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Preparation And Evaluation Of Tacrolimus-loaded Thermosensitive Solid Lipid Nanoparticles For Improved Dermal Distribution

Ji-Hyun Kang, Jinmann Chon, Y. Kim, Hye-jung Lee, Dong-Won Oh, Hong-Goo Lee, C. Han, D. Kim, C. Park
Published 2019 · Chemistry, Medicine

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Background: Tacrolimus (TCR), also known as FK-506, is a biopharmaceutics classification system (BCS) class II drug that is insoluble in water because of its high log P values. After dermal application, TCR remains in the stratum corneum and passes through the skin layers with difficulty. Purpose: The objectives of this study were to develop and evaluate solid lipid nanoparticles (SLNs) with thermosensitive properties to improve penetration and retention. Methods: We prepared TCR-loaded thermosensitive solid lipid nanoparticles (TCR-SLNs) with different types of surfactants on the shell of the particle, which conferred the advantages of enhancing skin permeation and distribution. We also characterized them from a physic point of view and performed in vitro and in vivo evaluations. Results: The TCR contained in the prepared TCR-SLN was in an amorphous state and entrapped in the particles with a high loading efficiency. The assessment of ex vivo skin penetration using excised rat dorsal skin showed that the TCR-SLNs penetrated to a deeper layer than the reference product (0.1% Protopic®). In addition, the in vivo skin penetration test demonstrated that TCR-SLNs delivered more drug into deeper skin layers than the reference product. FT-IR images also confirmed drug distribution of TCR-SLNs into deeper layers of the skin. Conclusion: These results revealed the potential application of thermosensitive SLNs for the delivery of difficult-to-permeate, poorly water-soluble drugs into deep skin layers.
This paper references
The effect of spray drying solutions of bendroflumethiazide/polyethylene glycol on the physicochemical properties of the resultant materials.
D. Corrigan (2003)
Dermal targeting of tacrolimus using colloidal carrier systems.
A. Goebel (2011)
Novel dual-reverse thermosensitive solid lipid nanoparticle-loaded hydrogel for rectal administration of flurbiprofen with improved bioavailability and reduced initial burst effect.
Fakhar ud Din (2015)
Formulation and evaluation of spray dried liposomes of lopinavir for topical application
M. Maniyar (2018)
Development and evaluation of colloidal modified nanolipid carrier: application to topical delivery of tacrolimus, Part II--in vivo assessment, drug targeting, efficacy, and safety in treatment for atopic dermatitis.
Pallavi V Pople (2013)
Preparation and characterization of solid lipid nanoparticles containing cyclosporine by the emulsification-diffusion method
Z. Urbán-Morlán (2010)
Preparation and valuation of a topical solution containing eutectic mixture of itraconazole and phenol
C. Park (2012)
Comparison of a revaprazan-loaded solid dispersion, solid SNEDDS and inclusion compound: Physicochemical characterisation and pharmacokinetics.
J. H. Park (2018)
Correlation between long-term stability of solid lipid nanoparticles (SLN) and crystallinity of the lipid phase.
C. Freitas (1999)
Preparation of solid lipid nanoparticles by a solvent emulsification-diffusion technique.
M. Trotta (2003)
Preparation, characterization and pharmacokinetics of enrofloxacin-loaded solid lipid nanoparticles: influences of fatty acids.
Shuyu Xie (2011)
Development of tacrolimus-loaded transfersomes for deeper skin penetration enhancement and therapeutic effect improvement in vivo
L. Wei (2013)
Simultaneous Evaluation of Thermal and Non-Thermal Effects of High-Intensity Focused Ultrasound on a Tissue-Mimicking Phantom.
Y. Kim (2018)
Ultra-small lipid nanoparticles promote the penetration of coenzyme Q10 in skin cells and counteract oxidative stress.
S. Lohan (2015)
Formulations based on solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for cutaneous use: A review
A. Garcés (2018)
Multifunctional Poly(methyl vinyl ether-co-maleic anhydride)-graft-hydroxypropyl-β-cyclodextrin Amphiphilic Copolymer as an Oral High-Performance Delivery Carrier of Tacrolimus.
