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The Use Of Calcium And Vitamin D In The Management Of Osteoporosis

John A Sunyecz
Published 2008 · Medicine
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Osteoporosis poses a significant public health issue, causing significant morbidity and mortality. Calcium and vitamin D utilization in the optimization of bone health is often overlooked by patients and health care providers. In addition, the optimal standard of care for osteoporosis should encompass adequate calcium and vitamin D intake. Dietary intake or supplementation with calcium and vitamin D will be reviewed, including recent recommendations for increased vitamin D intake. Compliance to calcium and vitamin D therapy is paramount for effective prevention of osteoporotic fractures. A recently released algorithm (FRAX) estimating absolute fracture risk allows the health care provider to decide when pharmacologic therapy is warranted in addition to calcium and vitamin D. When pharmacologic therapy is advised, continued use of calcium and vitamin D is recommended for optimal fracture risk reduction. A ‘bricks and mortar’ analogy is often helpful when counseling patients and this analogy will be explained. This manuscript reviews relevant data related to calcium and vitamin D use for patients at risk for fracture due to bone loss.
This paper references
2004
National Dairy Council (2008)
Estrogen therapy for osteoporosis prevention in postmenopausal women. Pharmacy Update-NIH, March/April
CE Daniels (2001)
Health Professionals' Drug Guide
M T Shannon (2000)
10.1359/jbmr.2003.18.2.343
Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial.
H. Bischoff (2003)
10.1056/NEJM199709043371003
Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older.
B. Dawson-Hughes (1997)
Vitamin D defi
P. Lips (2001)
Fracture Intervention Trial Randomized trial of effect of alendronate on risk of fracture in women with existing vertebral fractures: the Fracture Intervention Trial. FIT Research Group
Dm Black (1996)
RECORD Trial Group
AM SunyeczGrant (2005)
10.1093/ageing/afh002
A randomised, controlled comparison of different calcium and vitamin D supplementation regimens in elderly women after hip fracture: The Nottingham Neck of Femur (NONOF) Study.
R. Harwood (2004)
10.1016/j.amjmed.2005.02.007
Effects of proton pump inhibitors on calcium carbonate absorption in women: a randomized crossover trial.
M. B. O'Connell (2005)
10.4158/EP.14.3.279
Adrenal incidentalomas, 2003 to 2005: experience after publication of the National Institutes of Health consensus statement.
Leslie S Eldeiry (2008)
Standing Committee on the Scientifi c Evaluation of Dietary Reference Intakes. 1997. Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fl uoride
10.1210/jc.2006-1404
Need for additional calcium to reduce the risk of hip fracture with vitamin d supplementation: evidence from a comparative metaanalysis of randomized controlled trials.
S. Boonen (2007)
2008
National Osteoporosis Foundation (2008)
10.1016/S0140-6736(07)61342-7
Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis
B. Tang (2007)
10.1016/j.jada.2004.03.028
Vitamin D intake in the United States.
Carolyn Moore (2004)
Forteo prescribing information [online
Eli Lilly (2008)
10.1093/ajcn/76.1.187
Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994.
S. Nesby-O'Dell (2002)
Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fl uoride
(1997)
American Menopause Society Management of osteoporosis in the postmenopausal women: 2006 position statement of the North American Menopause Society
Nams North (2006)
10.1210/jcem-51-6-1359
Effect of estrogen on calcium absorption and serum vitamin D metabolites in postmenopausal osteoporosis.
J. Gallagher (1980)
Calcium, estrogen, and progestin in the treatment of osteoporosis.
Neil A. Breslau (1994)
Randomized trial of effect of alendronate on risk of fracture in women with existing vertebral fractures: the Fracture Intervention Trial
D M Black (1996)
Food and Nutrition Board Dietary reference intakes: calcium, phosphorus, magnesium, vitamin D and fl uoride
Iom (1997)
10.1172/JCI111254
An evaluation of the importance of gastric acid secretion in the absorption of dietary calcium.
G. Bo-Linn (1984)
10.1001/jama.296.24.2947
Long-term proton pump inhibitor therapy and risk of hip fracture.
