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Gadolinium3+-doped Mesoporous Silica Nanoparticles As A Potential Magnetic Resonance Tracer For Monitoring The Migration Of Stem Cells In Vivo

Y. Shen, Yuanzhi Shao, Haoqiang He, Y. Tan, Xiumei Tian, F. Xie, L. Li
Published 2013 · Materials Science, Medicine

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We investigated the tracking potential of a magnetic resonance imaging (MRI) probe made of gadolinium-doped mesoporous silica MCM-41 (Gd2O3@MCM-41) nanoparticles for transplanted bone mesenchymal stem cells (MSCs) and neural stem cells (NSCs) in vivo. The nanoparticles, synthesized using a one-step synthetic method, possess hexagonal mesoporous structures with appropriate assembly of nanoscale Gd2O3 clusters. They show little cytotoxicity against proliferation and have a lower effect on the inherent differentiation potential of these labeled stem cells. The tracking of labeled NSCs in murine brains was dynamically determined with a clinical 3T MRI system for at least 14 days. The migration of labeled NSCs identified by MRI corresponded to the results of immunofluorescence imaging. Our study confirms that Gd2O3@MCM-41 particles can serve as an ideal vector for long-term MRI tracking of MSCs and NSCs in vivo.
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