Dong Zhang (2015)
Nanodelivery systems for overcoming limited transportation of therapeutic molecules through the blood-brain barrier.
Ki-taek Kim (2018)
Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors
Fakhar ud Din (2017)
Preparation and Characterization of Bis-ethylhexyloxyphenolmethoxyphenyltriazine (BEMT) Loaded Solid Lipid Nano-particles (SLN)
Geun-Soo Lee (2007)
Polymeric micelle nanocarriers for the cutaneous delivery of tacrolimus: a targeted approach for the treatment of psoriasis.
M. Lapteva (2014)
Development and Evaluation of a Guideline for Monitoring Propylene Glycol Toxicity in Pediatric Intensive Care Unit Patients Receiving Continuous Infusion Lorazepam.
Lizbeth A Hansen (2015)
Solid lipid nanoparticles for the controlled delivery of poorly water soluble non-steroidal anti-inflammatory drugs.
R. Kumar (2018)
Miconazole-loaded solid lipid nanoparticles: formulation and evaluation of a novel formula with high bioavailability and antifungal activity
B. Aljaeid (2016)
smartLipids® as third solid lipid nanoparticle generation - stabilization of retinol for dermal application.
Y. Ding (2017)
Novel and effectual delivery of an antifungal agent for the treatment of persistent vulvovaginal candidiasis
Amita Sarwal (2018)
Development and evaluation of colloidal modified nanolipid carrier: application to topical delivery of tacrolimus.
Pallavi V Pople (2011)
Insoluble drug delivery strategies: review of recent advances and business prospects
Sandeep Kalepu (2015)
Effect of drug solubility and lipid carrier on drug release from lipid nanoparticles for dermal delivery
Gaith Zoubari (2017)
Image‐guided thermosensitive liposomes for focused ultrasound drug delivery: Using NIRF‐labelled lipids and topotecan to visualise the effects of hyperthermia in tumours
Miguel N. Centelles (2018)
Lipid nanoparticles for improved topical application of drugs for skin diseases.
M. Schäfer-Korting (2007)
Solid lipid Nano particles-A versatile carrier system
Anusha Rupenagunta (2016)
MRI Monitoring of Tumor-Selective Anticancer Drug Delivery with Stable Thermosensitive Liposomes Triggered by High-Intensity Focused Ultrasound.
H. R. Kim (2016)
Nanomedicines: current status and future perspectives in aspect of drug delivery and pharmacokinetics
Y. Choi (2017)
Evaluation of critical parameters for in vitro skin permeation and penetration studies using animal skin models
F. G. Praça (2018)
MRI monitoring of intratumoral drug delivery and prediction of the therapeutic effect with a multifunctional thermosensitive liposome.
T. Tagami (2011)
α-Tocopherol succinate improves encapsulation and anticancer activity of doxorubicin loaded in solid lipid nanoparticles.
M. B. Oliveira (2016)
Development of a novel celecoxib-loaded nanosuspension using a wet media milling process.
S. C. Jeong (2018)
Controlled release of insulin from pH/temperature-sensitive injectable pentablock copolymer hydrogel.
D. Huynh (2009)
Preparation and evaluation of tacrolimus-loaded nanoparticles for lymphatic delivery.
Sae-Byeok Shin (2010)
Formulation and Evaluation of Lidocaine Lipid Nanosystems for Dermal Delivery
P. Pathak (2009)
Targeting tacrolimus to deeper layers of skin with improved safety for treatment of atopic dermatitis.
Pallavi V Pople (2010)
Novel temperature-triggered liposome with high stability: formulation, in vitro evaluation, and in vivo study combined with high-intensity focused ultrasound (HIFU).
S. M. Park (2013)
Preparation and physicochemical characterization of spray-dried and jet-milled microparticles containing bosentan hydrate for dry powder inhalation aerosols
H. Lee (2016)
Review of data on the dermal penetration of mineral oils and waxes used in cosmetic applications.
T. Petry (2017)
Formulation and in vitro/in vivo evaluation of chitosan-based film forming gel containing ketoprofen
Dong-Won Oh (2017)
Light/magnetic hyperthermia triggered drug released from multi‐functional thermo‐sensitive magnetoliposomes for precise cancer synergetic theranostics
Y. Guo (2018)
Tacrolimus suppresses atopic dermatitis-associated cytokines and chemokines in monocytes.