Yu-Xiao Yang (2006)
Bone health and osteoporosis : a report of the Surgeon General
R Vieth (2004)
Clinical aspects of the use of vitamin D and its metabolites Osteoporosis: Pathophysiology and Clinical Management
Ir Reid (2003)
Randomized trial of effect of alendronate on risk of fracture in women with existing vertebral fractures : the Fracture Intervention Trial . FIT Research Group
DM Black (1996)
Dietary reference intakes: calcium, phosphorus, magnesium, vitamin D and fl uoride
(1997)
10.1001/jama.281.16.1505
Occult vitamin D deficiency in postmenopausal US women with acute hip fracture.
Meryl S. Leboff (1999)
National patterns of calcium use in osteoporosis in the United States.
Randall Scott Stafford (2005)
Continuing survey of food intakes by individuals
R. Rizek (1985)
The Nottingham Neck of Femur (NONOF) Study. 2004. A randomized, controlled comparison of different calcium and vitamin D supplementation regimens in elderly women after hip fracture: The NONOF study
R H Harwood
10.1161/CIRCULATIONAHA.105.171600
Heart disease and stroke statistics--2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee.
T. Thom (2006)
10.1093/ajcn/80.6.1735S
Vitamin D requirements: current and future.
C. Weaver (2004)
10.1089/jwh.2005.14.180
The role of calcium in osteoporosis drug therapy.
John A Sunyecz (2005)
Vitamin D defi ciency and secondary hyperparathyroidism in the elderly : consequences for bone loss and fractures and therapeutic implications
JA MacLaughlin (2001)
10.1016/0378-5122(95)99354-5
Rates of bone loss in postmenopausal women randomly assigned to one of two dosages of vitamin D.
B. Dawson-Hughes (1995)
10.1080/07315724.2001.10719038
Absorbability and Cost Effectiveness in Calcium Supplementation
R. Heaney (2001)
10.1001/jama.293.18.2257
Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials.
H. Bischoff-Ferrari (2005)
Bone and mineral metabolism in health and disease
FR Bringhurst (2005)
A randomized , controlled comparison of different calcium and vitamin D supplementation regimens in elderly women after hip fracture : The NONOF study
RH Harwood (2004)
Heart Disease and stroke statistics -2006 update: a report from the
T Thom (2006)
10.1002/14651858.CD004526.pub3
Calcium supplementation on bone loss in postmenopausal women.
Beverley J Shea (2004)
10.1097/01.ogx.0000180860.99260.dd
Prevalence of Vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy.
M. Holick (2005)
10.1359/jbmr.1997.12.9.1321
Calcium for prevention of osteoporotic fractures in postmenopausal women.
Robert Graham Cumming (1997)
Calcium absorption as a function of calcium intake.
Robert Proulx Heaney (1975)
10.1056/nejm198512053132319
Calcium absorption and achlorhydria.
Robert Roy Recker (1985)
A randomized , controlled comparison of different calcium and vitamin D supplementation regimens in elderly women after hip fracture : The NONOF study
RP Heaney (1975)
Forteo prescribing information
Eli Lilly
10.1007/s001980200023
Combined Calcium and Vitamin D3 Supplementation in Elderly Women: Confirmation of Reversal of Secondary Hyperparathyroidism and Hip Fracture Risk: The Decalyos II Study
M. C. Chapuy (2002)
10.1016/S0987-7053(99)80055-0
Harrison's principles of internal medicine
J. M. Guérit (1999)
10.1093/ajcn/77.6.1478
Fortification of orange juice with vitamin D: a novel approach for enhancing vitamin D nutritional health.
V. Tangpricha (2003)
10.1093/ajcn/79.3.362
Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis.
M. Holick (2004)
10.1002/14651858.CD000227
Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis.
W. Gillespie (2000)
10.1016/B978-0-323-18907-1.00059-7
Vitamin D: from photosynthesis, metabolism, and action to clinical applications
Roger Bouillon (2001)
USDA's Continuing survey of food intakes by individuals 1994-1996
10.1056/NEJMoa055218
Calcium plus vitamin D supplementation and the risk of fractures.
R. Jackson (2006)
Meta-analyses of therapies for postmenopausal osteoporosis. VIII: Meta-analysis of the efficacy of vitamin D treatment in preventing osteoporosis in postmenopausal women.
E. Papadimitropoulos (2002)
The calcium connection to bone health across a woman's lifespan: a roundtable.
