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The Effect Of Red-allotrope Selenium Nanoparticles On Head And Neck Squamous Cell Viability And Growth

Christopher Edward Hassan, Thomas J. Webster
Published 2016 · Biology, Medicine
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Given their low toxicity and natural presence in the human diet, selenium nanoparticles have been established as potential candidates for the treatment of numerous cancers. Red-allotrope selenium nanoparticles (rSeNPs) were synthesized and characterized in this study. Head and neck squamous cell carcinoma (HNSCC) and human dermal fibroblast (HDF) cells were cultured and exposed to rSeNPs at concentrations ranging from 0.01 to 100 μg rSeNP/mL media for 1–3 days. The toxicity of rSeNP toward HNSCC and HDFs was analyzed. Results indicated that the particles were approximately four times as cytotoxic toward HNSCC compared to HDFs, with their respective IC50 values at 19.22 and 59.61 μg rSeNP/mL media. Using statistical analysis, an effective dosage range for killing HNSCC cells while simultaneously minimizing damage to HDFs over a 3-day incubation period was established at 20–55 μg rSeNP/mL media. Observations showed that doses of rSeNP <5 μg rSeNP/mL media resulted in cell proliferation. Transmission electron microscopy images of HNSCC and HDF cells, both treated with rSeNPs, revealed that the rSeNPs became localized in the cytoplasm near the lysosomes and mitochondria. Analysis of cell morphology showed that the rSeNPs primarily induced HNSCC apoptosis. Collectively, these results indicated that rSeNPs are a promising option for treating HNSCC without adversely affecting healthy cells and without resorting to the use of harmful chemotherapeutics.
This paper references
10.2147/IJN.S38777
Short communication: inhibiting biofilm formation on paper towels through the use of selenium nanoparticles coatings
Qi Wang (2013)
10.2217/nnm.11.19
Nanoparticle PEGylation for imaging and therapy.
J. Jokerst (2011)
10.2147/IJN.S30940
PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction
Shanyuan Zheng (2012)
10.2147/IJN.S11513
Nano rare-earth oxides induced size-dependent vacuolization: an independent pathway from autophagy
Y. Zhang (2010)
10.1126/science.7973635
p53 status and the efficacy of cancer therapy in vivo.
S. Lowe (1994)
10.1038/352345a0
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
E. Yonish-Rouach (1991)
Selenite cytotoxicity in drug resistant and nonresistant human ovarian tumor cells.
Paula B. Caffrey (1992)
10.1126/science.1114397
Toxic Potential of Materials at the Nanolevel
A. Nel (2006)
10.1165/ajrcmb.10.4.8136153
Intraperitoneal in vivo gene therapy to deliver alpha 1-antitrypsin to the systemic circulation.
Y. Setoguchi (1994)
10.1073/pnas.90.12.5742
p53 mutations increase resistance to ionizing radiation.
J. Lee (1993)
10.2174/1568009043481614
Apoptosis is a critical cellular event in cancer chemoprevention and chemotherapy by selenium compounds.
R. Sinha (2004)
10.1021/nn202155y
Gold nanoparticles induce autophagosome accumulation through size-dependent nanoparticle uptake and lysosome impairment.
Xiaowei Ma (2011)
10.2147/IJN.S7289
Differential effects of nanoselenium doping on healthy and cancerous osteoblasts in coculture on titanium
Phong Tran (2010)
10.1099/mic.0.022038-0
In vivo measurement of cytosolic and mitochondrial pH using a pH-sensitive GFP derivative in Saccharomyces cerevisiae reveals a relation between intracellular pH and growth.
Rick Orij (2009)
Cancer Res
(1996)
10.1002/path.1711660402
P53 in tumour pathology: can we trust immunocytochemistry?
D. Wynfordthomas (1992)
Selenium and the thioredoxin redox system: effects on cell growth and death.
G. Powis (1997)
10.1038/ng1293-397
Adenovirus mediated expression of therapeutic plasma levels of human factor IX in mice
Theodore A. G. Smith (1993)
10.1093/TOXSCI/KFM221
Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: comparison with se-methylselenocysteine in mice.
J. Zhang (2008)
10.1146/annurev.bioeng.9.060906.152025
Nanotechnology applications in cancer.
Shuming Nie (2007)
10.1093/jnci/92.9.709
Evidence for a causal association between human papillomavirus and a subset of head and neck cancers.
M. Gillison (2000)
10.1001/archinte.1970.00310120093014
Physiology and physiopathology of the reticuloendothelial system.
T. M. Saba (1970)
10.1001/archoto.2009.122
A phase 2 trial of surgery with perioperative INGN 201 (Ad5CMV-p53) gene therapy followed by chemoradiotherapy for advanced, resectable squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx: report of the Southwest Oncology Group.
George H. Yoo (2009)
10.1021/ic301050v
Positive surface charge enhances selective cellular uptake and anticancer efficacy of selenium nanoparticles.
B. Yu (2012)
10.1136/mp.53.4.165
Molecular pathogenesis of oral squamous carcinoma
H. K. Williams (2000)
10.1007/978-3-319-09614-8_19
A perspective on chemoprevention by resveratrol in head and neck squamous cell carcinoma.
Sangeeta Shrotriya (2015)
10.1038/srep14361
Nanoparticles modulate autophagic effect in a dispersity-dependent manner
Dengtong Huang (2015)
10.1158/1535-7163.MCT-11-0047
The Role of Autophagy in Cancer: Therapeutic Implications
Z. J. Yang (2011)
10.1056/NEJMra001375
Head and neck cancer.