Kai-Ting Chang (2016)
A new mechanism of thermal sensitivity for rapid drug release and low systemic toxicity in hyperthermia and thermal ablation temperature ranges
M. A. Shukor (2015)
Lipid Nanoparticles and Their Hydrogel Composites for Drug Delivery: A Review
C. Desfrançois (2018)
Improvement of Antitumor Efficacy by Combination of Thermosensitive Liposome with High-Intensity Focused Ultrasound.
Jae Min Cha (2016)
FK506-loaded solid lipid nanoparticles: Preparation, characterization and in vitro transdermal drug delivery
R. Wang (2012)
Co-delivery of chloroquine phosphate and azithromycin nanoparticles to overcome drug resistance in malaria through intracellular targeting
n jawahar (2019)
Fluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study
Shaimaa El-Housiny (2018)
Comparative assessment of efficacy and safety potential of multifarious lipid based Tacrolimus loaded nanoformulations.
S. Jain (2019)
Co-delivery of paclitaxel and TOS-cisplatin via TAT-targeted solid lipid nanoparticles with synergistic antitumor activity against cervical cancer
B. Liu (2017)
Essential oil-loaded lipid nanoparticles for wound healing
Francesca Saporito (2018)
Pharmacokinetics of 0.1% tacrolimus ointment after first and repeated application to adults with moderate to severe atopic dermatitis.
A. Rubins (2005)
Fluconazoleloaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study
S El-Housiny (2018)
Preparation and in vitro/in vivo evaluation of PLGA microspheres containing norquetiapine for long-acting injection
C. Park (2018)
Irinotecan-encapsulated double-reverse thermosensitive nanocarrier system for rectal administration
Fakhar ud Din (2017)

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Development of Topical Antibacterial gel loaded with Cefadroxil solid lipid nanoparticles: In vivo wound healing activity and epithelialization study
Farhat Fatima Mohammad Ghouse (2020)
Preparation of Ergosterol-Loaded Nanostructured Lipid Carriers for Enhancing Oral Bioavailability and Antidiabetic Nephropathy Effects
Z. Dong (2020)
Solid lipid nanoparticles: a review on recent perspectives and patents
Rishi Paliwal (2020)
Surface functionalized mesoporous silica nanoparticles for intravitreal application of tacrolimus.
Mayara Rodrigues Brandão Paiva (2020)
Effect of a Product Containing Xyloglucan and Pea Protein on a Murine Model of Atopic Dermatitis
M. Campolo (2020)
Atopic Dermatitis as a Multifactorial Skin Disorder. Can the Analysis of Pathophysiological Targets Represent the Winning Therapeutic Strategy?
Irene Magnifico (2020)
Primary Studies on Construction and Evaluation of Ion-Sensitive in situ Gel Loaded with Paeonol-Solid Lipid Nanoparticles for Intranasal Drug Delivery
Y. Sun (2020)
Nanotechnology meets atopic dermatitis: Current solutions, challenges and future prospects. Insights and implications from a systematic review of the literature
G. Damiani (2019)
Nanocarriers Mediated Cutaneous Drug Delivery.
S. Güngör (2020)
Current and Future Therapies for Psoriasis with a Focus on Serotonergic Drugs
A. M. Martins (2020)
Production, characterization, and evaluation of two types of slow-releasing carbon source tablets for in-situ heterotrophic nitrate denitrification in aquifers.
Y. Yeum (2020)
Solid Lipid Nanoparticles of Mycophenolate Mofetil: An Attempt to Control the Release of an Immunosuppressant
Asma Iqbal (2020)
Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects
S. Scioli Montoto (2020)
Trends in nanoformulations for atopic dermatitis treatment
E. V. Ramos Campos (2020)
Formulation development of lipid nanoparticles: improved lipid screening and development of tacrolimus loaded nanostructured lipid carriers (NLC).
Anđelka B. Kovačević (2019)
SLN and NLC for topical, dermal, and transdermal drug delivery
E. B. Souto (2020)
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