S. Weisman (2005)
10.1097/01.gme.0000222475.93345.b3
Management of osteoporosis in postmenopausal women: 2006 position statement of The North American Menopause Society
(2006)
10.7326/0003-4819-120-2-199401150-00001
Calcium Supplementation with and without Hormone Replacement Therapy To Prevent Postmenopausal Bone Loss
John F Aloia (1994)
Total bone calcium in women: Effect of age and menopause status
JC Gallagher (1987)
Estrogen therapy for osteoporosis prevention in postmenopausal women
C E Daniels
Forteo prescribing information [online]. Accessed on May 12
Eli Lilly (2008)
National Osteoporosis Foundation Clinicians guide to prevention and treatment of osteoporosis [online]. Accessed on
(2008)
10.1093/ajcn/84.2.371
Absorbability and utility of calcium in mineral waters.
R. Heaney (2006)
Effect of cholecalciferal plus calcium on falling in ambulatory older men and women: a 3 year randomized controlled trial
HA Bischoff-Ferrari (2006)
Vitamin D defi ciency and secondary hyperparathyroidism in the elderly : consequences for bone loss and fractures and therapeutic implications
P Lips (2001)
10.1177/089033449501100230
Modern Nutrition in Health and Disease, 8th edition
Ann M. Twiggs (1995)
10.1097/01.SMJ.0000140865.32054.DB
Vitamin D: Important for Prevention of Osteoporosis, Cardiovascular Heart Disease, Type 1 Diabetes, Autoimmune Diseases, and Some Cancers
M. Holick (2005)
10.1126/science.6281884
Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin.
J. Maclaughlin (1982)
10.1093/ajcn/80.6.1678S
Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease.
M. Holick (2004)
10.1093/ajcn/80.6.1689S
Overview of general physiologic features and functions of vitamin D.
H. DeLuca (2004)
Vitamin D. In Modern nutrition in health and disease
MF Holick (2005)
10.1210/jc.2006-0510
Vitamin D status in relation to one-year risk of recurrent falling in older men and women.
M. Snijder (2006)
10.7326/0003-4819-126-7-199704010-00001
Comparison of Dietary Calcium with Supplemental Calcium and Other Nutrients as Factors Affecting the Risk for Kidney Stones in Women
G. Curhan (1997)
10.1016/S0140-6736(05)63013-9
Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial.
A. Grant (2005)
Clinicians guide to prevention and treatment of osteoporosis
10.1016/S0140-6736(05)61220-2
The Fracture Intervention Trial
Adrián Phillips (1997)
Department of Health and Human Services Bone health and osteoporosis: a report of the Surgeon General
Usdh (2004)
10.1093/ajcn/69.5.842
Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety.
R. Vieth (1999)
10.1172/JCI29449
Resurrection of vitamin D deficiency and rickets.
M. Holick (2006)
10.1210/JC.2007-2308
Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D.
M. Holick (2008)
NIH] National Institutes of Health consensus statement. 1994. Optimal calcium intake
10.1007/978-1-59745-459-9_13
Clinical Aspects of the Use of Vitamin D and Its Metabolites in Osteoporosis
Ian R. Reid (2010)
10.1108/nfs.2009.01739cab.005
It for Health Professionals
Russell Gurbutt (2006)
10.1056/NEJMoa010369
Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria.
L. Borghi (2002)
10.1097/00019616-199303000-00021
Vitamin D3 and calcium to prevent hip fractures in elderly women.
M. Chapuy (1992)
10.1016/0020-7292(91)90314-U
A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women.
B. Dawson-Hughes (1990)



This paper is referenced by
10.9790/1959-0602011120
Utilizing Health Belief Model to Enhance the Preventive Health Behavior about Osteoporosis among Young-Adult Females
Suzan El-Said Mansour (2017)
Barriers to food access and food security among seniors and the association between hypertension and dietary intake patterns in post-menopausal, African American women
Megan Oemichen (2015)
Review of the Risk Factor of Osteoporosis in the Malaysian Population
Mohd Sharkawi Ahmad (2015)
10.1007/s00198-018-4669-4
Bone management in hematologic stem cell transplant recipients
D.L. Kendler (2018)
10.3892/br.2018.1172
Osteogenic effects of Phlomis umbrosa via up-regulation of Runx2 in osteoporosis
Ji Eun Lee (2019)
Nutritional abnormalities in patients receiving long-term home parenteral nutrition
Sean Rhys Dodington (2018)
10.6065/apem.2020.25.1.1
Bone morbidity in pediatric acute lymphoblastic leukemia
Moon Bae Ahn (2020)
10.1021/acs.jafc.5b01468
Absorption and Bioavailability of Nano-Size Reduced Calcium Citrate Fortified Milk Powder in Ovariectomized and Ovariectomized-Osteoporosis Rats.