A. Forastiere (2001)
10.1016/j.scitotenv.2008.06.024
Selenium in food and the human body: a review.
M. Navarro-Alarcón (2008)
10.1016/j.jcis.2013.10.001
Colloidally stable selenium@copper selenide core@shell nanoparticles as selenium source for manufacturing of copper-indium-selenide solar cells.
Hailong Dong (2014)
10.1016/j.colsurfb.2010.11.023
Sialic acid surface decoration enhances cellular uptake and apoptosis-inducing activity of selenium nanoparticles.
J. Zheng (2011)
10.1038/ng1502
An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas
P. Roepman (2005)
10.1136/jcp.2003.007641
Molecular biology of squamous cell carcinoma of the head and neck
B. Perez-Ordóñez (2006)
10.1002/path.1711720103
p53 in tumour pathology: can we trust immunohistochemistry?--Revisited!
P. Hall (1994)
10.1038/sj.onc.1201116
p53 mediated sensitization of squamous cell carcinoma of the head and neck to radiotherapy
K. Pirollo (1997)
10.2147/IJN.S33767
Cytotoxicity of selenium nanoparticles in rat dermal fibroblasts
Joseph F Ramos (2012)
10.1016/j.biomaterials.2011.05.032
The suppression of prostate LNCaP cancer cells growth by Selenium nanoparticles through Akt/Mdm2/AR controlled apoptosis.
Ling Kong (2011)
10.1371/journal.pone.0048175
Susceptibility of Human Head and Neck Cancer Cells to Combined Inhibition of Glutathione and Thioredoxin Metabolism
Arya Sobhakumari (2012)
10.1002/ijc.20740
Trends in incidence and prognosis for head and neck cancer in the United States: a site-specific analysis of the SEER database.
A. Carvalho (2005)
10.1093/jnci/88.21.1580
p53 mutation and locoregional treatment failure in head and neck squamous cell carcinoma.
W. Koch (1996)
10.1002/cncr.20947
Recent advances in understanding the cell death pathways activated by anticancer therapy.
R. Kim (2005)
10.1002/biof.5520150103
Biological effects of a nano red elemental selenium.
J. Zhang (2001)
10.1046/j.1432-0436.2000.660209.x
Atmospheric oxygen accelerates the induction of a post-mitotic phenotype in human dermal fibroblasts: the key protective role of glutathione.
S. Alaluf (2000)
10.1016/j.freeradbiomed.2007.02.013
Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice.
H. Wang (2007)
10.1002/CHIN.201103264
Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives.
Katrin Knop (2011)
10.2147/IJN.S21729
Selenium nanoparticles inhibit Staphylococcus aureus growth
Phong Tran (2011)
10.1007/978-3-642-16483-5_3107
International Agency for Research on Cancer.
E. Somers (1985)
Human papillomavirus and cancer of the upper aerodigestive tract
R. Herrero (2003)
10.1038/362849a0
Thymocyte apoptosis induced by p53-dependent and independent pathways
A. Clarke (1993)
Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck.
J. M. Sabio (2001)
High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma.
A. Reed (1996)
10.1038/sj.onc.1208285
Gene expression signature predicts lymphatic metastasis in squamous cell carcinoma of the oral cavity
Rebekah K. O’Donnell (2005)



This paper is referenced by
10.1039/c7nr05429g
Redox-active nanomaterials for nanomedicine applications.
Christopher M. Sims (2017)
10.1016/J.COMMATSCI.2019.02.035
Adsorption and migration of selenium atoms on a hydrogen-terminated diamond (0 0 1) surface: A first-principles study
Xuejie Liu (2019)
10.3390/ijms18102209
A Summary of New Findings on the Biological Effects of Selenium in Selected Animal Species—A Critical Review
B. Hosnedlova (2017)
10.1166/jbn.2018.2521
Selenium and Iron Oxide Nanocomposites for Magnetically-Targeted Anti-Cancer Applications.
Halla Laufey Hauksdóttir (2018)
10.1002/jbm.a.36347
Synthesis and characterization of biogenic selenium nanoparticles with antimicrobial properties made by Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, and Pseudomonas aeruginosa.
David Medina Cruz (2018)
The Iraqi Journal of Veterinary Medicine, 43(1):197 – 209
Ahmed Thamer Wali (2019)
10.2147/IJN.S122666
Polyethylenimine-functionalized silver nanoparticle-based co-delivery of paclitaxel to induce HepG2 cell apoptosis
Y. Li (2016)
10.3390/ma13092077
Novel Hybrid Composites Based on PVA/SeTiO2 Nanoparticles and Natural Hydroxyapatite for Orthopedic Applications: Correlations between Structural, Morphological and Biocompatibility Properties
Simona Cavalu (2020)
10.1007/s13237-016-0183-2
Nano-Se as a novel candidate in the management of oxidative stress related disorders and cancer
Arin Bhattacharjee (2016)
10.1007/s11010-016-2839-2
Chemoprotective and chemosensitizing properties of selenium nanoparticle (Nano-Se) during adjuvant therapy with cyclophosphamide in tumor-bearing mice
Arin Bhattacharjee (2016)
10.1049/iet-nbt.2016.0107
Preparation, structural characterisation and release study of novel hybrid microspheres entrapping nanoselenium, produced by green synthesis.
Simona Cavalu (2017)
10.1007/978-3-319-48054-1_11
Role of Nutrition in Oral and Pharyngeal Cancers: From Etiology to Prevention
H. Bawadi (2017)
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