forty years of research.
G. Pasut (2012)
Enhancement of oral bioavailability of salmon calcitonin through chitosan‐modified, dual drug‐loaded nanoparticles
L. Liu (2019)
Airway delivery of peptides and proteins using nanoparticles.
C. Dombu (2013)
Temperature- and pH-Dependent Drug Release of Block Copolymers of Methacrylic Acid and Poly(Ethylene Glycol) Methyl Ether Methacrylates
Eduardo C. Atayde (2018)
Local delivery of parathyroid hormone-related protein-derived peptides coated onto a hydroxyapatite-based implant enhances bone regeneration in old and diabetic rats.
Juan A. Ardura (2016)
Preformulation Studies of Drug Substances, Protein, and Peptides: Role in Drug Discovery and Pharmaceutical Product Development
Shantanu Bandopadhyay (2018)
Preparation and characterization of insulin-loaded acrylic hydrogels containing absorption enhancers.
T. Uchida (2001)
pHEMA hydrogels: Devices for ocular drug delivery
Neha R. Tomar (2012)
Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes
L. L. Nielsen (2004)
Hydrogels for protein deliv
T Vermonden (2012)
Molecular design and in vitro studies of novel pH-sensitive hydrogels for the oral delivery of calcitonin. Macromolecules
M Torres-Lugo (1999)
Recent developments in liposomes, microparticles and nanoparticles for protein and peptide drug delivery
M. Tan (2010)
Innovative strategies for stabilization of therapeutic peptides in aqueous formulations
Christina Avanti (2012)
Targeting of gastrointestinal tract for amended delivery of protein/peptide therapeutics: strategies and industrial perspectives.
V. Pawar (2014)
Smart Polymeric Hydrogels for Cartilage Tissue Engineering: A Review on the Chemistry and Biological Functions.
Niloofar Eslahi (2016)
Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas.
J. Eng (1992)
Investigation of the cytotoxicity and insulin transport of acrylic-based copolymer protein delivery systems in contact with Caco-2 cultures.
Aaron C Foss (2004)
Polymeric hydrogels for oral insulin delivery.
K. Chaturvedi (2013)
Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers.
E. Batrakova (2008)
Linear and Hyperbranched Copolymers of PEG-Based Acrylates and Methacrylic Acid as pH-Responsive Hydrophobic Drug Carriers
Eduardo C. Atayde Jr. (2018)
Nanoarmoring of Proteins by Conjugation to Block Copolymer Micelles.
Nisaraporn Suthiwangcharoen (2017)
Updates on smart polymeric carrier systems for protein delivery
Ibrahim M. El-Sherbiny (2017)
growth through the regulation of osteoblast proliferation and differentiation
HH Rowshan (2008)
Gas-Phase Surface Engineering of Polystyrene Beads Used to Challenge Automated Particle Inspection Systems
V. Labonté (2016)
Value of phagocyte function screening for immunotoxicity of nanoparticles in vivo
E. Fröhlich (2015)
Polysaccharides in Alternative Methods for Insulin Delivery
Ana M. Morales-Burgos (2018)
Biocompatibility of hydrogel-based scaffolds for tissue engineering applications.
S. Naahidi (2017)
Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: concepts and applications.
E. Fleige (2012)
New generation of hybrid poly/oligosaccharide nanoparticles as carriers for the nasal delivery of macromolecules.
D. Teijeiro-Osorio (2009)
Preparation of poly(methacrylic acid-g-poly(ethylene glycol)) nanospheres from methacrylic monomers for pharmaceutical applications.
C. Donini (2002)
Combination Strategy with Complexation Hydrogels and Cell-Penetrating Peptides for Oral Delivery of Insulin.
Yu Fukuoka (2018)
The Activity of Peptides of the Calcitonin Family in Bone.
D. Naot (2019)
Stability of Desmopressin Loaded in Liposomes
S. Law (2003)
A long-acting formulation of a polypeptide drug exenatide in treatment of diabetes using an injectable block copolymer hydrogel.
Kun Li (2013)
Insulin receptors and insulin action in the brain: review and clinical implications
R. Schulingkamp (2000)
Thermogelling Poly(caprolactone-b-ethylene glycol-b-caprolactone) Aqueous Solutions
S. J. Bae (2005)
Liposomal delivery of proteins and peptides
Janani Swaminathan (2012)
Classification, processing and application of hydrogels: A review.
F. Ullah (2015)
Oral insulin product hexyl-insulin monoconjugate 2 (HIM2) in type 1 diabetes mellitus: the glucose stabilization effects of HIM2.
S. Clement (2002)
Elucidation of the mechanism of incorporation of insulin in controlled release systems based on complexation polymers.
M. Morishita (2002)
Parathyroid hormone mediates bone growth through the regulation of osteoblast proliferation and differentiation.
G. Pettway (2008)
The biological efficiency and bioavailability of human growth hormone delivered using injectable, ionic, thermosensitive poly(organophosphazene)-polyethylenimine conjugate hydrogels.
Bo-Bae Seo (2011)
Complexation hydrogels for intestinal delivery of interferon beta and calcitonin.