Arezoo Erfanian (2015)
10.1016/j.biopha.2018.09.083
Calcitriol combined with calcium chloride causes apoptosis in undifferentiated adipose tissue-derived human mesenchymal stem cells, but this effect decreases during adipogenic differentiation.
João Renato Pesarini (2018)
10.21276/IJMRP.2016.2.3.024
Vitamin D Status and its Association with BMI in Obese and Non-Obese Children in a Tertiary Care Level Hospital
Sudhir Shantilal Mavadia (2016)
Running head: OSTEOPOROSIS IN MEN 1 Osteoporosis in Men
Seunggee Hong (2015)
10.5606/ArchRheumatol.2017.6212
Vitamin D Deficiency in Axial Spondyloarthritis is Associated With Higher Disease Activity.
Sizheng Zhao Zhao (2017)
10.30635/2415-0142.2018.04.4
Nutritive Values of Passion Fruit (Passiflora Species) Seeds and Its Role in Human Health
Shiamala Devi Ramaiya (2018)
10.1038/mp.2016.213
Gestational vitamin D deficiency and autism-related traits: the Generation R Study
Anna A. E. Vinkhuyzen (2018)
Exploring the Usefulness of Peripheral and Central DualEnergy X-ray Absorptiometry Measures for Pediatric Research
Ana Raquel Ferreira Martins (2016)
10.1016/j.ajpath.2013.11.011
Bone matrix, cellularity, and structural changes in a rat model with high-turnover osteoporosis induced by combined ovariectomy and a multiple-deficient diet.
P. Govindarajan (2014)
10.1016/j.dhjo.2014.09.001
Nutrient intake and use of dietary supplements among US adults with disabilities.
Ruopeng An (2015)
10.1111/jcpt.12535
Evaluation of real‐life dosing of oral medicines with respect to fluid and food intake in a Dutch‐speaking population
Bart Hens (2017)
Addressing the needs of Malaysian postmenopausal women : a pharmacist-led osteoporosis screening programme in a teaching hospital primary-care clinic
L Toh (2016)
10.1016/j.foodchem.2015.05.092
Mineral decline due to modernization of food habits.
Christiani Jeyakumar Henry (2016)
10.1111/phpp.12311
A qualitative study of the knowledge, behaviour and attitudes of patients with skin cancer regarding sunlight exposure and vitamin D
david. rutkowski (2017)
10.1016/j.csda.2016.10.004
Non-inferiority test based on transformations for non-normal distributions
Santu Ghosh (2017)
10.3390/geriatrics3020024
Osteoporosis, Activities of Daily Living Skills, Quality of Life, and Dietary Adequacy of Congregate Meal Participants
F. Huffman (2018)
10.1111/clr.12641
Systemic vitamin D supplementation and local bone formation after maxillary sinus augmentation - a randomized, double-blind, placebo-controlled clinical investigation.
U. Schulze‐Späte (2016)
10.1007/s00296-011-2170-x
Hypovitaminosis D and response to cholecalciferol supplementation in patients with autoimmune and non-autoimmune rheumatic diseases
Pier Paolo Sainaghi (2011)
Correlates of Calcium Supplement Use in Older Community-dwelling Ontario Women
Mary N. Elias (2011)
Efecto diferencial del calcitriol y del paricalcitol sobre el proceso de calcificación en células de músculo liso vascular.Mecanismos intracelulares implicados
Julio Manuel Martinez-Moreno (2015)
Calcium supplement usage and potential health issues associated with the rate of usage in Las Vegas, NV
Tanesha Moss (2011)
The future of senior healthcare : nutritional issues and solutions for healthy aging
Dr Manfred Eggersdorfer (2018)
10.5530/JYP.2017.9.74
Potential Drug-Drug Interactions among Prescribed Drugs in Paediatric Outpatients Department of a Tertiary Care Teaching Hospital
Malkesh Mistry (2017)
10.31665/JFB.2018.3153
Gut microbiota, probiotics, prebiotics and bone health: a review
Nan Shang (2018)
10.6118/jmm.19193
Influence of Supplementary Vitamin D on Bone Mineral Density When Used in Combination with Selective Estrogen Receptor Modulators
Hyun Ju Liu (2019)
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