N. Kamei (2009)
Parathyroid hormone mediates
Hybrid hyaluronan hydrogel encapsulating nanogel as a protein nanocarrier: new system for sustained delivery of protein with a chaperone-like function.
T. Hirakura (2010)
The Hypothalamic-Pituitary-Thyroid Axis: Physiological Regulation and Clinical Implications
A. Gavrila (2019)
Status and future scope of plant-based green hydrogels in biomedical engineering
Reza Mohammadinejad (2019)
Effects of Intermittent Administration of Parathyroid Hormone (1-34) on Bone Differentiation in Stromal Precursor Antigen-1 Positive Human Periodontal Ligament Stem Cells
X. Wang (2016)
Nanoparticulate biopolymers deliver insulin orally eliciting pharmacological response.
C. Reis (2008)
DIFFERENT SUPPLEMENTS FOR FINISHING OF NELLORE CATTLE ON DEFERRED Brachiaria decumbens PASTURE DURING THE DRY SEASON
Antonio Tadeu de Andrade (2015)
Growth and growth hormone in Turner syndrome: Looking back, looking ahead
E. Los (2019)
H. Tager (1974)
Evaluation of pharmacological efficacy of 'insulin-surfoplex' encapsulated polymer vesicles.
R. Rastogi (2009)
Inflammation, Hormones, and Metabolism. In: Inflammation: From Molecular and Cellular Mechanisms to the Clinic
M Khpal (2017)
Novel strategies in the oral delivery of antidiabetic peptide drugs – Insulin, GLP 1 and its analogs
R. Ismail (2017)
Basics and recent advances in peptide and protein drug delivery.
Benjamin J. Bruno (2013)
Stimuli-responsive hydrogels in drug delivery and tissue engineering
Nikhil Sood (2016)
Controlled drug delivery systems: past forward and future back.
K. Park (2014)
Hydrogels for protein delivery.
T. Vermonden (2012)
Development of oral insulin: progress and current status.
J. Still (2002)
Design and applications of interpenetrating polymer network hydrogels. A review
E. Dragan (2014)
Molecular design and in vitro studies of novel pH-sensitive hydrogels for the oral delivery of calcitonin
M. Torres-Lugo (1999)
Mucosal insulin delivery systems based on complexation polymer hydrogels: effect of particle size on insulin enteral absorption.
M. Morishita (2004)
Encapsulation of exenatide in poly-(D,L-lactide-co-glycolide) microspheres produced an investigational long-acting once-weekly formulation for type 2 diabetes.
M. DeYoung (2011)
Stability of Protein Pharmaceuticals: An Update
M. Manning (2009)
Recent advances in oral delivery of peptide hormones
Pegah Varamini (2016)
Hydrogels in pharmaceutical formulations.
N. Peppas (2000)
Developments in human growth hormone preparations: sustained-release, prolonged half-life, novel injection devices, and alternative delivery routes
Y. Cai (2014)
Archaeosomes: an excellent carrier for drug and cell delivery
G. Kaur (2016)
Protein drug stability: a formulation challenge
S. Frokjaer (2005)
Nanosphere based oral insulin delivery.
G. Carino (2000)
Degradation pathways, analytical characterization and formulation strategies of a peptide and a protein. Calcitonine and human growth hormone in comparison.
M. Cholewinski (1996)
Pulmonary sustained release of insulin from microparticles composed of polyelectrolyte layer-by-layer assembly.
Kiran Prakash Amancha (2014)
Effect of Poly (Ethylene Glycol) Molecular Weight and Microparticle Size on Oral Insulin Delivery from P(MAA‐g‐EG) Microparticles
Jennifer E López (2004)
Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering.
J. Burdick (2002)
Bicaudal‐D binds clathrin heavy chain to promote its transport and augments synaptic vesicle recycling
Xuan Li (2010)
Alternative routes of insulin delivery
D. Owens (2003)
pH-Responsive Hydrogels with Dispersed Hydrophobic Nanoparticles for the Delivery of Hydrophobic Therapeutic Agents.
C. Schoener (2012)
Hydrogel: Preparation, characterization, and applications: A review
E. Ahmed (2015)
Protein/peptide drug delivery systems: practical considerations in pharmaceutical product development
PK Deb (2019)
Enteric-coated capsules filled with freeze-dried chitosan/poly (γ-glutamic acid) nanoparticles for oral insulin
K Sonaje (2010)
Human growth hormone.
S. Almqvist (1963)
The use of polyion complex micelles to enhance the oral delivery of salmon calcitonin and transport mechanism across the intestinal epithelial barrier.
N. Li (2012)
Synthesis and characterization of novel pH-, ionic strength and temperature- sensitive hydrogel for insulin delivery
Nadia Rasool (2010)
This paper is referenced by
Topoisomerase inhibitors: pharmacology and emerging nanoscale delivery systems.
A. Dehshahri (2019)
Multifunctional Polymeric Nanoplatforms for Brain Diseases Diagnosis, Therapy and Theranostics
Shahryar Shakeri (2020)
Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review
Mahshid Moballegh Nasery (2020)